{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:28:47Z","timestamp":1761762527269},"reference-count":24,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1053\/hupa.2001.29668","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T07:23:34Z","timestamp":1027668214000},"page":"1344-1350","source":"Crossref","is-referenced-by-count":10,"title":["Tyrosine kinase activation in breast carcinoma with correlation to HER-2\/neu gene amplification and receptor overexpression"],"prefix":"10.1053","volume":"32","author":[{"given":"Rohit","family":"Bhargava","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizwan","family":"Naeem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Marconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Luszcz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Garb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gasparini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher N.","family":"Otis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/hupa.2001.29668_bib1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/319226a0","article-title":"The neu oncogene encodes an epidermal growth factor receptor-related protein","volume":"319","author":"Bargmann","year":"1986","journal-title":"Nature"},{"key":"10.1053\/hupa.2001.29668_bib2","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1126\/science.2992090","article-title":"The neu gene: An erb B-homologous gene distinct from and unlinked to the gene encoding the EGF receptor","volume":"229","author":"Schechter","year":"1985","journal-title":"Science"},{"key":"10.1053\/hupa.2001.29668_bib3","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.2992089","article-title":"Amplification of a novel v-erbB-related gene in a human mammary carcinoma","volume":"229","author":"King","year":"1985","journal-title":"Science"},{"key":"10.1053\/hupa.2001.29668_bib4","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.2999974","article-title":"Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene","volume":"230","author":"Coussens","year":"1985","journal-title":"Science"},{"key":"10.1053\/hupa.2001.29668_bib5","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0888-7543(89)90343-1","article-title":"Localization of the erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32","volume":"4","author":"Popescu","year":"1989","journal-title":"Genomes"},{"key":"10.1053\/hupa.2001.29668_bib6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/312513a0","article-title":"The neu oncogene: An erb-B-related gene encoding a 185,000-Mr tumor antigen","volume":"312","author":"Schechter","year":"1984","journal-title":"Nature"},{"key":"10.1053\/hupa.2001.29668_bib7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/319230a0","article-title":"Similarity of protein encoded by the human c-erb B-2 gene to epidermal growth factor receptor","volume":"319","author":"Yamamoto","year":"1986","journal-title":"Nature"},{"key":"10.1053\/hupa.2001.29668_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/stem.150001","article-title":"HER-2\/neu signal transduction in human breast and ovarian cancer","volume":"15","author":"Reese","year":"1997","journal-title":"Stem Cells"},{"key":"10.1053\/hupa.2001.29668_bib9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0092-8674(90)90801-K","article-title":"Signal transduction by receptors with tyrosine kinase activity","volume":"61","author":"Ullrich","year":"1990","journal-title":"Cell"},{"key":"10.1053\/hupa.2001.29668_bib10","first-page":"7","article-title":"Protein tyrosine kinase receptors","volume":"27","author":"Heldin","year":"1996","journal-title":"Cancer Surv"},{"key":"10.1053\/hupa.2001.29668_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0968-0004(94)90130-9","article-title":"Regulation of signal transduction and signal diversity by receptor oligomerization","volume":"19","author":"Lemmon","year":"1994","journal-title":"Trends Biochem Sci"},{"key":"10.1053\/hupa.2001.29668_bib12","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1128\/MCB.11.2.833","article-title":"The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxy-terminal domain","volume":"11","author":"Akiyama","year":"1991","journal-title":"Mol Cell Biol"},{"key":"10.1053\/hupa.2001.29668_bib13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","article-title":"Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal regulated kinase activation","volume":"80","author":"Marshall","year":"1995","journal-title":"Cell"},{"key":"10.1053\/hupa.2001.29668_bib14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2559.1991.tb00229.x","article-title":"Pathological prognostic factors in breast cancer. I. The value of histological grades in breast cancer. Experience from a large study with long-term follow-up","volume":"19","author":"Elston","year":"1991","journal-title":"Histopathology"},{"key":"10.1053\/hupa.2001.29668_bib15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/ajcp\/103.2.195","article-title":"Interobserver reproducibility of the Nottingham modification of the Bloom and Richardson histologic grading scheme for infiltrating ductal carcinoma","volume":"103","author":"Frierson","year":"1995","journal-title":"Am J Clin Pathol"},{"key":"10.1053\/hupa.2001.29668_bib16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.3798106","article-title":"Human breast cancer: Correlation of relapse and survival with amplification of the HER-2\/neu oncogene","volume":"235","author":"Slamon","year":"1987","journal-title":"Science"},{"key":"10.1053\/hupa.2001.29668_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0140-6736(87)92736-X","article-title":"Overexpression of the c-erbB-2 oncoprotein in human breast carcinomas: Immunohistochemical assessment correlates with gene amplification","volume":"2","author":"Venter","year":"1987","journal-title":"Lancet"},{"key":"10.1053\/hupa.2001.29668_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ijc.2910450314","article-title":"Expression of the p185 encoded by HER-2 oncogene in normal and transformed human tissues","volume":"45","author":"Natali","year":"1990","journal-title":"Int J Cancer"},{"key":"10.1053\/hupa.2001.29668_bib19","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1200\/JCO.2001.19.2.354","article-title":"HER-2\/neu analysis in archival tissue samples of human breast cancer: Comparison of immunohistochemistry and fluorescence in situ hybridization","volume":"19","author":"Lebeau","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1053\/hupa.2001.29668_bib20","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1200\/JCO.2001.19.10.2714","article-title":"Discrepancies in clinical laboratory testing of eligibility for trastuzumab therapy: Apparent immunohistochemical false-positives do not get the message","volume":"19","author":"Tubbs","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1053\/hupa.2001.29668_bib21","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1046\/j.1365-2559.1998.00498.x","article-title":"Type 1 protein tyrosine kinases in benign and malignant breast lesions","volume":"33","author":"Suo","year":"1998","journal-title":"Histopathology"},{"key":"10.1053\/hupa.2001.29668_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1200\/JCO.1990.8.1.103","article-title":"Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project. Significance of erbB 2 protein overexpression in primary breast cancer","volume":"8","author":"Paik","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1053\/hupa.2001.29668_bib23","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1200\/JCO.1992.10.7.1044","article-title":"Prognostic significance of HER-2 oncoprotein expression in breast cancer: A 30-year follow up","volume":"10","author":"Toikkanen","year":"1992","journal-title":"J Clin Oncol"},{"key":"10.1053\/hupa.2001.29668_bib24","first-page":"2087","article-title":"Expression of c-erbB-2 oncoprotein: A prognostic indicator in human breast cancer","volume":"49","author":"Wright","year":"1989","journal-title":"Cancer Res"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817701629216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817701629216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T18:28:18Z","timestamp":1555007298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817701629216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["S0046817701629216"],"URL":"https:\/\/doi.org\/10.1053\/hupa.2001.29668","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}