{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T02:44:21Z","timestamp":1766544261831},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2001,10]]},"DOI":"10.1053\/gast.2001.28633","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T17:58:00Z","timestamp":1122659880000},"page":"757-766","source":"Crossref","is-referenced-by-count":52,"title":["Neural stem cells express RET, produce nitric oxide, and survive transplantation in the gastrointestinal tract"],"prefix":"10.1053","volume":"121","author":[{"given":"Maria\u2013Adelaide","family":"Micci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall D.","family":"Learish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bincy P.","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj Jay","family":"Pasricha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2001.28633_bib1","first-page":"129","article-title":"Isolation, characterization and utilization of CNS stem cells","author":"Ray","year":"1997"},{"key":"10.1053\/gast.2001.28633_bib2","doi-asserted-by":"crossref","first-page":"8591","DOI":"10.1073\/pnas.89.18.8591","article-title":"De novo generation of neuronal cells from the adult mouse brain","volume":"89","author":"Richards","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2001.28633_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1515\/REVNEURO.1994.5.1.43","article-title":"Proliferation of neuronal precursor cells from the central nervous system in culture","volume":"5","author":"Sensenbrenner","year":"1994","journal-title":"Rev Neurosci"},{"key":"10.1053\/gast.2001.28633_bib4","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0896-6273(93)90124-A","article-title":"bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal\/ astroglial) EGF-generated CNS progenitor cells","volume":"11","author":"Vescovi","year":"1993","journal-title":"Neuron"},{"key":"10.1053\/gast.2001.28633_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0166-2236(96)10035-7","article-title":"Is there a neural stem cell in the mammalian forebrain?","volume":"19","author":"Weiss","year":"1996","journal-title":"Trends Neurosci"},{"key":"10.1053\/gast.2001.28633_bib6","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1126\/science.287.5457.1433","article-title":"Mammalian neural stem cells","volume":"287","author":"Gage","year":"2000","journal-title":"Science"},{"key":"10.1053\/gast.2001.28633_bib7","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1073\/pnas.96.12.7029","article-title":"\u201cGlobal\u201d cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brain","volume":"96","author":"Yandava","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2001.28633_bib8","doi-asserted-by":"crossref","first-page":"11879","DOI":"10.1073\/pnas.92.25.11879","article-title":"Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain","volume":"92","author":"Gage","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2001.28633_bib9","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S1357-4310(99)01596-8","article-title":"The search for neural progenitor cells: prospects for the therapy of neurodegenerative disease","volume":"5","author":"Shihabuddin","year":"1999","journal-title":"Mol Med Today"},{"key":"10.1053\/gast.2001.28633_bib10","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1126\/science.283.5401.534","article-title":"Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo","volume":"283","author":"Bjornson","year":"1999","journal-title":"Science"},{"key":"10.1053\/gast.2001.28633_bib11","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1126\/science.288.5471.1660","article-title":"Generalized potential of adult neural stem cells","volume":"288","author":"Clarke","year":"2000","journal-title":"Science"},{"key":"10.1053\/gast.2001.28633_bib12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/86439","article-title":"Can stem cells cross lineage boundaries?","volume":"7","author":"Anderson","year":"2001","journal-title":"Nat Med"},{"key":"10.1053\/gast.2001.28633_bib13","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1126\/science.287.5457.1442","article-title":"Translating stem and progenitor cell biology to the clinic: barriers and opportunities","volume":"287","author":"Weissman","year":"2000","journal-title":"Science"},{"key":"10.1053\/gast.2001.28633_bib14","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/S0016-5085(99)70295-7","article-title":"Plasticity in the enteric nervous system","volume":"117","author":"Giaroni","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.28633_bib15","first-page":"219","article-title":"Achalasia","author":"Pasricha","year":"1997"},{"key":"10.1053\/gast.2001.28633_bib16","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1006\/exnr.1999.7127","article-title":"Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse","volume":"158","author":"Golden","year":"1999","journal-title":"Exp Neurol"},{"key":"10.1053\/gast.2001.28633_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0959-4388(99)00048-3","article-title":"The GDNF family ligands and receptors-implications for neural development","volume":"10","author":"Baloh","year":"2000","journal-title":"Curr Opin Neurobiol"},{"key":"10.1053\/gast.2001.28633_bib18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-3806(00)00064-X","article-title":"Inhibition of mitogen-activated protein kinase kinase blocks proliferation of neural progenitor cells","volume":"122","author":"Learish","year":"2000","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1053\/gast.2001.28633_bib19","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJM199604253341707","article-title":"The enteric nervous system","volume":"334","author":"Goyal","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1053\/gast.2001.28633_bib20","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0016-5085(93)90407-4","article-title":"Nitric oxide mediates inhibitory nerve input in human and canine jejunum","volume":"104","author":"Stark","year":"1993","journal-title":"Gastro-enterology"},{"key":"10.1053\/gast.2001.28633_bib21","first-page":"285","article-title":"Role of nitric oxide as an inhibitory neurotransmitter in the gastrointestinal tract","author":"Sanders","year":"1992"},{"key":"10.1053\/gast.2001.28633_bib22","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1089\/neu.1999.16.675","article-title":"Transplantation of neural progenitor and stem cells: developmental in-sights may suggest new therapies for spinal cord and other CNS dysfunction","volume":"16","author":"Park","year":"1999","journal-title":"J Neurotrauma"},{"key":"10.1053\/gast.2001.28633_bib23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1034\/j.1399-0004.1999.560403.x","article-title":"Neural stem cells: a versatile tool for cell replacement and gene therapy in the central nervous system","volume":"56","author":"Ourednik","year":"1999","journal-title":"Clin Genet"},{"key":"10.1053\/gast.2001.28633_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0079-6123(00)27003-9","article-title":"Neural stem cells in the developing central nervous system: implications for cell therapy through transplantation","volume":"127","author":"Svendsen","year":"2000","journal-title":"Prog Brain Res"},{"key":"10.1053\/gast.2001.28633_bib25","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1126\/science.287.5457.1442","article-title":"Translating stem and progenitor cell biology to the clinic: barriers and opportunities","volume":"287","author":"Weissman","year":"2000","journal-title":"Science"},{"key":"10.1053\/gast.2001.28633_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0166-2236(99)01428-9","article-title":"New prospects for human stem-cell therapy in the nervous system","volume":"22","author":"Svendsen","year":"1999","journal-title":"Trends Neurosci"},{"key":"10.1053\/gast.2001.28633_bib27","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)80583-8","article-title":"Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells","volume":"96","author":"Morrison","year":"1999","journal-title":"Cell"},{"key":"10.1053\/gast.2001.28633_bib28","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/3473","article-title":"Engraft-able human neural stem cells respond to developmental cues, replace neurons, and express foreign genes","volume":"16","author":"Flax","year":"1998","journal-title":"Nat Biotechnol"},{"key":"10.1053\/gast.2001.28633_bib29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0304-3940(96)12324-7","article-title":"Neuronal nitric oxide synthase expression in neuronal cell differentiation","volume":"204","author":"Ogura","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1053\/gast.2001.28633_bib30","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s004410051309","article-title":"Differential expression of nitric oxide synthases in EGF-responsive mouse neural precursor cells","volume":"296","author":"Wang","year":"1999","journal-title":"Cell Tissue Res"},{"key":"10.1053\/gast.2001.28633_bib31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/dbio.1998.8955","article-title":"Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro","volume":"200","author":"Hueckeroth","year":"1998","journal-title":"Dev Biol"},{"key":"10.1053\/gast.2001.28633_bib32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1242\/dev.126.1.157","article-title":"Multipotential progenitors of the mammalian enteric nervous system capable of colonizing aganglionic bowel in organ culture","volume":"126","author":"Natarajan","year":"1999","journal-title":"Development"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001650850116631X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001650850116631X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T06:00:50Z","timestamp":1626242450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001650850116631X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["S001650850116631X"],"URL":"https:\/\/doi.org\/10.1053\/gast.2001.28633","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2001,10]]}}}