{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:28:03Z","timestamp":1772782083653,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2001,6]]},"DOI":"10.1053\/gast.2001.24884","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T17:58:00Z","timestamp":1122659880000},"page":"1640-1656","source":"Crossref","is-referenced-by-count":80,"title":["Cost-utility of initial medical management for Crohn's disease perianal fistulae"],"prefix":"10.1053","volume":"120","author":[{"given":"Kristen O.","family":"Arseneau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Cohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Cominelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Alfred F.","family":"Connors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2001.24884_bib1","first-page":"223","article-title":"Purchasing population health: aligning financial incentives to improve health outcomes","volume":"33","author":"Kindig","year":"1998","journal-title":"Health Services Res"},{"key":"10.1053\/gast.2001.24884_bib2","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0016-5085(98)70421-4","article-title":"Crohn's disease in Olmstead County, Minnesota, 1940-1993: Incidence, prevalence, and survival","volume":"114","author":"Loftus","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.24884_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00004836-199206000-00009","article-title":"Inflammatory bowel disease: costs-of-illness","volume":"14","author":"Hay","year":"1992","journal-title":"J Clin Gastroenterol"},{"key":"10.1053\/gast.2001.24884_bib4","first-page":"3","article-title":"Inflammatory bowel disease","volume":"34","author":"Kodner","year":"1982","journal-title":"Clin Symposia"},{"key":"10.1053\/gast.2001.24884_bib5","first-page":"336","article-title":"Anal lesions complicating Crohn's disease","volume":"80","author":"Kangas","year":"1991","journal-title":"Ann Chir Gynaecol"},{"key":"10.1053\/gast.2001.24884_bib6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0016-5085(80)90155-9","article-title":"Healing of perianal Crohn's disease with metronidazole","volume":"79","author":"Bernstein","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.24884_bib7","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0016-5085(82)80332-6","article-title":"Metronidazole therapy for perianal Crohn's disease: a follow-up study","volume":"83","author":"Brandt","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.24884_bib8","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJM198005013021801","article-title":"Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study","volume":"302","author":"Present","year":"1980","journal-title":"N Engl J Med"},{"key":"10.1053\/gast.2001.24884_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/BF01318372","article-title":"Favorable effects of 6-mercaptopurine on fistulae of Crohn's disease","volume":"30","author":"Korelitz","year":"1985","journal-title":"Dig Dis Sci"},{"key":"10.1053\/gast.2001.24884_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF02053858","article-title":"Factors related to frequency, type, and outcome of anal fistulas in Crohn's disease","volume":"38","author":"Halme","year":"1995","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2001.24884_bib11","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1136\/gut.37.5.696","article-title":"Clinical course of perianal fistulas in Crohn's disease","volume":"37","author":"Makowiec","year":"1995","journal-title":"Gut"},{"key":"10.1053\/gast.2001.24884_bib12","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/BF02068066","article-title":"Perianal Crohn's disease\u2014is it all bad news?","volume":"39","author":"McKee","year":"1996","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2001.24884_bib13","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/BF02554504","article-title":"Surgical management of anorectal fistulas in Crohn's disease","volume":"32","author":"Morrison","year":"1989","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2001.24884_bib14","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/bjs.1800781004","article-title":"Seton treatment of high anal fistulae","volume":"78","author":"Williams","year":"1991","journal-title":"Br J Surg"},{"key":"10.1053\/gast.2001.24884_bib15","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1056\/NEJM199905063401804","article-title":"Infliximab for the treatment of fistulas in patients with Crohn's disease","volume":"340","author":"Present","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1053\/gast.2001.24884_bib16","doi-asserted-by":"crossref","first-page":"A565","DOI":"10.1016\/S0016-5085(00)84396-6","article-title":"Preliminary clinical experience with infliximab in the treatment of refractory and fistulizing Crohn's disease","volume":"118","author":"Arseneau","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.24884_bib17","doi-asserted-by":"crossref","first-page":"A566","DOI":"10.1016\/S0016-5085(00)84398-X","article-title":"Infliximab therapy in 100 Crohn's disease patients: Adverse events and clinical efficacy","volume":"118","author":"Farrell","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.24884_bib18","doi-asserted-by":"crossref","first-page":"A567","DOI":"10.1016\/S0016-5085(00)84403-0","article-title":"Treatment of Crohn's disease with infliximab\u2014an initial community practice experience","volume":"118","author":"McCabe","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.24884_bib19","doi-asserted-by":"crossref","first-page":"A568","DOI":"10.1016\/S0016-5085(00)84405-4","article-title":"Infliximab for Crohn's disease in clinical practice at the Mayo Clinic: the first 100 patients","volume":"118","author":"Ricart","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.24884_bib20","doi-asserted-by":"crossref","first-page":"A569","DOI":"10.1016\/S0016-5085(00)84413-3","article-title":"Infliximab therapy for Crohn's disease fistulae: number of infusions required for response and time to relapse","volume":"118","author":"Toy","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.24884_bib21","series-title":"Red Book","article-title":"2000 Drug Topics","year":"2000"},{"key":"10.1053\/gast.2001.24884_bib22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00054725-199811000-00014","article-title":"Infliximab approved for use in Crohn's disease: a report on the FDA GI Advisory Committee conference","volume":"4","author":"Kornbluth","year":"1998","journal-title":"Inflammatory Bowel Dis"},{"key":"10.1053\/gast.2001.24884_bib23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF02258390","article-title":"Perianal abscess in Crohn's disease","volume":"40","author":"Makowiec","year":"1997","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2001.24884_bib24","doi-asserted-by":"crossref","first-page":"A568","DOI":"10.1016\/S0016-5085(00)84408-X","article-title":"Clinical efficacy of treatment with infliximab in a German multicenter, prospective, open-label trial in refractory Crohn's disease","volume":"118","author":"Schreiber","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.24884_bib25","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/BF02139102","article-title":"Perirectal abscess in Crohn's disease: drainage and outcome","volume":"33","author":"Pritchard","year":"1990","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2001.24884_bib26","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0002-9610(80)90301-3","article-title":"Anorectal Crohn's disease: definitive surgery for fistulas and recurrent abscesses","volume":"139","author":"Sohn","year":"1980","journal-title":"Am J Surg"},{"key":"10.1053\/gast.2001.24884_bib27","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1002\/(SICI)1097-0258(19980815\/30)17:15\/16<1753::AID-SIM977>3.0.CO;2-X","article-title":"Some controversies in planning and analysing multicentre trials","volume":"17","author":"Senn","year":"1998","journal-title":"Stat Med"},{"key":"10.1053\/gast.2001.24884_bib28","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/0272989X9301300409","article-title":"Markov models in medical decision making","volume":"13","author":"Sonnenberg","year":"1993","journal-title":"Med Decision Making"},{"key":"10.1053\/gast.2001.24884_bib29","series-title":"Fundamentals of Biostatistics","author":"Rosner","year":"1995"},{"key":"10.1053\/gast.2001.24884_NEWBIB1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/0016-5085(79)90386-X","article-title":"National cooperative Crohn's disease study: adverse reactions to study drugs","volume":"77","author":"Singleton","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.24884_bib31","doi-asserted-by":"crossref","first-page":"964","DOI":"10.7326\/0003-4819-132-12-200006200-00007","article-title":"The quality of reporting in published cost-utility analyses, 1976-1997","volume":"132","author":"Neumann","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1053\/gast.2001.24884_bib32","series-title":"Cost-effectiveness in health and medicine","author":"Gold","year":"1996"},{"key":"10.1053\/gast.2001.24884_bib33","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/BF02068077","article-title":"Long-term seton drainage for high anal fistulas in Crohn's disease\u2014a sphincter-saving operation?","volume":"39","author":"Faucheron","year":"1996","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2001.24884_bib34","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/BF02052212","article-title":"Seton management of complex anorectal fistulas in patients with Crohn's disease","volume":"33","author":"White","year":"1990","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2001.24884_bib35","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/BF02058706","article-title":"Perianal Crohn's disease. Results of local surgical treatment","volume":"39","author":"Sangwan","year":"1996","journal-title":"Dis Colon Rectum"},{"issue":"Suppl 8","key":"10.1053\/gast.2001.24884_bib36","first-page":"143","article-title":"Surgery for Crohn's anal fistulas","volume":"30","author":"Sugita","year":"1995","journal-title":"J Gastroenterol"},{"key":"10.1053\/gast.2001.24884_bib37","first-page":"318","article-title":"Selective surgical management of Crohn's disease of the anus","volume":"29","author":"Bernard","year":"1986","journal-title":"Can J Surg"},{"key":"10.1053\/gast.2001.24884_bib38","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/BF02054696","article-title":"Evaluation of surgery for perianal Crohn's fistulas","volume":"39","author":"Scott","year":"1996","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2001.24884_bib39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/01.CIR.81.1.91","article-title":"An analysis of the cost effectiveness of the implantable defibrillator","volume":"81","author":"Kupperman","year":"1990","journal-title":"Circulation"},{"key":"10.1053\/gast.2001.24884_bib40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1525-1497.2000.02639.x","article-title":"What is heartburn worth? A cost-utility analysis of management strategies","volume":"15","author":"Heudebert","year":"2000","journal-title":"J Gen Intern Med"},{"key":"10.1053\/gast.2001.24884_bib41","first-page":"670","article-title":"A guide for surveillance of patients with Barrett's esophagus","volume":"89","author":"Provenzale","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2001.24884_bib42","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1056\/NEJM198909213211207","article-title":"Cost effectiveness of bone marrow transplantation in acute nonlymphocytic leukemia","author":"Welch","year":"1989","journal-title":"N Engl J Med"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001650850175771X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001650850175771X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T12:14:55Z","timestamp":1586348095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001650850175771X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["S001650850175771X"],"URL":"https:\/\/doi.org\/10.1053\/gast.2001.24884","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}