{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:27:00Z","timestamp":1790404020525,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2002,10]]},"DOI":"10.1053\/gast.2002.35990","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T19:52:28Z","timestamp":1033501948000},"page":"969-977","source":"Crossref","is-referenced-by-count":120,"title":["Condition-specific deactivation of brain regions by 5-HT3 receptor antagonist Alosetron"],"prefix":"10.1053","volume":"123","author":[{"given":"Steven M.","family":"Berman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandall","family":"Suyenobu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart W.","family":"Derbyshire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Stains","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"FitzGerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mandelkern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Hamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Naliboff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeran A.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2002.35990_bib1","doi-asserted-by":"crossref","first-page":"12S","DOI":"10.1016\/S0002-9343(99)00277-6","article-title":"Emerging disease model for functional gastrointestinal disorders","volume":"107","author":"Mayer","year":"1999","journal-title":"Am J Med"},{"key":"10.1053\/gast.2002.35990_bib2","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0140-6736(00)02033-X","article-title":"Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised placebo-controlled trial","volume":"355","author":"Camilleri","year":"2000","journal-title":"Lancet"},{"key":"10.1053\/gast.2002.35990_bib3","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1111\/j.1572-0241.2001.04128.x","article-title":"Alosetron controls bowel urgency and provides global symptom improvement in women with diarrhea-predominant irritable bowel syndrome","volume":"96","author":"Lembo","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/gast.2002.35990_bib4","doi-asserted-by":"crossref","first-page":"A217","DOI":"10.1016\/S0016-5085(08)81078-5","article-title":"Cilansetron shows efficacy in non-constipated irritable bowel syndrome patients independent of the definition of the patient population by ROME I or ROME II","volume":"120","author":"Caras","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.35990_bib5","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1056\/NEJM199003223221204","article-title":"Efficacy of ondansetron (GR38032F) and the role of serotonin in cisplatin-induced nausea and vomiting","volume":"322","author":"Cubeddu","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1053\/gast.2002.35990_bib6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0304-3959(98)00108-0","article-title":"Effect of ondansetron, a 5-HT3 receptor antagonist, on the dynamic association between bulimic behaviors and pain thresholds","volume":"77","author":"Faris","year":"1998","journal-title":"Pain"},{"key":"10.1053\/gast.2002.35990_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2036.1999.00002.x-i2","article-title":"Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel","volume":"13","author":"Gershon","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/gast.2002.35990_bib8","first-page":"483","article-title":"Gastrointestinal afferent fibers and sensation","author":"Sengupta","year":"1994"},{"key":"10.1053\/gast.2002.35990_bib9","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1365-2036.1998.00375.x","article-title":"Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome","volume":"12","author":"Delvaux","year":"1998","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/gast.2002.35990_bib10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2036.1994.tb00307.x","article-title":"Alosetron does not affect the visceral perception of gastric distension in healthy subjects","volume":"8","author":"Zerbib","year":"1994","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/gast.2002.35990_bib11","first-page":"157","article-title":"Autoradiographic mapping of central 5-HT3 receptors","author":"Laporte","year":"1992"},{"key":"10.1053\/gast.2002.35990_bib12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0014-2999(89)90700-0","article-title":"Binding of the 5-HT3 ligand [3H]GR65630, to rat postrema, vagus nerve and the brains of several species","volume":"159","author":"Kilpatrick","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/gast.2002.35990_bib13","doi-asserted-by":"crossref","first-page":"G519","DOI":"10.1152\/ajpgi.2001.280.4.G519","article-title":"Stress and the gastrointestinal tract: V. stress and irritable bowel syndrome","volume":"280","author":"Mayer","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/gast.2002.35990_bib14","first-page":"67","article-title":"The emotional motor system","volume":"30","author":"Holstege","year":"1992","journal-title":"Eur J Morphol"},{"key":"10.1053\/gast.2002.35990_bib15","first-page":"627","article-title":"The greater limbic system, the emotional motor system and the brain","author":"Nieuwenheuys","year":"1996"},{"key":"10.1053\/gast.2002.35990_bib16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00006842-200105000-00006","article-title":"Cerebral activation in irritable bowel syndrome patients and control subjects during rectosigmoid stimulation","volume":"63","author":"Naliboff","year":"2001","journal-title":"Psychosom Med"},{"key":"10.1053\/gast.2002.35990_bib17","doi-asserted-by":"crossref","first-page":"A67","DOI":"10.1016\/S0016-5085(08)80332-0","article-title":"The effect of the 5-HT3 receptor antagonist Alosetron on regional brain activation in IBS patients is not dependent on activation of nociceptive visceral afferents: a H215O PET study","volume":"120","author":"Mayer","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.35990_bib18","doi-asserted-by":"crossref","first-page":"A81","DOI":"10.1016\/S0016-5085(00)82400-2","article-title":"Evidence for selective effect of the 5-HT3 antagonist alosetron on amygdala and hippocampal activation in IBS patients","volume":"118","author":"Derbyshire","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.35990_bib19","first-page":"92","article-title":"Irritable bowel syndrome: guidelines for the diagnosis","volume":"2","author":"Thompson","year":"1989","journal-title":"Gastroenterology Intl"},{"key":"10.1053\/gast.2002.35990_bib20","first-page":"217","article-title":"SCL-90-R, brief symptom inventory, and matching clinical rating scales","author":"Derogatis","year":"1994"},{"key":"10.1053\/gast.2002.35990_bib21","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1046\/j.1365-2036.1999.00610.x","article-title":"Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5-HT3 receptor antagonist","volume":"13","author":"Camilleri","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/gast.2002.35990_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0016-5085(97)70219-1","article-title":"Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome","volume":"112","author":"Munakata","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.35990_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(78)90020-9","article-title":"Ratio scales of sensory and affective verbal pain descriptors","volume":"5","author":"Gracely","year":"1978","journal-title":"Pain"},{"key":"10.1053\/gast.2002.35990_bib24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hbm.460020402","article-title":"Statistical parametric maps in functional imaging: a general linear approach","volume":"2","author":"Friston","year":"1995","journal-title":"Hum Brain Mapp"},{"key":"10.1053\/gast.2002.35990_bib25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/nimg.1996.0033","article-title":"The trouble with cognitive subtraction","volume":"4","author":"Friston","year":"1996","journal-title":"Neuroimage"},{"key":"10.1053\/gast.2002.35990_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0924-977X(99)00065-6","article-title":"5-HT3 receptor antagonists and anxiety; a preclinical and clinical review","volume":"10","author":"Olivier","year":"2000","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1053\/gast.2002.35990_bib27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s11916-999-0044-7","article-title":"Meta-analysis of thirty-four independent samples studied using PET reveals a significantly attenuated central response to noxious stimulation in clinical pain patients","volume":"3","author":"Derbyshire","year":"1999","journal-title":"Curr Rev Pain"},{"key":"10.1053\/gast.2002.35990_bib28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1365-2036.1999.00006.x","article-title":"Review article: evaluation of drugs in experimental gut distension models","volume":"13","author":"Pappas","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/gast.2002.35990_bib29","first-page":"100","article-title":"A mechanism of 5-HT3 receptor mediation is involved etiologically in the psychological stress lesion in the stomach of the mouse","volume":"271","author":"Nomura","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1053\/gast.2002.35990_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/brain\/118.1.279","article-title":"Contributions of anterior cingulate cortex to behaviour","volume":"118","author":"Devinsky","year":"1995","journal-title":"Brain"},{"key":"10.1053\/gast.2002.35990_bib31","first-page":"333","article-title":"Brain mediation of active and passive emotional coping","author":"Bandler","year":"2000"},{"key":"10.1053\/gast.2002.35990_bib32","first-page":"248","article-title":"Antagonists at the serotonin-3 receptor can reduce the fear potentiated startle response in the rat: evidence for different types of anxiolytic activity","volume":"268","author":"Nevins","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1053\/gast.2002.35990_bib33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0016-5085(94)90086-8","article-title":"Basic and clinical aspects of visceral hyperalgesia","volume":"107","author":"Mayer","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.35990_bib34","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1152\/jn.1992.67.6.1599","article-title":"Characterization of descending facilitation and inhibition of spinal nociceptive transmission from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat","volume":"67","author":"Zhuo","year":"1992","journal-title":"J Neurophysiol"},{"key":"10.1053\/gast.2002.35990_bib35","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.1073\/pnas.96.14.7687","article-title":"Supraspinal contributions to hyperalgesia","volume":"96","author":"Urban","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/gast.2002.35990_bib36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1053\/eujp.2000.0167","article-title":"Gender differences in regional brain response to visceral pressure in IBS patients","volume":"4","author":"Berman","year":"2000","journal-title":"Eur J Pain"},{"key":"10.1053\/gast.2002.35990_bib37","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(00)70170-3","article-title":"Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distension","volume":"118","author":"Mertz","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.35990_bib38","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1523\/JNEUROSCI.20-07-02657.2000","article-title":"Cortical processing of human somatic and visceral sensation","volume":"20","author":"Aziz","year":"2000","journal-title":"J Neurosci"},{"key":"10.1053\/gast.2002.35990_bib39","doi-asserted-by":"crossref","first-page":"A615","DOI":"10.1016\/S0016-5085(00)84600-4","article-title":"Central processing of rectal pain in IBS patients: an fMRI study (abstr)","volume":"118","author":"Bonaz","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.35990_bib40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0165-0173(96)00011-2","article-title":"Circuitry and functional aspects of the insular lobe in primates including humans","volume":"22","author":"Augustine","year":"1996","journal-title":"Brain Res Rev"},{"key":"10.1053\/gast.2002.35990_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1364-6613(00)01483-2","article-title":"Cognitive and emotional influences in anterior cingulate cortex","volume":"4","author":"Bush","year":"2000","journal-title":"Trends Cognitive Sci"},{"key":"10.1053\/gast.2002.35990_bib42","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0166-2236(00)01662-3","article-title":"5-HT3 receptors and neurotransmitter release in the CNS: a nerve ending story?","volume":"23","author":"van Hooft","year":"2000","journal-title":"Trends Neurosci"},{"key":"10.1053\/gast.2002.35990_bib43","first-page":"26","article-title":"Vagal modulation of nociception","volume":"1","author":"Gebhart","year":"1992","journal-title":"Am Pain Soc J"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502001993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502001993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T05:27:21Z","timestamp":1704605241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508502001993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["S0016508502001993"],"URL":"https:\/\/doi.org\/10.1053\/gast.2002.35990","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}