{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:11:04Z","timestamp":1791040264117,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1053\/gast.2002.32537","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T13:58:00Z","timestamp":1122645480000},"page":"940-947","source":"Crossref","is-referenced-by-count":29,"title":["Hereditary nonpolyposis colorectal cancer in young colorectal cancer patients: High-risk clinic versus population-based registry"],"prefix":"10.1053","volume":"122","author":[{"given":"Jonathan P.","family":"Terdiman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore R.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James R.","family":"Gum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fishbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy G.","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn A.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Bachman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joann","family":"Bergoffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Stembridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil W.","family":"Toribara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin H.","family":"Sleisenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2002.32537_bib1","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1053\/gast.1996.v110.pm8612988","article-title":"Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis [published erratum appears in Gastroenterology 1996;111:1402]","volume":"110","author":"Vasen","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32537_bib2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0016-5085(00)70168-5","article-title":"Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer","volume":"118","author":"J\u00e4rvinen","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32537_bib3","first-page":"137","article-title":"Surveillance improves survival of colorectal cancer in patients with hereditary nonpolyposis colorectal cancer","volume":"24","author":"Renkonen-Sinisalo","year":"2000","journal-title":"Cancer Detect Prev"},{"key":"10.1053\/gast.2002.32537_bib4","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1053\/gast.1997.v113.pm9322509","article-title":"Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer","volume":"113","author":"Peltom\u00e4ki","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32537_bib5","first-page":"5248","article-title":"A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer","volume":"58","author":"Boland","year":"1998","journal-title":"Cancer Res"},{"key":"10.1053\/gast.2002.32537_bib6","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/S0016-5085(99)70510-X","article-title":"New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC","volume":"116","author":"Vasen","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32537_bib7","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1093\/jnci\/89.23.1758","article-title":"A National Cancer Institute workshop on hereditary nonpolyposis colorectal cancer syndrome: meeting highlights and Bethesda guidelines","volume":"89","author":"Rodriguez-Bigas","year":"1997","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/gast.2002.32537_bib8","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nm0495-348","article-title":"Genetic instability occurs in the majority of young patients with colorectal cancer","volume":"1","author":"Liu","year":"1995","journal-title":"Nat Med"},{"key":"10.1053\/gast.2002.32537_bib9","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1086\/301996","article-title":"Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls","volume":"63","author":"Farrington","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1053\/gast.2002.32537_bib10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2105\/AJPH.82.5.703","article-title":"Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology","volume":"82","author":"Krieger","year":"1992","journal-title":"Am J Public Health"},{"key":"10.1053\/gast.2002.32537_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1053\/gast.2001.20874","article-title":"Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing","volume":"120","author":"Terdiman","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32537_bib12","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1001\/jama.281.24.2316","article-title":"Novel hMLH1 and hMSH2 germline mutations in African Americans with colorectal cancer","volume":"281","author":"Weber","year":"1999","journal-title":"JAMA"},{"key":"10.1053\/gast.2002.32537_bib13","first-page":"255","article-title":"Functional significance of a novel H718Y hMLH1 alteration associated with increased colorectal cancer risk among African-Americans","volume":"69","author":"Weber","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1053\/gast.2002.32537_bib14","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/BF02235756","article-title":"Germline mutations of hMLH1 and hMSH2 genes in patients with suspected hereditary nonpolyposis colorectal cancer and sporadic early-onset colorectal cancer","volume":"41","author":"Yuan","year":"1998","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/gast.2002.32537_bib15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1056\/NEJM199808203390804","article-title":"Clinical findings with implications for genetic testing in families with clustering of colorectal cancer","volume":"339","author":"Wijnen","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1053\/gast.2002.32537_bib16","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/jmg.37.9.641","article-title":"Sensitivity and specificity of clinical criteria for hereditary non-polyposis colorectal cancer associated mutations in MSH2 and MLH1","volume":"37","author":"Syngal","year":"2000","journal-title":"J Med Genet"},{"key":"10.1053\/gast.2002.32537_bib17","first-page":"793","article-title":"Second primary cancers after sporadic and familial colorectal cancer","volume":"10","author":"Hemminki","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/gast.2002.32537_bib18","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/3795","article-title":"MSH2 genomic deletions are a frequent cause of HNPCC","volume":"20","author":"Wijnen","year":"1998","journal-title":"Nat Genet"},{"key":"10.1053\/gast.2002.32537_bib19","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1136\/gut.44.6.839","article-title":"Microsatellite instability\u2014a useful diagnostic tool to select patients at high risk for hereditary non-polyposis colorectal cancer: a study in different groups of patients with colorectal cancer","volume":"44","author":"Lamberti","year":"1999","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32537_bib20","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1056\/NEJM199805213382101","article-title":"Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease","volume":"338","author":"Aaltonen","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1053\/gast.2002.32537_bib21","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1200\/JCO.2000.18.11.2193","article-title":"Population-based molecular detection of hereditary nonpolyposis colorectal cancer","volume":"18","author":"Salovaara","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1053\/gast.2002.32537_bib22","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1053\/gast.1996.v110.pm8608876","article-title":"Better survival rates in patients with MLH1-associated hereditary colorectal cancer","volume":"110","author":"Sankila","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32537_bib23","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3109\/00365529709025102","article-title":"Hereditary non-polyposis colorectal cancer: clinical features and survival. Results from the Danish HNPCC register","volume":"32","author":"Myrh\u00f8j","year":"1997","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/gast.2002.32537_bib24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/(SICI)1097-0142(19980715)83:2<259::AID-CNCR9>3.0.CO;2-L","article-title":"Colorectal carcinoma survival among hereditary nonpolyposis colorectal carcinoma family members","volume":"83","author":"Watson","year":"1998","journal-title":"Cancer"},{"key":"10.1053\/gast.2002.32537_bib25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/(SICI)1097-0215(19990118)80:2<183::AID-IJC4>3.0.CO;2-W","article-title":"Survival of patients with hereditary colorectal cancer: comparison of HNPCC and colorectal cancer in FAP patients with sporadic colorectal cancer","volume":"80","author":"Bertario","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1053\/gast.2002.32537_bib26","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1136\/jmg.33.12.981","article-title":"Microsatellite instability in early onset and familial colorectal cancer","volume":"33","author":"Brassett","year":"1996","journal-title":"J Med Genet"},{"key":"10.1053\/gast.2002.32537_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJM200001133420201","article-title":"Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer","volume":"342","author":"Gryfe","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1053\/gast.2002.32537_bib28","first-page":"79","article-title":"Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer","volume":"105","author":"Wang","year":"1999","journal-title":"Hum Genet"},{"key":"10.1053\/gast.2002.32537_bib29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1001\/jama.282.3.247","article-title":"Interpretation of genetic test results for hereditary nonpolyposis colorectal cancer: implications for clinical predisposition testing","volume":"282","author":"Syngal","year":"1999","journal-title":"JAMA"},{"key":"10.1053\/gast.2002.32537_bib30","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/35002251","article-title":"Conversion of diploidy to haploidy","volume":"403","author":"Yan","year":"2000","journal-title":"Nature"},{"key":"10.1053\/gast.2002.32537_bib31","first-page":"1713","article-title":"Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1","volume":"58","author":"Thibodeau","year":"1998","journal-title":"Cancer Res"},{"key":"10.1053\/gast.2002.32537_bib32","first-page":"3455","article-title":"Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability","volume":"58","author":"Cunningham","year":"1998","journal-title":"Cancer Res"},{"key":"10.1053\/gast.2002.32537_bib33","doi-asserted-by":"crossref","first-page":"8698","DOI":"10.1073\/pnas.95.15.8698","article-title":"Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers","volume":"95","author":"Veigl","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2002.32537_bib34","doi-asserted-by":"crossref","first-page":"566","DOI":"10.7326\/0003-4819-135-8_Part_1-200110160-00007","article-title":"Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer","volume":"135","author":"Raedle","year":"2001","journal-title":"Ann Intern Med"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502805054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502805054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T23:21:05Z","timestamp":1548285665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508502805054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["S0016508502805054"],"URL":"https:\/\/doi.org\/10.1053\/gast.2002.32537","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}