{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:13:01Z","timestamp":1787004781629,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1053\/gast.2001.29332","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T13:58:00Z","timestamp":1122645480000},"page":"1120-1126","source":"Crossref","is-referenced-by-count":162,"title":["Helicobacter pylori eradication does not exacerbate reflux symptoms in gastroesophageal reflux disease"],"prefix":"10.1053","volume":"121","author":[{"given":"Paul","family":"Moayyedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandu","family":"Bardhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony T.R.","family":"Axon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl 2","key":"10.1053\/gast.2001.29332_bib1","first-page":"S51","article-title":"Helicobacter pylori and reflux disease","volume":"11","author":"Dent","year":"1999","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/gast.2001.29332_bib2","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJM199604183341603","article-title":"Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication","volume":"334","author":"Kuipers","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1053\/gast.2001.29332_bib3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1046\/j.1523-5378.2000.00032.x","article-title":"Changing patterns of gastritis in long-standing acid suppression: effect of Helicobacter pylori eradication","volume":"5","author":"Moayyedi","year":"2000","journal-title":"Helicobacter"},{"key":"10.1053\/gast.2001.29332_bib4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1080\/110241598750005381","article-title":"Outcome of open antireflux surgery as assessed in a Nordic multicentre prospective clinical trial","volume":"164","author":"Lundell","year":"1998","journal-title":"Eur J Surg"},{"key":"10.1053\/gast.2001.29332_bib5","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/S0016-5085(97)70024-6","article-title":"Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux esophagitis","volume":"112","author":"Labenz","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.29332_bib6","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/j.1572-0241.2000.01929.x","article-title":"Is Helicobacter pylori eradication associated with gastroesophageal reflux disease?","volume":"95","author":"Fallone","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2001.29332_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1365-2036.2000.00677.x","article-title":"Recurrent symptoms and gastrooesophageal reflux disease in patients with duodenal ulcer treated for Helicobacter pylori infection","volume":"14","author":"Vakil","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/gast.2001.29332_bib8","first-page":"101","article-title":"Symptomatic benefit 1-3 years after H. pylori eradication in ulcer patients: impact of gastroesophageal reflux disease","volume":"95","author":"McColl","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2001.29332_bib9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1365-2036.2000.00714.x","article-title":"Helicobacter pylori infection is associated with milder gastro-oesophageal reflux disease","volume":"14","author":"Wu","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/gast.2001.29332_bib10","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1053\/gast.1996.v110.pm8608881","article-title":"Helicobacter pyloriaugments the pH-increasing effect of omeprazole in patients with duodenal ulcer","volume":"110","author":"Labenz","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.29332_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0016-5085(99)70544-5","article-title":"Gastric Helicobacter pylori infection accelerates healing of reflux esophagitis during treatment with the proton pump inhibitor pantoprazole","volume":"117","author":"Holtmann","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.29332_bib12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0016-5085(99)70118-6","article-title":"Rebound hypersecretion after omeprazole and its relation to on-treatment acid suppression and Helicobacter pylori status","volume":"116","author":"Gillen","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.29332_bib13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/00042737-199703000-00010","article-title":"Do patients need to fast for a 13C-urea breath test?","volume":"9","author":"Moayyedi","year":"1997","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/gast.2001.29332_bib14","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1136\/gut.35.5.590","article-title":"Omeprazole v ranitidine for prevention of relapse in reflux oesophagitis. A controlled double blind trial of their efficacy and safety","volume":"35","author":"Dent","year":"1994","journal-title":"Gut"},{"issue":"suppl 1","key":"10.1053\/gast.2001.29332_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000200917","article-title":"Appropriate acid suppression for the management of gastro-esophageal reflux disease","volume":"52","author":"Bell","year":"1992","journal-title":"Digestion"},{"key":"10.1053\/gast.2001.29332_bib16","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1136\/bmj.319.7209.550","article-title":"Heartburn treatment in primary care: randomised, double blind study for 8 weeks","volume":"319","author":"Hatlebakk","year":"1999","journal-title":"BMJ"},{"key":"10.1053\/gast.2001.29332_bib17","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0016-5085(00)70135-1","article-title":"Long-term omeprazole treatment in resistant gastroesophageal reflux disease: efficacy, safety, and influence on gastric mucosa","volume":"118","author":"Klinkenberg-Knol","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.29332_bib18","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1046\/j.1365-2036.1999.00556.x","article-title":"The influence of Helicobacter pylori on oesophageal acid exposure in GERD during acid suppressive therapy","volume":"13","author":"Peters","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/gast.2001.29332_bib19","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1046\/j.1365-2036.1999.00544.x","article-title":"The effect of Helicobacter pylori eradication on gastro-oesophageal reflux","volume":"13","author":"Tefera","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/gast.2001.29332_bib20","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/0016-5085(91)90644-Z","article-title":"Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status","volume":"100","author":"Graham","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.29332_bib21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1046\/j.1523-5378.1998.08031.x","article-title":"H. pylori and cagA: relationships with gastric cancer, duodenal ulcer, and reflux esophagitis and its complications","volume":"3","author":"Graham","year":"1998","journal-title":"Helicobacter"},{"key":"10.1053\/gast.2001.29332_bib22","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0016-5085(99)70492-0","article-title":"Duodenogastroesophageal reflux and esophageal mucosal injury in mechanically ventilated patients","volume":"116","author":"Wilmer","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.29332_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0140-6736(90)90287-F","article-title":"Symptoms in gastro-oesophageal reflux disease","volume":"335","author":"Klauser","year":"1990","journal-title":"Lancet"},{"key":"10.1053\/gast.2001.29332_bib24","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1111\/j.1572-0241.1999.01502.x","article-title":"The usefulness of the likelihood ratio in the diagnosis of dyspepsia and gastroesophageal reflux disease","volume":"94","author":"Moayyedi","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2001.29332_bib25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1046\/j.1365-2036.2000.00733.x","article-title":"The omeprazole test is as sensitive as 24-h oesophageal pH monitoring in diagnosing gastro-oesophageal reflux disease in symptomatic patients with erosive oesophagitis","volume":"14","author":"Fass","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/gast.2001.29332_bib26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0002-9343(99)00219-3","article-title":"The cost-effectiveness of the omeprazole test in patients with noncardiac chest pain","volume":"107","author":"Ofman","year":"1999","journal-title":"Am J Med"},{"key":"10.1053\/gast.2001.29332_bib27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0016-5085(98)70364-6","article-title":"The seroprevalence of cagA-positive Helicobacter pylori strains in the spectrum of gastroesophageal reflux disease","volume":"115","author":"Vicari","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2001.29332_bib28","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1572-0241.2000.01970.x","article-title":"Association of Helicobacter pylori genotype with gastroesophageal reflux disease and other upper gastrointestinal diseases","volume":"95","author":"Fallone","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2001.29332_bib29","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/bmj.321.7262.659","article-title":"Systematic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia","volume":"321","author":"Moayyedi","year":"2000","journal-title":"BMJ"},{"key":"10.1053\/gast.2001.29332_bib30","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0140-6736(00)02236-4","article-title":"The effect of population H. pylori screening and treatment on dyspepsia and quality of life in the community: results of a randomised controlled trial","volume":"355","author":"Moayyedi","year":"2000","journal-title":"Lancet"},{"key":"10.1053\/gast.2001.29332_bib31","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1111\/j.1572-0241.1999.01593.x","article-title":"Helicobacter pylori infection inhibits reflux esophagitis by inducing atrophic gastritis","volume":"94","author":"Koike","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2001.29332_bib32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1046\/j.1523-5378.2000.00003.x","article-title":"Negative association between Helicobacter pylori infection and reflux esophagitis in older patients: case-control study in Japan","volume":"5","author":"Haruma","year":"2000","journal-title":"Helicobacter"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508501569978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508501569978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T11:14:09Z","timestamp":1552130049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508501569978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S0016508501569978"],"URL":"https:\/\/doi.org\/10.1053\/gast.2001.29332","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}