{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:17:30Z","timestamp":1790097450841,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1053\/gast.2001.23246","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T17:58:00Z","timestamp":1122659880000},"page":"1128-1139","source":"Crossref","is-referenced-by-count":89,"title":["Mechanism of action of the calcium-sensing receptor in human antral gastrin cells"],"prefix":"10.1053","volume":"120","author":[{"given":"Alison M.J.","family":"Buchan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Squires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.Mark","family":"Meloche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2001.23246_bib1","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1172\/JCI119413","article-title":"Expression of the calcium-sensing receptor on human antral gastrin cells in culture","volume":"99","author":"Ray","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1053\/gast.2001.23246_bib2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/0272-6386(95)90118-3","article-title":"Sensing of extracellular calcium by parathyroid and kidney cells: cloning and characterization of an extracellular calcium-sensing receptor","volume":"25","author":"Brown","year":"1995","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/gast.2001.23246_bib3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1507\/endocrj.47.517","article-title":"Effect of calcimimetic agent, KRN568, on gastrin secretion in healthy subjects","volume":"47","author":"Igarashi","year":"2000","journal-title":"Endocrine J"},{"key":"10.1053\/gast.2001.23246_bib4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1006\/mgme.1998.2716","article-title":"Activating mutations of the Ca2+ sensing receptor","volume":"64","author":"Mancilla","year":"1998","journal-title":"Molec Gen Metab"},{"key":"10.1053\/gast.2001.23246_bib5","doi-asserted-by":"crossref","first-page":"21267","DOI":"10.1074\/jbc.273.33.21267","article-title":"Protein kinase C phosphorylation of threonine at position 888 in calcium sensing receptor (CaR) inhibits coupling to calcium store release","volume":"273","author":"Bai","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23246_bib6","first-page":"G281","article-title":"Expression of L-type voltage dependent calcium channels in human antral G cells: their role in \u03b2-adrenergic and calcium stimulated gastrin release","volume":"36","author":"Ray","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1053\/gast.2001.23246_bib7","first-page":"G227","article-title":"Bombesin-evoked gastrin release and calcium-signaling in human antral G-cells in culture","volume":"276","author":"Squires","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1053\/gast.2001.23246_bib8","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1046\/j.1460-9568.1999.00619.x","article-title":"Control of neuronal excitability by anion-sensing receptor","volume":"11","author":"Washburn","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1053\/gast.2001.23246_bib9","doi-asserted-by":"crossref","first-page":"23901","DOI":"10.1074\/jbc.274.34.23901","article-title":"Multiple protein kinase pathways are involved in gastrin-releasing peptide receptor\u2013regulated secretion","volume":"274","author":"Hellmich","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23246_bib10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0016-5085(90)91226-V","article-title":"Gastrin secretion from human antral G cells in culture","volume":"99","author":"Campos","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.23246_bib11","doi-asserted-by":"crossref","first-page":"12919","DOI":"10.1074\/jbc.270.21.12919","article-title":"Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs","volume":"270","author":"Garrett","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23246_bib12","doi-asserted-by":"crossref","first-page":"22493","DOI":"10.1074\/jbc.274.32.22493","article-title":"The role of protein kinase C isozymes in bombesin-stimulated gastrin release from human antral gastrin cells","volume":"274","author":"Moore","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23246_bib13","doi-asserted-by":"crossref","first-page":"17095","DOI":"10.1016\/S0021-9258(17)32525-5","article-title":"Background Ca2+ influx mediated by a dihydropyridine- and voltage-insensitive channel in pancreatic beta-cells. Modulation by Ni2+, diphenylamine-2-car-boxylate, and glucose metabolism","volume":"269","author":"Silva","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23246_bib14","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s004240050198","article-title":"Simultaneous presence of cAMP and cGMP exert a co-ordinated inhibitory effect on the agonist-evoked Ca2+ signal in pancreatic acinar cells","volume":"432","author":"Camello","year":"1996","journal-title":"Pflugers Arch Eur J Physiol"},{"key":"10.1053\/gast.2001.23246_bib15","first-page":"G435","article-title":"High-affinity CCK receptors are coupled to phospholipase A2 pathways to mediate pancreatic amylase secretion","volume":"269","author":"Tsunoda","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1053\/gast.2001.23246_bib16","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1046\/j.1471-4159.1998.71041405.x","article-title":"Differential effects of two protein kinase C inhibitors, calphostin C and Go6976, on pineal cyclic nucleotide accumulation","volume":"71","author":"Ogiwara","year":"1998","journal-title":"J Neurochem"},{"key":"10.1053\/gast.2001.23246_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1054\/ceca.1999.0066","article-title":"Cell surface, Ca2+ (cation)-sensing receptor(s): one or many?","volume":"26","author":"Riccardi","year":"1999","journal-title":"Cell Calcium"},{"key":"10.1053\/gast.2001.23246_bib18","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S1043-2760(98)00090-3","article-title":"Ca2+ receptor from brain to gut: common stimulus, diverse actions","volume":"9","author":"Chattopadhyay","year":"1998","journal-title":"Trends Endocrinol Metab"},{"key":"10.1053\/gast.2001.23246_bib19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1677\/joe.0.1650173","article-title":"Non\u2013Ca2+-homeostatic functions of the extracellular Ca2+-sensing receptor (CaR) in endocrine tissues","volume":"165","author":"Squires","year":"2000","journal-title":"J Endocrinol"},{"key":"10.1053\/gast.2001.23246_bib20","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0002-9343(98)00418-5","article-title":"Physiology and pathophysiology of the extracellular calcium\u2013sensing receptor","volume":"106","author":"Brown","year":"1999","journal-title":"Am J Med"},{"key":"10.1053\/gast.2001.23246_bib21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ng1194-303","article-title":"Autosomal dominant hypocalcaemia caused by Ca2+ sensing receptor gene mutation","volume":"8","author":"Pollak","year":"1994","journal-title":"Nat Genet"},{"key":"10.1053\/gast.2001.23246_bib22","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1046\/j.1523-1755.1998.00790.x","article-title":"Extracellular Mg2+ and Ca2+ sensing in mouse distal convoluted tubule cells","volume":"53","author":"Bapty","year":"1998","journal-title":"Kidney Int"},{"key":"10.1053\/gast.2001.23246_bib23","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1359\/jbmr.1998.13.4.570","article-title":"Coupling of calcium receptors to inositol phosphate and cyclic AMP generation in mammalian cells and Xenopus laevis oocytes and immunodetection of receptor protein by region-specific antisera","volume":"13","author":"Chang","year":"1998","journal-title":"J Bone Miner Res"},{"key":"10.1053\/gast.2001.23246_bib24","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1074\/jbc.273.2.1114","article-title":"Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium","volume":"273","author":"McNeil","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23246_bib25","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1172\/JCI118987","article-title":"Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells","volume":"98","author":"Pearce","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1053\/gast.2001.23246_bib26","doi-asserted-by":"crossref","first-page":"19955","DOI":"10.1074\/jbc.M909613199","article-title":"Amino acids in the second and third intracellular loops of the parathyroid Ca2+ sensing receptor mediate efficient coupling to phospholipase C","volume":"275","author":"Chang","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23246_bib27","doi-asserted-by":"crossref","first-page":"10557","DOI":"10.1074\/jbc.274.15.10557","volume":"274","author":"Liu","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23246_bib28","first-page":"81","article-title":"Protein kinase C isozyme specific modulation of cyclic AMP\u2013dependent phosphodiesterase in hypertrophic cardiomyopathic hamster hearts","volume":"49","author":"Cai","year":"1996","journal-title":"Mol Pharmacol"},{"key":"10.1053\/gast.2001.23246_bib29","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1046\/j.1432-1327.1999.00123.x","article-title":"Activation of a cGMP-stimulated cAMP phosphodiesterase by protein kinase C in a liver Golgi-endosomal fraction","volume":"259","author":"Geoffroy","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1053\/gast.2001.23246_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6603(08)60718-7","article-title":"The molecular biology of cyclic nucleotide phosphodiesterases","volume":"63","author":"Conti","year":"1999","journal-title":"Progr Nucleic Acid Res Mol Biol"},{"key":"10.1053\/gast.2001.23246_bib31","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/00001756-199302000-00021","article-title":"The calmodulin antagonist calmidazolium stimulates release of nitric oxide in neuroblastoma N1E-115 cells","volume":"4","author":"Hu","year":"1993","journal-title":"Neuroreport"},{"key":"10.1053\/gast.2001.23246_bib32","doi-asserted-by":"crossref","first-page":"A637","DOI":"10.1016\/S0016-5085(00)82441-5","article-title":"Down regulation of protein kinase C gamma inhibits bombesin-stimulated gastrin release from human antral cells (abstr)","volume":"118","author":"Ring","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.23246_bib33","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.1704151","article-title":"Generation of cAMP-activated chloride currents by expression of CFTR","volume":"251","author":"Anderson","year":"1991","journal-title":"Science"},{"key":"10.1053\/gast.2001.23246_bib34","doi-asserted-by":"crossref","first-page":"13266","DOI":"10.1074\/jbc.275.18.13266","article-title":"Engelhardt J, Kleyman TR. Epithelial sodium channels regulate cystic fibrosis transmembrane conductance regulator chloride channels in Xenopus oocytes","volume":"275","author":"Jiang","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23246_bib35","first-page":"429","article-title":"Protein kinases, protein phosphorylation and the regulation of insulin secretion from pancreatic \u03b2-cells","volume":"19","author":"Jones","year":"1998","journal-title":"Endocr Rev"},{"key":"10.1053\/gast.2001.23246_bib36","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2337\/diabetes.49.3.409","article-title":"The extracellular calcium-sensing receptor on human \u03b2-cells negatively modulates insulin secretion","volume":"49","author":"Squires","year":"2000","journal-title":"Diabetes"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508501780407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508501780407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T05:58:50Z","timestamp":1626242330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508501780407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["S0016508501780407"],"URL":"https:\/\/doi.org\/10.1053\/gast.2001.23246","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}