{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:10:25Z","timestamp":1791907825258,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":3660,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>The lateral part of the ventromedial thalamus (VM<jats:italic>l<\/jats:italic>) relays nociceptive inputs from the whole body surface to the dorsolateral frontal cortex. The aim of the present study was to investigate the effects of systemic morphine on nociceptive activity evoked in VM<jats:italic>l<\/jats:italic> neurones either by thermal (48 \u00b0C) or by supramaximal percutaneous electrical stimuli. The noxious thermal evoked responses were depressed by 10.8 \u00b1 10.1%, 48.3 \u00b1 23.0% and 67.3 \u00b1 10.1%, 5 min after i.v. injections of 1.0, 1.73 and 3.0 mg\/kg of morphine, respectively. Moreover, strong depressive effects on the A\u03b4\u2010and C\u2010fibre responses were already present 5 min after the injection. The responses were significantly reduced by 7.2 \u00b1 5.9%, 32.5 \u00b1 11.1% and 37.2 \u00b1 11.8% for A\u03b4 fibres after i.v. injections of 1.0, 1.73 and 3.0 mg\/kg of morphine, respectively. The corresponding values for C\u2010fibre evoked responses were 16.3 \u00b1 16.2%, 57.0 \u00b1 12.0% and 69.0 \u00b1 8.2%. The dose of morphine that reduced VM<jats:italic>l<\/jats:italic> neuronal nociceptive responses by 50% (1.73 mg\/kg) was around 3.5 times lower than that necessary to inhibit the responses of its spinal or medullary relays under similar experimental conditions. These results, added to the data of the literature, suggest that supraspinal effects of morphine are primarily mediated at the thalamic level. It is tempting to speculate that morphine\u2010induced reductions of attentional or psychomotor responses related to pain may be mediated by its action on VM<jats:italic>l<\/jats:italic>. \u00a9 2002 European Federation of Chapters of the International Association for the Study of Pain<\/jats:p>","DOI":"10.1053\/eujp.2001.0308","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T13:56:27Z","timestamp":1032443787000},"page":"81-87","source":"Crossref","is-referenced-by-count":13,"title":["Systemic morphine selectively depresses a thalamic link of widespread nociceptive inputs in the rat"],"prefix":"10.1002","volume":"6","author":[{"given":"L\u00e9na\u00efc","family":"Monconduit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Bourgeais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Villanueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90965-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90070-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90234-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-05-01671.1998"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90043-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903450104"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00537-6"},{"key":"e_1_2_6_9_1","first-page":"219","article-title":"Electrophysiology of opioids","volume":"35","author":"Duggan AW","year":"1984","journal-title":"Pharmacol Rev"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2149-1_11"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1978.tb08650.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(82)90149-7"},{"key":"e_1_2_6_13_1","first-page":"277","volume-title":"Electrical Stimulation of the Brain","author":"Jasper HH","year":"1961"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.60.133"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91057-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90659-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90093-8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903500307"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)93946-U"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-20-09063.1999"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1941.135.2.281"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(49)90219-9"},{"key":"e_1_2_6_23_1","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"1997"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960415)367:4<503::AID-CNE3>3.0.CO;2-8"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980105)390:1<133::AID-CNE11>3.0.CO;2-Y"},{"key":"e_1_2_6_26_1","first-page":"371","volume-title":"Progress in Brain Research","author":"Yaksh TL","year":"1988"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(99)00042-8"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Feujp.2001.0308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1053\/eujp.2001.0308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:45:34Z","timestamp":1697532334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1053\/eujp.2001.0308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1053\/eujp.2001.0308"],"URL":"https:\/\/doi.org\/10.1053\/eujp.2001.0308","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}