{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T22:45:30Z","timestamp":1768776330830,"version":"3.49.0"},"reference-count":176,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007197","name":"USPHS","doi-asserted-by":"publisher","award":["HL107555"],"award-info":[{"award-number":["HL107555"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ackdjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Chronic Kidney Disease"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1053\/j.ackd.2014.12.005","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T01:16:24Z","timestamp":1429578984000},"page":"232-244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Endogenous Cardiotonic Steroids in Kidney Failure: A Review and an Hypothesis"],"prefix":"10.1053","volume":"22","author":[{"given":"John M.","family":"Hamlyn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Manunta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.ackd.2014.12.005_bib1","first-page":"249","article-title":"Studies on the efferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog","volume":"21","author":"de Wardener","year":"1961","journal-title":"Clin Sci"},{"key":"10.1053\/j.ackd.2014.12.005_bib2","first-page":"497","article-title":"The natriuretic activity of jugular vein blood during carotid occlusion","volume":"12","author":"Cort","year":"1963","journal-title":"Physiol Bohemoslov"},{"key":"10.1053\/j.ackd.2014.12.005_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fendo.2014.00199","article-title":"Natriuretic hormones, endogenous ouabain and related sodium transport inhibitors","volume":"5","author":"Hamlyn","year":"2014","journal-title":"Front Endocrinol"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/10641968609074770","article-title":"A circulating Na+-K+ATPase inhibitor, erythrocyte sodium transport and hypertension in patients with chronic renal failure","volume":"8","author":"Kariya","year":"1986","journal-title":"Clin Exp Hypertens A"},{"issue":"14","key":"10.1053\/j.ackd.2014.12.005_bib5","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/S0024-3205(02)01855-6","article-title":"The effect of hemodialysis on the transport of sodium in erythrocytes from chronic renal failure patients maintained on hemodialysis","volume":"71","author":"Gambhir","year":"2002","journal-title":"Life Sci"},{"issue":"6","key":"10.1053\/j.ackd.2014.12.005_bib6","first-page":"1087","article-title":"Modulation of ouabain sensitive sodium potassium pump of erythrocytes from patients with chronic renal failure: role of acute hemodialysis","volume":"40","author":"Prasad","year":"1996","journal-title":"Biochem Mol Biol Int"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000185723","article-title":"Effects of dialysis and transplantation on red cell Na pump function in renal failure","volume":"53","author":"Fervenza","year":"1989","journal-title":"Nephron"},{"issue":"6","key":"10.1053\/j.ackd.2014.12.005_bib8","first-page":"325","article-title":"Effect of hemodialysis on the level of serum digoxin-like substance and sodium-potassium pump activity in erythrocytes from patients with chronic renal failure","volume":"87","author":"Czarkowski","year":"1992","journal-title":"Pol Arch Med Wewn"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib9","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1042\/cs0600555","article-title":"Relations between sodium transport and sodium concentration in human erythrocytes in health and disease","volume":"60","author":"Cumberbatch","year":"1981","journal-title":"Clin Sci (Lond)"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib10","first-page":"21","article-title":"Erythrocyte sodium and sodium flux in relation to hypertension in chronic renal failure","volume":"4","author":"Thomas","year":"1989","journal-title":"Nephrol Dial Transplant"},{"issue":"9","key":"10.1053\/j.ackd.2014.12.005_bib11","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1681\/ASN.V591689","article-title":"Impaired cation transport in thymocytes of rats with chronic uremia includes the Na+\/H+ antiporter","volume":"5","author":"Greiber","year":"1995","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib12","first-page":"264","article-title":"An Na,K-ATPase inhibitor from ultrafiltrate obtained by hemodialysis of patients with uremia","volume":"120","author":"Sohn","year":"1992","journal-title":"J Lab Clin Med"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib13","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/ki.1996.61","article-title":"Specificity of the volume-sensitive sodium pump inhibitor isolated from human peritoneal dialysate in chronic renal failure","volume":"49","author":"Tao","year":"1996","journal-title":"Kidney Int"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib14","first-page":"39","article-title":"Endogenous digitalis-like substance and Na-K-ATPase inhibitor in cardiovascular and renal disease","volume":"64","author":"Okamoto","year":"1988","journal-title":"Nihon Naibunpi Gakkai Zasshi"},{"issue":"9","key":"10.1053\/j.ackd.2014.12.005_bib15","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1093\/ndt\/gfq772","article-title":"Endogenous cardiotonic steroids in chronic renal failure","volume":"26","author":"Kolmakova","year":"2011","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"10.1053\/j.ackd.2014.12.005_bib16","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1172\/JCI113435","article-title":"Abnormal cation transport in uremia. Mechanisms in adipocytes and skeletal muscle from uremic rats","volume":"81","author":"Druml","year":"1988","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1053\/j.ackd.2014.12.005_bib17","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1161\/01.HYP.8.7.632","article-title":"Plasma digitalislike activity in essential hypertension or end-stage renal disease","volume":"8","author":"Deray","year":"1986","journal-title":"Hypertension"},{"issue":"suppl 2","key":"10.1053\/j.ackd.2014.12.005_bib18","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1097\/00005344-199322002-00018","article-title":"Volume expansion in renal failure patients: a paradigm for a clinically relevant [Na,K]ATPase inhibitor","volume":"22","author":"Graves","year":"1993","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib19","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/0006-291X(92)91334-M","article-title":"Identification and preliminary characterization of two human digitalis-like substances that are structurally related to digoxin and ouabain","volume":"188","author":"Weinberg","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib20","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0272-6386(89)80023-X","article-title":"Digitalislike immunoreactive substances and extracellular fluid volume status in chronic hemodialysis patients","volume":"13","author":"Bisordi","year":"1989","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1053\/j.ackd.2014.12.005_bib21","first-page":"169","article-title":"Plasma endogenous digitalis-like factors in healthy individuals and in dialysis-dependent and kidney transplant patients","volume":"27","author":"Vasdev","year":"1987","journal-title":"Clin Nephrol"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-99-5-604","article-title":"An endogenous digoxin-like substance in patients with renal impairment","volume":"99","author":"Graves","year":"1983","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib23","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2796.2007.01883.x","article-title":"Endogenous ouabain and cardiomyopathy in dialysis patients","volume":"263","author":"Stella","year":"2008","journal-title":"J Intern Med"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.clinbiochem.2004.08.005","article-title":"A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure","volume":"38","author":"Komiyama","year":"2005","journal-title":"Clin Biochem"},{"issue":"9","key":"10.1053\/j.ackd.2014.12.005_bib25","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1093\/clinchem\/31.9.1525","article-title":"Endogenous digoxin-like immunoreactive factors: impact on digoxin measurements and potential physiological implications","volume":"31","author":"Valdes","year":"1985","journal-title":"Clin Chem"},{"issue":"9","key":"10.1053\/j.ackd.2014.12.005_bib26","first-page":"1418","article-title":"Digoxin-like substance in term pregnancy, newborns, and renal failure","volume":"27","author":"Witherspoon","year":"1986","journal-title":"J Nucl Med"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib27","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/clinchem\/33.3.420","article-title":"Digoxin radioimmunoassay that does not detect digoxin-like substance in serum of newborns, infants, or patients with renal failure","volume":"33","author":"Witherspoon","year":"1987","journal-title":"Clin Chem"},{"issue":"10 Pt 1","key":"10.1053\/j.ackd.2014.12.005_bib28","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/ajh\/4.10.795","article-title":"Variation in apparent serum digitalis-like factor levels with different digoxin antibodies. The \u201cimmunochemical fingerprint\u201d","volume":"4","author":"Naomi","year":"1991","journal-title":"Am J Hypertens"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000183482","article-title":"Digoxin-like immunoreacting substance(s) in the serum of patients with chronic uremia","volume":"40","author":"Kramer","year":"1985","journal-title":"Nephron"},{"key":"10.1053\/j.ackd.2014.12.005_bib30","first-page":"277","article-title":"Demonstration of a low molecular weight natriuretic factor in uremic serum","volume":"83","author":"Bourgoignie","year":"1970","journal-title":"Trans Assoc Am Physicians"},{"issue":"6","key":"10.1053\/j.ackd.2014.12.005_bib31","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1172\/JCI107707","article-title":"The effects of the natriuretic factor from uremic urine on sodium transport, water and electrolyte content, and pyruvate oxidation by the isolated toad bladder","volume":"53","author":"Kaplan","year":"1974","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1053\/j.ackd.2014.12.005_bib32","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1172\/JCI107725","article-title":"On the adaptation in sodium excretion in chronic uremia. The effects of \u201cproportional reduction\u201d of sodium intake","volume":"53","author":"Schmidt","year":"1974","journal-title":"J Clin Invest"},{"issue":"20","key":"10.1053\/j.ackd.2014.12.005_bib33","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1056\/NEJM197205182862009","article-title":"On the pathogenesis of the uremic state. An exposition of the \u201ctrade-off hypothesis\u201d","volume":"286","author":"Bricker","year":"1972","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1053\/j.ackd.2014.12.005_bib34","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0024-3205(76)90284-8","article-title":"The role of humoral agents in volume expanded hypertension","volume":"19","author":"Haddy","year":"1976","journal-title":"Life Sci"},{"issue":"14","key":"10.1053\/j.ackd.2014.12.005_bib35","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.1073\/pnas.88.14.6259","article-title":"Identification and characterization of a ouabain-like compound from human plasma","volume":"88","author":"Hamlyn","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib36","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1161\/01.HYP.31.5.1097","article-title":"Characterization of a urinary bufodienolide Na+,K+-ATPase inhibitor in patients after acute myocardial infarction","volume":"31","author":"Bagrov","year":"1998","journal-title":"Hypertension"},{"issue":"6 Pt 2","key":"10.1053\/j.ackd.2014.12.005_bib37","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1161\/01.HYP.17.6.936","article-title":"Development of an immunoassay for endogenous digitalislike factor","volume":"17","author":"Harris","year":"1991","journal-title":"Hypertension"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1124\/pr.108.000711","article-title":"Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets","volume":"61","author":"Bagrov","year":"2009","journal-title":"Pharmacol Rev"},{"issue":"4","key":"10.1053\/j.ackd.2014.12.005_bib39","doi-asserted-by":"crossref","first-page":"C324","DOI":"10.1152\/ajpcell.00337.2012","article-title":"Activation of c-SRC underlies the differential effects of ouabain and digoxin on Ca2+ signaling in arterial smooth muscle cells","volume":"304","author":"Zulian","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"issue":"11","key":"10.1053\/j.ackd.2014.12.005_bib40","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.biopsych.2008.10.033","article-title":"Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders","volume":"65","author":"Goldstein","year":"2009","journal-title":"Biol Psychiatry"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1161\/01.HYP.0000252409.36927.05","article-title":"Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy","volume":"49","author":"Elkareh","year":"2007","journal-title":"Hypertension"},{"key":"10.1053\/j.ackd.2014.12.005_bib42","doi-asserted-by":"crossref","DOI":"10.1681\/ASN.2014020130","article-title":"Reduction in Maternal circulating ouabain impairs offspring growth and kidney development","author":"Dvela-Levitt","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib43","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1432-1033.1993.tb18141.x","article-title":"Identification of digitalis-like compounds in human cataractous lenses","volume":"216","author":"Lichtstein","year":"1993","journal-title":"Eur J Biochem"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib44","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1053\/j.ajkd.2010.01.023","article-title":"Emerging role of the bufadienolides in cardiovascular and kidney diseases","volume":"56","author":"Puschett","year":"2010","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib45","doi-asserted-by":"crossref","first-page":"C509","DOI":"10.1152\/ajpcell.00098.2007","article-title":"Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth","volume":"293","author":"Schoner","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3 Pt 1","key":"10.1053\/j.ackd.2014.12.005_bib46","first-page":"E413","article-title":"Ouabain is secreted by the adrenal gland in awake dogs","volume":"264","author":"Boulanger","year":"1993","journal-title":"Am J Physiol"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib47","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1210\/endo.135.2.8033829","article-title":"Ouabain is secreted by bovine adrenocortical cells","volume":"135","author":"Laredo","year":"1994","journal-title":"Endocrinology"},{"key":"10.1053\/j.ackd.2014.12.005_bib48","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1749-6632.2003.tb07283.x","article-title":"11-hydroxylation in the biosynthesis of endogenous ouabain: multiple implications","volume":"986","author":"Hamlyn","year":"2003","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib49","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/HJH.0b013e32831cf2c6","article-title":"Endogenous ouabain in cardiovascular function and disease","volume":"27","author":"Manunta","year":"2009","journal-title":"J Hypertens"},{"issue":"23","key":"10.1053\/j.ackd.2014.12.005_bib50","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/S0024-3205(98)00186-6","article-title":"Biosynthesis of digitalis-like compounds in rat adrenal cells: hydroxycholesterol as possible precursor","volume":"62","author":"Lichtstein","year":"1998","journal-title":"Life Sci"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib51","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1373\/clinchem.2003.022715","article-title":"De novo biosynthesis and radiolabeling of mammalian digitalis-like factors","volume":"50","author":"Qazzaz","year":"2004","journal-title":"Clin Chem"},{"issue":"5-6","key":"10.1053\/j.ackd.2014.12.005_bib52","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3109\/10641969809053240","article-title":"Simultaneous measurement of marinobufagenin, ouabain, and hypertension-associated protein in various disease states","volume":"20","author":"Gonick","year":"1998","journal-title":"Clin Exp Hypertens"},{"issue":"11 Pt 1","key":"10.1053\/j.ackd.2014.12.005_bib53","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/S0895-7061(01)02219-1","article-title":"Plasma OLC is elevated in mild experimental uremia but is not associated with hypertension","volume":"14","author":"Harwood","year":"2001","journal-title":"Am J Hypertens"},{"issue":"4","key":"10.1053\/j.ackd.2014.12.005_bib54","doi-asserted-by":"crossref","first-page":"F922","DOI":"10.1152\/ajprenal.90605.2008","article-title":"The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition","volume":"296","author":"Fedorova","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib55","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/CCM.0b013e3182741599","article-title":"Preoperative endogenous ouabain predicts acute kidney injury in cardiac surgery patients","volume":"41","author":"Bignami","year":"2013","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib56","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1124\/jpet.114.217133","article-title":"Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain","volume":"351","author":"Ferrandi","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"issue":"10","key":"10.1053\/j.ackd.2014.12.005_bib57","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1053\/j.ackd.2014.12.005_bib58","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.amjmed.2006.03.038","article-title":"Aldosterone blockade: an emerging strategy for abrogating progressive renal disease","volume":"119","author":"Epstein","year":"2006","journal-title":"Am J Med"},{"issue":"suppl 1","key":"10.1053\/j.ackd.2014.12.005_bib59","doi-asserted-by":"crossref","first-page":"i62","DOI":"10.1093\/ndt\/gft402","article-title":"Aldosterone synthase inhibitors in cardiovascular and renal diseases","volume":"29","author":"Namsolleck","year":"2014","journal-title":"Nephrol Dial Transpl"},{"issue":"6","key":"10.1053\/j.ackd.2014.12.005_bib60","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1161\/HYPERTENSIONAHA.109.140038","article-title":"Spironolactone attenuates experimental uremic cardiomyopathy by antagonizing marinobufagenin","volume":"54","author":"Tian","year":"2009","journal-title":"Hypertension"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib61","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0022-3565(25)32607-8","article-title":"Canrenone as a partial agonist at the digitalis receptor site of sodium-potassium-activated adenosine triphosphatase","volume":"217","author":"Finotti","year":"1981","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"10.1053\/j.ackd.2014.12.005_bib62","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00005344-199610000-00007","article-title":"Increase in the basal tone of guinea pig thoracic aorta induced by ouabain is inhibited by spironolactone canrenone and potassium canrenoate","volume":"28","author":"Sorrentino","year":"1996","journal-title":"J Cardiovasc Pharmacol"},{"issue":"4","key":"10.1053\/j.ackd.2014.12.005_bib63","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0161-4630(81)90135-X","article-title":"Spironolactone inhibits vascular reactivity by a prostaglandin related mechanism unconnected with aldosterone","volume":"7","author":"Oka","year":"1981","journal-title":"Prostaglandins Med"},{"issue":"8","key":"10.1053\/j.ackd.2014.12.005_bib64","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/ajh\/hpu066","article-title":"Actions of circulating angiotensin II and aldosterone in the brain contributing to hypertension","volume":"27","author":"Leenen","year":"2014","journal-title":"Am J Hypertens"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib65","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11897-009-0013-9","article-title":"The brain renin-angiotensin-aldosterone system: a major mechanism for sympathetic hyperactivity and left ventricular remodeling and dysfunction after myocardial infarction","volume":"6","author":"Huang","year":"2009","journal-title":"Curr Heart Fail Rep"},{"issue":"9","key":"10.1053\/j.ackd.2014.12.005_bib66","doi-asserted-by":"crossref","first-page":"e108916","DOI":"10.1371\/journal.pone.0108916","article-title":"Neuroendocrine humoral and vascular components in the pressor pathway for brain angiotensin II: a new axis in long term blood pressure control","volume":"9","author":"Hamlyn","year":"2014","journal-title":"PLos One"},{"issue":"8","key":"10.1053\/j.ackd.2014.12.005_bib67","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/jhh.2011.60","article-title":"Long-term effects of aldosterone blockade in resistant hypertension associated with chronic kidney disease","volume":"26","author":"Pisoni","year":"2012","journal-title":"J Hum Hypertens"},{"issue":"12","key":"10.1053\/j.ackd.2014.12.005_bib68","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1038\/sj.ki.5001854","article-title":"Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease","volume":"70","author":"Bianchi","year":"2006","journal-title":"Kidney Int"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib69","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1161\/01.CIR.86.2.420","article-title":"Elevated concentrations of endogenous ouabain in patients with congestive heart failure","volume":"86","author":"Gottlieb","year":"1992","journal-title":"Circulation"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib70","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ejheart.2005.07.010","article-title":"Independent and incremental prognostic value of endogenous ouabain in idiopathic dilated cardiomyopathy","volume":"8","author":"Pitzalis","year":"2006","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib71","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-2796.1994.tb01033.x","article-title":"Endogenous digoxin-like factor in acute myocardial infarction","volume":"235","author":"Bagrov","year":"1994","journal-title":"J Intern Med"},{"key":"10.1053\/j.ackd.2014.12.005_bib72","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.2741\/1679","article-title":"Uremic cardiomyopathy: role of circulating digitalis-like substances","volume":"10","author":"Mohmand","year":"2005","journal-title":"Front Biosci"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib73","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1681\/ASN.V1251079","article-title":"Left ventricular hypertrophy in the renal patient","volume":"12","author":"Middleton","year":"2001","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib74","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/01.ASN.0000037403.95126.03","article-title":"Effect of chronic renal failure on cardiac contractile function, calcium cycling, and gene expression of proteins important for calcium homeostasis in the rat","volume":"14","author":"Kennedy","year":"2003","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib75","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/01.HYP.0000202594.82271.92","article-title":"Central role for the\u00a0cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy","volume":"47","author":"Kennedy","year":"2006","journal-title":"Hypertension"},{"issue":"6","key":"10.1053\/j.ackd.2014.12.005_bib76","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/ajh.2012.17","article-title":"Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure","volume":"25","author":"Haller","year":"2012","journal-title":"Am J Hypertens"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib77","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11906-010-0161-z","article-title":"Endogenous ouabain: a link between sodium intake and hypertension","volume":"13","author":"Hamlyn","year":"2011","journal-title":"Curr Hypertens Rep"},{"key":"10.1053\/j.ackd.2014.12.005_bib78","first-page":"549","article-title":"Ouabain induced hypertension in the rat: relationships among circulating and tissue ouabain and blood pressure","volume":"12","author":"Manunta","year":"1994","journal-title":"J Hypertens"},{"issue":"suppl","key":"10.1053\/j.ackd.2014.12.005_bib79","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1291\/hypres.23.Supplement_S77","article-title":"Chronic hypertension induced by ouabain but not digoxin in the rat: antihypertensive effect of digoxin and digitoxin","volume":"23","author":"Manunta","year":"2000","journal-title":"Hypertens Res"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib80","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/00004872-199602000-00002","article-title":"Endogenous ouabain, sodium balance and blood pressure: a review and a hypothesis","volume":"14","author":"Hamlyn","year":"1996","journal-title":"J Hypertens"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib81","doi-asserted-by":"crossref","first-page":"H1031","DOI":"10.1152\/ajpheart.00899.2011","article-title":"How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension","volume":"302","author":"Blaustein","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"11","key":"10.1053\/j.ackd.2014.12.005_bib82","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/nm1118","article-title":"Salt-sensitive hypertension is triggered by Ca2+ entry via Na+\/Ca2+ exchanger type-1 in vascular smooth muscle","volume":"10","author":"Iwamoto","year":"2004","journal-title":"Nat Med"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib83","doi-asserted-by":"crossref","first-page":"H1140","DOI":"10.1152\/ajpheart.00436.2009","article-title":"Low-dose ouabain constricts small arteries from ouabain-hypertensive rats: implications for sustained elevation of vascular resistance","volume":"297","author":"Zhang","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"12","key":"10.1053\/j.ackd.2014.12.005_bib84","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.bbadis.2010.03.004","article-title":"The central role of the brain aldosterone-\u201couabain\u201d pathway in salt-sensitive hypertension","volume":"1802","author":"Leenen","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib85","doi-asserted-by":"crossref","first-page":"H422","DOI":"10.1152\/ajpheart.00256.2010","article-title":"Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-\u201couabain\u201d pathway","volume":"299","author":"Huang","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib86","doi-asserted-by":"crossref","first-page":"R635","DOI":"10.1152\/ajpregu.2001.281.2.R635","article-title":"Synaptic plasticity in sympathetic ganglia from acquired and inherited forms of ouabain-dependent hypertension","volume":"281","author":"Aileru","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"10.1053\/j.ackd.2014.12.005_bib87","doi-asserted-by":"crossref","first-page":"H2093","DOI":"10.1152\/ajpheart.01045.2009","article-title":"Sympathetic nerves and the endothelium influence the vasoconstrictor effect of low concentrations of ouabain in pressurized small arteries","volume":"298","author":"Raina","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib88","doi-asserted-by":"crossref","first-page":"H263","DOI":"10.1152\/ajpheart.00784.2009","article-title":"Upregulation of Na+ and Ca2+ transporters in arterial smooth muscle from ouabain-induced hypertensive rats","volume":"298","author":"Pulina","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"7","key":"10.1053\/j.ackd.2014.12.005_bib89","doi-asserted-by":"crossref","first-page":"H784","DOI":"10.1152\/ajpheart.00399.2012","article-title":"Nanomolar ouabain increases NCX1 expression and enhances Ca2+ signaling in human arterial myocytes: a mechanism that links salt to increased vascular resistance?","volume":"303","author":"Linde","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib90","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/HYPERTENSIONAHA.110.155564","article-title":"Renal ischemia regulates marinobufagenin release in humans","volume":"56","author":"Tian","year":"2010","journal-title":"Hypertension"},{"key":"10.1053\/j.ackd.2014.12.005_bib91","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fendo.2014.00097","article-title":"The trade-off between dietary salt and cardiovascular disease; a role for Na\/K-ATPase signaling?","volume":"5","author":"Xie","year":"2014","journal-title":"Front Endocrinol (lausanne)"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib92","doi-asserted-by":"crossref","first-page":"R553","DOI":"10.1152\/ajpregu.00648.2005","article-title":"Salt intake and depletion increase circulating levels of endogenous ouabain in normal men","volume":"290","author":"Manunta","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"4","key":"10.1053\/j.ackd.2014.12.005_bib93","first-page":"175","article-title":"Digitalis therapy in renal failure with special regard to digitoxin","volume":"19","author":"V\u00f6hringer","year":"1981","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"10.1053\/j.ackd.2014.12.005_bib94","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1073\/pnas.0304987101","article-title":"Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney","volume":"101","author":"Mikkaichi","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.ackd.2014.12.005_bib95","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1046\/j.1523-1755.2000.00251.x","article-title":"Cellular and molecular aspects of drug transport in the kidney","volume":"58","author":"Inui","year":"2000","journal-title":"Kidney Int"},{"issue":"4","key":"10.1053\/j.ackd.2014.12.005_bib96","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ajh.2009.3","article-title":"Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain","volume":"22","author":"Tripodi","year":"2009","journal-title":"Am J Hypertens"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib97","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/HJH.0b013e32833ea821","article-title":"Endogenous ouabain and the renin-angiotensin-aldosterone system: distinct effects on Na handling and blood pressure in human hypertension","volume":"29","author":"Manunta","year":"2011","journal-title":"J Hypertens"},{"key":"10.1053\/j.ackd.2014.12.005_bib98","article-title":"Endogenous ouabain changes rapidly during cardiac pulmonary by pass","author":"Bignami","year":"2011","journal-title":"J Steroids Hormon Sci"},{"issue":"9","key":"10.1053\/j.ackd.2014.12.005_bib99","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1093\/ndt\/gfu200","article-title":"A new clinical multivariable model that predicts postoperative acute kidney injury: impact of endogenous ouabain","volume":"29","author":"Simonini","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib100","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0022-3565(24)37374-4","article-title":"PST2238: a new antihypertensive compound that antagonizes the long-term pressor effect of ouabain","volume":"285","author":"Ferrari","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"10.1053\/j.ackd.2014.12.005_bib101","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1021\/jm970162e","article-title":"17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action","volume":"40","author":"Quadri","year":"1997","journal-title":"J Med Chem"},{"key":"10.1053\/j.ackd.2014.12.005_bib102","doi-asserted-by":"crossref","first-page":"17250","DOI":"10.1074\/jbc.M313239200","article-title":"Ouabain assembles signaling cascades through the caveolar Na+\/K+-ATPase","volume":"279","author":"Wang","year":"2004","journal-title":"J Biol Chem"},{"issue":"32","key":"10.1053\/j.ackd.2014.12.005_bib103","doi-asserted-by":"crossref","first-page":"33306","DOI":"10.1074\/jbc.M402187200","article-title":"Organ hypertrophic signaling within caveolae membrane subdomains triggered by ouabain and antagonized by PST 2238","volume":"279","author":"Ferrandi","year":"2004","journal-title":"J Biol Chem"},{"issue":"Pt 5","key":"10.1053\/j.ackd.2014.12.005_bib104","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1113\/jphysiol.2013.266866","article-title":"Ouabain-digoxin antagonism in rat arteries and neurones","volume":"592","author":"Song","year":"2014","journal-title":"J Physiol"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib105","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/HJH.0000000000000059","article-title":"Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na+K+-ATPase\/cSRC pathway","volume":"32","author":"Wenceslau","year":"2014","journal-title":"J Hypertens"},{"issue":"10","key":"10.1053\/j.ackd.2014.12.005_bib106","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1097\/00004872-199510000-00013","article-title":"Immunoreactive endogenous ouabain in primary aldosteronism and essential hypertension: relationship with plasma renin, aldosterone and blood pressure levels","volume":"13","author":"Rossi","year":"1995","journal-title":"J Hypertens"},{"issue":"59","key":"10.1053\/j.ackd.2014.12.005_bib107","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001814","article-title":"Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies","volume":"2","author":"Lanzani","year":"2010","journal-title":"Sci Transl Med"},{"key":"10.1053\/j.ackd.2014.12.005_bib108","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1745-6215-12-13","article-title":"Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin","volume":"12","author":"Staessen","year":"2011","journal-title":"Trials"},{"key":"10.1053\/j.ackd.2014.12.005_bib109","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1042\/cs0630121","article-title":"Plasma renin in long-term diuretic treatment of hypertension: effect of discontinuation and restarting therapy","volume":"63","author":"Swart","year":"1982","journal-title":"Clin Sci"},{"key":"10.1053\/j.ackd.2014.12.005_bib110","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1097\/00004872-200108000-00007","article-title":"Persistent cardiovascular effects of chronic renin-angiotensin system inhibition following withdrawal in adult spontaneously hypertensive rats","volume":"19","author":"Paull","year":"2001","journal-title":"J Hypertens"},{"issue":"8","key":"10.1053\/j.ackd.2014.12.005_bib111","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.jacc.2014.05.044","article-title":"2014 Eighth Joint National Committee panel recommendation for blood pressure targets revisited: results from the INVEST study","volume":"64","author":"Bangalore","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"10.1053\/j.ackd.2014.12.005_bib112","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1681\/ASN.2009101047","article-title":"Digoxin associates with mortality in ESRD","volume":"21","author":"Chan","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib113","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cardfail.2013.03.002","article-title":"Potential effects of digoxin on long-term renal and clinical outcomes in chronic heart failure","volume":"19","author":"Testani","year":"2013","journal-title":"J Card Fail"},{"issue":"4","key":"10.1053\/j.ackd.2014.12.005_bib114","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1053\/j.ajkd.2003.12.036","article-title":"Hypertension in the hemodialysis patient and the \u201clag phenomenon\u201d: insights into pathophysiology and clinical management","volume":"43","author":"Khosla","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2014.12.005_bib115","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1542-4758.2008.00304.x","article-title":"Sodium, hypertension, and an explanation of the \u201clag phenomenon\u201d in hemodialysis patients","volume":"12","author":"Twardowski","year":"2008","journal-title":"Hemodial Int"},{"key":"10.1053\/j.ackd.2014.12.005_bib116","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/ncpneph0403","article-title":"Beneficial effect of strict volume control on blood pressure and mortality in patients on hemodialysis","volume":"3","author":"Shaldon","year":"2007","journal-title":"Nat Clin Pract Nephrol"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib117","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ncpneph0979","article-title":"The advantages and challenges of increasing the duration and frequency of maintenance dialysis sessions","volume":"5","author":"Chazot","year":"2009","journal-title":"Nat Clin Pract Nephrol"},{"issue":"Suppl 2","key":"10.1053\/j.ackd.2014.12.005_bib118","first-page":"19","article-title":"From adequate to optimal dialysis long 3 x 8 hr dialysis: a reasonable compromise","volume":"25","author":"Charra","year":"2005","journal-title":"Nefrologia"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib119","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/01.HYP.22.2.178","article-title":"Long-term ouabain administration produces hypertension in rats","volume":"22","author":"Yuan","year":"1993","journal-title":"Hypertension"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib120","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0022-3565(25)29787-7","article-title":"Renal and gastrointestinal excretion of ouabain in dog and man","volume":"188","author":"Selden","year":"1974","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib121","doi-asserted-by":"crossref","first-page":"15","DOI":"10.7326\/0003-4819-83-1-15","article-title":"Ouabain plasma level kinetics and removal by dialysis in chronic renal failure. A study in fourteen patients","volume":"83","author":"Selden","year":"1975","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib122","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jim.2008.05.005","article-title":"Comparison of non-digitalis binding properties of digoxin-specific Fabs using direct binding methods","volume":"336","author":"Pullen","year":"2008","journal-title":"J Immunol Methods"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib123","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1113\/expphysiol.2009.048900","article-title":"Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension","volume":"95","author":"Gomez-Sanchez","year":"2010","journal-title":"Exp Physiol"},{"issue":"1 Pt 1","key":"10.1053\/j.ackd.2014.12.005_bib124","first-page":"E96","article-title":"Central mineralocorticoid receptor antagonism blocks hypertension in Dahl S\/JR rats","volume":"262","author":"Gomez-Sanchez","year":"1992","journal-title":"Am J Physiol"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib125","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/01.HYP.0000022659.17774.E4","article-title":"Brain sodium channels mediate increases in brain \u201couabain\u201d and blood pressure in Dahl S rats","volume":"40","author":"Wang","year":"2002","journal-title":"Hypertension"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib126","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/10641969809053211","article-title":"Brain \u201couabain\u201d, a neurosteroid, mediates sympathetic hyperactivity in salt-sensitive hypertension","volume":"20","author":"Budzikowski","year":"1998","journal-title":"Clin Exp Hypertens"},{"issue":"4","key":"10.1053\/j.ackd.2014.12.005_bib127","doi-asserted-by":"crossref","first-page":"R994","DOI":"10.1152\/ajpregu.90903.2008","article-title":"Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats","volume":"296","author":"Huang","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7 Pt 1","key":"10.1053\/j.ackd.2014.12.005_bib128","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/ajh\/7.7.591","article-title":"Immunization of Dahl SS\/jr rats with an ouabain conjugate mitigates hypertension","volume":"7","author":"Gomez-Sanchez","year":"1994","journal-title":"Am J Hypertens"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib129","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1113\/expphysiol.1982.sp002605","article-title":"Internalization of ouabain and replacement of sodium pumps in the plasma membranes of HeLa cells following block with cardiac glycosides","volume":"67","author":"Lamb","year":"1982","journal-title":"Q J Exp Physiol"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib130","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1291\/hypres.21.47","article-title":"Exogenous ouabain is accumulated in the adrenals and mimics the kinetics of endogenous digitalis-like factor in rats","volume":"21","author":"Kitano","year":"1998","journal-title":"Hypertens Res"},{"key":"10.1053\/j.ackd.2014.12.005_bib131","series-title":"The Organization of Behavior","first-page":"335","author":"Hebb","year":"1949"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib132","doi-asserted-by":"crossref","first-page":"H807","DOI":"10.1152\/ajpheart.00259.2008","article-title":"Plasticity of pre- and postsynaptic GABAB receptor function in the paraventricular nucleus in spontaneously hypertensive rats","volume":"295","author":"Li","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5-6","key":"10.1053\/j.ackd.2014.12.005_bib133","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1440-1681.2005.04206.x","article-title":"Translation of salt retention to central activation of the sympathetic nervous system in hypertension","volume":"32","author":"Brooks","year":"2005","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"1-2","key":"10.1053\/j.ackd.2014.12.005_bib134","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0006-8993(89)90382-X","article-title":"Neuronal-glial and synaptic plasticity in the adult rat paraventricular nucleus","volume":"484","author":"Theodosis","year":"1989","journal-title":"Brain Res"},{"issue":"11","key":"10.1053\/j.ackd.2014.12.005_bib135","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1177\/153537020122601109","article-title":"Inhibition of ganglionic long-term potentiation decreases blood pressure in spontaneously hypertensive rats","volume":"226","author":"Alkadhi","year":"2001","journal-title":"Exp Biol Med (Maywood)"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib136","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.coph.2011.06.008","article-title":"Studying synaptic plasticity in the human brain and opportunities for drug discovery","volume":"11","author":"Nathan","year":"2011","journal-title":"Curr Opin Pharmacol"},{"issue":"2 Pt 2","key":"10.1053\/j.ackd.2014.12.005_bib137","doi-asserted-by":"crossref","first-page":"I89","DOI":"10.1161\/01.HYP.5.2_Pt_2.I89","article-title":"Effect of anteroventral third ventricle lesions on vascular sodium-pump activity in two-kidney Goldblatt hypertension","volume":"5","author":"Songu-Mize","year":"1983","journal-title":"Hypertension"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib138","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0006-8993(81)90337-1","article-title":"Prevention of renal hypertension and of the central pressor effect of angiotensin by ventromedial hypothalamic ablation","volume":"205","author":"Johnson","year":"1981","journal-title":"Brain Res"},{"issue":"6 Pt 3","key":"10.1053\/j.ackd.2014.12.005_bib139","doi-asserted-by":"crossref","first-page":"V90","DOI":"10.1161\/01.HYP.5.6_Pt_3.V90","article-title":"Anteroventral third ventricle and renin-angiotensin system interaction in the two-kidney, one clip hypertensive rat","volume":"5","author":"Marson","year":"1983","journal-title":"Hypertension"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib140","first-page":"25","article-title":"Periventricular forebrain mechanisms for blood pressure regulation","volume":"43","author":"Buggy","year":"1984","journal-title":"Fed Proc"},{"issue":"Suppl 7","key":"10.1053\/j.ackd.2014.12.005_bib141","doi-asserted-by":"crossref","first-page":"49s","DOI":"10.1042\/cs061049s","article-title":"Paraventricular\u2013suprachiasmatic lesions prevent salt-induced hypertension in Dahl rats","volume":"61","author":"Azar","year":"1981","journal-title":"Clin Sci (Lond)"},{"issue":"6","key":"10.1053\/j.ackd.2014.12.005_bib142","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0361-9230(85)90214-X","article-title":"The role of the anteromedial hypothalamus in Dahl hypertension","volume":"15","author":"Ernsberger","year":"1985","journal-title":"Brain Res Bull"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib143","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/01.HYP.4.5.575","article-title":"Effect of AV3V lesions on development of DOCA-salt hypertension and vascular Na+-pump activity","volume":"4","author":"Songu-Mize","year":"1982","journal-title":"Hypertension"},{"issue":"1 Pt 2","key":"10.1053\/j.ackd.2014.12.005_bib144","first-page":"H63","article-title":"Ouabain- and central sodium-induced hypertension depend on the ventral anteroventral third ventricle region","volume":"276","author":"Veerasingham","year":"1999","journal-title":"Am J Physiol"},{"issue":"6","key":"10.1053\/j.ackd.2014.12.005_bib145","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1161\/HYPERTENSIONAHA.111.170308","article-title":"Prevalence of resistant hypertension in the United States, 2003-2008","volume":"57","author":"Persell","year":"2011","journal-title":"Hypertension"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib146","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev-med-042711-135929","article-title":"Hyperaldosteronism as a common cause of resistant hypertension","volume":"64","author":"Calhoun","year":"2013","journal-title":"Annu Rev Med"},{"key":"10.1053\/j.ackd.2014.12.005_bib147","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1056\/NEJM200109203451215","article-title":"Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease","volume":"345","author":"Chrysostomou","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2014.12.005_bib148","doi-asserted-by":"crossref","first-page":"29932","DOI":"10.1074\/jbc.M110.131342","article-title":"A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule","volume":"285","author":"Fagart","year":"2010","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib149","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1254\/jphs.10285FP","article-title":"SM-368229, a novel selective and potent non-steroidal mineralocorticoid receptor antagonist with strong urinary Na+ excretion activity","volume":"115","author":"Nariai","year":"2011","journal-title":"J Pharmacol Sci"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib150","doi-asserted-by":"crossref","first-page":"R618","DOI":"10.1152\/ajpregu.90417.2008","article-title":"Mechanisms in the PVN mediating local and central sodium-induced hypertension in Wistar rats","volume":"296","author":"Gabor","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib151","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/HYPERTENSIONAHA.113.01557","article-title":"Role of brain corticosterone and aldosterone in central angiotensin II-induced hypertension","volume":"62","author":"Huang","year":"2013","journal-title":"Hypertension"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib152","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1161\/HYPERTENSIONAHA.111.00797","article-title":"Central mineralocorticoid receptors and the role of angiotensin II and glutamate in the paraventricular nucleus of rats with angiotensin II-induced hypertension","volume":"61","author":"Gabor","year":"2013","journal-title":"Hypertension"},{"issue":"7","key":"10.1053\/j.ackd.2014.12.005_bib153","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1161\/01.RES.0000244092.95152.86","article-title":"Novel effect of mineralocorticoid receptor antagonism to reduce proinflammatory cytokines and hypothalamic activation in rats with ischemia-induced heart failure","volume":"99","author":"Kang","year":"2006","journal-title":"Circ Res"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib154","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1139\/cjpp-78-1-45","article-title":"Chronic blockade of brain \u201couabain\u201d prevents sympathetic hyper-reactivity and impairment of acute baroreflex resetting in rats with congestive heart failure","volume":"78","author":"Huang","year":"2000","journal-title":"Can J Physiol Pharmacol"},{"issue":"5 Pt 2","key":"10.1053\/j.ackd.2014.12.005_bib155","first-page":"H1786","article-title":"Brain \u201couabain\u201d and angiotensin II contribute to cardiac dysfunction after myocardial infarction","volume":"277","author":"Leenen","year":"1999","journal-title":"Am J Physiol"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib156","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/01.RES.77.5.993","article-title":"Brain 'ouabain' mediates sympathetic hyperactivity in congestive heart failure","volume":"77","author":"Leenen","year":"1995","journal-title":"Circ Res"},{"issue":"3881","key":"10.1053\/j.ackd.2014.12.005_bib157","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.164.3881.842","article-title":"Digitoxin poisoning: prevention by spironolactone","volume":"164","author":"Selye","year":"1969","journal-title":"Science"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib158","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00502063","article-title":"Extrarenal actions of aldosterone antagonists in guinea pigs. II. Reduction of the toxicity of beta-methyl-digoxin","volume":"279","author":"Schaumann","year":"1973","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib159","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0014-2999(72)90002-7","article-title":"Prevention and abolition of ouabain-induced ventricular tachycardia by potassium canrenoate in dogs","volume":"19","author":"Yeh","year":"1972","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib160","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0002-9149(75)90035-1","article-title":"Potassium canrenoate in the treatment of long-term digoxin-induced arrhythmias in conscious dogs","volume":"35","author":"deGuzman","year":"1975","journal-title":"Am J Cardiol"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib161","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0002-8703(76)80112-3","article-title":"Antiarrhythmic activity of potassium canrenoate in man","volume":"92","author":"Yeh","year":"1976","journal-title":"Am Heart J"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib162","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/00005344-199811000-00001","article-title":"Small doses of canrenone block the effects of ouabain on the mechanical activity of the heart and vessels of the rat","volume":"32","author":"Vassallo","year":"1998","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1053\/j.ackd.2014.12.005_bib163","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/0167-5273(89)90092-2","article-title":"Erythrocyte Na+, K+ pump inhibition after saline infusion in essentially hypertensive subjects: effects of canrenone administration","volume":"25 Suppl 1","author":"Boero","year":"1989","journal-title":"Int J Cardiol"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib164","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00005344-200307000-00005","article-title":"Effect of canrenone on the digitalis site of Na+\/K(+)-ATPase in human placental membranes and in erythrocytes","volume":"42","author":"Balzan","year":"2003","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib165","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00005344-198801000-00012","article-title":"Antihypertensive effect of canrenone in a model where endogenous ouabain-like factors are present","volume":"11","author":"de Mendon\u00e7a","year":"1988","journal-title":"J Cardiovasc Pharmacol"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib166","doi-asserted-by":"crossref","first-page":"917","DOI":"10.3109\/10641969109042097","article-title":"Effects of canrenone on RRM-sucrose hypertension in WKY","volume":"13","author":"Preuss","year":"1991","journal-title":"Clin Exp Hypertens A"},{"issue":"1","key":"10.1053\/j.ackd.2014.12.005_bib167","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0039-128X(94)00005-W","article-title":"Ouabain-inhibiting activity of aldosterone antagonists","volume":"60","author":"Semplicini","year":"1995","journal-title":"Steroids"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib168","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/ajh\/3.3.188","article-title":"Effects of canrenone on blood pressure in rats with reduced renal mass","volume":"3","author":"Pamnani","year":"1990","journal-title":"Am J Hypertens"},{"issue":"Pt 1","key":"10.1053\/j.ackd.2014.12.005_bib169","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1113\/jphysiol.2005.091801","article-title":"Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice","volume":"569","author":"Zhang","year":"2005","journal-title":"J Physiol"},{"issue":"5","key":"10.1053\/j.ackd.2014.12.005_bib170","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1097\/00005344-200105000-00006","article-title":"Effects of canrenone on aorta and right ventricle of the rat","volume":"37","author":"Cargnelli","year":"2001","journal-title":"J Cardiovasc Pharmacol"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib171","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1476-5381.2009.00329.x","article-title":"The negative inotropic action of canrenone is mediated by L-type calcium current blockade and reduced intracellular calcium transients","volume":"158","author":"Costa","year":"2009","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib172","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/jhh.2013.88","article-title":"Blood pressure changes after renal denervation at 10 European Expert Centers","volume":"8","author":"Persu","year":"2013","journal-title":"J Hum Hypertens"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib173","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0272-6386(12)80563-4","article-title":"Isokinetic muscle strength predicts maximum exercise tolerance in renal patients on chronic hemodialysis","volume":"16","author":"Diesel","year":"1990","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1053\/j.ackd.2014.12.005_bib174","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1046\/j.1365-201X.1998.0343f.x","article-title":"Skeletal muscle fatigue in normal subjects and heart failure patients. Is there a common mechanism?","volume":"162","author":"Lunde","year":"1998","journal-title":"Acta Physiol Scand"},{"issue":"suppl 1","key":"10.1053\/j.ackd.2014.12.005_bib175","first-page":"I25","article-title":"Sodium pump isoform expression in heart failure: implication for treatment","volume":"97","author":"M\u00fcller-Ehmsen","year":"2002","journal-title":"Basic Res Cardiol"},{"issue":"2","key":"10.1053\/j.ackd.2014.12.005_bib176","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1074\/jbc.M112.424663","article-title":"Tissue-specific role of the Na,K-ATPase \u03b12 isozyme in skeletal muscle","volume":"288","author":"Radzyukevich","year":"2013","journal-title":"J Biol Chem"}],"container-title":["Advances in Chronic Kidney Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559515000026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559515000026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T19:45:11Z","timestamp":1747943111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1548559515000026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":176,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S1548559515000026"],"URL":"https:\/\/doi.org\/10.1053\/j.ackd.2014.12.005","relation":{},"ISSN":["1548-5595"],"issn-type":[{"value":"1548-5595","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endogenous Cardiotonic Steroids in Kidney Failure: A Review and an Hypothesis","name":"articletitle","label":"Article Title"},{"value":"Advances in Chronic Kidney Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ackd.2014.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}