{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:25:34Z","timestamp":1772828734334,"version":"3.50.1"},"reference-count":65,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1053\/gast.2001.23260","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T17:58:00Z","timestamp":1122659880000},"page":"1212-1226","source":"Crossref","is-referenced-by-count":81,"title":["Expression of the peripheral-type benzodiazepine receptor and apoptosis induction in hepatic stellate cells"],"prefix":"10.1053","volume":"120","author":[{"given":"Richard","family":"Fischer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes G.","family":"Bode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"H\u00e4ussinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2001.23260_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0676.1998.tb00120.x","article-title":"Signal transduction in hepatic stellate cells","volume":"18","author":"Pinzani","year":"1998","journal-title":"Liver"},{"key":"10.1053\/gast.2001.23260_bib2","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJM199306243282508","article-title":"The cellular basis of hepatic fibrosis: mechanisms and treatment strategies","volume":"328","author":"Friedman","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1053\/gast.2001.23260_bib3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s004410051073","article-title":"The biology of liver fibrogenesis\u2014an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts","volume":"292","author":"Gressner","year":"1998","journal-title":"Cell Tissue Res"},{"issue":"suppl","key":"10.1053\/gast.2001.23260_bib4","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1111\/j.1440-1746.1995.tb01806.x","article-title":"Hepatic sinusoidal cells and sinusoidal circulation","volume":"10","author":"Tanikawa","year":"1995","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1053\/gast.2001.23260_bib5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/hep.1840190220","article-title":"Transforming growth factor-beta 1 and mannose 6-phosphate\/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat","volume":"19","author":"Saperstein","year":"1994","journal-title":"Hepatology"},{"key":"10.1053\/gast.2001.23260_bib6","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1073\/pnas.82.24.8681","article-title":"Hepatic lipocytes: the principal collagen-producing cells of normal rat liver","volume":"82","author":"Friedman","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1053\/gast.2001.23260_bib7","first-page":"141","article-title":"Comparison of sulphated glycosaminoglycan and hyaluronate synthesis and secretion in cultured hepatocytes, fat storing cells, and Kupffer cells","volume":"27","author":"Gressner","year":"1989","journal-title":"J Clin Chem Clin Biochem"},{"key":"10.1053\/gast.2001.23260_bib8","first-page":"193","article-title":"Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture","volume":"24","author":"Rockey","year":"1992","journal-title":"J Submicrosc Cytol Pathol"},{"key":"10.1053\/gast.2001.23260_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0168-8278(92)90160-Q","article-title":"Phenotypical modulation of liver fat-storing cells by retinoids. Influence on unstimulated and growth factor-induced cell proliferation","volume":"14","author":"Pinzani","year":"1992","journal-title":"J Hepatol"},{"key":"10.1053\/gast.2001.23260_bib10","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/hep.1840130628","article-title":"Tissue distribution, quantitation and proliferation kinetics of fat-storing cells in carbon tetrachloride-injured rat liver","volume":"13","author":"Geerts","year":"1991","journal-title":"Hepatology"},{"key":"10.1053\/gast.2001.23260_bib11","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/hep.510280617","article-title":"Activation of rat hepatic stellate cells in culture is associated with increased sensitivity to endothelin-1","volume":"28","author":"Reinehr","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/gast.2001.23260_bib12","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1053\/gast.1996.v110.pm8566602","article-title":"Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells","volume":"110","author":"Pinzani","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.23260_bib13","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/hep.510230634","article-title":"Comparison of glial fibrillary acidic protein and desmin staining in normal and CCl4-induced fibrotic rat livers","volume":"23","author":"Niki","year":"1996","journal-title":"Hepatology"},{"key":"10.1053\/gast.2001.23260_bib14","doi-asserted-by":"crossref","first-page":"0","DOI":"10.1055\/s-2008-1040455","article-title":"Cellular sources of noncollagenous matrix proteins: role of fat-storing cells in fibrogenesis","volume":"10","author":"Gressner","year":"1990","journal-title":"Semin Liver Dis"},{"key":"10.1053\/gast.2001.23260_bib15","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1172\/JCI114643","article-title":"Cellular distribution of transforming growth factor-\u03b2 1 and procollagen types I, III, IV transcripts in carbon tetrachloride induced rat liver fibrosis","volume":"85","author":"Nakatsukasa","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1053\/gast.2001.23260_bib16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.510290111","article-title":"Organic osmolyte transport in quiescent and activated rat hepatic stellate cells (Ito cells)","volume":"29","author":"Peters-Regehr","year":"1999","journal-title":"Hepatology"},{"key":"10.1053\/gast.2001.23260_bib17","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1042\/bj3350697","article-title":"De novo expression of glutamine synthetase during transformation of hepatic stellate cells into myofibroblast-like cells","volume":"335","author":"Bode","year":"1998","journal-title":"Biochem J"},{"key":"10.1053\/gast.2001.23260_bib18","first-page":"1265","article-title":"CD95\/ CD95L- mediated apoptosis of the hepatic stellate cell","volume":"151","author":"Saile","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1053\/gast.2001.23260_bib19","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/hep.510300144","article-title":"Transforming growth factor \u03b2 and tumor necrosis factor inhibit both apoptosis and proliferation of activated rat hepatic stellate cells","volume":"30","author":"Saile","year":"1999","journal-title":"Hepatology"},{"key":"10.1053\/gast.2001.23260_bib20","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/hep.510280229","article-title":"Transformation-dependent susceptibility of rat hepatic stellate cells to apoptosis induced by soluble Fas ligand","volume":"28","author":"Gong","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/gast.2001.23260_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nm0198-031","article-title":"Downregulation of Fas ligand by shedding","volume":"4","author":"Tanaka","year":"1998","journal-title":"Nat Med"},{"key":"10.1053\/gast.2001.23260_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.510290101","article-title":"Death receptors in liver biology and pathobiology","volume":"29","author":"Faubion","year":"1999","journal-title":"Hepatology"},{"key":"10.1053\/gast.2001.23260_bib23","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0168-8278(97)80189-4","article-title":"Apoptosis in liver disease","volume":"27","author":"Galle","year":"1997","journal-title":"J Hepatol"},{"key":"10.1053\/gast.2001.23260_bib24","first-page":"1725","article-title":"Apoptosis and hepatobiliary disease","volume":"21","author":"Patel","year":"1995","journal-title":"Hepatology"},{"key":"10.1053\/gast.2001.23260_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0167-5699(97)80014-X","article-title":"Mitochondrial control of apoptosis","volume":"18","author":"Kroemer","year":"1997","journal-title":"Immunol Today"},{"key":"10.1053\/gast.2001.23260_bib26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0005-2728(98)00110-8","article-title":"Mitochondria as regulators of apoptosis: doubt no more","volume":"1366","author":"Susin","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/gast.2001.23260_bib27","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1053\/gast.2001.23260_bib28","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","article-title":"Caspases:enemies within","volume":"281","author":"Thornberry","year":"1998","journal-title":"Science"},{"key":"10.1053\/gast.2001.23260_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Caspases: the executioners of apoptosis","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem J"},{"key":"10.1053\/gast.2001.23260_bib30","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0092-8674(00)80450-X","article-title":"Bcl-XL regulates the membrane potential and volume homeostasis of mitochondria","volume":"91","author":"Vander Heiden","year":"1997","journal-title":"Cell"},{"key":"10.1053\/gast.2001.23260_bib31","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1126\/science.281.5385.2027","article-title":"Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis","volume":"281","author":"Marzo","year":"1998","journal-title":"Science"},{"key":"10.1053\/gast.2001.23260_bib32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/0014-5793(93)80274-X","article-title":"The mitochondrial permeability transition pore may comprise VDAC moleculaes","volume":"3330","author":"Szabo","year":"1993","journal-title":"FEBS Lett"},{"key":"10.1053\/gast.2001.23260_bib33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0306-3623(96)00473-9","article-title":"Peripheral-type benzodiazepine receptors","volume":"29","author":"Zisterer","year":"1997","journal-title":"Gen Pharmacol"},{"key":"10.1053\/gast.2001.23260_bib34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2220\/biomedres.12.97","article-title":"Sensitive enzyme immunoassay for rat Mn superoxide dismutase: tissue distribution and developmental profiles in the rat central nervous tissue, liver, and kidney","volume":"12","author":"Kurobe","year":"1991","journal-title":"Biomed Res"},{"key":"10.1053\/gast.2001.23260_bib35","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0006-8993(91)90028-T","article-title":"Increase in w3 (peripheral type benzodiazepine) binding sites in the rat cortex and striatum after local injection of interleukin-1, tumor necrosis factor-\u03b1 and lipopolysaccharide","volume":"543","author":"Bourdiol","year":"1991","journal-title":"Brain Res"},{"key":"10.1053\/gast.2001.23260_bib36","first-page":"453","article-title":"Molecular and functional properties of mitochondrial benzodiazepine receptors","volume":"1241","author":"Krueger","year":"1995","journal-title":"Biochem Biophys Acta"},{"key":"10.1053\/gast.2001.23260_bib37","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/0006-2952(96)00034-2","article-title":"Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver","volume":"51","author":"Woods","year":"1996","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/gast.2001.23260_bib38","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1096\/fasebj.4.5.2155149","article-title":"Molecular biology of GABAA receptors","volume":"4","author":"Olson","year":"1990","journal-title":"FASEB J"},{"key":"10.1053\/gast.2001.23260_bib39","first-page":"222","article-title":"Peripheral-type benzodiazepine\/diazepam binding inhibitor receptor: biological role in steroidogenic cell function","volume":"12","author":"Papadopoulos","year":"1993","journal-title":"Endocr Rev"},{"key":"10.1053\/gast.2001.23260_bib40","first-page":"349","article-title":"Structural requirements for the binding of benzodiazepines to their peripheral sites","volume":"25","author":"Wang","year":"1984","journal-title":"Mol Pharmacol"},{"key":"10.1053\/gast.2001.23260_bib41","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/oxfordjournals.jbchem.a122958","article-title":"Peripheral-type benzodiazepine receptors are involved in the regulation of cholesterol side chain cleavage in adrenocortical mitochondria","volume":"106","author":"Yanagibashi","year":"1989","journal-title":"J Biochem"},{"key":"10.1053\/gast.2001.23260_bib42","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1073\/pnas.89.11.5113","article-title":"Pregnenolone biosynthesis in C6 glioma cell mitochondria: regulation by a diazepam binding inhibitor mitochondrial receptor","volume":"89","author":"Papadopoulos","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1053\/gast.2001.23260_bib43","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0006-2952(98)00149-X","article-title":"Antiproliferative and differentiating effects of benzodiazepine receptor ligands on B16 melanoma cells","volume":"56","author":"Landau","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/gast.2001.23260_bib44","first-page":"831","article-title":"Peripheral-type zodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization and PBR-mediated cell proliferation and nuclear transport of cholesterol","volume":"59","author":"Hardwick","year":"1999","journal-title":"Cancer Res"},{"key":"10.1053\/gast.2001.23260_bib45","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-2999(89)90426-3","article-title":"Peripheral benzodiazepine binding sites in Nb 2 node lymphoma cells: effects on prolactin-stimulated proliferation and ornithine decarboxylase activity","volume":"171","author":"Laird","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/gast.2001.23260_bib46","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1254\/jjp.79.177","article-title":"Benzodiazepine receptor agonists modulate thymocyte apoptosis through reduction of the mitochondrial transmembrane potential","volume":"79","author":"Tanimoto","year":"1999","journal-title":"Jpn J Pharmacol"},{"key":"10.1053\/gast.2001.23260_bib47","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1038\/sj.onc.1202625","article-title":"Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore","volume":"18","author":"Ravagnan","year":"1999","journal-title":"Oncogene"},{"key":"10.1053\/gast.2001.23260_bib48","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0006-2952(99)00215-4","article-title":"Mitochondrial peripheral-type benzodiazepine receptor expression: correlation with gonadotropin-releasing hormone agonist-induced apoptosis in the corpus luteum","volume":"58","author":"Papadopoulos","year":"1999","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/gast.2001.23260_bib49","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI1018","article-title":"Mechanism of spontaneous resolution of rat liver fibrosis","volume":"102","author":"Iredale","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1053\/gast.2001.23260_bib50","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23260_bib51","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1016\/S0021-9258(19)34062-1","article-title":"Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers","volume":"265","author":"Andree","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23260_bib52","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1126\/science.1439804","article-title":"The annexins and exocytosis","volume":"258","author":"Creutz","year":"1992","journal-title":"Science"},{"key":"10.1053\/gast.2001.23260_bib53","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-1759(95)00072-I","article-title":"A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled annexin V","volume":"184","author":"Vermes","year":"1995","journal-title":"J Immunol Methods"},{"key":"10.1053\/gast.2001.23260_bib54","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0962-8924(99)01519-6","article-title":"PTEN: a tumour suppressor that functions as a phospholipid phosphatase","volume":"9","author":"Maehama","year":"1999","journal-title":"Trends Cell Biol"},{"key":"10.1053\/gast.2001.23260_bib55","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1146\/annurev.biochem.68.1.965","article-title":"Akt\/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation","volume":"68","author":"Chan","year":"1999","journal-title":"Annu Rev Biochem"},{"key":"10.1053\/gast.2001.23260_bib56","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1101\/gad.13.15.1899","article-title":"Bcl-2 family members and the mitochondria in apoptosis","volume":"13","author":"Gross","year":"1999","journal-title":"Genes Devel"},{"key":"10.1053\/gast.2001.23260_bib57","doi-asserted-by":"crossref","first-page":"29792","DOI":"10.1074\/jbc.271.47.29792","article-title":"The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition","volume":"271","author":"Pastorino","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23260_bib58","doi-asserted-by":"crossref","first-page":"31041","DOI":"10.1016\/S0021-9258(18)47387-5","article-title":"Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone","volume":"269","author":"Pastorino","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2001.23260_bib59","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1073\/pnas.84.8.2256","article-title":"Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepine receptor","volume":"84","author":"Verma","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2001.23260_bib60","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.4049\/jimmunol.157.11.4830","article-title":"Mitochondrial permeability transition triggers lymphocyte apoptosis","volume":"157","author":"Marchetti","year":"1996","journal-title":"J Immunol"},{"key":"10.1053\/gast.2001.23260_bib61","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0024-3205(83)90794-4","article-title":"Differentiation between two different ligands for peripheral benzodiazepine binding sites, [1H]Ro5-4864 and [1H]PK11195, by thermodynamic studies","volume":"33","author":"Le Fur","year":"1983","journal-title":"Life Sci"},{"key":"10.1053\/gast.2001.23260_bib62","first-page":"533","article-title":"An endogenous protein modulates the affinity of GABA and benzodiazepine receptors in rat brain","volume":"257","author":"Guidotti","year":"1978","journal-title":"Nature"},{"key":"10.1053\/gast.2001.23260_bib63","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1073\/pnas.86.13.4897","article-title":"Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral-type benzodiazepine receptor","volume":"86","author":"Besman","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2001.23260_bib64","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0167-0115(90)90089-F","article-title":"Distribution and characterization of diazepam binding inhibitor (DBI) in peripheral tissues of rat","volume":"29","author":"Bovolin","year":"1990","journal-title":"Regul Pept"},{"key":"10.1053\/gast.2001.23260_bib65","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1074\/jbc.274.5.2938","article-title":"Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor","volume":"274","author":"Gali\u00e8gue","year":"1999","journal-title":"J Biol Chem"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508501802316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508501802316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T19:58:56Z","timestamp":1735847936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508501802316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["S0016508501802316"],"URL":"https:\/\/doi.org\/10.1053\/gast.2001.23260","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}