{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T01:02:23Z","timestamp":1774573343678,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Chronic Kidney Disease"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1053\/j.ackd.2005.11.001","type":"journal-article","created":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T15:08:30Z","timestamp":1137078510000},"page":"47-55","source":"Crossref","is-referenced-by-count":72,"title":["Calcineurin Nephrotoxicity"],"prefix":"10.1053","volume":"13","author":[{"given":"David","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Haragsim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.ackd.2005.11.001_bib1","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1097\/00007890-199812270-00029","article-title":"Histopathologic findings from 2-year protocol biopsies from a U.S. multicenter kidney transplant trial comparing tacrolimus versus cyclosporine","volume":"66","author":"Solez","year":"1998","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib2","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1600-6143.2004.00515.x","article-title":"Long-term renal allograft survival","volume":"4","author":"Meier-Kriesche","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1053\/j.ackd.2005.11.001_bib3","series-title":"Comprehensive Clinical Nephrology","first-page":"1057","article-title":"Immunosuppressive Agents Used in Transplantation","author":"Melk","year":"2000"},{"key":"10.1053\/j.ackd.2005.11.001_bib4","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1161\/01.HYP.19.5.464","article-title":"Renal Injury from angiotensin II mediated hypertension","volume":"19","author":"Johnson","year":"1992","journal-title":"Hypertension"},{"key":"10.1053\/j.ackd.2005.11.001_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1389200023337964","article-title":"Interaction of cyclosporine A and the renin-angiotensin system","volume":"3","author":"Lassila","year":"2002","journal-title":"Curr Drug Metab"},{"key":"10.1053\/j.ackd.2005.11.001_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ki.1987.166","article-title":"Glomerular hemodynamics and hormonal participation on cyclosporine nephrotoxicity","volume":"32","author":"Barros","year":"1987","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2005.11.001_bib7","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/ki.1985.196","article-title":"Effect of cyclosporine administration on renal hemodynamics in conscious rats","volume":"28","author":"Murray","year":"1985","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2005.11.001_bib8","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1681\/ASN.V641186","article-title":"Pathogenesis of cyclosporine nephropathy","volume":"6","author":"Pichler","year":"1995","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2005.11.001_bib9","first-page":"418","article-title":"Differential diagnosis of cyclosporine nephrotoxicity versus rejection by fine needle aspiration biopsy","volume":"24","author":"Von Willebrand","year":"1983","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2005.11.001_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0140-6736(83)90173-3","article-title":"Cyclosporine A deposits in renal allografts","volume":"2","author":"Von Willebrand","year":"1983","journal-title":"Lancet"},{"key":"10.1053\/j.ackd.2005.11.001_bib11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0955-470X(10)80033-3","article-title":"Cyclosporine-induced renal dysfunction in experimental animals and humans","volume":"5","author":"Perico","year":"1991","journal-title":"Transplant Rev"},{"key":"10.1053\/j.ackd.2005.11.001_bib12","first-page":"F443","article-title":"Effects of Ang II, ETA, and Txa2 receptor antagonists on cyclosporine A renal vasoconstriction","volume":"267","author":"Conger","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1053\/j.ackd.2005.11.001_bib13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00007890-199107000-00042","article-title":"Increased urinary excretion of endothelin-1 and its precursor big endothelin-1 in rats chronically treated with cyclosporine","volume":"52","author":"Benigni","year":"1991","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib14","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1097\/01.TP.0000121502.60664.AB","article-title":"Suppression of cyclosporine A nephrotoxicity in vivo by transforming growth factor B receptor immunoglobulin G chimeric protein","volume":"77","author":"Xin","year":"2004","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib15","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1046\/j.1523-1755.2000.00273.x","article-title":"Effect of nitric oxide modulation on TGF- Beta1 and matrix proteins in chronic cyclosporine neprotoxicity","volume":"58","author":"Shihab","year":"2000","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2005.11.001_bib16","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1046\/j.1523-1755.1999.00299.x","article-title":"The Banff 97 working classification of renal allograft pathology","volume":"5","author":"Racusen","year":"1999","journal-title":"Kidney Int"},{"issue":"suppl 52","key":"10.1053\/j.ackd.2005.11.001_bib17","first-page":"S63","article-title":"The differential diagnosis between rejection and cyclosporine toxicity","volume":"48","author":"Mihatsch","year":"1995","journal-title":"Kidney Int"},{"issue":"suppl 3","key":"10.1053\/j.ackd.2005.11.001_bib18","first-page":"759","article-title":"Histopathology of cyclosporine nephrotoxicity","volume":"20","author":"Mihatsch","year":"1988","journal-title":"Transplantation Proc"},{"issue":"suppl","key":"10.1053\/j.ackd.2005.11.001_bib19","first-page":"S37","article-title":"Beneficial effects of renal denervation and prazosin on GFR and renal blood flow after cyclosporine in rats","volume":"25","author":"Murray","year":"1986","journal-title":"Clin Nephrol"},{"key":"10.1053\/j.ackd.2005.11.001_bib20","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1097\/00007890-199306000-00009","article-title":"The effects of cyclosporine in Lewis rats with native and transplanted kidneys","volume":"55","author":"Churchill","year":"1993","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib21","doi-asserted-by":"crossref","first-page":"764","DOI":"10.2165\/00003495-199346040-00009","article-title":"Tacrolimus","volume":"46","author":"Peters","year":"1993","journal-title":"Drugs"},{"key":"10.1053\/j.ackd.2005.11.001_bib22","series-title":"Solid Organ Allograft Rejection","first-page":"587","article-title":"Nephrotoxicity of cyclosporine and newer immunosuppressive agents","author":"Solez","year":"1996"},{"key":"10.1053\/j.ackd.2005.11.001_bib23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/00007890-199608150-00011","article-title":"Progressive histologic injury in kidneys from heart and liver transplant recipients receiving cyclosporine","volume":"62","author":"Falkenheim","year":"1996","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib24","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/ki.1988.38","article-title":"The long-term course of cyclosporine associated chronic nephropathy","volume":"33","author":"Myers","year":"1988","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2005.11.001_bib25","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1097\/00007890-199211000-00021","article-title":"Cyclosporine nephrotoxicity in lung transplant recipients","volume":"54","author":"Zaltman","year":"1992","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib26","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1056\/NEJMoa020009","article-title":"The natural history of chronic allograft nephropathy","volume":"349","author":"Nankivell","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2005.11.001_bib27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00007890-198803000-00015","article-title":"An analysis of cyclosporine efficacy and toxicity after liver transplantation","volume":"45","author":"O\u2019Grady","year":"1988","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib28","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/00007890-199803150-00010","article-title":"Long-term improvement in renal function after cyclosporine reduction in renal transplant recipients with histologically proven chronic cyclosporine nephropathy","volume":"65","author":"Mourad","year":"1998","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00007890-199601270-00018","article-title":"A multicenter analysis of the first experience with FK506 for induction and rescue therapy after pancreas transplantation","volume":"61","author":"Gruessner","year":"1996","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib30","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1097\/00007890-199006000-00013","article-title":"Chronic cyclosporine-associated nephrotoxicity in bone marrow transplant patients","volume":"49","author":"Dieterle","year":"1990","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib31","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1056\/NEJM199206183262502","article-title":"International kidney biopsy registry of cyclosporine in autoimmune diseases. Risk factors for cyclosporine-induced nephropathy in patients with autoimmune diseases","volume":"326","author":"Feutren","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2005.11.001_bib32","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1097\/01.TP.0000063830.60937.06","article-title":"Chronic allograft nephropathy uniformly affects recipients of cadaveric, nonidentical living-related, and living-unrelated grafts","volume":"75","author":"Krieger","year":"2003","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib33","series-title":"Clinical Transplants 2000","article-title":"Then UNOS Scientific Renal Transplant Registry","author":"Cecka","year":"2001"},{"key":"10.1053\/j.ackd.2005.11.001_bib34","series-title":"Comprehensive Clinical Nephrology","first-page":"1057","article-title":"Immunosuppressive agents used in transplantation","author":"Melk","year":"2000"},{"key":"10.1053\/j.ackd.2005.11.001_bib35","series-title":"Comprehensive Clinical Nephrology","first-page":"1057","article-title":"Immunosuppressive Agents Used in Transplantation","author":"Melk","year":"2000"},{"key":"10.1053\/j.ackd.2005.11.001_bib36","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/01.TP.0000151630.25127.3A","article-title":"Cutaneous adverse events in renal transplant recipients receiving sirolimus based therapy","volume":"79","author":"Mahe","year":"2005","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib37","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1097\/01.TP.0000123082.31092.53","article-title":"Wound healing complications after kidney transplantation","volume":"77","author":"Dean","year":"2004","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib38","doi-asserted-by":"crossref","first-page":"143S","DOI":"10.1016\/S0041-1345(03)00233-1","article-title":"Sirolimus changes lipid concentrations and lipoprotein metabolism in kidney transplant patients","volume":"35","author":"Morrisett","year":"2003","journal-title":"Transplant Proc"},{"key":"10.1053\/j.ackd.2005.11.001_bib39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1432-2277.2004.tb00431.x","article-title":"Rapamycin associated post-transplantation glomerulonephritis and its remisssion after reintroduction of calcineurin-inhibition therapy","volume":"17","author":"Dittrich","year":"2004","journal-title":"Transplant Int"},{"key":"10.1053\/j.ackd.2005.11.001_bib40","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0140-6736(00)02480-6","article-title":"Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: A randomized multicentre study. The Rapamune U.S. Study Group","volume":"356","author":"Kahan","year":"2000","journal-title":"Lancet"},{"key":"10.1053\/j.ackd.2005.11.001_bib41","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00007890-200101270-00019","article-title":"A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus\/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts","volume":"71","author":"MacDonald","year":"2001","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib42","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1097\/00007890-199904150-00017","article-title":"Sirolimus based therapy in human renal transplantation: Similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group","volume":"67","author":"Groth","year":"1999","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib43","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1097\/00007890-200004150-00009","article-title":"Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients","volume":"74:v69","author":"Kreis","year":"2000","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib44","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1097\/01.TP.0000068868.01424.61","article-title":"Clinical benefits of neoral C2 monitoring in the long-term management of renal transplant recipients","volume":"75","author":"Cole","year":"2003","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib45","series-title":"A prospective randomized study of CSA monotherapy versus CSA + mycophenolate mofetil in cadaveric renal recipients, in Program and Abstracts of the 3rd International Conference on New Trends in Clinical and Experimental Immunosuppression","author":"Sells","year":"1998"},{"key":"10.1053\/j.ackd.2005.11.001_bib46","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1097\/00007890-199712270-00013","article-title":"A novel approach to the treatment of chronic allograft nephropathy","volume":"64","author":"Weir","year":"1997","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib47","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1016\/j.transproceed.2004.09.035","article-title":"Chronic cyclosporine-induced nephrotoxicity in heart transplant patients","volume":"36","author":"Sanchez","year":"2004","journal-title":"Transplantation Proc"},{"key":"10.1053\/j.ackd.2005.11.001_bib48","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1159\/000079390","article-title":"Late calcineurin inhibitor withdrawal as a strategy to prevent graft loss in patients with suboptimal kidney transplant function","volume":"24","author":"Weir","year":"2004","journal-title":"Am J Nephrol"},{"key":"10.1053\/j.ackd.2005.11.001_bib49","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/01.TP.0000151632.21551.00","article-title":"Mycophenolate mofetil substitution for cyclosporine A in renal transplant recipients with chronic progressive allograft dysfunction","volume":"79","author":"Dudley","year":"2005","journal-title":"Transplantation"},{"key":"10.1053\/j.ackd.2005.11.001_bib50","unstructured":"RAPAMUNE (sirolimus) 3-year safety update, Protocol No. 0468H1-310-GL. Madison, NJ, Wyeth Pharmaceuticals"},{"key":"10.1053\/j.ackd.2005.11.001_bib51","first-page":"820","article-title":"Calcineurin inhibitor free immunosuppression based on antithymocyte globulin and mycophenolate mofetilin cadaveric kidney transplantation","volume":"16","author":"Grinyo","year":"2003","journal-title":"Transplant Int"}],"container-title":["Advances in Chronic Kidney Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559505002028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559505002028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T15:18:25Z","timestamp":1626967105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1548559505002028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S1548559505002028"],"URL":"https:\/\/doi.org\/10.1053\/j.ackd.2005.11.001","relation":{},"ISSN":["1548-5595"],"issn-type":[{"value":"1548-5595","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}