{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T21:29:59Z","timestamp":1784150999763,"version":"3.55.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK051391"],"award-info":[{"award-number":["R01 DK051391"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK079307"],"award-info":[{"award-number":["P30 DK079307"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK061296"],"award-info":[{"award-number":["T32 DK061296"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ackdjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Chronic Kidney Disease"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1053\/j.ackd.2014.11.006","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T01:16:42Z","timestamp":1429579002000},"page":"179-184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Sodium Retention and Volume Expansion in Nephrotic Syndrome: Implications for Hypertension"],"prefix":"10.1053","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1491-4869","authenticated-orcid":false,"given":"Evan C.","family":"Ray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7109-146X","authenticated-orcid":false,"given":"Helbert","family":"Rondon-Berrios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cary R.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Kleyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8310","key":"10.1053\/j.ackd.2014.11.006_bib1","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S0140-6736(82)90102-7","article-title":"Evidence that some mechanism other than the renin system causes sodium retention in nephrotic syndrome","volume":"2","author":"Brown","year":"1982","journal-title":"Lancet"},{"issue":"2","key":"10.1053\/j.ackd.2014.11.006_bib2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000185283","article-title":"The kallikrein-kinin and renin-angiotensin systems in nephrotic syndrome","volume":"51","author":"Cumming","year":"1989","journal-title":"Nephron"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000168800","article-title":"Considerations on the sodium retention in nephrotic syndrome","volume":"15","author":"Usberti","year":"1995","journal-title":"Am J Nephrol"},{"issue":"2","key":"10.1053\/j.ackd.2014.11.006_bib4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/00365518209168064","article-title":"Interstitial fluid colloid osmotic and hydrostatic pressures in subcutaneous tissue of patients with nephrotic syndrome","volume":"42","author":"Noddeland","year":"1982","journal-title":"Scand J Clin Lab Invest"},{"issue":"6","key":"10.1053\/j.ackd.2014.11.006_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/00000441-198906000-00001","article-title":"The role of lymphatic flow in edema formation of nephrotic syndrome","volume":"297","author":"Beach","year":"1989","journal-title":"Am J Med Sci"},{"issue":"5","key":"10.1053\/j.ackd.2014.11.006_bib6","doi-asserted-by":"crossref","first-page":"688","DOI":"10.7326\/0003-4819-91-5-688","article-title":"Nephrotic syndrome: vasoconstriction and hypervolemic types indicated by renin-sodium profiling","volume":"91","author":"Meltzer","year":"1979","journal-title":"Ann Intern Med"},{"issue":"11","key":"10.1053\/j.ackd.2014.11.006_bib7","first-page":"664","article-title":"Congenital analbuminaemia: biochemical and clinical implications. A case report and literature review","volume":"163","author":"Koot","year":"2004","journal-title":"Eur J Pediatr"},{"key":"10.1053\/j.ackd.2014.11.006_bib8","first-page":"449","article-title":"Physiologic Responses Associated with Steroid-Induced Diuresis in the Nephrotic Syndrome","volume":"62","author":"Oliver","year":"1963","journal-title":"J Lab Clin Med"},{"issue":"4","key":"10.1053\/j.ackd.2014.11.006_bib9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000166814","article-title":"Effects of plasma volume expansion on renal salt handling in patients with the nephrotic syndrome","volume":"4","author":"Koomans","year":"1984","journal-title":"Am J Nephrol"},{"issue":"3","key":"10.1053\/j.ackd.2014.11.006_bib10","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000183302","article-title":"Plasma and blood volumes in patients with the nephrotic syndrome","volume":"38","author":"Geers","year":"1984","journal-title":"Nephron"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000168052","article-title":"Role of aldosterone in the sodium retention of patients with nephrotic syndrome","volume":"10","author":"Shapiro","year":"1990","journal-title":"Am J Nephrol"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000183206","article-title":"Lack of effect of captopril on the sodium retention of the nephrotic syndrome","volume":"37","author":"Brown","year":"1984","journal-title":"Nephron"},{"issue":"3","key":"10.1053\/j.ackd.2014.11.006_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000013347","article-title":"Hyporeninemic hypoaldosteronism in patients with nephrotic syndrome","volume":"18","author":"Usberti","year":"1998","journal-title":"Am J Nephrol"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib14","doi-asserted-by":"crossref","first-page":"F208","DOI":"10.1152\/ajprenal.00399.2005","article-title":"Increased expression but not targeting of ENaC in adrenalectomized rats with PAN-induced nephrotic syndrome","volume":"291","author":"de Seigneux","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1172\/JCI110756","article-title":"Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome","volume":"71","author":"Ichikawa","year":"1983","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1053\/j.ackd.2014.11.006_bib16","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1681\/ASN.V123598","article-title":"Collecting duct is a site of sodium retention in PAN nephrosis: a rationale for amiloride therapy","volume":"12","author":"Deschenes","year":"2001","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"10.1053\/j.ackd.2014.11.006_bib17","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1681\/ASN.2005040363","article-title":"Hyperaldosteronemia and activation of the epithelial sodium channel are not required for sodium retention in puromycin-induced nephrosis","volume":"16","author":"Lourdel","year":"2005","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"10.1053\/j.ackd.2014.11.006_bib18","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1681\/ASN.2008020225","article-title":"Mechanisms of ENaC regulation and clinical implications","volume":"19","author":"Bhalla","year":"2008","journal-title":"J Am Soc Nephrol"},{"issue":"31","key":"10.1053\/j.ackd.2014.11.006_bib19","doi-asserted-by":"crossref","first-page":"20447","DOI":"10.1074\/jbc.R800083200","article-title":"ENaC at the cutting edge: regulation of epithelial sodium channels by proteases","volume":"284","author":"Kleyman","year":"2009","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1053\/j.ackd.2014.11.006_bib20","first-page":"F459","article-title":"Inhibition of short-circuit current in toad urinary bladder by inhibitors of glandular kallikrein","volume":"239","author":"Orce","year":"1980","journal-title":"Am J Physiol"},{"issue":"6651","key":"10.1053\/j.ackd.2014.11.006_bib21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/39329","article-title":"An epithelial serine protease activates the amiloride-sensitive sodium channel","volume":"389","author":"Vallet","year":"1997","journal-title":"Nature"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1085\/jgp.111.1.127","article-title":"Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocytes","volume":"111","author":"Chraibi","year":"1998","journal-title":"J Gen Physiol"},{"issue":"18","key":"10.1053\/j.ackd.2014.11.006_bib23","doi-asserted-by":"crossref","first-page":"18111","DOI":"10.1074\/jbc.C400080200","article-title":"Epithelial sodium channels are activated by furin-dependent proteolysis","volume":"279","author":"Hughey","year":"2004","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1053\/j.ackd.2014.11.006_bib24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1085\/jgp.20028598","article-title":"Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus Oocytes","volume":"120","author":"Vuagniaux","year":"2002","journal-title":"J Gen Physiol"},{"issue":"5","key":"10.1053\/j.ackd.2014.11.006_bib25","doi-asserted-by":"crossref","first-page":"L813","DOI":"10.1152\/ajplung.00435.2004","article-title":"Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport","volume":"288","author":"Caldwell","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"6","key":"10.1053\/j.ackd.2014.11.006_bib26","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1085\/jgp.200709781","article-title":"A segment of gamma ENaC mediates elastase activation of Na+ transport","volume":"130","author":"Adebamiro","year":"2007","journal-title":"J Gen Physiol"},{"issue":"8","key":"10.1053\/j.ackd.2014.11.006_bib27","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1074\/jbc.M705664200","article-title":"Defective ENaC processing and function in tissue kallikrein-deficient mice","volume":"283","author":"Picard","year":"2008","journal-title":"J Biol Chem"},{"issue":"36","key":"10.1053\/j.ackd.2014.11.006_bib28","doi-asserted-by":"crossref","first-page":"30073","DOI":"10.1074\/jbc.M111.338574","article-title":"Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity","volume":"287","author":"Alli","year":"2012","journal-title":"J Biol Chem"},{"issue":"39","key":"10.1053\/j.ackd.2014.11.006_bib29","doi-asserted-by":"crossref","first-page":"32556","DOI":"10.1074\/jbc.M112.369520","article-title":"Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa","volume":"287","author":"Butterworth","year":"2012","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib30","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4161\/chan.5.1.13759","article-title":"Activation of the epithelial sodium channel by the metalloprotease meprin beta subunit","volume":"5","author":"Garcia-Caballero","year":"2011","journal-title":"Channels (Austin)"},{"issue":"52","key":"10.1053\/j.ackd.2014.11.006_bib31","doi-asserted-by":"crossref","first-page":"36586","DOI":"10.1074\/jbc.M805676200","article-title":"Plasmin activates epithelial Na+ channels by cleaving the gamma subunit","volume":"283","author":"Passero","year":"2008","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1053\/j.ackd.2014.11.006_bib32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1681\/ASN.2008040364","article-title":"Plasmin in nephrotic urine activates the epithelial sodium channel","volume":"20","author":"Svenningsen","year":"2009","journal-title":"J Am Soc Nephrol"},{"issue":"6462","key":"10.1053\/j.ackd.2014.11.006_bib33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/367463a0","article-title":"Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits","volume":"367","author":"Canessa","year":"1994","journal-title":"Nature"},{"issue":"27","key":"10.1053\/j.ackd.2014.11.006_bib34","doi-asserted-by":"crossref","first-page":"18901","DOI":"10.1074\/jbc.M604109200","article-title":"The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit","volume":"281","author":"Carattino","year":"2006","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1053\/j.ackd.2014.11.006_bib35","doi-asserted-by":"crossref","first-page":"F1488","DOI":"10.1152\/ajprenal.00439.2005","article-title":"Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition","volume":"290","author":"Sheng","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"issue":"9","key":"10.1053\/j.ackd.2014.11.006_bib36","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.1074\/jbc.M610636200","article-title":"Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit","volume":"282","author":"Bruns","year":"2007","journal-title":"J Biol Chem"},{"issue":"37","key":"10.1053\/j.ackd.2014.11.006_bib37","doi-asserted-by":"crossref","first-page":"25290","DOI":"10.1074\/jbc.M803931200","article-title":"Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation","volume":"283","author":"Carattino","year":"2008","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1053\/j.ackd.2014.11.006_bib38","doi-asserted-by":"crossref","first-page":"F854","DOI":"10.1152\/ajprenal.00316.2010","article-title":"Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel","volume":"299","author":"Passero","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib39","doi-asserted-by":"crossref","first-page":"F112","DOI":"10.1152\/ajprenal.2001.280.1.F112","article-title":"Activation of epithelial Na channels during short-term Na deprivation","volume":"280","author":"Frindt","year":"2001","journal-title":"Am J Physiol Renal Physiol"},{"issue":"7","key":"10.1053\/j.ackd.2014.11.006_bib40","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1172\/JCI7840","article-title":"Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney","volume":"104","author":"Masilamani","year":"1999","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1053\/j.ackd.2014.11.006_bib41","doi-asserted-by":"crossref","first-page":"F1249","DOI":"10.1152\/ajprenal.00401.2009","article-title":"Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium","volume":"297","author":"Frindt","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3","key":"10.1053\/j.ackd.2014.11.006_bib42","doi-asserted-by":"crossref","first-page":"F683","DOI":"10.1152\/ajprenal.00422.2005","article-title":"Regulation of maturation and processing of ENaC subunits in the rat kidney","volume":"291","author":"Ergonul","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"issue":"7","key":"10.1053\/j.ackd.2014.11.006_bib43","doi-asserted-by":"crossref","first-page":"F939","DOI":"10.1152\/ajprenal.00705.2011","article-title":"In vivo contribution of serine proteases to the proteolytic activation of gammaENaC in aldosterone-infused rats","volume":"303","author":"Uchimura","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"issue":"9","key":"10.1053\/j.ackd.2014.11.006_bib44","doi-asserted-by":"crossref","first-page":"F1080","DOI":"10.1152\/ajprenal.00157.2014","article-title":"Prostasin interacts with the epithelial sodium channel and facilitates cleavage of the gamma subunit by a second protease","volume":"307","author":"Carattino","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"issue":"45","key":"10.1053\/j.ackd.2014.11.006_bib45","doi-asserted-by":"crossref","first-page":"35216","DOI":"10.1074\/jbc.M110.167064","article-title":"Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains","volume":"285","author":"Kashlan","year":"2010","journal-title":"J Biol Chem"},{"issue":"24","key":"10.1053\/j.ackd.2014.11.006_bib46","doi-asserted-by":"crossref","first-page":"20720","DOI":"10.1074\/jbc.M112.358218","article-title":"Inhibitory tract traps the epithelial Na+ channel in a low activity conformation","volume":"287","author":"Kashlan","year":"2012","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1053\/j.ackd.2014.11.006_bib47","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1681\/ASN.2013090936","article-title":"Colon-Specific Deletion of Epithelial Sodium Channel Causes Sodium Loss and Aldosterone Resistance","volume":"25","author":"Malsure","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"10.1053\/j.ackd.2014.11.006_bib48","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1085\/jgp.200810030","article-title":"ENaC proteolytic regulation by channel-activating protease 2","volume":"132","author":"Garcia-Caballero","year":"2008","journal-title":"J Gen Physiol"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib49","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.00330.2011","article-title":"TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the gamma-subunit distal to the furin cleavage site","volume":"302","author":"Passero","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"issue":"16","key":"10.1053\/j.ackd.2014.11.006_bib50","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1021\/bi2014773","article-title":"Energetic and structural basis for activation of the epithelial sodium channel by matriptase","volume":"51","author":"Kota","year":"2012","journal-title":"Biochemistry"},{"issue":"Pt 23","key":"10.1053\/j.ackd.2014.11.006_bib51","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1113\/jphysiol.2013.267286","article-title":"Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures","volume":"592","author":"Tan","year":"2014","journal-title":"J Physiol"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib52","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1074\/jbc.M605125200","article-title":"A novel neutrophil elastase inhibitor prevents elastase activation and surface cleavage of the epithelial sodium channel expressed in Xenopus laevis oocytes","volume":"282","author":"Harris","year":"2007","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1053\/j.ackd.2014.11.006_bib53","doi-asserted-by":"crossref","first-page":"F540","DOI":"10.1152\/ajprenal.00133.2012","article-title":"Tissue kallikrein activation of the epithelial Na channel","volume":"303","author":"Patel","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"10.1053\/j.ackd.2014.11.006_bib54","doi-asserted-by":"crossref","first-page":"F922","DOI":"10.1152\/ajprenal.00277.2003","article-title":"Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats","volume":"286","author":"Kim","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3 Pt 1","key":"10.1053\/j.ackd.2014.11.006_bib55","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0022-3476(80)80678-0","article-title":"Plasminogen and antithrombin III deficiencies in the childhood nephrotic syndrome associated with plasminogenuria and antithrombinuria","volume":"96","author":"Lau","year":"1980","journal-title":"J Pediatr"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib56","first-page":"118","article-title":"Plasma levels and urinary excretion of fibrinolytic and protease inhibitory proteins in nephrotic syndrome","volume":"124","author":"Vaziri","year":"1994","journal-title":"J Lab Clin Med"},{"issue":"5","key":"10.1053\/j.ackd.2014.11.006_bib57","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1161\/HYPERTENSIONAHA.112.198879","article-title":"Urinary plasmin activates collecting duct ENaC current in preeclampsia","volume":"60","author":"Buhl","year":"2012","journal-title":"Hypertension"},{"issue":"8","key":"10.1053\/j.ackd.2014.11.006_bib58","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1097\/HJH.0000000000000216","article-title":"Plasmin in urine from patients with type 2 diabetes and treatment-resistant hypertension activates ENaC in vitro","volume":"32","author":"Buhl","year":"2014","journal-title":"J Hypertens"},{"issue":"3","key":"10.1053\/j.ackd.2014.11.006_bib59","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1177\/39.3.1899685","article-title":"Localization of urokinase-type plasminogen activator messenger RNA in the normal mouse by in situ hybridization","volume":"39","author":"Kristensen","year":"1991","journal-title":"J Histochem Cytochem"},{"issue":"2","key":"10.1053\/j.ackd.2014.11.006_bib60","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/jcp.20485","article-title":"Urokinase (u-PA) is produced by collecting duct principal cells and is post-transcriptionally regulated by SV40 large-T, arginine vasopressin, and epidermal growth factor","volume":"206","author":"Piedagnel","year":"2006","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib61","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01450878","article-title":"Sites of urokinase-type plasminogen activator expression and distribution of its receptor in the normal human kidney","volume":"105","author":"Wagner","year":"1996","journal-title":"Histochem Cell Biol"},{"issue":"8","key":"10.1053\/j.ackd.2014.11.006_bib62","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s00467-013-2439-2","article-title":"Remission of nephrotic syndrome diminishes urinary plasmin content and abolishes activation of ENaC","volume":"28","author":"Andersen","year":"2013","journal-title":"Pediatr Nephrol"},{"issue":"6","key":"10.1053\/j.ackd.2014.11.006_bib63","doi-asserted-by":"crossref","first-page":"R1733","DOI":"10.1152\/ajpregu.00321.2009","article-title":"Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations","volume":"297","author":"Svenningsen","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"4","key":"10.1053\/j.ackd.2014.11.006_bib64","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1681\/ASN.2005060637","article-title":"Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1","volume":"17","author":"Andreasen","year":"2006","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"10.1053\/j.ackd.2014.11.006_bib65","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.arcped.2004.03.029","volume":"11","author":"Deschenes","year":"2004","journal-title":"Arch Pediatr"},{"issue":"6008","key":"10.1053\/j.ackd.2014.11.006_bib66","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/314264a0","article-title":"Atrial natriuretic factor\u2013a circulating hormone stimulated by volume loading","volume":"314","author":"Lang","year":"1985","journal-title":"Nature"},{"issue":"2","key":"10.1053\/j.ackd.2014.11.006_bib67","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0006-291X(84)91606-1","article-title":"Atrial natriuretic factor in rat hypothalamus, atria and plasma: determination by specific radioimmunoassay","volume":"124","author":"Tanaka","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib68","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0024-3205(81)90370-2","article-title":"A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats","volume":"28","author":"de Bold","year":"1981","journal-title":"Life Sci"},{"issue":"2 Pt 2","key":"10.1053\/j.ackd.2014.11.006_bib69","first-page":"F313","article-title":"Tubular site(s) of action of atrial natriuretic peptide in the rat","volume":"255","author":"Fried","year":"1988","journal-title":"Am J Physiol"},{"issue":"6 Pt 2","key":"10.1053\/j.ackd.2014.11.006_bib70","first-page":"F963","article-title":"Atrial natriuretic factor inhibits sodium transport in medullary collecting duct","volume":"250","author":"Sonnenberg","year":"1986","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1053\/j.ackd.2014.11.006_bib71","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/01.RES.59.3.237","article-title":"Renal and systemic hemodynamic effects of synthetic atrial natriuretic peptide in the anesthetized rat","volume":"59","author":"Dunn","year":"1986","journal-title":"Circ Res"},{"issue":"3","key":"10.1053\/j.ackd.2014.11.006_bib72","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1172\/JCI113663","article-title":"Atrial natriuretic peptides inhibit conductive sodium uptake by rabbit inner medullary collecting duct cells","volume":"82","author":"Zeidel","year":"1988","journal-title":"J Clin Invest"},{"issue":"6114","key":"10.1053\/j.ackd.2014.11.006_bib73","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/326697a0","article-title":"Atrial natriuretic peptide inhibits angiotensin-stimulated proximal tubular sodium and water reabsorption","volume":"326","author":"Harris","year":"1987","journal-title":"Nature"},{"issue":"4","key":"10.1053\/j.ackd.2014.11.006_bib74","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1172\/JCI115995","article-title":"Cellular basis for blunted volume expansion natriuresis in experimental nephrotic syndrome","volume":"90","author":"Valentin","year":"1992","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib75","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/ki.1989.161","article-title":"Blunted excretory response to atrial natriuretic peptide in experimental nephrosis","volume":"36","author":"Perico","year":"1989","journal-title":"Kidney Int"},{"issue":"5 Pt 2","key":"10.1053\/j.ackd.2014.11.006_bib76","first-page":"F865","article-title":"Blunted natriuresis to atrial natriuretic peptide in chronic sodium-retaining disorders","volume":"252","author":"Koepke","year":"1987","journal-title":"Am J Physiol"},{"issue":"6","key":"10.1053\/j.ackd.2014.11.006_bib77","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/ki.1988.256","article-title":"Atrial natriuretic peptide and the renal response to hypervolemia in nephrotic humans","volume":"34","author":"Peterson","year":"1988","journal-title":"Kidney Int"},{"issue":"1 Pt 2","key":"10.1053\/j.ackd.2014.11.006_bib78","first-page":"F3","article-title":"Phosphodiesterase activity as a mediator of renal resistance to ANP in pathological salt retention","volume":"271","author":"Lee","year":"1996","journal-title":"Am J Physiol"},{"issue":"15","key":"10.1053\/j.ackd.2014.11.006_bib79","doi-asserted-by":"crossref","first-page":"8525","DOI":"10.1073\/pnas.150149097","article-title":"Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme","volume":"97","author":"Yan","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1053\/j.ackd.2014.11.006_bib80","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/ki.2010.197","article-title":"Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases","volume":"78","author":"Polzin","year":"2010","journal-title":"Kidney Int"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib81","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/ki.2012.41","article-title":"Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice","volume":"82","author":"Wang","year":"2012","journal-title":"Kidney Int"},{"issue":"2","key":"10.1053\/j.ackd.2014.11.006_bib82","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0925-4439(03)00061-9","article-title":"Downregulation of nitric oxide synthase in nephrotic syndrome: role of proteinuria","volume":"1638","author":"Ni","year":"2003","journal-title":"Biochim Biophys Acta"},{"issue":"3 Pt 2","key":"10.1053\/j.ackd.2014.11.006_bib83","first-page":"F516","article-title":"Neuronal nitric oxide synthase modulates rat renal microvascular function","volume":"274","author":"Ichihara","year":"1998","journal-title":"Am J Physiol"},{"issue":"4 Pt 2","key":"10.1053\/j.ackd.2014.11.006_bib84","first-page":"F606","article-title":"Inhibition of locally produced nitric oxide resets tubuloglomerular feedback mechanism","volume":"267","author":"Thorup","year":"1994","journal-title":"Am J Physiol"},{"issue":"1","key":"10.1053\/j.ackd.2014.11.006_bib85","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1681\/ASN.V6189","article-title":"Nitric oxide inhibits sodium reabsorption in the isolated perfused cortical collecting duct","volume":"6","author":"Stoos","year":"1995","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"10.1053\/j.ackd.2014.11.006_bib86","doi-asserted-by":"crossref","first-page":"C717","DOI":"10.1152\/ajpcell.00006.2005","article-title":"Role of SGK1 in nitric oxide inhibition of ENaC in Na+-transporting epithelia","volume":"289","author":"Helms","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"issue":"7","key":"10.1053\/j.ackd.2014.11.006_bib87","doi-asserted-by":"crossref","first-page":"F930","DOI":"10.1152\/ajprenal.00638.2012","article-title":"ENaC is regulated by natriuretic peptide receptor-dependent cGMP signaling","volume":"304","author":"Guo","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"issue":"12","key":"10.1053\/j.ackd.2014.11.006_bib88","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/nm.1879","article-title":"Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease","volume":"14","author":"Shibata","year":"2008","journal-title":"Nat Med"},{"issue":"6","key":"10.1053\/j.ackd.2014.11.006_bib89","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/ki.1988.120","article-title":"Renal disease and the development of hypertension in salt-sensitive Dahl rats","volume":"33","author":"Sterzel","year":"1988","journal-title":"Kidney Int"},{"issue":"8","key":"10.1053\/j.ackd.2014.11.006_bib90","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1172\/JCI43124","article-title":"Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway","volume":"121","author":"Shibata","year":"2011","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1053\/j.ackd.2014.11.006_bib91","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1097\/HJH.0b013e32832c7d23","article-title":"Aberrant ENaC activation in Dahl salt-sensitive rats","volume":"27","author":"Kakizoe","year":"2009","journal-title":"J Hypertens"}],"container-title":["Advances in Chronic Kidney Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559514001918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559514001918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T16:03:39Z","timestamp":1651766619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1548559514001918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":91,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S1548559514001918"],"URL":"https:\/\/doi.org\/10.1053\/j.ackd.2014.11.006","relation":{},"ISSN":["1548-5595"],"issn-type":[{"value":"1548-5595","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sodium Retention and Volume Expansion in Nephrotic Syndrome: Implications for Hypertension","name":"articletitle","label":"Article Title"},{"value":"Advances in Chronic Kidney Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ackd.2014.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}