{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:14:34Z","timestamp":1790374474355,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1053\/gast.2000.16500","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T17:58:00Z","timestamp":1122659880000},"page":"724-733","source":"Crossref","is-referenced-by-count":72,"title":["Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis"],"prefix":"10.1053","volume":"119","author":[{"given":"Taeko","family":"Dohi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohtaro","family":"Fujihashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kiyono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles O.","family":"Elson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry R.","family":"McGhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2000.16500_bib1","first-page":"135","article-title":"Immune mechanisms in chronic inflammatory bowel disease","volume":"72","author":"Braegger","year":"1994","journal-title":"Ann Allergy"},{"key":"10.1053\/gast.2000.16500_bib2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/BF00824058","article-title":"Immunopathology of human inflammatory bowel disease","volume":"18","author":"Brandtzaeg","year":"1997","journal-title":"Springer Semin Immunopathol"},{"key":"10.1053\/gast.2000.16500_bib3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin-10\u2014deficient mice develop chronic enterocolitis","volume":"75","author":"K\u00fchn","year":"1993","journal-title":"Cell"},{"key":"10.1053\/gast.2000.16500_bib4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ng0695-143","article-title":"Ulcerative colitis and adenocarcinoma of the colon in G\u03b1i2-deficient mice","volume":"10","author":"Rudolph","year":"1995","journal-title":"Nat Genet"},{"key":"10.1053\/gast.2000.16500_bib5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1084\/jem.178.1.237","article-title":"CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells","volume":"178","author":"Morrissey","year":"1993","journal-title":"J Exp Med"},{"key":"10.1053\/gast.2000.16500_bib6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/1074-7613(94)90045-0","article-title":"Inhibition of Th1 responses prevents inflammatory bowel disease in SCID mice reconstituted with CD45RBhi CD4+ T cells","volume":"1","author":"Powrie","year":"1994","journal-title":"Immunity"},{"key":"10.1053\/gast.2000.16500_bib7","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1084\/jem.183.3.847","article-title":"Cytokine imbalance and autoantibody production in T cell receptor\u2014\u03b1 mutant mice with inflammatory bowel disease","volume":"183","author":"Mizoguchi","year":"1996","journal-title":"J Exp Med"},{"key":"10.1053\/gast.2000.16500_bib8","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1053\/gast.1997.v112.pm9178680","article-title":"CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor \u03b1 chain\u2014deficient mice","volume":"112","author":"Takahashi","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2000.16500_bib9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1084\/jem.190.5.607","article-title":"Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell\u2014dominated inflammatory bowel disease in T cell receptor chain \u03b1\u2014deficient mice","volume":"190","author":"Iijima","year":"1999","journal-title":"J Exp Med"},{"key":"10.1053\/gast.2000.16500_bib10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0016-5085(99)70128-9","article-title":"The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor \u03b1 mutant mice","volume":"116","author":"Mizoguchi","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2000.16500_bib11","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1084\/jem.188.10.1929","article-title":"Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4","volume":"188","author":"Boirivant","year":"1998","journal-title":"J Exp Med"},{"key":"10.1053\/gast.2000.16500_bib12","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1084\/jem.182.5.1281","article-title":"Antibodies to interleukin-12 abrogate established experimental colitis in mice","volume":"182","author":"Neurath","year":"1995","journal-title":"J Exp Med"},{"key":"10.1053\/gast.2000.16500_bib13","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.4049\/jimmunol.157.5.2174","article-title":"Hapten-induced model of murine IBD: mucosal immune response and protection by tolerance","volume":"157","author":"Elson","year":"1996","journal-title":"J Immunol"},{"key":"10.1053\/gast.2000.16500_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0167-5699(97)01000-1","article-title":"Reciprocal IFN-\u03b3 and TGF-\u03b2 responses regulate the occurrence of mucosal inflammation","volume":"18","author":"Strober","year":"1997","journal-title":"Immunol Today"},{"key":"10.1053\/gast.2000.16500_bib15","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1084\/jem.189.8.1169","article-title":"Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses","volume":"189","author":"Dohi","year":"1999","journal-title":"J Exp Med"},{"key":"10.1053\/gast.2000.16500_bib16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4049\/jimmunol.145.1.68","article-title":"Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-\u03b3 and IL-5","volume":"145","author":"Taguchi","year":"1990","journal-title":"J Immunol"},{"key":"10.1053\/gast.2000.16500_bib17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1053\/gast.2000.16500_bib18","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1002\/eji.1830251005","article-title":"Polarized Th2 cytokine expression by both mucosal \u03b3\u03b4 and \u03b1\u03b2 T cells","volume":"25","author":"Hiroi","year":"1995","journal-title":"Eur J Immunol"},{"key":"10.1053\/gast.2000.16500_bib19","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/intimm\/5.11.1473","article-title":"Function of \u03b1\u03b2 TCR+ intestinal intraepithelial lymphocytes: Th1- and Th2-type cytokine production by CD4+ CD8\u2212 and CD4+ CD8+ T cells for helper activity","volume":"5","author":"Fujihashi","year":"1993","journal-title":"Int Immunol"},{"key":"10.1053\/gast.2000.16500_bib20","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.4049\/jimmunol.156.4.1504","article-title":"Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella","volume":"156","author":"VanCott","year":"1996","journal-title":"J Immunol"},{"key":"10.1053\/gast.2000.16500_bib0095","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/S0016-5085(99)70392-6","article-title":"Anti\u2014interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice","volume":"117","author":"Fuss","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2000.16500_bib22","first-page":"127","article-title":"Interleukin-2 and interferon-\u03b3\u2014secreting T cells in normal and disease human intestinal mucosa","volume":"78","author":"Breese","year":"1993","journal-title":"Immunology"},{"key":"10.1053\/gast.2000.16500_bib23","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2249.1995.tb03130.x","article-title":"Altered Th1\/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)","volume":"101","author":"Niessner","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"10.1053\/gast.2000.16500_bib24","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.4049\/jimmunol.157.3.1261","article-title":"Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease","volume":"157","author":"Fuss","year":"1996","journal-title":"J Immunol"},{"key":"10.1053\/gast.2000.16500_bib25","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0016-5085(97)70128-8","article-title":"Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells","volume":"112","author":"Monteleone","year":"1997","journal-title":"Gastroenterology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508500162833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508500162833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T21:55:13Z","timestamp":1683150913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508500162833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0016508500162833"],"URL":"https:\/\/doi.org\/10.1053\/gast.2000.16500","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}