{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:22:45Z","timestamp":1756992165985},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>SAFE PACE is a multicentre randomized controlled trial to assess the efficacy of dual-chamber pacing in older patients with carotid sinus hypersensitivity and recurrent un-explained falls. Patients are eligible if they have had two or more unexplained falls (\u00b1 up to one syncope) and if they have a cardio-inhibitory response (&gt;3\u2009s asystole) to carotid sinus massage. Patients will be randomized to receive either a Medtronic Kappa 700(Europe)\/Kappa 400(North America) pacemaker or an implantable loop recorder (ILR)(control group). Patients will be required to complete weekly fall diaries. The primary outcome measure is the number of patients who fall in the 24-month follow-up period. Recruitment began in October 1998 and continues for 12 months; the follow-up is for 24 months.<\/jats:p>","DOI":"10.1053\/eupc.1998.0016","type":"journal-article","created":{"date-parts":[[2003,7,22]],"date-time":"2003-07-22T20:16:03Z","timestamp":1058904963000},"page":"69-72","source":"Crossref","is-referenced-by-count":22,"title":["SAFE PACE 2: Syncope and Falls in the Elderly\u2009\u2014\u2009Pacing and Carotid Sinus Evaluation"],"prefix":"10.1093","volume":"1","author":[{"given":"R. A.","family":"Kenny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,1,1]]},"reference":[{"key":"2019091808551726700_b1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1532-5415.1988.tb06155.x","article-title":"Forgetting falls: the limited accuracy of recall of falls in the elderly","volume":"36","author":"Cummings","year":"1988","journal-title":"J Am Geriatr Soc"},{"key":"2019091808551726700_b2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0002-9343(93)90261-M","article-title":"Clinical characteristics of vasodepressor, cardioinhibitory and mixed carotid sinus syndrome in the elderly","volume":"95","author":"McIntosh","year":"1993","journal-title":"Am J Med"},{"key":"2019091808551726700_b3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/hrt.47.5.411","article-title":"Carotid sinus syncope treated by pacing. Analysis of persistent symptoms and role of atrioventricular sequential pacing","volume":"47","author":"Morley","year":"1982","journal-title":"Br Heart J"},{"key":"2019091808551726700_b4","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1540-8159.1997.tb03917.x","article-title":"The rate drop response in carotid sinus syndrome: the Newcastle experience","volume":"20","author":"Bexton","year":"1997","journal-title":"PACE"},{"key":"2019091808551726700_b5","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/oxfordjournals.aje.a116681","article-title":"Incidence of and risk factors for falls and injurious falls among the community-dwelling elderly","volume":"137","author":"O'Loughlin","year":"1993","journal-title":"Am J Epidemiol"},{"key":"2019091808551726700_b6","first-page":"286","article-title":"Falls","volume-title":"Syncope in the Older Patient","author":"Rubenstein","year":"1996"},{"key":"2019091808551726700_b7","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1540-8159.1997.tb03912.x","article-title":"Prevalence of cardioinhibitory carotid sinus hypersensitivity (CICSH) in accident and emergency attendances with falls or syncope","volume":"20","author":"Richardson","year":"1997","journal-title":"PACE"},{"key":"2019091808551726700_b8","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1161\/01.CIR.92.7.1819","article-title":"The etiology of syncope in patients with negative tilt table and electrophysiological testing","volume":"92","author":"Krahn","year":"1995","journal-title":"Circulation"},{"key":"2019091808551726700_b9","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1111\/j.1540-8159.1997.tb03540.x","article-title":"Maturation of the sensed electrogram amplitude over time in a new subcutaneous implantable loop recorder","volume":"20","author":"Krahn","year":"1997","journal-title":"PACE"},{"key":"2019091808551726700_b10","first-page":"1325","article-title":"ACC\/AHA Guidelines for Implementation of Cardiac pacemakers and anti-arrhythmic devices: executive summary","volume":"97","author":"Gregorates","year":"1998","journal-title":"Circulation"},{"key":"2019091808551726700_b11","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1001\/archotol.1990.01870040046011","article-title":"The development of the dizziness handicap inventory","volume":"116","author":"Jacobson","year":"1990","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"2019091808551726700_b12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MoS 36 \u2013 item short form health survey (SF-36): conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med Care"},{"key":"2019091808551726700_b13","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/ageing\/25.5.362","article-title":"Falls presenting to the accident and emergency department\u2014types of presentation and risk factor profile","volume":"25","author":"Davies","year":"1996","journal-title":"Age and Ageing"},{"key":"2019091808551726700_b14","article-title":"Non parametric statistics for the behavioural sciences","author":"Siegel","year":"1988"},{"key":"2019091808551726700_b15","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4899-3115-3","article-title":"Modelling survival data in medical research","author":"Collet","year":"1994"},{"key":"2019091808551726700_b16","article-title":"Multi Level Statistical Models","author":"Goldstein","year":"1995"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/1\/1\/69\/30034557\/69.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T08:58:13Z","timestamp":1568797093000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/1\/1\/69\/445238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1,1]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1999,1,1]]},"published-print":{"date-parts":[[1999,1,1]]}},"URL":"https:\/\/doi.org\/10.1053\/eupc.1998.0016","relation":{},"ISSN":["1532-2092","1099-5129"],"issn-type":[{"value":"1532-2092","type":"electronic"},{"value":"1099-5129","type":"print"}],"subject":[],"published-other":{"date-parts":[[1999,1,1]]},"published":{"date-parts":[[1999,1,1]]}}}