{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T05:43:27Z","timestamp":1772948607161,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1053\/hupa.2002.32221","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"355-364","source":"Crossref","is-referenced-by-count":78,"title":["Ectopic localization of matrix metalloproteinase-9 in chronic cutaneous wounds"],"prefix":"10.1053","volume":"33","author":[{"given":"Ursula","family":"Mirastschijski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Impola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiina","family":"Jahkola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonny","family":"Karlsmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus S.","family":"\u00c5gren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulpu","family":"Saarialho-Kere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/hupa.2002.32221_bib1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/bjs.1800641113","article-title":"Epidermal repair in chronic venous ulcers","volume":"64","author":"Adair","year":"1977","journal-title":"Br J Surg"},{"key":"10.1053\/hupa.2002.32221_bib2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/ajcp\/92.4.430","article-title":"Impaired migration of epidermal cells from decubitus ulcers in cell cultures. A cause of protracted wound healing?","volume":"92","author":"Seiler","year":"1989","journal-title":"Am J Clin Pathol"},{"key":"10.1053\/hupa.2002.32221_bib3","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2340\/0001555575459462","article-title":"Epidermal proliferation is not impaired in chronic venous ulcers","volume":"75","author":"Andriessen","year":"1995","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"10.1053\/hupa.2002.32221_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/00015555210317","article-title":"Causes and effects of the chronic inflammation in venous leg ulcers","volume":"210","author":"\u00c5gren","year":"2000","journal-title":"Acta Derm Venereol (Stockh) Suppl"},{"key":"10.1053\/hupa.2002.32221_bib5","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/1523-1747.ep12340167","article-title":"Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers","volume":"106","author":"Weckroth","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1053\/hupa.2002.32221_bib6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1046\/j.1524-475X.1999.00442.x","article-title":"Analysis of the acute and chronic wound environments: The role of proteases and their inhibitors","volume":"7","author":"Trengove","year":"1999","journal-title":"Wound Repair Regen"},{"key":"10.1053\/hupa.2002.32221_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/1523-1747.ep12359590","article-title":"Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9","volume":"101","author":"Wysocki","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1053\/hupa.2002.32221_bib8","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/1523-1747.ep12365637","article-title":"Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids","volume":"107","author":"Yager","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1053\/hupa.2002.32221_bib9","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1365-2133.1997.tb03779.x","article-title":"Postsurgical wound progression monitored by temporal changes in the expression of matrix metalloproteinase-9","volume":"137","author":"Tarlton","year":"1997","journal-title":"Br J Dermatol"},{"key":"10.1053\/hupa.2002.32221_bib10","first-page":"391","article-title":"Matrix metalloproteinases in wound repair [review]","volume":"6","author":"Ravanti","year":"2000","journal-title":"Int J Mol Med"},{"key":"10.1053\/hupa.2002.32221_bib11","first-page":"115","article-title":"Gelatinase B: Structure, regulation and function","author":"Vu","year":"1998"},{"key":"10.1053\/hupa.2002.32221_bib12","first-page":"176","article-title":"Expression of matrix metalloproteinase-2 and -9 during early human wound healing","volume":"70","author":"Salo","year":"1994","journal-title":"Lab Invest"},{"key":"10.1053\/hupa.2002.32221_bib13","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1083\/jcb.148.3.615","article-title":"Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5","volume":"148","author":"Koshikawa","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1053\/hupa.2002.32221_bib14","doi-asserted-by":"crossref","first-page":"16098","DOI":"10.1074\/jbc.273.26.16098","article-title":"TIMP-2 promotes activation of progelatinase A by membrane-type 1 matrix metalloproteinase immobilized on agarose beads","volume":"273","author":"Kinoshita","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1053\/hupa.2002.32221_bib15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-2133.1996.tb03607.x","article-title":"Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds","volume":"135","author":"Vaalamo","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1053\/hupa.2002.32221_bib16","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1046\/j.1523-1747.2000.00135.x","article-title":"Stromelysin-2 is upregulated during normal wound repair and is induced by cytokines","volume":"115","author":"Rechardt","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1053\/hupa.2002.32221_bib17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1042\/bj2390793","article-title":"Direct extraction and assay of bone tissue collagenase and its relation to parathyroid hormone-induced bone resorption","volume":"239","author":"Eeckhout","year":"1986","journal-title":"Biochem J"},{"key":"10.1053\/hupa.2002.32221_bib18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1523-1747.1999.00547.x","article-title":"Enhanced expression of human metalloelastase (MMP-12) in cutaneous granulomas and macrophage migration","volume":"112","author":"Vaalamo","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1053\/hupa.2002.32221_bib19","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1172\/JCI116906","article-title":"Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing","volume":"92","author":"Saarialho-Kere","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1053\/hupa.2002.32221_bib20","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/S0002-9440(10)64834-1","article-title":"Ligation of \u03b14\u03b21 integrin on human intestinal mucosal mesenchymal cells selectively up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotype","volume":"157","author":"Pender","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1053\/hupa.2002.32221_bib21","first-page":"1073","article-title":"Regional heterogeneity of elastin and collagen gene expression in intralobar arteries in response to hypoxic pulmonary hypertension as demonstrated by in situ hybridization","volume":"135","author":"Prosser","year":"1989","journal-title":"Am J Pathol"},{"key":"10.1053\/hupa.2002.32221_bib22","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1007\/PL00007453","article-title":"Patterns of matrix metalloproteinases and TIMP expression in chronic ulcers","volume":"290","author":"Saarialho-Kere","year":"1998","journal-title":"Arch Dermatol Res [Suppl]"},{"key":"10.1053\/hupa.2002.32221_bib23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1034\/j.1600-0625.2001.100506.x","article-title":"Topical synthetic inhibitor of matrix metalloproteinases delays epidermal regeneration of human wounds","volume":"10","author":"\u00c5gren","year":"2001","journal-title":"Exp Dermatol"},{"key":"10.1053\/hupa.2002.32221_bib24","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1046\/j.1523-1747.2001.01352.x","article-title":"\u03b1v\u03b26 Integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes","volume":"116","author":"Thomas","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1053\/hupa.2002.32221_bib25","first-page":"1085","article-title":"Sequential changes in histologic pattern and extracellular matrix deposition during the healing of chronic venous ulcers","volume":"141","author":"Herrick","year":"1992","journal-title":"Am J Pathol"},{"key":"10.1053\/hupa.2002.32221_bib26","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1189\/jlb.68.5.737","article-title":"Fibronectin-bound TNF-alpha stimulates monocyte matrix metalloproteinase-9 expression and regulates chemotaxis","volume":"68","author":"Vaday","year":"2000","journal-title":"J Leukoc Biol"},{"key":"10.1053\/hupa.2002.32221_bib27","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s004030100234","article-title":"Reconstruction of basement membrane in skin equivalent: Role of laminin-1","volume":"293","author":"Yi","year":"2001","journal-title":"Arch Dermatol Res"},{"key":"10.1053\/hupa.2002.32221_bib28","first-page":"1287","article-title":"Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury","volume":"149","author":"Fini","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1053\/hupa.2002.32221_bib29","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/1523-1747.ep12612786","article-title":"Tissue inhibitor of metalloproteinases-1 is decreased and activated gelatinases are increased in chronic wounds","volume":"104","author":"Bullen","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1053\/hupa.2002.32221_bib30","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1046\/j.1365-2168.1998.00556.x","article-title":"Matrix metalloproteinase-9 level predicts optimal collagen deposition during early wound repair in humans","volume":"85","author":"\u00c5gren","year":"1998","journal-title":"Br J Surg"},{"key":"10.1053\/hupa.2002.32221_bib31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/1523-1747.ep12363823","article-title":"Demonstration of 72-kDa and 92-kDa forms of type IV collagenase in human skin: Variable expression in various blistering diseases, induction during re-epithelialization, and decrease by topical glucocorticoids","volume":"101","author":"Oikarinen","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1053\/hupa.2002.32221_bib32","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s004410050963","article-title":"Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humans","volume":"290","author":"Ashcroft","year":"1997","journal-title":"Cell Tissue Res"},{"key":"10.1053\/hupa.2002.32221_bib33","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1523-1747.2000.00044.x","article-title":"Defective extracellular matrix reorganization by chronic wound fibroblasts is associated with alterations in TIMP-1, TIMP-2, and MMP-2 activity","volume":"115","author":"Cook","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1053\/hupa.2002.32221_bib34","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1699-0463.1999.tb01536.x","article-title":"Membrane-type matrix metalloproteinases","volume":"107","author":"Seiki","year":"1999","journal-title":"APMIS"},{"key":"10.1053\/hupa.2002.32221_bib35","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1073\/pnas.060037197","article-title":"Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I","volume":"97","author":"Zhou","year":"2000","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817702350615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817702350615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T22:20:02Z","timestamp":1704320402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817702350615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["S0046817702350615"],"URL":"https:\/\/doi.org\/10.1053\/hupa.2002.32221","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}