{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T20:16:41Z","timestamp":1768594601179,"version":"3.49.0"},"reference-count":127,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Chronic Kidney Disease"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1053\/j.ackd.2011.02.004","type":"journal-article","created":{"date-parts":[[2011,3,13]],"date-time":"2011-03-13T08:34:35Z","timestamp":1300005275000},"page":"120-131","source":"Crossref","is-referenced-by-count":33,"title":["Derangements in Phosphate Metabolism in Chronic Kidney Diseases\/Endstage Renal Disease: Therapeutic Considerations"],"prefix":"10.1053","volume":"18","author":[{"given":"Donald A.","family":"Molony","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett W.","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.ackd.2011.02.004_bib1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11255-008-9346-7","article-title":"Bone and mineral disorders in pre-dialysis CKD","volume":"40","author":"Kovesdy","year":"2008","journal-title":"Int Urol Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib2","doi-asserted-by":"crossref","first-page":"F1170","DOI":"10.1152\/ajprenal.00072.2005","article-title":"\u201cPhosphatonins\u201d and the regulation of phosphorus homeostasis","volume":"289","author":"Berndt","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1053\/j.ackd.2011.02.004_bib3","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.2215\/CJN.01520407","article-title":"Dynamics of parathyroid hormone secretion in health and secondary hyperparathyroidism","volume":"2","author":"Felsenfeld","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/ndt\/17.5.723","article-title":"Management of disturbances of calcium and phosphate metabolism in chronic renal insufficiency, with emphasis on the control of hyperphosphatemia","volume":"17","author":"Locatelli","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/sj.ki.5002163","article-title":"Klotho: an antiaging protein involved in mineral and vitamin D metabolism","volume":"71","author":"Torres","year":"2007","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4158\/EP.14.1.18","article-title":"Management of secondary hyperparathyroidism in stages 3 and 4 chronic kidney disease","volume":"14","author":"Andress","year":"2008","journal-title":"Endocr Pract"},{"key":"10.1053\/j.ackd.2011.02.004_bib7","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1002\/jbmr.170","article-title":"FGF-23: more than a regulator of renal phosphate handling?","volume":"25","author":"J\u00fcppner","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2011.02.004_bib8","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/ndt\/gfp699","article-title":"Fibroblast growth factor-23 and early decrements in kidney function: the Heart and Soul Study","volume":"25","author":"Ix","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib9","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1210\/jc.2004-0724","article-title":"FGF-23 is elevated by chronic hyperphosphatemia","volume":"89","author":"Gupta","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ackd.2011.02.004_bib10","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1681\/ASN.2005010052","article-title":"Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease","volume":"16","author":"Gutierrez","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib11","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1172\/JCI29463","article-title":"Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF 23 production in osteoblasts","volume":"116","author":"Masuyama","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1053\/j.ackd.2011.02.004_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.ki.5002009","article-title":"Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease","volume":"71","author":"Levin","year":"2007","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib13","first-page":"F432","article-title":"Phosphorus restriction reverses hyperparathyroidism in uremia independent of changes in calcium and calcitriol","volume":"259","author":"Lopez-Hilker","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1053\/j.ackd.2011.02.004_bib14","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1172\/JCI118701","article-title":"Phosphorus restriction prevents parathyroid gland growth","volume":"97","author":"Slatopolsky","year":"1996","journal-title":"J Clin Invest"},{"issue":"suppl 9","key":"10.1053\/j.ackd.2011.02.004_bib15","doi-asserted-by":"crossref","first-page":"S300","DOI":"10.1097\/01.ASN.0000081663.52165.66","article-title":"Vascular calcification: in vitro evidence for the role of inorganic phosphate","volume":"14","author":"Giachelli","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib16","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/01.RES.0000141775.67189.98","article-title":"Pathophysiology of vascular calcification in chronic kidney disease","volume":"95","author":"Moe","year":"2004","journal-title":"Circ Res"},{"key":"10.1053\/j.ackd.2011.02.004_bib17","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1038\/sj.ki.5001996","article-title":"Novel insights into vascular calcification","volume":"105","author":"Ketteler","year":"2006","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib18","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/sj.ki.5001514","article-title":"Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients","volume":"70","author":"Kalantar-Zadeh","year":"2006","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib19","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0272-6386(12)70364-5","article-title":"Death risk in Hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities","volume":"15","author":"Lowrie","year":"1990","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2011.02.004_bib20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/ajkd.1998.v32.pm9669435","article-title":"Noncompliance in hemodialysis: predictors and survival analysis","volume":"32","author":"Leggat","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2011.02.004_bib21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1053\/ajkd.1998.v31.pm9531176","article-title":"Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study","volume":"31","author":"Block","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2011.02.004_bib22","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1681\/ASN.V12102131","article-title":"Association of elevated serum PO4, Ca X PO4 product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients","volume":"12","author":"Ganesh","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib23","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1046\/j.1523-1755.63.s85.26.x","article-title":"Higher impact of mineral metabolism on cardiovascular mortality in a European hemodialysis population","volume":"85","author":"Marco","year":"2003","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib24","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1097\/01.ASN.0000133041.27682.A2","article-title":"Mineral metabolism, mortality, and morbidity in maintenance hemodialysis","volume":"15","author":"Block","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib25","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1523-1755.2005.00185.x","article-title":"Predictors and consequences of altered mineral metabolism: the Dialysis Outcomes and Practice Patterns Study","volume":"67","author":"Young","year":"2005","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib26","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1681\/ASN.2004040275","article-title":"Calcium, phosphorus, parathyroid hormone, and cardiovascular disease in hemodialysis patients: the USRDS waves 1, 3, and 4 study","volume":"16","author":"Slinin","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1053\/j.ajkd.2005.04.006","article-title":"Mild hyperphosphatemia and mortality in hemodialysis patients","volume":"46","author":"Rodriguez-Benot","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2011.02.004_bib28","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/sj.ki.5001542","article-title":"Changes in serum calcium, phosphate, and PTH and the risk of death in incident dialysis patients: a longitudinal study","volume":"70","author":"Melamed","year":"2006","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1744-9987.2007.00540.x","article-title":"Effects of serum calcium, phosphorus, and intact parathyroid hormone levels on survival in chronic hemodialysis patients in Japan","volume":"12","author":"Nakai","year":"2008","journal-title":"Ther Apher Dial"},{"key":"10.1053\/j.ackd.2011.02.004_bib30","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1093\/ndt\/gfl257","article-title":"Mineral metabolism and cardiovascular morbidity and mortality risk: peritoneal dialysis patients compared with haemodialysis patients","volume":"21","author":"Noordzij","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000118847","article-title":"Mineral metabolism and mortality in dialysis patients: a reassessment of the K\/DOQI guideline","volume":"26","author":"Noordzij","year":"2008","journal-title":"Blood Purif"},{"key":"10.1053\/j.ackd.2011.02.004_bib32","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1001\/archinte.167.9.879","article-title":"Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community","volume":"167","author":"Dhingra","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.ackd.2011.02.004_bib33","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1161\/CIRCULATIONAHA.105.553198","article-title":"Relation between serum phosphate level and cardiovascular event rate in people with coronary disease","volume":"112","author":"Tonelli","year":"2005","journal-title":"Circulation"},{"key":"10.1053\/j.ackd.2011.02.004_bib34","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1681\/ASN.2004070602","article-title":"Serum phosphate levels and mortality risk among people with chronic kidney disease","volume":"16","author":"Kestenbaum","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib35","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1681\/ASN.2007060673","article-title":"Postprandial mineral metabolism and secondary hyperparathyroidism in early CKD","volume":"19","author":"Isakova","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib36","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/ndt\/gfl718","article-title":"Mineral metabolism parameters throughout chronic kidney disease stages 1\u20135\u2014achievement of K\/DOQI target ranges","volume":"22","author":"Craver","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib37","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1681\/ASN.2005060663","article-title":"Control of hyperphosphatemia among patients with ESRD","volume":"16","author":"Coladonato","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib38","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1053\/j.jrn.2004.09.007","article-title":"The role of dietary phosphorus restriction in the conservative management of chronic renal disease","volume":"15","author":"Barsotti","year":"2005","journal-title":"J Renal Nutr"},{"key":"10.1053\/j.ackd.2011.02.004_bib39","first-page":"E1","article-title":"Hidden phosphorus in popular beverages: part 1","volume":"15","author":"Murphy-Gutekunst","year":"2005","journal-title":"J Ren Nutr"},{"issue":"suppl 3","key":"10.1053\/j.ackd.2011.02.004_bib40","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease","volume":"42","year":"2003","journal-title":"Am J Kidney Dis"},{"issue":"suppl 1","key":"10.1053\/j.ackd.2011.02.004_bib41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1755-6686.2009.00064.x","article-title":"Early initiation of phosphate lowering dietary therapy in non-dialysis chronic kidney disease: a critical review","volume":"35","author":"Sigrist","year":"2009","journal-title":"J Ren Care"},{"key":"10.1053\/j.ackd.2011.02.004_bib42","unstructured":"Lynch KE, Lynch R, Curhan GC, et\u00a0al. The association between prescribed dietary phosphate restriction and mortality among hemodialysis patients. Clin J Am Soc Nephrol. In press."},{"key":"10.1053\/j.ackd.2011.02.004_bib43","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1681\/ASN.V451214","article-title":"Phosphate kinetics during high-flux hemodialysis","volume":"4","author":"DeSoi","year":"1993","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000067866","article-title":"A kinetic model of inorganic phosphorus mass balance in hemodialysis therapy","volume":"21","author":"Gotch","year":"2003","journal-title":"Blood Purif"},{"key":"10.1053\/j.ackd.2011.02.004_bib45","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1046\/j.1525-139X.2003.16037.x","article-title":"Hidden sources of phosphorus in the typical American diet: does it matter in nephrology?","volume":"16","author":"Uribarri","year":"2003","journal-title":"Semin Dial"},{"key":"10.1053\/j.ackd.2011.02.004_bib46","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1053\/j.ajkd.2009.05.018","article-title":"Phosphate removal with several thrice weekly dialysis methods in overweight hemodialysis patients","volume":"54","author":"Tonelli","year":"2009","journal-title":"Am J Kidney Dis"},{"issue":"suppl 1","key":"10.1053\/j.ackd.2011.02.004_bib47","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0272-6386(03)00534-1","article-title":"Calcium and phosphate balance with quotidian hemodialysis","volume":"42","author":"Lindsay","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2011.02.004_bib48","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1681\/ASN.2005040392","article-title":"Effects of short daily versus conventional hemodialysis on left ventricular hypertrophy and inflammatory markers: a prospective controlled study","volume":"16","author":"Ayus","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib49","doi-asserted-by":"crossref","first-page":"778","DOI":"10.2215\/CJN.05221008","article-title":"In-center nocturnal hemodialysis: another option in the management of chronic kidney disease","volume":"4","author":"Bugeja","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib50","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1001\/jama.298.11.1291","article-title":"Effect of frequent nocturnal hemodialysis vs conventional hemodialysis on left ventricular mass and quality of life","volume":"298","author":"Culleton","year":"2007","journal-title":"JAMA"},{"key":"10.1053\/j.ackd.2011.02.004_bib51","doi-asserted-by":"crossref","first-page":"137K","DOI":"10.1159\/000245640","article-title":"Phosphate elimination in modalities of hemodialysis and peritoneal dialysis","volume":"29","author":"Kuhlmann","year":"2010","journal-title":"Blood Purif"},{"issue":"suppl 6","key":"10.1053\/j.ackd.2011.02.004_bib52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/ndt\/13.suppl_6.43","article-title":"Behaviour of phosphate removal with different dialysis schedules","volume":"13","author":"Mesa","year":"1998","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib53","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1046\/j.1523-1755.2003.00310.x","article-title":"Removal of middle molecules and protein bound solutes by peritoneal dialysis and relation with uremic symptoms","volume":"64","author":"Bammens","year":"2003","journal-title":"Kidney Int"},{"issue":"suppl 90","key":"10.1053\/j.ackd.2011.02.004_bib54","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1111\/j.1523-1755.2004.09005.x","article-title":"A comparison of clinically useful phosphorus binders for patients with chronic kidney failure","volume":"66","author":"Emmett","year":"2004","journal-title":"Kidney Int"},{"issue":"suppl 1","key":"10.1053\/j.ackd.2011.02.004_bib55","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000083712","article-title":"Accumulation of metals and minerals from phosphate binders","volume":"23","author":"Molony","year":"2005","journal-title":"Blood Purif"},{"key":"10.1053\/j.ackd.2011.02.004_bib56","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00007691-199312000-00025","article-title":"Aluminum toxicity in patients with chronic renal failure","volume":"15","author":"Alfrey","year":"1993","journal-title":"Ther Drug Monit"},{"issue":"suppl 2","key":"10.1053\/j.ackd.2011.02.004_bib57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/ndt\/17.suppl_2.9","article-title":"The clinical impact of aluminium overload in renal failure","volume":"17","author":"Cannata-And\u00eda","year":"2002","journal-title":"Nephrol Dial Transplant"},{"issue":"suppl 2","key":"10.1053\/j.ackd.2011.02.004_bib58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/ndt\/17.suppl_2.17","article-title":"The potential role of aluminium in Alzheimer\u2019s disease","volume":"17","author":"Campbell","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib59","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1056\/NEJM197601222940402","article-title":"The dialysis encephalopathy syndrome. Possible aluminum intoxication","volume":"294","author":"Alfrey","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2011.02.004_bib60","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1056\/NEJM198404263101704","article-title":"Aluminum intoxication from aluminum-containing phosphate binders in children with azotemia not undergoing dialysis","volume":"310","author":"Andreoli","year":"1984","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2011.02.004_bib61","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1056\/NEJM199102213240804","article-title":"Aluminum accumulation during treatment with aluminum hydroxide and dialysis in children and young adults with chronic renal disease","volume":"324","author":"Salusky","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2011.02.004_bib62","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1525-139x.2001.00002.x","article-title":"Reconsidering the importance of long-term low-level aluminum exposure in renal failure patients","volume":"14","author":"Cannata-Andia","year":"2001","journal-title":"Semin Dial"},{"key":"10.1053\/j.ackd.2011.02.004_bib63","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/oxfordjournals.ndt.a091716","article-title":"Enhanced gastrointestinal absorption of aluminium in uraemia: time course and effect of vitamin D","volume":"3","author":"Ittel","year":"1988","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib64","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1600-0773.1990.tb00692.x","article-title":"Aluminium toxicokinetics","volume":"66","author":"Wilhelm","year":"1990","journal-title":"Pharmacol Toxicol"},{"key":"10.1053\/j.ackd.2011.02.004_bib65","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1002\/jps.20956","article-title":"Relative in vitro efficacy of the phosphate binders lanthanum carbonate and sevelamer hydrochloride","volume":"96","author":"Autissier","year":"2007","journal-title":"J Pharm Sci"},{"key":"10.1053\/j.ackd.2011.02.004_bib66","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/S0140-6736(02)11507-8","article-title":"Novel phosphate binder is effective in patients on haemodialysis","volume":"360","author":"Nelson","year":"2002","journal-title":"Lancet"},{"key":"10.1053\/j.ackd.2011.02.004_bib67","doi-asserted-by":"crossref","first-page":"C61","DOI":"10.1159\/000088932","article-title":"Long-term efficacy and tolerability of lanthanum carbonate: results from a 3-year study","volume":"102","author":"Hutchison","year":"2006","journal-title":"Nephron Clin Pract"},{"key":"10.1053\/j.ackd.2011.02.004_bib68","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1046\/j.1523-1755.63.s85.18.x","article-title":"A multicenter study on the effects of lanthanum carbonate (Fosrenol) and calcium carbonate on renal bone disease in dialysis patients","volume":"63","author":"D\u2019Haese","year":"2003","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib69","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1185\/030079905X41453","article-title":"A long-term, open-label extension study on the safety of treatment with lanthanum carbonate, a new phosphate binder, in patients receiving hemodialysis","volume":"21","author":"Finn","year":"2005","journal-title":"Curr Med Res Opin"},{"key":"10.1053\/j.ackd.2011.02.004_bib70","first-page":"428","article-title":"The effects of lanthanum carbonate and calcium carbonate on bone abnormalities in patients with end-stage renal disease","volume":"64","author":"Freemont","year":"2005","journal-title":"Clin Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib71","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/sj.ki.5001932","article-title":"Cognitive function in stage 5 chronic kidney disease patients on hemodialysis: no adverse effects of lanthanum carbonate compared with standard phosphate-binder therapy","volume":"71","author":"Altamnn","year":"2006","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib72","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/ki.1996.22","article-title":"Magnesium carbonate as a phosphorus binder: a prospective, controlled, crossover study","volume":"49","author":"Delmez","year":"1996","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib73","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0272-6386(99)70106-X","article-title":"Relationship between serum magnesium and parathyroid hormone levels in hemodialysis patients","volume":"34","author":"Navarro","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2011.02.004_bib74","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1053\/j.jrn.2007.08.005","article-title":"Magnesium carbonate is an effective phosphate binder for chronic hemodialysis patients: a\u00a0pilot study","volume":"17","author":"Spiegel","year":"2007","journal-title":"J Ren Nutr"},{"key":"10.1053\/j.ackd.2011.02.004_bib75","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/ki.1989.247","article-title":"Calcium acetate, an effective phosphorous binder in patients with renal failure","volume":"36","author":"Mai","year":"1989","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib76","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S0272-6386(12)80496-3","article-title":"Calcium acetate control of serum phosphorus in hemodialysis patients","volume":"17","author":"Emmett","year":"1991","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2011.02.004_bib77","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/ndt\/6.3.170","article-title":"The treatment of uraemic hyperphosphataemia with calcium acetate and calcium carbonate: a comparative study","volume":"6","author":"Schaefer","year":"1991","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib78","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1681\/ASN.V3196","article-title":"Calcium acetate as a phosphorus binder in hemodialysis patients","volume":"3","author":"Delmez","year":"1992","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib79","first-page":"341","article-title":"Calcium acetate versus calcium carbonate as phosphorus binders in patients on chronic haemodialysis: a controlled study","volume":"8","author":"Ring","year":"1993","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib80","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1681\/ASN.2004100885","article-title":"Sevelamer controls parathyroid hormone-induced bone disease as efficiently as calcium carbonate without increasing serum calcium levels during therapy with active vitamin D sterols","volume":"16","author":"Salusky","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib81","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2215\/CJN.02190507","article-title":"Progressive vascular calcification over 2 years is associated with arterial stiffening and increased mortality in patients with stages 4 and 5 chronic kidney disease","volume":"2","author":"Sigrist","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib82","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1053\/j.ajkd.2004.07.022","article-title":"Coronary artery calcification in patients with CRF not undergoing dialysis","volume":"44","author":"Russo","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2011.02.004_bib83","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/sj.ki.5002518","article-title":"The progression of coronary artery calcification in predialysis patients on calcium carbonate or sevelamer","volume":"72","author":"Russo","year":"2007","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib84","unstructured":"Institute of Medicine of the National Academy of Sciences. Dietary Reference Intakes for Calcium and Vitamin D. Released: 11\/30\/2010."},{"key":"10.1053\/j.ackd.2011.02.004_bib85","doi-asserted-by":"crossref","first-page":"704","DOI":"10.2215\/CJN.01831105","article-title":"Calcium-based phosphate binders are appropriate in chronic renal failure","volume":"1","author":"Friedman","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib86","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/ncpneph0710","article-title":"Should we be using calcium-containing phosphate binders in patients on dialysis?","volume":"4","author":"Spiegel","year":"2008","journal-title":"Nat Clin Pract Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib87","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bmj.39440.525752.BE","article-title":"Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial","volume":"336","author":"Bolland","year":"2008","journal-title":"BMJ"},{"key":"10.1053\/j.ackd.2011.02.004_bib88","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/ajcn\/86.6.1780","article-title":"Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials","volume":"86","author":"Bischoff-Ferrari","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.ackd.2011.02.004_bib89","doi-asserted-by":"crossref","first-page":"c3691","DOI":"10.1136\/bmj.c3691","article-title":"Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis","volume":"341","author":"Bollad","year":"2010","journal-title":"BMJ"},{"key":"10.1053\/j.ackd.2011.02.004_bib90","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.maturitas.2009.03.006","article-title":"Use of calcium supplements and the risk of coronary heart disease in 52\u201362-year-old women: the Kuopio Osteoporosis Risk Factor and Prevention Study","volume":"63","author":"Pentti","year":"2009","journal-title":"Maturitas"},{"key":"10.1053\/j.ackd.2011.02.004_bib91","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/ATVBAHA.109.196675","article-title":"Conjoint effects of serum calcium and phosphate on risk of total, cardiovascular, and noncardiovascular mortality in the community","volume":"30","author":"Larsson","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.ackd.2011.02.004_bib92","first-page":"117","article-title":"Adynamic bone disease: an update and overview","volume":"18","author":"Coen","year":"2005","journal-title":"J Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib93","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/ki.1994.342","article-title":"Evidence for abnormal calcium homeostasis in patients with adynamic bone disease","volume":"46","author":"Kurz","year":"1994","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib94","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/ndt\/gfg414","article-title":"Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality","volume":"18","author":"London","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib95","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/ndt\/15.7.1014","article-title":"Arterial stiffening and vascular calcifications in end-stage renal disease","volume":"15","author":"Guerin","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib96","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.CIR.103.7.987","article-title":"Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure","volume":"103","author":"Guerin","year":"2001","journal-title":"Circulation"},{"key":"10.1053\/j.ackd.2011.02.004_bib97","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1161\/hy1001.096358","article-title":"Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease","volume":"38","author":"Blacher","year":"2001","journal-title":"Hypertension"},{"key":"10.1053\/j.ackd.2011.02.004_bib98","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1681\/ASN.2007050622","article-title":"Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD","volume":"19","author":"London","year":"2008","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib99","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/ndt\/12.8.1640","article-title":"RenaGel, a novel calcium- and aluminium-free phosphate binder, inhibits phosphate absorption in normal volunteers","volume":"12","author":"Burke","year":"1997","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib100","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1523-1755.1999.00240.x","article-title":"RenaGel, a nonabsorbed calcium- and aluminum-free phosphate binder, lowers serum phosphorus and parathyroid hormone. The RenaGel Study Group","volume":"55","author":"Slatopolsky","year":"1999","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib101","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0731-7085(02)00007-9","article-title":"Determination of the binding parameter constants of Renagel capsules and tablets utilizing the Langmuir approximation at various pH by ion chromatography","volume":"29","author":"Swearingen","year":"2002","journal-title":"J Pharm Biomed Anal"},{"issue":"suppl 3","key":"10.1053\/j.ackd.2011.02.004_bib102","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1111\/j.1542-4758.2007.00224.x","article-title":"Effect of sevelamer on aortic pulse wave velocity in patients on hemodialysis: a prospective observational study","volume":"11","author":"Othmane Tel","year":"2007","journal-title":"Hemodial Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib103","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2215\/CJN.02810707","article-title":"Short-term treatment with sevelamer increases serum Fetuin-A concentration and improves endothelial dysfunction in chronic kidney disease stage 4 patients","volume":"3","author":"Cagler","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib104","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000111061","article-title":"Effects of sevelamer and calcium-based phosphate binders on lipid and inflammatory markers in hemodialysis patients","volume":"28","author":"Shantouf","year":"2008","journal-title":"Am J Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib105","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1038\/sj.ki.5001994","article-title":"Pleiotropic effects of the non-calcium phosphate binder sevelamer","volume":"70","author":"Nikolov","year":"2006","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib106","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/sj.ki.5002059","article-title":"Mortality effect of coronary calcification and phosphate binder choice in incident hemodialysis patients","volume":"71","author":"Block","year":"2007","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib107","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000100044","article-title":"Progression of coronary artery calcification in predialysis patients","volume":"27","author":"Russo","year":"2007","journal-title":"Am J Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib108","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1053\/j.ajkd.2008.02.298","article-title":"A 1-year randomized trial of calcium acetate versus sevelamer on progression of coronary artery calcification in hemodialysis patients with comparable lipid control: the Calcium Acetate Renagel Evaluation-2 (CARE-2) study","volume":"51","author":"Qunibi","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2011.02.004_bib109","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1046\/j.1523-1755.2002.00434.x","article-title":"Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients","volume":"62","author":"Chertow","year":"2002","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib110","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5414\/CNP62104","article-title":"Long-term comparison of a calcium-free phosphate binder and calcium carbonate - phosphorus metabolism and cardiovascular calcification","volume":"62","author":"Braun","year":"2004","journal-title":"Clin Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib111","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1359\/JBMR.041221","article-title":"Decrease in thoracic vertebral bone attenuation with calcium-based phosphate binders in hemodialysis","volume":"20","author":"Raggi","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2011.02.004_bib112","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/ndt\/gfh894","article-title":"Two year comparison of sevelamer and calcium carbonate effects on cardiovascular calcification and bone density","volume":"20","author":"Asmus","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ackd.2011.02.004_bib113","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/j.1523-1755.2005.00600.x","article-title":"Effects of sevelamer and calcium on coronary artery calcification in patients new to hemodialysis","volume":"68","author":"Block","year":"2005","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib114","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1681\/ASN.2006101089","article-title":"Effects of sevelamer hydrochloride and calcium carbonate on renal osteodystrophy in hemodialysis patients","volume":"19","author":"Ferreira","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib115","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/sj.ki.5002466","article-title":"Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients","volume":"72","author":"Suki","year":"2007","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib116","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1053\/j.ajkd.2007.12.002","article-title":"A comparison of sevelamer and calcium-based phosphate binders on mortality, hospitalization, and morbidity in hemodialysis: a secondary analysis of the Dialysis Clinical Outcomes Revisited (DCOR) randomized trial using claims data","volume":"51","author":"St Peter","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2011.02.004_bib117","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/j.1523-1755.2004.00482.x","article-title":"Nicotinamide suppresses hyperphosphatemia in hemodialysis patients","volume":"65","author":"Takahashi","year":"2004","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib118","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2215\/CJN.04211007","article-title":"A randomized, double-blind, placebo-controlled trial of niacinamide for reduction of phosphorus in hemodialysis patients","volume":"3","author":"Cheng","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib119","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/089686080902900515","article-title":"The effect of oral niacinamide on plasma phosphorus levels in peritoneal dialysis patients","volume":"29","author":"Young","year":"2009","journal-title":"Perit Dial Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2215\/CJN.03591006","article-title":"The OPTIMA study: assessing a new cinacalcet (Sensipar\/Mimpara) treatment algorithm for secondary hyperparathyroidism","volume":"3","author":"Messa","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2011.02.004_bib121","first-page":"1","article-title":"Combined therapy with cinacalcet and low doses of vitamin D sterols in patients with moderate to severe secondary hyperparathyroidism","author":"Block","year":"2008","journal-title":"Nephrol Dial Trans"},{"key":"10.1053\/j.ackd.2011.02.004_bib122","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/j.1523-1755.2005.67139.x","article-title":"Achieving NKF-K\/DOQI bone metabolism and disease treatment goals with cinacalcet HCl","volume":"76","author":"Moe","year":"2005","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2011.02.004_bib123","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.ajkd.2006.01.015","article-title":"Meta-analysis of biochemical and patient-level effects of calcimimetic therapy","volume":"47","author":"Strippoli","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2011.02.004_bib124","doi-asserted-by":"crossref","DOI":"10.3310\/hta11180","article-title":"The effectiveness and cost-effectiveness of cinacalcet for secondary hyperparathyroidism in end-stage renal disease patients on dialysis: a systematic review and economic evaluation","volume":"11","author":"Garside","year":"2007","journal-title":"Health Technol Assess"},{"key":"10.1053\/j.ackd.2011.02.004_bib125","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1053\/j.ajkd.2005.04.013","article-title":"Cinacalcet Hydrochloride is an effective treatment for secondary hyperparathyroidism in patients with CKD not receiving dialysis","volume":"46","author":"Charytan","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2011.02.004_bib126","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000197562","article-title":"Phosphate\u2014the silent stealthy cardiorenal culprit in all stages of chronic kidney disease. A systematic review","volume":"27","author":"Kanbay","year":"2009","journal-title":"Blood Purif"},{"key":"10.1053\/j.ackd.2011.02.004_bib127","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1053\/j.ajkd.2009.09.023","article-title":"Short-term effects of online hemodiafiltration on phosphate control: a\u00a0result from the randomized controlled convective transport study (CONTRAST)","volume":"55","author":"Penne","year":"2009","journal-title":"Am J Kidney Dis"}],"container-title":["Advances in Chronic Kidney Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559511000279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559511000279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T08:09:44Z","timestamp":1637395784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1548559511000279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":127,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S1548559511000279"],"URL":"https:\/\/doi.org\/10.1053\/j.ackd.2011.02.004","relation":{},"ISSN":["1548-5595"],"issn-type":[{"value":"1548-5595","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}