{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:04:08Z","timestamp":1787313848464,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ackdjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Chronic Kidney Disease"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1053\/j.ackd.2016.11.004","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T06:34:29Z","timestamp":1489041269000},"page":"64-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"title":["Mechanisms of Drug-Induced Interstitial Nephritis"],"prefix":"10.1053","volume":"24","author":[{"given":"Rajeev","family":"Raghavan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4602-5700","authenticated-orcid":false,"given":"Saed","family":"Shawar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1053\/j.ackd.2016.11.004_bib1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5414\/CN10838","article-title":"Acute interstitial nephritis\u2014a reappraisal and update","volume":"82","author":"Raghavan","year":"2014","journal-title":"Clin Nephrol"},{"key":"10.1053\/j.ackd.2016.11.004_bib2","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1093\/ndt\/gft241","article-title":"Tubulointerstitial nephritis and cancer chemotherapy: update on a neglected clinical entity","volume":"28","author":"Airy","year":"2013","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2016.11.004_bib3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nrneph.2010.71","article-title":"Drug-induced acute interstitial nephritis","volume":"6","author":"Perazella","year":"2010","journal-title":"Nat Rev Nephrol"},{"issue":"5","key":"10.1053\/j.ackd.2016.11.004_bib4","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1365-2125.2010.03774.x","article-title":"Epidemiology and risk factors for drug allergy","volume":"71","author":"Thong","year":"2011","journal-title":"Br J Clin Pharmacol"},{"issue":"8","key":"10.1053\/j.ackd.2016.11.004_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1056\/NEJM197408222910803","article-title":"Antitubular basement-membrane antibodies in methicillin-associated interstitial nephritis","volume":"291","author":"Border","year":"1974","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1053\/j.ackd.2016.11.004_bib6","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.4049\/jimmunol.1202949","article-title":"HLA haplotype determines hapten or p-i T cell reactivity to flucloxacillin","volume":"190","author":"Wuillemin","year":"2013","journal-title":"J Immunol"},{"issue":"6","key":"10.1053\/j.ackd.2016.11.004_bib7","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.jaci.2011.08.013","article-title":"Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome","volume":"128","author":"Ko","year":"2011","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1053\/j.ackd.2016.11.004_bib8","first-page":"3","article-title":"Drug-induced acute interstitial nephritis","volume":"9","author":"Krishnan","year":"2015","journal-title":"Iran J Kidney Dis"},{"issue":"3","key":"10.1053\/j.ackd.2016.11.004_bib9","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1124\/jpet.111.183871","article-title":"Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients","volume":"338","author":"Meng","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"issue":"9","key":"10.1053\/j.ackd.2016.11.004_bib10","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.4049\/jimmunol.178.9.5533","article-title":"Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling","volume":"178","author":"Sanderson","year":"2007","journal-title":"J Immunol"},{"issue":"6","key":"10.1053\/j.ackd.2016.11.004_bib11","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1056\/NEJMcp043986","article-title":"Clinical practice. Antibiotic allergy","volume":"354","author":"Gruchalla","year":"2006","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1053\/j.ackd.2016.11.004_bib12","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/j.1365-2133.2003.05584.x","article-title":"A 6-month prospective survey of cutaneous drug reactions in a hospital setting","volume":"149","author":"Fiszenson-Albala","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1053\/j.ackd.2016.11.004_bib13","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/ki.2010.89","article-title":"Acute interstitial nephritis","volume":"77","author":"Praga","year":"2010","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2016.11.004_bib14","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1067\/mai.2001.118509","article-title":"Drug metabolism, danger signals, and drug-induced hypersensitivity","volume":"108","author":"Gruchalla","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1053\/j.ackd.2016.11.004_bib15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/ki.2008.189","article-title":"Macrophages and dendritic cells: what is the difference?","volume":"74","author":"Ferenbach","year":"2008","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2016.11.004_bib16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/sj.ki.5001567","article-title":"CX3CR1+ interstitial dendritic cells form contiguous network throughout the entire kidney","volume":"70","author":"Soos","year":"2006","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2016.11.004_bib17","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1681\/ASN.2007030273","article-title":"Dendritic cells in the kidney","volume":"18","author":"John","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2016.11.004_bib18","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1523-1755.2005.00502.x","article-title":"Antigen presentation by dendritic cells in renal lymph nodes is linked to systemic and local injury to the kidney","volume":"68","author":"Dong","year":"2005","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2016.11.004_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1681\/ASN.2007111233","article-title":"Proteosomal processing of albumin by dendritic cells generates antigenic peptides","volume":"20","author":"Macconi","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2016.11.004_bib20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1681\/ASN.2008111200","article-title":"Cross dendritic cells anger T cells after kidney injury","volume":"20","author":"Rees","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2016.11.004_bib21","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1681\/ASN.2013020164","article-title":"The renal lymph node and immune tolerance to filtered antigens","volume":"24","author":"Pindjakova","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2016.11.004_bib22","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"10.1053\/j.ackd.2016.11.004_bib23","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1365-2125.2010.03764.x","article-title":"Delayed drug hypersensitivity: models of T cell stimulation","volume":"71","author":"Adam","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1053\/j.ackd.2016.11.004_bib24","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1681\/ASN.2013050502","article-title":"Regulatory T-cells in AKI","volume":"24","author":"Kinsey","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2016.11.004_bib25","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1681\/ASN.2006080839","article-title":"The downside of a drug crazed world","volume":"17","author":"Neilson","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2016.11.004_bib26","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1681\/ASN.2006050418","article-title":"Involvement of drug-specific T-cells in acute drug-induced interstitial nephritis","volume":"17","author":"Spanou","year":"2006","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1053\/j.ackd.2016.11.004_bib27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/157488412799218815","article-title":"Structure-activity relationships and drug allergy","volume":"7","author":"Hasdenteufel","year":"2012","journal-title":"Curr Clin Pharmacol"},{"issue":"1","key":"10.1053\/j.ackd.2016.11.004_bib28","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4049\/jimmunol.1100647","article-title":"Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis","volume":"187","author":"Whitaker","year":"2011","journal-title":"J Immunol"},{"key":"10.1053\/j.ackd.2016.11.004_bib29","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1097\/00007611-200194080-00014","article-title":"Practical issues in the management of hypersensitivity reactions: sulfonamides","volume":"94","author":"Tilles","year":"2001","journal-title":"South Med J"},{"issue":"5","key":"10.1053\/j.ackd.2016.11.004_bib30","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1124\/mol.62.5.1011","article-title":"Haptenation of sulfonamide reactive metabolites to cellular proteins","volume":"62","author":"Manchanda","year":"2002","journal-title":"Mol Pharmacol"},{"issue":"6","key":"10.1053\/j.ackd.2016.11.004_bib31","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.jaci.2010.12.1119","article-title":"Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis","volume":"127","author":"Elsheikh","year":"2011","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"10.1053\/j.ackd.2016.11.004_bib32","doi-asserted-by":"crossref","first-page":"971","DOI":"10.2174\/138920009790711841","article-title":"Hypersensitivity reactions to non-steroidal anti-inflammatory drugs","volume":"10","author":"Cornejo-Garcia","year":"2009","journal-title":"Curr Drug Metab"},{"issue":"22","key":"10.1053\/j.ackd.2016.11.004_bib33","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1056\/NEJM198005293022206","article-title":"Nonsteroidal antiinflammatory drugs (second of two parts)","volume":"302","author":"Simon","year":"1980","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1053\/j.ackd.2016.11.004_bib34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5414\/CNP68065","article-title":"Proton pump inhibitors and the kidney: critical review","volume":"68","author":"Brewster","year":"2007","journal-title":"Clin Nephrol"},{"issue":"Suppl 2","key":"10.1053\/j.ackd.2016.11.004_bib35","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2036.2006.02943.x","article-title":"Review article: the clinical pharmacology of proton pump inhibitors","volume":"23","author":"Sachs","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.ackd.2016.11.004_bib36","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1365-2125.2007.02927.x","article-title":"Proton pump inhibitor-induced acute interstitial nephritis","volume":"64","author":"H\u00e4rmark","year":"2007","journal-title":"Br J Clin Pharmacol"},{"key":"10.1053\/j.ackd.2016.11.004_bib37","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/ACI.0b013e328355b8d3","article-title":"Hypersensitivity reactions to proton pump inhibitors","volume":"12","author":"Chang","year":"2012","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"6","key":"10.1053\/j.ackd.2016.11.004_bib38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/nep.12226","article-title":"Omeprazole-induced acute interstitial nephritis: a possible Th1-Th17 mediated injury?","volume":"19","author":"Berney-Meyer","year":"2014","journal-title":"Nephrology (Carlton)"},{"key":"10.1053\/j.ackd.2016.11.004_bib39","first-page":"57","article-title":"Nine cases of omeprazole allergy. Cross-reactivity between proton pump inhibitors","volume":"19","author":"Lobera","year":"2009","journal-title":"J Investig Allergol Clin Immunol"},{"issue":"3","key":"10.1053\/j.ackd.2016.11.004_bib40","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.jaci.2005.11.001","article-title":"Hypersensitivity to lansoprazole and rabeprazole with tolerance to other proton pump inhibitors","volume":"117","author":"Perez Pimiento","year":"2006","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1053\/j.ackd.2016.11.004_bib41","doi-asserted-by":"crossref","first-page":"381","DOI":"10.5414\/CN108301","article-title":"Diagnosing drug-induced AIN in the hospitalized patient: a challenge for the clinician","volume":"81","author":"Perazella","year":"2014","journal-title":"Clin Nephrol"},{"issue":"3","key":"10.1053\/j.ackd.2016.11.004_bib42","doi-asserted-by":"crossref","first-page":"304","DOI":"10.7326\/0003-4819-84-3-304","article-title":"Glucocorticosteroid therapy: mechanisms of action and clinical considerations","volume":"84","author":"Fauci","year":"1976","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1053\/j.ackd.2016.11.004_bib43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrd3838","article-title":"Targeting eosinophils in allergy, inflammation and beyond","volume":"12","author":"Fulkerson","year":"2013","journal-title":"Nat Rev Drug Discov"},{"issue":"1-3","key":"10.1053\/j.ackd.2016.11.004_bib44","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000334155","article-title":"Plasmapheresis in immunologic renal disease","volume":"33","author":"Pusey","year":"2012","journal-title":"Blood Purif"},{"issue":"4","key":"10.1053\/j.ackd.2016.11.004_bib45","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1046\/j.1526-0968.2001.00316.x","article-title":"Membrane plasmapheresis in the United States: a review over the last 20 years","volume":"5","author":"Siami","year":"2001","journal-title":"Ther Apher"},{"key":"10.1053\/j.ackd.2016.11.004_bib46","first-page":"12","article-title":"Hypersensitivity reactions to \u03b2-lactams: relevance of hapten-protein conjugates","volume":"25","author":"Ariza","year":"2015","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1053\/j.ackd.2016.11.004_bib47","first-page":"329","article-title":"The multiple faces of nonsteroidal antiinflammatory drug hypersensitivity","volume":"14","author":"Sanchez-Borges","year":"2004","journal-title":"J Invest Allergol Clin Immunol"},{"issue":"17","key":"10.1053\/j.ackd.2016.11.004_bib48","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1056\/NEJMoa022963","article-title":"Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics","volume":"349","author":"Strom","year":"2003","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1053\/j.ackd.2016.11.004_bib49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2165\/00002018-200124040-00001","article-title":"Should celecoxib be contraindicated in patients who are allergic to sulfonamides? Revisiting the meaning of \u2018sulfa\u2019 allergy","volume":"24","author":"Knowles","year":"2001","journal-title":"Drug Saf"},{"issue":"2","key":"10.1053\/j.ackd.2016.11.004_bib50","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1345\/aph.1E350","article-title":"Sulfonamide cross-reactivity: fact or fiction?","volume":"39","author":"Johnson","year":"2005","journal-title":"Ann Pharmacother"},{"key":"10.1053\/j.ackd.2016.11.004_bib51","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1111\/all.12008","article-title":"Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA","volume":"67","author":"Yun","year":"2012","journal-title":"Allergy"}],"container-title":["Advances in Chronic Kidney Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559516301288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559516301288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T18:14:56Z","timestamp":1719080096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1548559516301288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S1548559516301288"],"URL":"https:\/\/doi.org\/10.1053\/j.ackd.2016.11.004","relation":{},"ISSN":["1548-5595"],"issn-type":[{"value":"1548-5595","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of Drug-Induced Interstitial Nephritis","name":"articletitle","label":"Article Title"},{"value":"Advances in Chronic Kidney Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ackd.2016.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the National Kidney Foundation, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}