{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:57:17Z","timestamp":1791064637611,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2002,10]]},"DOI":"10.1053\/gast.2002.36029","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T19:52:28Z","timestamp":1033501948000},"page":"1216-1225","source":"Crossref","is-referenced-by-count":34,"title":["Long-lasting changes in central nervous system responsivity to colonic distention after stress in rats"],"prefix":"10.1053","volume":"123","author":[{"given":"Rianne","family":"Stam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Ekkelenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ank C.","family":"Frankhuijzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrie W.","family":"Bruijnzeel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis M.A.","family":"Akkermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Wiegant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/gast.2002.36029_bib1","first-page":"507","article-title":"The relationship between trauma, post-traumatic stress disorder, and physical health","author":"Friedman","year":"1995"},{"key":"10.1053\/gast.2002.36029_bib2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.4088\/JCP.v57n1204","article-title":"Comorbidity of posttraumatic stress disorder and irritable bowel syndrome","volume":"57","author":"Irwin","year":"1996","journal-title":"J Clin Psychiatry"},{"key":"10.1053\/gast.2002.36029_bib3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0022-3999(97)00009-3","article-title":"Posttraumatic stress disorder, tenderness and fibromyalgia","volume":"42","author":"Amir","year":"1997","journal-title":"J Psychosom Res"},{"key":"10.1053\/gast.2002.36029_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-2999(00)00555-0","article-title":"Long-lasting stress sensitisation","volume":"405","author":"Stam","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/gast.2002.36029_bib5","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1016\/S0024-3205(99)00553-6","article-title":"Sex differences in long-term stress-induced colonic, behavioural and hormonal disturbances","volume":"65","author":"Stam","year":"1999","journal-title":"Life Sci"},{"key":"10.1053\/gast.2002.36029_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0166-4328(01)00387-4","article-title":"Variability factors in the expression of stress-induced behavioural sensitisation","volume":"132","author":"Stam","year":"2002","journal-title":"Behav Brain Res"},{"key":"10.1053\/gast.2002.36029_bib7","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/0016-5085(88)90006-6","article-title":"Effect of anger on colon motor and myoelectric activity in irritable bowel syndrome","volume":"94","author":"Welgan","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.36029_bib8","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/0016-5085(95)90434-4","article-title":"Selective dysfunction of mechanosensitive intestinal afferents in irritable bowel syndrome","volume":"108","author":"Accarino","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.36029_bib9","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/BF02212678","article-title":"Heightened visceral sensation in functional gastrointestinal disease is not site-specific","volume":"40","author":"Trimble","year":"1995","journal-title":"Dig Dis Sci"},{"key":"10.1053\/gast.2002.36029_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1152\/physrev.1994.74.1.95","article-title":"Sensory innervation of the viscera: peripheral basis of visceral pain","volume":"74","author":"Cervero","year":"1994","journal-title":"Physiol Rev"},{"key":"10.1053\/gast.2002.36029_bib11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0079-6123(08)62142-1","article-title":"Pain as a visceral sensation","volume":"122","author":"Saper","year":"2000","journal-title":"Prog Brain Res"},{"key":"10.1053\/gast.2002.36029_bib12","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0140-6736(99)01306-9","article-title":"Visceral pain","volume":"353","author":"Cervero","year":"1999","journal-title":"Lancet"},{"key":"10.1053\/gast.2002.36029_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0006-8993(88)91555-7","article-title":"Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudoaffective reflexes in the rat","volume":"450","author":"Ness","year":"1988","journal-title":"Brain Res"},{"key":"10.1053\/gast.2002.36029_bib14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0304-3959(90)90035-C","article-title":"A psychophysiological study in humans using phasic colonic distension as a noxious visceral stimulus","volume":"43","author":"Ness","year":"1990","journal-title":"Pain"},{"key":"10.1053\/gast.2002.36029_bib15","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/S0016-5085(96)70064-1","article-title":"but not u or d, opioids attenuate responses to distention of afferent fibers innervating the rat colon","volume":"111","author":"Sengupta","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.36029_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-2999(94)90710-2","article-title":"Role of vagal afferents in the antinociception produced by morphine and U-50,488H in the colonic pain reflex in rats","volume":"257","author":"Diop","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/gast.2002.36029_bib17","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/(SICI)1096-9861(19960311)366:3<495::AID-CNE9>3.0.CO;2-#","article-title":"Common patterns of increased and decreased Fos expression in midbrain and pons evoked by noxious deep somatic and noxious visceral manipulations in the rat","volume":"366","author":"Clement","year":"1996","journal-title":"J Comp Neurol"},{"key":"10.1053\/gast.2002.36029_bib18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0197-0186(98)00023-0","article-title":"c-Fos as a transcription factor: a stressful (re)view from a functional map","volume":"33","author":"Kovacs","year":"1998","journal-title":"Neurochem Int"},{"key":"10.1053\/gast.2002.36029_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0361-9230(97)00277-3","article-title":"Using c-fos as a neural marker of pain","volume":"45","author":"Harris","year":"1998","journal-title":"Brain Res Bull"},{"key":"10.1053\/gast.2002.36029_bib20","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0306-4522(93)90439-M","article-title":"Spinal and hindbrain structures involved in visceroception and visceronociception as revealed by the expression of Fos, Jun and Krox-24 proteins","volume":"55","author":"Lant\u00e9ri-Minet","year":"1993","journal-title":"Neuroscience"},{"key":"10.1053\/gast.2002.36029_bib21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0304-3940(96)12978-5","article-title":"Noxious colorectal distention induced c-Fos protein in limbic brain structures in the rat","volume":"215","author":"Traub","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1053\/gast.2002.36029_bib22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-3940(93)90394-Z","article-title":"Differential expression of c-fos and c-jun in two regions of the rat spinal cord following noxious colorectal distention","volume":"160","author":"Traub","year":"1993","journal-title":"Neurosci Lett"},{"key":"10.1053\/gast.2002.36029_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0014-2999(99)00870-5","article-title":"Endogenous corticotropin-releasing hormone inhibits conditioned fear-induced vagal activation in the rat","volume":"389","author":"Nijsen","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/gast.2002.36029_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0031-9384(01)00435-8","article-title":"Long-term sensitization of cardiovascular responses after a single stressful experience","volume":"73","author":"Bruijnzeel","year":"2001","journal-title":"Physiol Behav"},{"key":"10.1053\/gast.2002.36029_bib25","series-title":"The rat brain in stereotactic coordinates","author":"Paxinos","year":"1998"},{"key":"10.1053\/gast.2002.36029_bib26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0014-2999(94)90780-3","article-title":"Effect of fedotozine on the cardiovascular pain reflex induced by distension of the irritated colon in the anesthetized rat","volume":"271","author":"Langlois","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/gast.2002.36029_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0165-1838(94)90120-1","article-title":"Neuronal expression of Fos protein in the rat brain after baroreceptor stimulation","volume":"50","author":"Miura","year":"1994","journal-title":"J Auton Nerv Syst"},{"key":"10.1053\/gast.2002.36029_bib28","first-page":"88","article-title":"Central autonomic pathways","author":"Loewy","year":"1990"},{"key":"10.1053\/gast.2002.36029_bib29","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/cne.903080210","article-title":"Efferent projections of the infralimbic cortex of the rat","volume":"308","author":"Hurley","year":"1991","journal-title":"J Comp Neurol"},{"key":"10.1053\/gast.2002.36029_bib30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0006-8993(96)00989-4","article-title":"Estrous cycle phase variations in visceromotor and cardiovascular responses to colonic distension in the anesthetized rat","volume":"742","author":"Sapsed-Byrne","year":"1996","journal-title":"Brain Res"},{"key":"10.1053\/gast.2002.36029_bib31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0006-8993(98)01350-X","article-title":"Long-term sensitization of Fos-responsivity in the rat central nervous system after a single stressful experience","volume":"819","author":"Bruijnzeel","year":"1999","journal-title":"Brain Res"},{"key":"10.1053\/gast.2002.36029_bib32","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/cne.902960402","article-title":"Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat","volume":"296","author":"Bullitt","year":"1990","journal-title":"J Comp Neurol"},{"key":"10.1053\/gast.2002.36029_bib33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0006-8993(97)00116-9","article-title":"Locus coeruleus activation by colonic distention: role of corticotropin-releasing factor and excitatory amino acids","volume":"756","author":"Lechner","year":"1997","journal-title":"Brain Res"},{"key":"10.1053\/gast.2002.36029_bib34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0304-3959(96)03127-2","article-title":"Is there a pathway in the posterior funiculus that signals visceral pain?","volume":"67","author":"Hirshberg","year":"1996","journal-title":"Pain"},{"key":"10.1053\/gast.2002.36029_bib35","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00000542-199208000-00021","article-title":"Selective effects of pentobarbital and halothane on c-fos and Jun-B gene expression in rat brain","volume":"77","author":"Marota","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1053\/gast.2002.36029_bib36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0304-3959(01)00285-8","article-title":"Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome","volume":"93","author":"Verne","year":"2001","journal-title":"Pain"},{"key":"10.1053\/gast.2002.36029_bib37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0304-3959(99)00215-8","article-title":"Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia","volume":"84","author":"Chang","year":"2000","journal-title":"Pain"},{"key":"10.1053\/gast.2002.36029_bib38","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0006-8993(99)01134-8","article-title":"Decrease in stress-induced c-Fos-like immunoreactivity in the lateral septal nucleus of learned helplessness rats","volume":"822","author":"Steciuk","year":"1999","journal-title":"Brain Res"},{"key":"10.1053\/gast.2002.36029_bib39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0006-8993(99)01250-0","article-title":"Noxious tooth pulp stimulation suppresses c-fos expression in the rat hippocampal formation","volume":"827","author":"Funahashi","year":"1999","journal-title":"Brain Res"},{"key":"10.1053\/gast.2002.36029_bib40","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1053\/gast.2000.19576","article-title":"A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development","volume":"119","author":"Al-Chaer","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.36029_bib41","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1126\/science.277.5332.1659","article-title":"Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress","volume":"277","author":"Liu","year":"1997","journal-title":"Science"},{"key":"10.1053\/gast.2002.36029_bib42","first-page":"G307","article-title":"Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat","volume":"282","author":"Coutinho","year":"2002","journal-title":"Am J Physiol"},{"key":"10.1053\/gast.2002.36029_bib43","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/gut.40.6.704","article-title":"Trauma and the gut: interactions between stressful experience and intestinal function","volume":"40","author":"Stam","year":"1997","journal-title":"Gut"},{"key":"10.1053\/gast.2002.36029_bib44","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0016-5085(90)90332-U","article-title":"Tolerance for rectosigmoid distention in irritable bowel syndrome","volume":"98","author":"Whitehead","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.36029_bib45","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/gut.41.4.505","article-title":"Evidence for two distinct perceptual alterations in irritable bowel syndrome","volume":"41","author":"Naliboff","year":"1997","journal-title":"Gut"},{"key":"10.1053\/gast.2002.36029_bib46","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0016-5085(98)70540-2","article-title":"Brain-gut axis in health and disease","volume":"114","author":"Aziz","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.36029_bib47","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0016-5085(97)70220-8","article-title":"Regional cerebral activity in normal and pathological perception of visceral pain","volume":"112","author":"Silverman","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.36029_bib48","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(00)70170-3","article-title":"Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention","volume":"118","author":"Mertz","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.36029_bib49","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1136\/gut.43.2.256","article-title":"Level of chronic life stress predict outcome in irritable bowel syndrome","volume":"43","author":"Bennett","year":"1998","journal-title":"Gut"},{"key":"10.1053\/gast.2002.36029_bib50","doi-asserted-by":"crossref","first-page":"782","DOI":"10.7326\/0003-4819-123-10-199511150-00007","article-title":"Sexual and physical abuse and gastrointestinal illness. Review and recommendations","volume":"123","author":"Drossman","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1053\/gast.2002.36029_bib51","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/003655200750023534","article-title":"Perceptual hyperreactivity to auditory stimuli in patients with irritable bowel syndrome","volume":"35","author":"Blomhoff","year":"2000","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/gast.2002.36029_bib52","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1053\/gast.1996.v110.pm8566585","article-title":"Jejunal sensorimotor dysfunction in irritable bowel syndrome: clinical and psychosocial features","volume":"110","author":"Evans","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/gast.2002.36029_bib53","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1136\/gut.44.3.400","article-title":"The role of psychological and biological factors in postinfective gut dysfunction","volume":"44","author":"Gwee","year":"1999","journal-title":"Gut"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502002263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508502002263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T03:22:36Z","timestamp":1554780156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508502002263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["S0016508502002263"],"URL":"https:\/\/doi.org\/10.1053\/gast.2002.36029","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}