{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:29:29Z","timestamp":1791178169476,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5631,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Hepatocyte transplantation improves the survival of laboratory animals with experimentally induced acute liver failure and the physiological abnormalities associated with liver-based metabolic deficiencies. The role of hepatocyte transplantation in treating decompensated liver cirrhosis, however, has not been studied in depth. To address this issue, cirrhosis was induced using phenobarbital and carbon tetrachloride (CCL\n                      <jats:sub>4<\/jats:sub>\n                      ) and animals were studied only when evidence of liver failure did not improve when CCL\n                      <jats:sub>4<\/jats:sub>\n                      was held for 4 weeks. Animals received intrasplenic transplantation of syngeneic rat hepatocytes (G1); intraperitoneal transplantation of syngeneic rat hepatocytes (G2); intraperitoneal transplantation of a cellular homogenate of syngeneic rat hepatocytes (G3); intraperitoneal transplantation of syngeneic rat bone marrow cells (G4); or intrasplenic injection of Dulbecco\u2019s modified Eagle medium (DMEM) (G5). After transplantation, body weight and serum albumin levels deteriorated over time in all control (G2-G5) animals but did not deteriorate in animals receiving intrasplenic hepatocyte transplantation (G1) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .01). Prothrombin time (PT), total bilirubin, serum ammonia, and hepatic encephalopathy score were also significantly improved toward normal in animals receiving intrasplenic hepatocyte transplantation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .01). More importantly, survival was prolonged after a single infusion of hepatocytes and a second infusion prolonged survival from 15 to 128 days (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .01). Thus, hepatocyte transplantation can improve liver function and prolong the survival of rats with irreversible, decompensated cirrhosis and may be useful in the treatment of cirrhosis in humans.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1053\/he.2000.5636","type":"journal-article","created":{"date-parts":[[2004,3,19]],"date-time":"2004-03-19T13:30:42Z","timestamp":1079703042000},"page":"851-857","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":120,"title":["Hepatocyte transplantation in rats with decompensated cirrhosis"],"prefix":"10.1097","volume":"31","author":[{"given":"Naoya","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junta","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Hammel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira J.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1053\/he.2000.5636-BIB1","first-page":"202","volume":"27","author":"Starzl","year":"1990","journal-title":"Curr Probl Surg"},{"key":"10.1053\/he.2000.5636-BIB2","first-page":"1273","volume":"151","author":"Overturf","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1053\/he.2000.5636-BIB3","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1126\/science.8108734","volume":"263","author":"Rhim","year":"1994","journal-title":"Science"},{"key":"10.1053\/he.2000.5636-BIB4","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1073\/pnas.92.11.4942","volume":"92","author":"Rhim","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/he.2000.5636-BIB5","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1126\/science.818706","volume":"192","author":"Matas","year":"1976","journal-title":"Science"},{"key":"10.1053\/he.2000.5636-BIB6","first-page":"313","volume":"9","author":"Groth","year":"1977","journal-title":"Transplant Proc"},{"key":"10.1053\/he.2000.5636-BIB7","first-page":"578","volume":"11","author":"Sommer","year":"1977","journal-title":"Transplant Proc"},{"key":"10.1053\/he.2000.5636-BIB8","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/hep.1840080505","volume":"8","author":"Demetriou","year":"1988","journal-title":"Hepatology"},{"key":"10.1053\/he.2000.5636-BIB9","first-page":"2833","volume":"24","author":"Rivas","year":"1992","journal-title":"Transplant Proc"},{"key":"10.1053\/he.2000.5636-BIB10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/cryo.1993.1002","volume":"30","author":"DeLoecker","year":"1993","journal-title":"Cryobiology"},{"key":"10.1053\/he.2000.5636-BIB11","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/hep.1840120615","volume":"12","author":"Dixit","year":"1990","journal-title":"Hepatology"},{"key":"10.1053\/he.2000.5636-BIB12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF01851995","volume":"186","author":"Grundmann","year":"1986","journal-title":"Res Exp Med"},{"key":"10.1053\/he.2000.5636-BIB13","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1097\/00007890-199906270-00016","volume":"67","author":"Feng","year":"1999","journal-title":"Transplantation"},{"key":"10.1053\/he.2000.5636-BIB14","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0041-1345(99)00003-2","volume":"31","author":"Hammel","year":"1999","journal-title":"Transpl Proc"},{"key":"10.1053\/he.2000.5636-BIB15","doi-asserted-by":"crossref","first-page":"251a","DOI":"10.1002\/hep.510260422","volume":"26","author":"Ilan","year":"1997","journal-title":"Hepatology"},{"key":"10.1053\/he.2000.5636-BIB16","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJM199805143382004","volume":"338","author":"Fox","year":"1998","journal-title":"New Engl J Med"},{"key":"10.1053\/he.2000.5636-BIB17","first-page":"353","volume":"47","author":"Quinn","year":"1965","journal-title":"Am J Pathol"},{"key":"10.1053\/he.2000.5636-BIB18","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0016-5085(82)80126-1","volume":"83","author":"Proctor","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1053\/he.2000.5636-BIB19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000128407","volume":"16","author":"Proctor","year":"1984","journal-title":"Eur Surg Res"},{"key":"10.1053\/he.2000.5636-BIB20","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1083\/jcb.43.3.506","volume":"43","author":"Berry","year":"1969","journal-title":"J Cell Biol"},{"key":"10.1053\/he.2000.5636-BIB21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0091-679X(08)61797-5","volume":"13","author":"Seglen","year":"1976","journal-title":"Methods Cell Biol"},{"key":"10.1053\/he.2000.5636-BIB22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0022-4804(90)90223-O","volume":"48","author":"Yu","year":"1990","journal-title":"J Surg Res"},{"key":"10.1053\/he.2000.5636-BIB23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/B978-0-444-41502-8.50006-5","volume-title":"Innate and motivated behavior. Techniques and basic experiments for the study of brain and behavior","author":"Bures","year":"1976","unstructured":"Innate and motivated behavior. Techniques and basic experiments for the study of brain and behavior. New York: Elsevier; 1976;37-45."},{"key":"10.1053\/he.2000.5636-BIB24","first-page":"39","volume":"24","author":"Makowka","year":"1981","journal-title":"Can J Surg"},{"key":"10.1053\/he.2000.5636-BIB25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000128344","volume":"15","author":"Baumgartner","year":"1983","journal-title":"Eur Surg Res"},{"key":"10.1053\/he.2000.5636-BIB26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/hep.1840150104","volume":"15","author":"Ribeiro","year":"1992","journal-title":"Hepatology"},{"key":"10.1053\/he.2000.5636-BIB27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/hep.510240209","volume":"24","author":"Schumacher","year":"1996","journal-title":"Hepatology"},{"key":"10.1053\/he.2000.5636-BIB28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1700420104","volume":"42","author":"Cameron","year":"1936","journal-title":"J Pathol Bact"},{"key":"10.1053\/he.2000.5636-BIB29","first-page":"381","volume":"18","author":"Moon","year":"1934","journal-title":"Arch Pathol"},{"key":"10.1053\/he.2000.5636-BIB30","first-page":"411","volume":"92","author":"Montfort","year":"1978","journal-title":"Am J Pathol"},{"key":"10.1053\/he.2000.5636-BIB31","first-page":"715","volume":"42","author":"Rubin","year":"1963","journal-title":"Am J Pathol"},{"key":"10.1053\/he.2000.5636-BIB32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0006-2952(69)90089-6","volume":"18","author":"Garner","year":"1969","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/he.2000.5636-BIB33","first-page":"502","volume":"50","author":"McLean","year":"1969","journal-title":"Br J Exp Pathol"},{"key":"10.1053\/he.2000.5636-BIB34","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/BF02774914","volume":"13","author":"Mito","year":"1978","journal-title":"Gastroenterol Jpn"},{"key":"10.1053\/he.2000.5636-BIB35","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/0016-5085(82)90303-1","volume":"82","author":"Kusano","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1053\/he.2000.5636-BIB36","first-page":"60","volume":"24","author":"D'Errico","year":"1996","journal-title":"Hepatology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fhe.2000.5636","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200004000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T06:26:45Z","timestamp":1733034405000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200004000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000]]}},"URL":"https:\/\/doi.org\/10.1053\/he.2000.5636","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}