{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:08:59Z","timestamp":1792807739459,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1053\/gast.2002.32362","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T13:58:00Z","timestamp":1122645480000},"page":"875-880","source":"Crossref","is-referenced-by-count":981,"title":["The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota"],"prefix":"10.1053","volume":"122","author":[{"given":"David A.","family":"Schwartz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Edward V.","family":"Loftus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Tremaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remo","family":"Panaccione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.Scott","family":"Harmsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Zinsmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Sandborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2002.32362_bib1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/gut.29.5.588","article-title":"Perforating and non-perforating indications for repeated operations in Crohn's disease: evidence for two clinical forms","volume":"29","author":"Greenstein","year":"1988","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32362_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00054725-200002000-00002","article-title":"A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998","volume":"6","author":"Gasche","year":"2000","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/gast.2002.32362_bib3","first-page":"141","article-title":"Proposed classification of patient subgroups in Crohn's disease","volume":"5","author":"Sachar","year":"1992","journal-title":"Gastroenterol Int"},{"key":"10.1053\/gast.2002.32362_bib4","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1136\/gut.14.11.865","article-title":"Abscess and fistulae in Crohn's disease","volume":"14","author":"Steinberg","year":"1973","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32362_bib5","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/0016-5085(79)90391-3","article-title":"National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications","volume":"77","author":"Rankin","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32362_bib6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0016-5085(75)80270-8","article-title":"Clinical patterns in Crohn's disease: a statistical study of 615 cases","volume":"68","author":"Farmer","year":"1975","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32362_bib7","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1136\/gut.21.6.525","article-title":"Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease","volume":"21","author":"Hellers","year":"1980","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32362_bib8","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0016-5085(98)70421-4","article-title":"Crohn's disease in Olmsted County, Minnesota, 1940\u20131993: incidence, prevalence and survival","volume":"114","author":"Loftus","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32362_bib9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4065\/71.3.266","article-title":"History of the Rochester Epidemiology Project","volume":"71","author":"Melton","year":"1996","journal-title":"Mayo Clin Proc"},{"key":"10.1053\/gast.2002.32362_bib10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/scientificamerican1081-54","article-title":"The patient record in epidemiology","volume":"245","author":"Kurland","year":"1981","journal-title":"Sci Am"},{"key":"10.1053\/gast.2002.32362_bib11","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1056\/NEJM199711133372012","article-title":"The threat to medical-records research","volume":"337","author":"Melton","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1053\/gast.2002.32362_bib12","first-page":"A810","article-title":"Phenotypic classification of Crohn's disease patients in Olmsted County, Minnesota: application of the Vienna classification","volume":"116","author":"Panaccione","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32362_bib13","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1136\/gut.37.5.696","article-title":"Clinical course of perianal fistulas in Crohn's disease","volume":"37","author":"Makowiec","year":"1995","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32362_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF02053858","article-title":"Factors related to frequency, type, and outcome of anal fistulas in Crohn's disease","volume":"38","author":"Halme","year":"1995","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2002.32362_bib15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF02054227","article-title":"Twenty-year review of the surgical management of perianal Crohn's disease","volume":"38","author":"Williamson","year":"1995","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2002.32362_bib16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/bjs.1800680802","article-title":"Anal fistulas in Crohn's disease","volume":"68","author":"Marks","year":"1981","journal-title":"Br J Surg"},{"key":"10.1053\/gast.2002.32362_bib17","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/BF02053687","article-title":"Fistula-in-ano in Crohn's disease","volume":"34","author":"Williams","year":"1991","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2002.32362_bib18","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/BF02587272","article-title":"Crohn's disease: anal lesions","volume":"18","author":"Lockhart-Mummery","year":"1975","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2002.32362_bib19","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0016-5085(80)90402-3","article-title":"Healing of perineal Crohn's disease with metronidazole (letter)","volume":"79","author":"Bernstein","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32362_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF02052437","article-title":"Management of perianal Crohn's disease. Results of a multicenter study in Italy","volume":"38","author":"Pescatori","year":"1995","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2002.32362_bib21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/BF02058706","article-title":"Perianal Crohn's disease. Results of local surgical treatment","volume":"39","author":"Sangwan","year":"1996","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2002.32362_bib22","first-page":"1","article-title":"Preservation of the anorectum","volume":"18","author":"Wolff","year":"1984","journal-title":"Adv Surg"},{"key":"10.1053\/gast.2002.32362_bib23","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/BF00341224","article-title":"Anal fistulas in Crohn's disease: incidence and outcome of surgical treatment","volume":"7","author":"Nordgren","year":"1992","journal-title":"Int J Colorectal Dis"},{"key":"10.1053\/gast.2002.32362_bib24","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJM198005013021801","article-title":"Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study","volume":"302","author":"Present","year":"1980","journal-title":"N Engl J Med"},{"key":"10.1053\/gast.2002.32362_bib25","first-page":"603","article-title":"Combination of cyclosporine, azathioprine and prednisolone for perianal fistulas in Crohn's disease","volume":"35","author":"Hinterleitner","year":"1997","journal-title":"Z Gastroenterol"},{"key":"10.1053\/gast.2002.32362_bib26","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1572-0241.1998.00442.x","article-title":"Clinical outcome following treatment of refractory inflammatory and fistulizing Crohn's disease with intravenous cyclosporine","volume":"93","author":"Egan","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2002.32362_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00054725-199911000-00001","article-title":"Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment-refractory Crohn's disease perianal fistulae","volume":"5","author":"Lowry","year":"1999","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/gast.2002.32362_bib28","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1056\/NEJM199905063401804","article-title":"Infliximab for the treatment of fistulas in patients with Crohn's disease","volume":"340","author":"Present","year":"1999","journal-title":"N Engl J Med"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502126412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502126412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T08:16:10Z","timestamp":1586333770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508502126412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["S0016508502126412"],"URL":"https:\/\/doi.org\/10.1053\/gast.2002.32362","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}