{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:11:31Z","timestamp":1787987491752,"version":"build-2784847793"},"reference-count":68,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1053\/gast.2002.32963","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T17:58:00Z","timestamp":1122659880000},"page":"1248-1257","source":"Crossref","is-referenced-by-count":143,"title":["Dietary nitrate generates potentially mutagenic concentrations of nitric oxide at the gastroesophageal junction"],"prefix":"10.1053","volume":"122","author":[{"given":"K.","family":"Iijima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Moriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wirz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.W.","family":"Kelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.E.L.","family":"McColl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2002.32963_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0165-1110(95)90004-7","article-title":"Potential genotoxicity of chronically elevated nitric oxide: a review","volume":"339","author":"Liu","year":"1995","journal-title":"Mutat Res"},{"key":"10.1053\/gast.2002.32963_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1023\/A:1005948420548","article-title":"Role of nitric oxide in genotoxicity: implication for carcinogenesis","volume":"17","author":"Felley-Bosco","year":"1998","journal-title":"Cancer Metastasis Rev"},{"key":"10.1053\/gast.2002.32963_bib3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/gut.40.2.211","article-title":"Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans","volume":"40","author":"McKnight","year":"1997","journal-title":"Gut"},{"issue":"6","key":"10.1053\/gast.2002.32963_bib4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1080\/02652039009373938","article-title":"Nitrates, nitrites and N-nitrosocompounds: a review of the occurrence in food and diet and the toxicological implications","volume":"7","author":"Walker","year":"1990","journal-title":"Food Addit Contam"},{"key":"10.1053\/gast.2002.32963_bib5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0278-6915(88)90104-4","article-title":"The reproducibility of the conversion of nitrate to nitrite in human saliva after a nitrate load","volume":"26","author":"Bos","year":"1988","journal-title":"Food Chem Toxicol"},{"key":"10.1053\/gast.2002.32963_bib6","first-page":"1921","article-title":"Metabolic fate of an oral dose of 15N-labeled nitrate in humans: effect of diet supplementation with ascorbic acid","volume":"43","author":"Wagner","year":"1983","journal-title":"Cancer Res"},{"key":"10.1053\/gast.2002.32963_bib7","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0278-6915(89)90122-1","article-title":"Nitrate and nitrite concentrations in human saliva: variations with salivary flow-rate","volume":"27","author":"Granli","year":"1989","journal-title":"Food Chem Toxicol"},{"key":"10.1053\/gast.2002.32963_bib8","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/0278-6915(84)90116-9","article-title":"The pharmacology of dietary nitrate and the origin of urinary nitrate","volume":"22","author":"Bartholomew","year":"1984","journal-title":"Food Chem Toxicol"},{"key":"10.1053\/gast.2002.32963_bib9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0015-6264(76)80006-5","article-title":"The effect of nitrate intake on nitrite formation in human saliva","volume":"14","author":"Tannenbaum","year":"1976","journal-title":"Food Cosmet Toxicol"},{"key":"10.1053\/gast.2002.32963_bib10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0016-5085(99)70064-8","article-title":"Omeprazole and dietary nitrate independently affect levels of Vitamin C and nitrite in gastric juice","volume":"116","author":"Mowat","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32963_bib11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1053\/gast.2000.9367","article-title":"Omeprazole, Helicobacter pylori status, and alterations in the intragastric milieu facilitating bacterial N-nitrosation","volume":"119","author":"Mowat","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32963_bib12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/003655202317284147","article-title":"In vitro studies indicate that acid catalysed generation of N-nitrosocompounds from dietary nitrate will be maximal at the gastro-oesophageal junction","volume":"37","author":"Moriya","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/gast.2002.32963_bib13","first-page":"G1039","article-title":"Continuous measurement of gastric nitric oxide production","volume":"27","author":"Aneman","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1053\/gast.2002.32963_bib14","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/368502a0","article-title":"Stomach NO synthesis [letter]","volume":"368","author":"Benjamin","year":"1994","journal-title":"Nature"},{"key":"10.1053\/gast.2002.32963_bib15","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nm0695-546","article-title":"Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate","volume":"1","author":"Duncan","year":"1995","journal-title":"Nat Med"},{"key":"10.1053\/gast.2002.32963_bib16","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1136\/gut.35.11.1543","article-title":"Intragastric nitric oxide production in humans: measurements in expelled air","volume":"35","author":"Lundberg","year":"1994","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32963_bib17","first-page":"A469","article-title":"Oxygen facilitates nitrosoamine synthesis by depleting ascorbic acid in acid stomach: relevance to proximal gastric cancer (abstr)","volume":"116","author":"Moriya","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32963_bib18","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1053\/gast.2001.27997","article-title":"Unbuffered highly acidic gastric juice occurs at the gastro-oesophageal junction following a meal","volume":"121","author":"Fletcher","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32963_bib19","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0956-7135(98)00019-X","article-title":"Dietary exposure models for nitrates and nitrites","volume":"9","author":"Pennington","year":"1998","journal-title":"Food Control"},{"key":"10.1053\/gast.2002.32963_bib20","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1021\/ba-1982-0200.ch024","article-title":"Effects of ascorbic acid on the nitrosation of dialkyl amines","volume":"200","author":"Kim","year":"1982","journal-title":"Adv Chem Series"},{"key":"10.1053\/gast.2002.32963_bib21","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0006-3495(98)77564-2","article-title":"Diffusion and reaction of nitric oxide in suspension cell cultures","volume":"75","author":"Chen","year":"1998","journal-title":"Biophys J"},{"key":"10.1053\/gast.2002.32963_bib22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/183163a0","article-title":"Oxidation of ascorbic acid and similar reductones by nitrous acid","volume":"4655","author":"Bunton","year":"1959","journal-title":"Nature"},{"key":"10.1053\/gast.2002.32963_bib23","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1073\/pnas.95.5.2175","article-title":"Accelerated reaction of nitric oxide with O2 within the hydrophobic interior of biological membranes","volume":"95","author":"Liu","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2002.32963_bib24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1136\/gut.35.3.317","article-title":"Effect of Helicobacter pylori and its eradication on gastric juice ascorbic acid","volume":"35","author":"Banerjee","year":"1994","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32963_bib25","doi-asserted-by":"crossref","first-page":"287S","DOI":"10.1093\/ajcn\/53.1.287S","article-title":"Gastric juice ascorbic acid: effects of disease and implications for gastric carcinogenesis","volume":"53","author":"Schorah","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/gast.2002.32963_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0016-5085(89)90071-1","article-title":"Ascorbic acid in the human stomach","volume":"97","author":"Sobala","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32963_bib27","first-page":"533","article-title":"Vitamin C concentration in gastric juice before and after anti-Helicobacter pylori treatment","volume":"89","author":"Ruiz","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2002.32963_bib28","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/00000658-199710000-00013","article-title":"Inflammation and specialised intestinal metaplasia of cardiac mucosa is a manifestation of gastroesophageal reflux disease","volume":"226","author":"Oberg","year":"1997","journal-title":"Ann Surg"},{"key":"10.1053\/gast.2002.32963_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/gut.43.1.17","article-title":"Intestinal metaplasia at the gastroesophageal junction: Helicobacter pylori gastritis or gastroesophageal reflux disease?","volume":"43","author":"Hackelsberger","year":"1998","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32963_bib30","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1572-0241.1999.00778.x","article-title":"Comparative study of intestinal metaplasia and mucin staining at the cardia and esophagogastric junction in 225 symptomatic patients presenting for diagnostic open-access gastroscopy","volume":"94","author":"Byrne","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2002.32963_bib31","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/gut.40.6.710","article-title":"Short segment Barrett's oesophagus: prevalence, diagnosis and associations","volume":"40","author":"Nandurkar","year":"1997","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32963_bib32","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1136\/gut.41.5.585","article-title":"Intestinal metaplasia at the squamocolumnar junction in patients attending for diagnostic gastroscopy","volume":"41","author":"Trudgill","year":"1997","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32963_bib33","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/S0140-6736(94)90349-2","article-title":"Prevalence of metaplasia at the gastroesophageal junction","volume":"344","author":"Spechler","year":"1994","journal-title":"Lancet"},{"key":"10.1053\/gast.2002.32963_bib34","first-page":"245","article-title":"The chemical biology of nitric oxide","author":"Wink","year":"1999"},{"key":"10.1053\/gast.2002.32963_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(93)81748-O","article-title":"Autoxidation kinetics of aqueous nitric oxide","volume":"326","author":"Ford","year":"1993","journal-title":"FEBS Lett"},{"key":"10.1053\/gast.2002.32963_bib36","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/hep.510280420","article-title":"Nitric oxide inactivates rat hepatic methionine adenosyltransferase in vivo by nitrosylation","volume":"28","author":"Ruiz","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/gast.2002.32963_bib37","first-page":"175","article-title":"A discussion of mechanisms of NO genotoxicity: implication of inhibition of DNA repair proteins","volume":"131","author":"Laval","year":"1997","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"10.1053\/gast.2002.32963_bib38","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/carcin\/13.5.837","article-title":"Specific amino-acid sequences required for O6-methylguanine-DNA methyltransferase activity: analysis of three residues at or near the methyl acceptor site","volume":"13","author":"Ling-Ling","year":"1992","journal-title":"Carcinogenesis"},{"key":"10.1053\/gast.2002.32963_bib39","first-page":"184","article-title":"Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism","volume":"60","author":"Jaiswal","year":"2000","journal-title":"Cancer Res"},{"key":"10.1053\/gast.2002.32963_bib40","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0959-440X(94)90056-6","article-title":"Zinc finger diversity","volume":"4","author":"Schmeidescamp","year":"1994","journal-title":"Curr Opin Struct Biol"},{"key":"10.1053\/gast.2002.32963_bib41","doi-asserted-by":"crossref","first-page":"9063","DOI":"10.1016\/S0021-9258(18)52978-1","article-title":"Fpg protein of E. coli is a zinc finger protein whose cysteine residues have a structural and\/or functional role","volume":"268","author":"O'Connor","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2002.32963_bib42","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.bi.61.070192.001343","article-title":"Mammalian DNA ligase","volume":"61","author":"Lindhal","year":"1992","journal-title":"Annu Rev Biochem"},{"key":"10.1053\/gast.2002.32963_bib43","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1093\/carcin\/21.11.1989","article-title":"The role of nitric oxide in neoplastic transformation of C3H 10T1\/2 embryonic fibroblasts","volume":"21","author":"Burnett","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1053\/gast.2002.32963_bib44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1128\/JB.183.1.131-138.2001","article-title":"Recombinational repair is critical for survival of Escherichia coli exposed to nitric oxide","volume":"183","author":"Spek","year":"2001","journal-title":"J Bacteriol"},{"key":"10.1053\/gast.2002.32963_bib45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1098-2280(2000)35:1<39::AID-EM6>3.0.CO;2-H","article-title":"Nitric oxide-induced mutations in the HPRT gene of human lymphoblastoid TK6 cells and in Salmonella typhimurium","volume":"35","author":"Zhuang","year":"2000","journal-title":"Environ Mol Mutagen"},{"key":"10.1053\/gast.2002.32963_bib46","first-page":"32","article-title":"Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multi-organ carcinogenesis model","volume":"53","author":"Hirose","year":"1993","journal-title":"Cancer Res"},{"key":"10.1053\/gast.2002.32963_bib47","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/ijc.2910560122","article-title":"Induction and promotion of forestomach tumors by sodium nitrite in combination with ascorbic acid or sodium ascorbate in rats with or without N-methyl-N'-nitrosoguanidine pre-treatment","volume":"56","author":"Yoshida","year":"1994","journal-title":"Int J Cancer"},{"key":"10.1053\/gast.2002.32963_bib48","first-page":"317","article-title":"Induction of forestomach lesions in rats by oral administrations of naturally occurring antioxidants for 4 weeks","volume":"78","author":"Hirose","year":"1987","journal-title":"Jpn J Cancer Res"},{"key":"10.1053\/gast.2002.32963_bib49","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0278-6915(86)90306-6","article-title":"Effects of BHA and related phenols on the forestomach of rats","volume":"24","author":"Altmann","year":"1986","journal-title":"Food Chem Toxicol"},{"key":"10.1053\/gast.2002.32963_bib50","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0278-6915(97)00157-9","article-title":"Variation in susceptibility to the induction of forestomach tumours by butylated hydroxyanisole among rats of different strains","volume":"36","author":"Tamano","year":"1998","journal-title":"Food Chem Toxicol"},{"key":"10.1053\/gast.2002.32963_bib51","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/0278-6915(86)90292-9","article-title":"Forestomach carcinogens: possible mechanisms of action","volume":"24","author":"Kroes","year":"1986","journal-title":"Food Chem Toxicol"},{"key":"10.1053\/gast.2002.32963_bib52","first-page":"81","article-title":"Liver and forestomach tumors and other forestomach lesions in rats treated with morpholine and sodium nitrite, with and without sodium ascorbate","volume":"71","author":"Mirvish","year":"1983","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/gast.2002.32963_bib53","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0304-3835(76)80018-3","article-title":"Effect of sodium ascorbate on tumor induction in rats treated with morpholine and sodium nitrite, and with nitrosomorpholine","volume":"2","author":"Mirvish","year":"1976","journal-title":"Cancer Lett"},{"key":"10.1053\/gast.2002.32963_bib54","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0140-6736(75)90498-5","article-title":"A model for gastric cancer epidemiology","volume":"2","author":"Correa","year":"1975","journal-title":"Lancet"},{"key":"10.1053\/gast.2002.32963_bib55","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-3835(95)03786-V","article-title":"Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC","volume":"93","author":"Mirvish","year":"1995","journal-title":"Cancer Lett"},{"key":"10.1053\/gast.2002.32963_bib56","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1001\/jama.1991.03460100089030","article-title":"Rising incidence of adenocarcinoma of the esophagus and gastric cardia","volume":"13","author":"Blot","year":"1991","journal-title":"JAMA"},{"key":"10.1053\/gast.2002.32963_bib57","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(05)63269-2","article-title":"Increasing incidence of Barrett's oesophagus: education, enthusiasm, or epidemiology?","volume":"350","author":"Prach","year":"1997","journal-title":"Lancet"},{"key":"10.1053\/gast.2002.32963_bib58","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/bjs.1800800338","article-title":"Increasing incidence of carcinoma of the gastric cardia in Sweden from 1970 to 1985","volume":"80","author":"Hansson","year":"1993","journal-title":"Br J Surg"},{"key":"10.1053\/gast.2002.32963_bib59","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/bjc.1990.314","article-title":"Increasing incidence of adenocarcinoma of the gastric cardia and adjacent sites","volume":"62","author":"Powell","year":"1990","journal-title":"Br J Cancer"},{"key":"10.1053\/gast.2002.32963_bib60","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/(SICI)1097-0215(19970502)71:3<340::AID-IJC5>3.0.CO;2-Y","article-title":"Esophageal and gastric carcinoma in Norway 1958-1992: incidence time trend variability according to morphological subtypes and organ subtypes","volume":"71","author":"Hansen","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1053\/gast.2002.32963_bib61","unstructured":"International Fertilizer Industry Association webstite. Available at: http:\/\/www.fertilizer.org\/ifa\/statistics.asp."},{"key":"10.1053\/gast.2002.32963_bib62","first-page":"87","article-title":"Average fertiliser use and estimates of nitrogen uptake by major arable crops in England and Wales","author":"Wilson","year":"1999"},{"key":"10.1053\/gast.2002.32963_bib63","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1098\/rstb.1982.0007","article-title":"Fertiliser trends in relation to biological productivity within the U.K","volume":"B296","author":"Hood","year":"1982","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1053\/gast.2002.32963_bib64","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1054\/bjoc.2000.1110","article-title":"Socioeconomic status and risk of adenocarcinoma of the oesophagus and cancer of the gastric cardia in Scotland","volume":"83","author":"Brewster","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1053\/gast.2002.32963_bib65","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/313620a0","article-title":"Nitrates, nitrites and gastric cancer in Great Britain","volume":"313","author":"Forman","year":"1985","journal-title":"Nature"},{"key":"10.1053\/gast.2002.32963_bib66","first-page":"901","article-title":"Geographic and social class variation within the UK in levels of salivary nitrates and nitrites. A preliminary report","author":"Forman","year":"1984"},{"key":"10.1053\/gast.2002.32963_bib67","first-page":"533","article-title":"Vitamin C concentration in gastric juice before and after anti-Helicobacter pylori treatment","volume":"89","author":"Ruiz","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2002.32963_bib68","first-page":"588","article-title":"An inverse relation between cagA+ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma","volume":"58","author":"Chow","year":"1998","journal-title":"Cancer Res"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502543134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502543134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T06:05:08Z","timestamp":1626242708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508502543134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S0016508502543134"],"URL":"https:\/\/doi.org\/10.1053\/gast.2002.32963","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}