{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:21:18Z","timestamp":1791159678091,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1053\/gast.2002.32959","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T17:58:00Z","timestamp":1122659880000},"page":"1346-1354","source":"Crossref","is-referenced-by-count":72,"title":["Monoassociation of SCID mice with Helicobacter muridarum, but not four other enterics, provokes IBD upon receipt of T cells"],"prefix":"10.1053","volume":"122","author":[{"given":"Han-Qing","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Kushnir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.Christine","family":"Thurnheer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas A.","family":"Bos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Cebra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2002.32959_bib1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1084\/jem.178.1.237","article-title":"CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells","volume":"178","author":"Morrissey","year":"1993","journal-title":"J Exp Med"},{"key":"10.1053\/gast.2002.32959_bib2","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/intimm\/5.11.1461","article-title":"Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C.B-17 scid mice","volume":"5","author":"Powrie","year":"1993","journal-title":"Int Immunol"},{"key":"10.1053\/gast.2002.32959_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0092-8674(93)80067-O","article-title":"Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene","volume":"75","author":"Sadlack","year":"1993","journal-title":"Cell"},{"key":"10.1053\/gast.2002.32959_bib4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin10-deficient mice develop chronic enterocolitis","volume":"75","author":"Kuhn","year":"1993","journal-title":"Cell"},{"key":"10.1053\/gast.2002.32959_bib5","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1128\/IAI.66.11.5224-5231.1998","article-title":"Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice","volume":"66","author":"Sellon","year":"1998","journal-title":"Infect Immun"},{"key":"10.1053\/gast.2002.32959_bib6","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.4049\/jimmunol.158.7.3464","article-title":"Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients","volume":"158","author":"Aranda","year":"1997","journal-title":"J Immunol"},{"key":"10.1053\/gast.2002.32959_bib7","first-page":"19","article-title":"Mucosal microbiota","author":"Savage","year":"1999"},{"key":"10.1053\/gast.2002.32959_bib8","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1128\/IAI.67.4.1992-2000.1999","article-title":"Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system","volume":"67","author":"Talham","year":"1999","journal-title":"Infect Immun"},{"key":"10.1053\/gast.2002.32959_bib9","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1128\/IAI.63.10.3904-3913.1995","article-title":"Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut","volume":"63","author":"Shroff","year":"1995","journal-title":"Infect Immun"},{"key":"10.1053\/gast.2002.32959_bib10","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1128\/IAI.69.6.3542-3549.2001","article-title":"Gut colonization of mice with actA-negative mutant of Listeria monocytogenes can stimulate a humoral mucosal immune response","volume":"69","author":"Manohar","year":"2001","journal-title":"Infect Immun"},{"key":"10.1053\/gast.2002.32959_bib11","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1136\/gut.48.6.762","article-title":"T cell control of the gut IgA response against commensal bacteria","volume":"48","author":"Bos","year":"2001","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32959_bib12","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1099\/00207713-48-3-759","article-title":"Evaluation of the relatedness of Brucella spp. and Ochrobactrum anthropi and description of Ochrobactrum intermedium sp. nov., a new species with a closer relationship to Brucella spp","volume":"48","author":"Velasco","year":"1998","journal-title":"Int J Syst Bacteriol"},{"key":"10.1053\/gast.2002.32959_bib13","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1128\/AEM.45.2.675-683.1983","article-title":"Isolation and characterization of a spiral bacterium from the crypts of rodent gastrointestinal tracts","volume":"45","author":"Phillips","year":"1983","journal-title":"Appl Envir Microbiol"},{"key":"10.1053\/gast.2002.32959_bib14","first-page":"85","article-title":"Comparison of four diagnostic methods for detection of Helicobacter species in laboratory mice","volume":"48","author":"Mahler","year":"1998","journal-title":"Lab Anim Sci"},{"key":"10.1053\/gast.2002.32959_bib15","first-page":"327","article-title":"Gastrointestinal microflora","volume":"Volume III","author":"Schaedler","year":"1983"},{"key":"10.1053\/gast.2002.32959_bib16","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1172\/JCI118878","article-title":"Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27\/human beta2 microglobulin transgenic rats","volume":"98","author":"Rath","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1053\/gast.2002.32959_bib17","first-page":"251","article-title":"The role for the gut microflora in the development of inflammatory bowel disease (abstr)","author":"Kushnir","year":"1998","journal-title":"Abstract in Immunology"},{"key":"10.1053\/gast.2002.32959_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4049\/jimmunol.160.1.385","article-title":"Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice","volume":"160","author":"Contractor","year":"1998","journal-title":"J Immunol"},{"key":"10.1053\/gast.2002.32959_bib19","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1084\/jem.180.6.2359","article-title":"The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats","volume":"180","author":"Taurog","year":"1994","journal-title":"J Exp Med"},{"key":"10.1053\/gast.2002.32959_bib20","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1084\/jem.187.6.855","article-title":"CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H\/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease","volume":"187","author":"Cong","year":"1998","journal-title":"J Exp Med"},{"key":"10.1053\/gast.2002.32959_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/1521-4141(200101)31:1<23::AID-IMMU23>3.0.CO;2-2","article-title":"Enteric bacterial antigens activate CD4+ T cells from scid mice with inflammatory bowel disease","volume":"31","author":"Brimnes","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1053\/gast.2002.32959_bib22","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.4049\/jimmunol.164.5.2797","article-title":"Systemic activation and antigen-driven oligoclonal expansion of T cells in a mouse model of colitis","volume":"164","author":"Matsuda","year":"2000","journal-title":"J Immunol"},{"key":"10.1053\/gast.2002.32959_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1099\/00207713-42-1-27","article-title":"Helicobacter muridarum sp. nov., a microaerophilic helical bacterium with a novel ultrastructure islolated from the intestinal mucosa of rodents","volume":"42","author":"Lee","year":"1992","journal-title":"Int J Syst Bacteriol"},{"key":"10.1053\/gast.2002.32959_bib24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1258\/002367792780745760","article-title":"Spiral bacterium associated with gastric, ileal and caecal mucosa of mice","volume":"26","author":"Queiroz","year":"1992","journal-title":"Lab Anim"},{"key":"10.1053\/gast.2002.32959_bib25","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/eji.1830230208","article-title":"Selective engraftment of memory CD4+ T cells with an unusual recirculation pattern and a diverse T cell receptor-V beta repertoire into scid mice","volume":"23","author":"Reimann","year":"1993","journal-title":"Eur J Immunol"},{"key":"10.1053\/gast.2002.32959_bib26","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1084\/jem.190.10.1479","article-title":"Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombinant activating gene (RAG)2\u2212\/\u2212 mice upon transfer of CD4+CD45RBhi T cells","volume":"190","author":"Corazza","year":"1999","journal-title":"J Exp Med"},{"key":"10.1053\/gast.2002.32959_bib27","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/1074-7613(94)90045-0","article-title":"Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells","volume":"1","author":"Powrie","year":"1994","journal-title":"Immunity"},{"key":"10.1053\/gast.2002.32959_bib28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI117676","article-title":"A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion","volume":"95","author":"Jung","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1053\/gast.2002.32959_bib29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0016-5085(89)80057-5","article-title":"Campylobacter pylori and peptic ulcer disease","volume":"96","author":"Graham","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32959_bib30","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1128\/IAI.61.5.1601-1610.1993","article-title":"The pathogenicity of Helicobacter pylori: a perspective","volume":"61","author":"Lee","year":"1993","journal-title":"Infect Immun"},{"key":"10.1053\/gast.2002.32959_bib31","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"1","author":"Marshall","year":"1984","journal-title":"Lancet"},{"key":"10.1053\/gast.2002.32959_bib32","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1128\/IAI.64.9.3673-3681.1996","article-title":"Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus","volume":"64","author":"Fox","year":"1996","journal-title":"Infect Immun"},{"key":"10.1053\/gast.2002.32959_bib33","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1128\/IAI.65.8.3126-3131.1997","article-title":"Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus","volume":"65","author":"Cahill","year":"1997","journal-title":"Infect Immun"},{"key":"10.1053\/gast.2002.32959_bib34","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1128\/IAI.65.11.4858-4864.1997","article-title":"Helicobacter bilis induced inflammatory bowel disease in scid mice with defined flora","volume":"65","author":"Shomer","year":"1997","journal-title":"Infect Immun"},{"key":"10.1053\/gast.2002.32959_bib35","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.4049\/jimmunol.165.10.5891","article-title":"Alteration of V\u03b2 usage and cytokine production of CD4+ TCR\u03b2\u03b2 homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR \u03b1-chain-deficient mice","volume":"165","author":"Kishi","year":"2000","journal-title":"J Immunol"},{"key":"10.1053\/gast.2002.32959_bib36","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1136\/gut.44.6.812","article-title":"T cell specificity and cross reactivity towards enterobacteria, Bacteroides, Bifidobacterium, and antigen from resident intestinal flora in humans","volume":"44","author":"Duchmann","year":"1999","journal-title":"Gut"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502042579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502042579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T06:47:11Z","timestamp":1706424431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508502042579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S0016508502042579"],"URL":"https:\/\/doi.org\/10.1053\/gast.2002.32959","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}