{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:10:24Z","timestamp":1784383824793,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1053\/gast.2002.32993","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T17:58:00Z","timestamp":1122659880000},"page":"1235-1241","source":"Crossref","is-referenced-by-count":178,"title":["The true impact of fatigue in primary biliary cirrhosis: A population study"],"prefix":"10.1053","volume":"122","author":[{"given":"Jennifer","family":"Goldblatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.S.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Lipman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin I.","family":"Prince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Baragiotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret F.","family":"Bassendine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver F.W.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.J.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2002.32993_bib1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/hep.510270143","article-title":"In the eye of the beholder: assessment of health-related quality of life","volume":"27","author":"Owens","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/gast.2002.32993_bib2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(97)05419-6","article-title":"Primary biliary cirrhosis","volume":"350","author":"Neuberger","year":"1997","journal-title":"Lancet"},{"key":"10.1053\/gast.2002.32993_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1136\/pmj.76.894.199","article-title":"Primary biliary cirrhosis: new perspectives in diagnosis and treatment","volume":"76","author":"Prince","year":"2000","journal-title":"Postgrad Med J"},{"key":"10.1053\/gast.2002.32993_bib4","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1046\/j.1365-2648.1999.01106.x","article-title":"The experience of women with primary biliary cirrhosis: a literature review","volume":"30","author":"Fahey","year":"1999","journal-title":"J Adv Nurs"},{"key":"10.1053\/gast.2002.32993_bib5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/hep.1840120116","article-title":"The demography of primary biliary cirrhosis in Ontario, Canada","volume":"12","author":"Witt-Sullivan","year":"1990","journal-title":"Hepatology"},{"key":"10.1053\/gast.2002.32993_bib6","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/ije\/26.4.830","article-title":"Incidence and prevalence of primary biliary cirrhosis in the city of Newcastle-upon-Tyne, England","volume":"26","author":"Metcalf","year":"1997","journal-title":"Int J Epidemiol"},{"key":"10.1053\/gast.2002.32993_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/gut.42.1.120","article-title":"The association between primary biliary cirrhosis and coeliac disease: a study of relative prevalences","volume":"42","author":"Kingham","year":"1998","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32993_bib8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0016-5085(80)90571-5","article-title":"Clinical pattern and course of disease in primary biliary cirrhosis based on an analysis of 236 patients","volume":"78","author":"Christensen","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.32993_bib9","first-page":"1278","article-title":"Primary biliary cirrhosis: a revised clinical spectrum","volume":"i","author":"James","year":"1981","journal-title":"Lancet"},{"key":"10.1053\/gast.2002.32993_bib10","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1093\/clinids\/18.Supplement_1.S79","article-title":"Measuring the functional impact of fatigue: initial validation of the Fatigue Impact Scale","volume":"18","author":"Fisk","year":"1994","journal-title":"Clin Infect Dis"},{"key":"10.1053\/gast.2002.32993_bib11","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0168-8278(00)80385-2","article-title":"Validation of a fatigue impact score in primary biliary cirrhosis: towards a standard for clinical and trial use","volume":"32","author":"Prince","year":"2000","journal-title":"J Hepatol"},{"key":"10.1053\/gast.2002.32993_bib12","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/j.1572-0241.2000.01857.x","article-title":"Impact of fatigue on the quality of life in patients with primary biliary cirrhosis","volume":"95","author":"Huet","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2002.32993_bib13","first-page":"208","article-title":"Is the revised international autoimmune hepatitis group (IAHG) scoring system useful (abstr)?","volume":"34","author":"Baragiotta","year":"2001","journal-title":"J Hepatol"},{"key":"10.1053\/gast.2002.32993_bib14","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/hep.510300213","article-title":"Primary biliary cirrhosis once rare, now common in the UK?","volume":"30","author":"James","year":"1999","journal-title":"Hepatology"},{"key":"10.1053\/gast.2002.32993_bib15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0168-8278(99)80067-1","article-title":"Tumour necrosis factor-alpha promoter polymorphisms in primary biliary cirrhosis","volume":"30","author":"Jones","year":"1999","journal-title":"J Hepatol"},{"key":"10.1053\/gast.2002.32993_bib16","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/00005650-198808000-00004","article-title":"Development of a brief screening instrument for detecting depressive disorders","volume":"26","author":"Burnham","year":"1988","journal-title":"Med Care"},{"key":"10.1053\/gast.2002.32993_bib17","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1136\/bmj.312.7040.1181","article-title":"Primary biliary cirrhosis: epidemiology helping the clinician","volume":"312","author":"Metcalf","year":"1996","journal-title":"BMJ"},{"key":"10.1053\/gast.2002.32993_bib18","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"Review of criteria for the diagnosis of autoimmune hepatitis","volume":"31","author":"International Autoimmune Hepatitis Group","year":"1999","journal-title":"J Hepatol"},{"key":"10.1053\/gast.2002.32993_bib19","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1001\/jama.285.17.2196","article-title":"Grip strength and subjective fatigue in patients with primary biliary cirrhosis","volume":"285","author":"Goldblatt","year":"2001","journal-title":"JAMA"},{"key":"10.1053\/gast.2002.32993_bib20","first-page":"371A","article-title":"Fatigue in primary biliary cirrhosis is associated with early autonomic failure (abstr)","volume":"34","author":"Johns","year":"2001","journal-title":"Hepatology"},{"key":"10.1053\/gast.2002.32993_bib21","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/gut.43.5.705","article-title":"Fatigue in primary biliary cirrhosis","volume":"43","author":"Cauch-Dudek","year":"1998","journal-title":"Gut"},{"key":"10.1053\/gast.2002.32993_bib22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/hep.510270132","article-title":"Chronic hepatitis C infection causes a significant reduction in quality of life in the absence of cirrhosis","volume":"27","author":"Foster","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/gast.2002.32993_bib23","first-page":"251A","article-title":"Health-related quality of life assessment in nonalcoholic steatohepatitis (abstr)","volume":"2001","author":"Talwalker","year":"2001","journal-title":"Hepatology"},{"key":"10.1053\/gast.2002.32993_bib24","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1046\/j.1440-1746.1999.01968.x","article-title":"Case report: oral anti-oxidant therapy for the treatment of primary biliary cirrhosis: a pilot study","volume":"14","author":"Watson","year":"1999","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1053\/gast.2002.32993_bib25","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/hep.510290229","article-title":"Quality of life before and after liver transplantation for cholestatic liver disease","volume":"29","author":"Gross","year":"1999","journal-title":"Hepatology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502466966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502466966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T12:16:20Z","timestamp":1586348180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508502466966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S0016508502466966"],"URL":"https:\/\/doi.org\/10.1053\/gast.2002.32993","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}