{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T09:03:48Z","timestamp":1746695028601},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ackdjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Chronic Kidney Disease"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1053\/j.ackd.2017.05.010","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T21:31:58Z","timestamp":1501623118000},"page":"261-266","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Getting to the Heart of the Matter: Review of Treatment of Cardiorenal Syndrome"],"prefix":"10.1053","volume":"24","author":[{"given":"Kausik","family":"Umanath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitaramesh","family":"Emani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.ackd.2017.05.010_bib1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/01.CCM.0000296264.41365.80","article-title":"Acute heart failure in the intensive care unit: epidemiology","volume":"36","author":"Dar","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1053\/j.ackd.2017.05.010_bib2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/ncpneph0673","article-title":"Cardiorenal versus renocardiac syndrome: is there a difference?","volume":"3","author":"Schrier","year":"2007","journal-title":"Nat Clin Pract Nephrol"},{"key":"10.1053\/j.ackd.2017.05.010_bib3","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jacc.2008.07.051","article-title":"Cardiorenal syndrome","volume":"52","author":"Ronco","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.ackd.2017.05.010_bib4","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00134-008-1017-8","article-title":"Cardiorenal syndrome: refining the definition of a complex symbiosis gone wrong","volume":"34","author":"Ronco","year":"2008","journal-title":"Intensive Care Med"},{"key":"10.1053\/j.ackd.2017.05.010_bib5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ahj.2010.03.033","article-title":"Associations between worsening renal function and 30-day outcomes among Medicare beneficiaries hospitalized with heart failure","volume":"160","author":"Patel","year":"2010","journal-title":"Am Heart J"},{"key":"10.1053\/j.ackd.2017.05.010_bib6","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.amjcard.2012.01.362","article-title":"Acute kidney injury (AKI) and risk of readmissions in patients with heart failure","volume":"109","author":"Thakar","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1053\/j.ackd.2017.05.010_bib7","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1053\/j.ajkd.2010.04.012","article-title":"Therapeutic strategies for heart failure in cardiorenal syndromes","volume":"56","author":"House","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2017.05.010_bib8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000168841","article-title":"Comparison between the effects of indapamide and hydrochlorothiazide on creatinine clearance in patients with impaired renal function and hypertension","volume":"15","author":"Madkour","year":"1995","journal-title":"Am J Nephrol"},{"issue":"3","key":"10.1053\/j.ackd.2017.05.010_bib9","first-page":"CD003178","article-title":"Continuous infusion versus bolus injection of loop diuretics in congestive heart failure","author":"Salvador","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.ackd.2017.05.010_bib10","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/j.amjcard.2010.01.355","article-title":"Continuous versus bolus dosing of Furosemide for patients hospitalized for heart failure","volume":"105","author":"Allen","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1053\/j.ackd.2017.05.010_bib11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1056\/NEJMoa1005419","article-title":"Diuretic strategies in patients with acute decompensated heart failure","volume":"364","author":"Felker","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2017.05.010_bib12","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jacc.2008.05.068","article-title":"Importance of venous congestion for worsening of renal function in advanced decompensated heart failure","volume":"53","author":"Mullens","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.ackd.2017.05.010_bib13","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jacc.2008.11.012","article-title":"The cardiorenal syndrome: do we need a change of strategy or a change of tactics?","volume":"53","author":"Jessup","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.ackd.2017.05.010_bib14","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1053\/j.ackd.2017.05.010_bib15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/eurheartj\/ehv755","article-title":"Agents with vasodilator properties in acute heart failure","volume":"38","author":"Singh","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1053\/j.ackd.2017.05.010_bib16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1056\/NEJMoa1100171","article-title":"Effect of nesiritide in patients with acute decompensated heart failure","volume":"365","author":"O'Connor","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2017.05.010_bib17","first-page":"1531","article-title":"Intravenous nesiritide vs nitroglycerin for treatment of decompensated congestive heart failure: a randomized controlled trial","volume":"287","year":"2002","journal-title":"JAMA"},{"key":"10.1053\/j.ackd.2017.05.010_bib18","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.1990.70.3.665","article-title":"Diverse biological actions of atrial natriuretic peptide","volume":"70","author":"Brenner","year":"1990","journal-title":"Physiol Rev"},{"key":"10.1053\/j.ackd.2017.05.010_bib19","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/ki.1992.172","article-title":"Atrial natriuretic factor: its (patho)physiological significance in humans","volume":"41","author":"de Zeeuw","year":"1992","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2017.05.010_bib20","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1172\/JCI115146","article-title":"Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an","volume":"87","author":"Mukoyama","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1053\/j.ackd.2017.05.010_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1210\/er.2005-0014","article-title":"Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions","volume":"27","author":"Potter","year":"2006","journal-title":"Endocr Rev"},{"key":"10.1053\/j.ackd.2017.05.010_bib22","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2217\/fca.15.53","article-title":"Ularitide: a natriuretic peptide candidate for the treatment of acutely decompensated heart failure","volume":"11","author":"Emani","year":"2015","journal-title":"Future Cardiol"},{"key":"10.1053\/j.ackd.2017.05.010_bib23","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1056\/NEJM200007273430403","article-title":"Intravenous nesiritide, a natriuretic peptide, in the treatment of decompensated congestive heart failure. Nesiritide Study Group","volume":"343","author":"Colucci","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2017.05.010_bib24","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/01.CIR.0000159340.93220.E4","article-title":"Risk of worsening renal function with nesiritide in patients with acutely decompensated heart failure","volume":"111","author":"Sackner-Bernstein","year":"2005","journal-title":"Circulation"},{"key":"10.1053\/j.ackd.2017.05.010_bib25","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1001\/jama.293.15.1900","article-title":"Short-term risk of death after treatment with nesiritide for decompensated heart failure: a pooled analysis of randomized controlled trials","volume":"293","author":"Sackner-Bernstein","year":"2005","journal-title":"JAMA"},{"key":"10.1053\/j.ackd.2017.05.010_bib26","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1001\/jama.2013.282190","article-title":"Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial","volume":"310","author":"Chen","year":"2013","journal-title":"JAMA"},{"key":"10.1053\/j.ackd.2017.05.010_bib27","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.healun.2012.02.019","article-title":"Impact of low-dose B-type natriuretic peptide infusion on urine output after total artificial heart implantation","volume":"31","author":"Shah","year":"2012","journal-title":"J Heart Lung Transpl"},{"key":"10.1053\/j.ackd.2017.05.010_bib28","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000047405","article-title":"A novel approach to the treatment of chronic fluid overload with a new plasma separation device","volume":"96","author":"Ronco","year":"2001","journal-title":"Cardiology"},{"key":"10.1053\/j.ackd.2017.05.010_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2005.07.067","article-title":"Role of diminished renal function in cardiovascular mortality: marker or pathogenetic factor?","volume":"47","author":"Schrier","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.ackd.2017.05.010_bib30","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/j.jacc.2005.05.099","article-title":"Early ultrafiltration in patients with decompensated heart failure and diuretic resistance","volume":"46","author":"Costanzo","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.ackd.2017.05.010_bib31","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jacc.2006.07.073","article-title":"Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure","volume":"49","author":"Costanzo","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.ackd.2017.05.010_bib32","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cardfail.2011.12.009","article-title":"Cardiorenal rescue study in acute decompensated heart failure: rationale and design of CARRESS-HF, for the Heart Failure Clinical Research Network","volume":"18","author":"Bart","year":"2012","journal-title":"J Card Fail"},{"key":"10.1053\/j.ackd.2017.05.010_bib33","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1056\/NEJMoa1210357","article-title":"Ultrafiltration in decompensated heart failure with cardiorenal syndrome","volume":"367","author":"Bart","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2017.05.010_bib34","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1056\/NEJMc1300456","article-title":"Ultrafiltration in heart failure with cardiorenal syndrome","volume":"368","author":"Rossi","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2017.05.010_bib35","first-page":"1158","article-title":"Ultrafiltration in heart failure with cardiorenal syndrome","volume":"368","author":"Costanzo","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2017.05.010_bib36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cardfail.2013.11.004","article-title":"Continuous ultrafiltration for congestive heart failure: the CUORE trial","volume":"20","author":"Marenzi","year":"2014","journal-title":"J Card Fail"},{"key":"10.1053\/j.ackd.2017.05.010_bib37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jchf.2015.08.005","article-title":"Aquapheresis versus intravenous diuretics and hospitalizations for heart failure","volume":"4","author":"Costanzo","year":"2016","journal-title":"JACC Heart Fail"},{"key":"10.1053\/j.ackd.2017.05.010_bib38","doi-asserted-by":"crossref","first-page":"R267","DOI":"10.1152\/ajpregu.00156.2011","article-title":"Maternal vasodilation in pregnancy: the emerging role of relaxin","volume":"301","author":"Conrad","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1053\/j.ackd.2017.05.010_bib39","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cardfail.2009.01.008","article-title":"Intravenous recombinant human relaxin in compensated heart failure: a safety, tolerability, and pharmacodynamic trial","volume":"15","author":"Dschietzig","year":"2009","journal-title":"J Card Fail"},{"key":"10.1053\/j.ackd.2017.05.010_bib40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11897-010-0010-z","article-title":"Relaxin: review of biology and potential role in treating heart failure","volume":"7","author":"Teichman","year":"2010","journal-title":"Curr Heart Fail Rep"},{"key":"10.1053\/j.ackd.2017.05.010_bib41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0140-6736(12)61855-8","article-title":"Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial","volume":"381","author":"Teerlink","year":"2013","journal-title":"Lancet"},{"key":"10.1053\/j.ackd.2017.05.010_bib42","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jacc.2012.11.005","article-title":"Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: correlation with outcomes","volume":"61","author":"Metra","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.ackd.2017.05.010_bib43","unstructured":"Effect of serelaxin versus standard of care in acute heart failure (AHF) patients (RELAX-AHF-EU). Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02064868. Accessed January 8, 2017."},{"key":"10.1053\/j.ackd.2017.05.010_bib44","unstructured":"Efficacy, safety and tolerability of serelaxin when added to standard therapy in AHF (RELAX-AHF-2). Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01870778. Accessed January 8, 2017."}],"container-title":["Advances in Chronic Kidney Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559517300873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559517300873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T18:58:43Z","timestamp":1569956323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1548559517300873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1548559517300873"],"URL":"https:\/\/doi.org\/10.1053\/j.ackd.2017.05.010","relation":{},"ISSN":["1548-5595"],"issn-type":[{"value":"1548-5595","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Getting to the Heart of the Matter: Review of Treatment of Cardiorenal Syndrome","name":"articletitle","label":"Article Title"},{"value":"Advances in Chronic Kidney Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ackd.2017.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the National Kidney Foundation, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}