{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:15:24Z","timestamp":1793812524835,"version":"4.6.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2002,8]]},"DOI":"10.1053\/gast.2002.34781","type":"journal-article","created":{"date-parts":[[2002,8,24]],"date-time":"2002-08-24T23:46:10Z","timestamp":1030232770000},"page":"414-424","source":"Crossref","is-referenced-by-count":257,"title":["Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production"],"prefix":"10.1053","volume":"123","author":[{"given":"Yoshio","family":"Yamaoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala M.T.","family":"El\u2013Zimaity","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Osato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Y.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2002.34781_bib1","doi-asserted-by":"crossref","first-page":"14648","DOI":"10.1073\/pnas.93.25.14648","article-title":"cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors","volume":"93","author":"Censini","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2002.34781_bib2","first-page":"2111","article-title":"Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach","volume":"55","author":"Blaser","year":"1995","journal-title":"Cancer Res"},{"key":"10.1053\/gast.2002.34781_bib3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/gut.40.3.297","article-title":"Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection","volume":"40","author":"Parsonnet","year":"1997","journal-title":"Gut"},{"key":"10.1053\/gast.2002.34781_bib4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0016-5085(98)70365-8","article-title":"Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori","volume":"115","author":"van Doorn","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.34781_bib5","doi-asserted-by":"crossref","first-page":"17771","DOI":"10.1074\/jbc.270.30.17771","article-title":"Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori","volume":"270","author":"Atherton","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1053\/gast.2002.34781_bib6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0016-5085(97)70223-3","article-title":"Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori","volume":"112","author":"Atherton","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.34781_bib7","first-page":"531","article-title":"Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome","volume":"110","author":"Peek","year":"1998","journal-title":"Proc Assoc Am Phys"},{"key":"10.1053\/gast.2002.34781_bib8","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0002-9440(10)64006-0","article-title":"Helicobacter pylori genotypes may determine gastric histopathology","volume":"158","author":"Nogueira","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1053\/gast.2002.34781_bib9","doi-asserted-by":"crossref","first-page":"12778","DOI":"10.1073\/pnas.96.22.12778","article-title":"Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin","volume":"96","author":"Gerhard","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2002.34781_bib10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.279.5349.373","article-title":"Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging","volume":"279","author":"Ilver","year":"1998","journal-title":"Science"},{"key":"10.1053\/gast.2002.34781_bib11","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.1073\/pnas.130079797","article-title":"A M(r) 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori","volume":"97","author":"Yamaoka","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2002.34781_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0046-8177(94)90191-0","article-title":"Simultaneous visualization of Helicobacter pylori and gastric morphology: a new stain","volume":"25","author":"Genta","year":"1994","journal-title":"Hum Pathol"},{"key":"10.1053\/gast.2002.34781_bib13","first-page":"732","article-title":"A new stain for Helicobacter pylori suitable for the autostainer","volume":"122","author":"El-Zimaity","year":"1998","journal-title":"Arch Pathol Lab Med"},{"key":"10.1053\/gast.2002.34781_bib14","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1136\/jcp.54.9.679","article-title":"Gastric intestinal metaplasia: subtypes and natural history","volume":"54","author":"El-Zimaity","year":"2000","journal-title":"J Clin Pathol"},{"key":"10.1053\/gast.2002.34781_bib15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0046-8177(96)90135-5","article-title":"Interobserver variation in the histopathological assessment of Helicobacter pylori gastritis","volume":"27","author":"El-Zimaity","year":"1996","journal-title":"Hum Pathol"},{"key":"10.1053\/gast.2002.34781_bib16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1523-5378.1998.08056.x","article-title":"Relationship of vacA genotypes of Helicobacter pylori to cagA status, cytotoxin production, and clinical outcome","volume":"4","author":"Yamaoka","year":"1998","journal-title":"Helicobacter"},{"key":"10.1053\/gast.2002.34781_bib17","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1128\/JCM.37.7.2274-2279.1999","article-title":"Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries","volume":"37","author":"Yamaoka","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1053\/gast.2002.34781_bib18","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/41483","article-title":"The complete genome sequence of the gastric pathogen Helicobacter pylori","volume":"388","author":"Tomb","year":"1997","journal-title":"Nature"},{"key":"10.1053\/gast.2002.34781_bib19","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1126\/science.284.5418.1328","article-title":"Helicobacter pylori virulence and genetic geography","volume":"284","author":"Covacci","year":"1999","journal-title":"Science"},{"key":"10.1053\/gast.2002.34781_bib20","doi-asserted-by":"crossref","first-page":"14559","DOI":"10.1073\/pnas.96.25.14559","article-title":"Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori","volume":"96","author":"Segal","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2002.34781_bib21","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1073\/pnas.97.3.1263","article-title":"Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation","volume":"97","author":"Stein","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2002.34781_bib22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1084\/jem.191.4.593","article-title":"Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastricepithelial cells","volume":"191","author":"Asahi","year":"2000","journal-title":"J Exp Med"},{"key":"10.1053\/gast.2002.34781_bib23","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.287.5457.1497","article-title":"Translocation of Helicobacter pylori CagA into gastric epithelial cells by typeIV secretion","volume":"287","author":"Odenbreit","year":"2000","journal-title":"Science"},{"key":"10.1053\/gast.2002.34781_bib24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1128\/CDLI.8.1.181-186.2001","article-title":"Determination of Helicobacter pylori virulence by simple gene analysis of the cag pathogenicity island","volume":"8","author":"Ikenoue","year":"2001","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1053\/gast.2002.34781_bib25","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1128\/JB.182.11.3219-3227.2000","article-title":"Distinctiveness of genotypes of Helicobacter pylori in Calcutta, India","volume":"182","author":"Mukhopadhyay","year":"2000","journal-title":"J Bacteriol"},{"key":"10.1053\/gast.2002.34781_bib26","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/gut.41.4.442","article-title":"Induction of various cytokines and development of severe mucosal inflammation by cagA gene-positive Helicobacter pylori strains","volume":"41","author":"Yamaoka","year":"1997","journal-title":"Gut"},{"key":"10.1053\/gast.2002.34781_bib27","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/gut.42.5.609","article-title":"Chemokines in the gastric mucosa in Helicobacter pylori infection","volume":"42","author":"Yamaoka","year":"1998","journal-title":"Gut"},{"key":"10.1053\/gast.2002.34781_bib28","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/gut.45.6.804","article-title":"Relation between clinical presentation, Helicobacter pylori density, interleukin-1\u03b2 and -8 production and cagA status","volume":"45","author":"Yamaoka","year":"1999","journal-title":"Gut"},{"key":"10.1053\/gast.2002.34781_bib29","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/003655201750065861","article-title":"Helicobacter pylori genotypes are associated with clinical outcome in Portuguese patients and show a high prevalence of infections with multiple strains","volume":"36","author":"Figueiredo","year":"2001","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/gast.2002.34781_bib30","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/gut.47.1.18","article-title":"Association of peptic ulcer with increased expression of Lewis antigens but not cagA, iceA, and vacA in Helicobacter pylori isolates in an Asian population","volume":"47","author":"Zheng","year":"2000","journal-title":"Gut"},{"key":"10.1053\/gast.2002.34781_bib31","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1572-0241.2001.03685.x","article-title":"Helicobacter pylori vacA, iceA, and cagA status and pattern of gastritis in patients with malignant and benign gastroduodenal disease","volume":"96","author":"Miehlke","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2002.34781_bib32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/gut.49.5.629","article-title":"Analysis of iceA genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease","volume":"49","author":"Kidd","year":"2001","journal-title":"Gut"},{"key":"10.1053\/gast.2002.34781_bib33","first-page":"1903","article-title":"Key Importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation","volume":"61","author":"Prinz","year":"2001","journal-title":"Cancer Res"},{"key":"10.1053\/gast.2002.34781_bib34","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/(SICI)1097-0142(19980315)82:6<1013::AID-CNCR2>3.0.CO;2-F","article-title":"The role of the HLA-DQA1 gene in resistance to atrophic gastritis and gastric adenocarcinoma induced by Helicobacter pylori infection","volume":"82","author":"Azuma","year":"1998","journal-title":"Cancer"},{"key":"10.1053\/gast.2002.34781_bib35","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/35006081","article-title":"Interleukin-1 polymorphisms associated with increased risk of gastric cancer","volume":"404","author":"El-Omar","year":"2000","journal-title":"Nature"},{"key":"10.1053\/gast.2002.34781_bib36","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1053\/gast.2001.28000","article-title":"Interleukin 1\u03b2 and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma","volume":"121","author":"Machado","year":"2001","journal-title":"Gastroenterology"},{"issue":"suppl 1","key":"10.1053\/gast.2002.34781_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2036.1998.00011.x","article-title":"Is there significant variation in the risk of gastric cancer associated with Helicobacter pylori infection?","volume":"12","author":"Forman","year":"1998","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/gast.2002.34781_bib38","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/S0016-5085(97)70019-2","article-title":"Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: a model","volume":"113","author":"Graham","year":"1997","journal-title":"Gastroenterology"},{"issue":"suppl 12","key":"10.1053\/gast.2002.34781_bib39","first-page":"90","article-title":"Helicobacter pylori infection is the primary cause of gastric cancer","volume":"35","author":"Graham","year":"2000","journal-title":"J Gastroenterol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502001191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502001191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T01:00:35Z","timestamp":1622077235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508502001191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["S0016508502001191"],"URL":"https:\/\/doi.org\/10.1053\/gast.2002.34781","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}