{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:53:29Z","timestamp":1767707609329},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2002,2]]},"DOI":"10.1053\/hupa.2002.31297","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"191-197","source":"Crossref","is-referenced-by-count":38,"title":["Loss of heterozygosity analysis of cutaneous melanoma and benign melanocytic nevi: Laser capture microdissection demonstrates clonal genetic changes in acquired nevocellular nevi"],"prefix":"10.1053","volume":"33","author":[{"given":"Anirban","family":"Maitra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi F.","family":"Gazdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd O.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Yen","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/hupa.2002.31297_bib1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0046-8177(84)80310-X","article-title":"A study of tumor progression: The precursor lesions of superficial spreading and nodular melanoma","volume":"15","author":"Clark","year":"1984","journal-title":"Hum Pathol"},{"key":"10.1053\/hupa.2002.31297_bib2","first-page":"756","article-title":"Melanocytic nevi and malignant melanoma","author":"Lever","year":"1990"},{"key":"10.1053\/hupa.2002.31297_bib3","first-page":"462","article-title":"Pinkus's Guide to Dermatopathology","author":"Mehregan","year":"1995"},{"key":"10.1053\/hupa.2002.31297_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000246468","article-title":"What is a nevus? A proposed definition of a common medical term","volume":"191","author":"Happle","year":"1995","journal-title":"Dermatology"},{"key":"10.1053\/hupa.2002.31297_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/1097-0142(19900715)66:2<387::AID-CNCR2820660232>3.0.CO;2-J","article-title":"Count of benign melanocytic nevi as a major indicator of risk for nonfamilial nodular and superficial spreading melanoma","volume":"66","author":"Grob","year":"1990","journal-title":"Cancer"},{"key":"10.1053\/hupa.2002.31297_bib6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-1-4615-3080-0_8","article-title":"Molecular genetics of human malignant melanoma","volume":"65","author":"Albino","year":"1993","journal-title":"Cancer Treat Res"},{"key":"10.1053\/hupa.2002.31297_bib7","first-page":"667","article-title":"The genetics of cutaneous melanoma","volume":"20","author":"Pollock","year":"2000","journal-title":"Clin Lab Med"},{"key":"10.1053\/hupa.2002.31297_bib8","first-page":"207","article-title":"Molecular pathology of cutaneous melanoma","author":"Hayward","year":"1999"},{"key":"10.1053\/hupa.2002.31297_bib9","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/gcc.2870120211","article-title":"Loss of heterozygosity in sporadic primary cutaneous melanoma","volume":"12","author":"Healy","year":"1995","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1053\/hupa.2002.31297_bib10","first-page":"589","article-title":"Allelotypes of primary cutaneous melanoma and benign melanocytic nevi","volume":"56","author":"Healy","year":"1996","journal-title":"Cancer Res"},{"key":"10.1053\/hupa.2002.31297_bib11","first-page":"3111","article-title":"Loss of heterozygosity for 10q22-10qter in malignant melanoma progression","volume":"54","author":"Herbst","year":"1994","journal-title":"Cancer Res"},{"key":"10.1053\/hupa.2002.31297_bib12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/gcc.2870080307","article-title":"Chromosome 10 allelic loss in malignant melanoma","volume":"8","author":"Isshiki","year":"1993","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1053\/hupa.2002.31297_bib13","first-page":"1649","article-title":"Chromosome 9 deletion in sporadic and familial melanomas in vivo","volume":"9","author":"Isshiki","year":"1994","journal-title":"Oncogene"},{"key":"10.1053\/hupa.2002.31297_bib14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/gcc.2870120208","article-title":"A genetic model of melanoma tumorigenesis based on allelic losses","volume":"12","author":"Walker","year":"1995","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1053\/hupa.2002.31297_bib15","first-page":"3222","article-title":"11q23 allelic loss is associated with regional lymph node metastasis in melanoma","volume":"6","author":"Herbst","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1053\/hupa.2002.31297_bib16","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/1523-1747.ep12337678","article-title":"Clonality in nevocellular nevus and melanoma: An expression-based clonality analysis at the X-linked genes by polymerase chain reaction","volume":"109","author":"Harada","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1053\/hupa.2002.31297_bib17","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/00008390-199812000-00004","article-title":"Human acquired naevi are clonal","volume":"8","author":"Robinson","year":"1998","journal-title":"Melanoma Res"},{"key":"10.1053\/hupa.2002.31297_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0046-8177(98)90221-0","article-title":"Allelic deletion at chromosome 9p21(p16) and 17p13(p53) in microdissected sporadic dysplastic nevus","volume":"29","author":"Park","year":"1998","journal-title":"Hum Pathol"},{"key":"10.1053\/hupa.2002.31297_bib19","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1006\/bbrc.1997.7212","article-title":"Genetic alterations of p16INK4a and p53 genes in sporadic dysplastic nevus","volume":"237","author":"Lee","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/hupa.2002.31297_bib20","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/archderm.134.7.882","article-title":"Loss of heterozygosity detected on 1p and 9q in microdissected atypical nevi","volume":"134","author":"Boni","year":"1998","journal-title":"Arch Dermatol"},{"key":"10.1053\/hupa.2002.31297_bib21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1097-0215(20000415)86:2<255::AID-IJC16>3.0.CO;2-L","article-title":"Detection of microsatellite alterations in the spectrum of melanocytic nevi in patients with or without individual or family history of melanoma","volume":"86","author":"Birindelli","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1053\/hupa.2002.31297_bib22","first-page":"2170","article-title":"Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization","volume":"58","author":"Bastian","year":"1998","journal-title":"Cancer Res"},{"key":"10.1053\/hupa.2002.31297_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/(SICI)1097-0215(19990118)80:2<205::AID-IJC8>3.0.CO;2-J","article-title":"Identification of two distinct deletion targets at 11q23 in cutaneous malignant melanoma","volume":"80","author":"Herbst","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1053\/hupa.2002.31297_bib24","first-page":"5449","article-title":"Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma","volume":"51","author":"Millikin","year":"1991","journal-title":"Cancer Res"},{"key":"10.1053\/hupa.2002.31297_bib25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0165-4608(88)90200-2","article-title":"Possible involvement of the chromosome region 10q24-q26 in early stages of melanocytic neoplasia","volume":"30","author":"Parmiter","year":"1988","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1053\/hupa.2002.31297_bib26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s004280050477","article-title":"Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas","volume":"436","author":"Reifenberger","year":"2000","journal-title":"Virchows Arch"},{"key":"10.1053\/hupa.2002.31297_bib27","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/0959-8049(96)00198-0","article-title":"Allele loss on chromosome 11q and microsatellite instability in malignant melanoma","volume":"32A","author":"Tomlinson","year":"1996","journal-title":"Eur J Cancer"},{"key":"10.1053\/hupa.2002.31297_bib28","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1126\/science.278.5342.1481","article-title":"Laser capture microdissection: Molecular analysis of tissue","volume":"278","author":"Bonner","year":"1997","journal-title":"Science"},{"key":"10.1053\/hupa.2002.31297_bib29","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1001\/jama.279.19.1554","article-title":"Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects","volume":"279","author":"Wistuba","year":"1998","journal-title":"JAMA"},{"key":"10.1053\/hupa.2002.31297_bib30","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0190-9622(82)70016-7","article-title":"The malignant potential of small congenital nevocellular nevi. An estimate of association based on a histologic study of 234 primary cutaneous melanomas","volume":"6","author":"Rhodes","year":"1982","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/hupa.2002.31297_bib31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/7458","article-title":"Enrichment of epithelial cells for molecular studies","volume":"5","author":"Maitra","year":"1999","journal-title":"Nat Med"},{"key":"10.1053\/hupa.2002.31297_bib32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-1-4615-1657-6_3","article-title":"Tissue microdissection and processing","volume":"106","author":"Maitra","year":"2001","journal-title":"Cancer Treat Res"},{"key":"10.1053\/hupa.2002.31297_bib33","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/(SICI)1097-0142(19991225)87:6<372::AID-CNCR8>3.0.CO;2-5","article-title":"Use of archival fine-needle aspirates for the allelotyping of tumors","volume":"87","author":"Euhus","year":"1999","journal-title":"Cancer"},{"key":"10.1053\/hupa.2002.31297_bib34","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/S0046-8177(00)80013-1","article-title":"PCR artifacts in LOH and MSI analysis of microdissected tumor cells","volume":"31","author":"Sieben","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1053\/hupa.2002.31297_bib35","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/(SICI)1097-0215(20000215)85:4<492::AID-IJC8>3.0.CO;2-#","article-title":"Clonal heterogeneity in sporadic melanomas as revealed by loss-of-heterozygosity analysis","volume":"85","author":"Takata","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1053\/hupa.2002.31297_bib36","first-page":"150","article-title":"Superficial congenital nevus vs. deep congenital nevus","author":"Ackerman","year":"1993"},{"key":"10.1053\/hupa.2002.31297_bib37","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1001\/archderm.1990.01670300070010","article-title":"Suntan, sunburn, and pigmentation factors and the frequency of acquired melanocytic nevi in children. Similarities to melanoma: the Vancouver Mole Study","volume":"126","author":"Gallagher","year":"1990","journal-title":"Arch Dermatol"},{"key":"10.1053\/hupa.2002.31297_bib38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/bmj.299.6691.88","article-title":"Excess benign melanocytic naevi after chemotherapy for malignancy in childhood","volume":"299","author":"Hughes","year":"1989","journal-title":"BMJ"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817702423234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817702423234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:22:21Z","timestamp":1555028541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817702423234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["S0046817702423234"],"URL":"https:\/\/doi.org\/10.1053\/hupa.2002.31297","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}