{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:34:51Z","timestamp":1790948091612,"version":"4.1.0"},"reference-count":170,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ackdjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Chronic Kidney Disease"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1053\/j.ackd.2019.09.006","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T20:33:04Z","timestamp":1575923584000},"page":"472-483","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["Bone-Vascular Axis in Chronic Kidney Disease"],"prefix":"10.1053","volume":"26","author":[{"given":"Pieter","family":"Evenepoel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Opdebeeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C.","family":"D'Haese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.ackd.2019.09.006_bib1","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.2215\/CJN.09500916","article-title":"Fractures in patients with CKD: time for action","volume":"11","author":"Moe","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1053\/j.ajkd.2011.04.024","article-title":"Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study","volume":"58","author":"Budoff","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2019.09.006_bib3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0272-6386(96)90461-8","article-title":"Prevalence and risk factors for osteopenia in dialysis patients","volume":"28","author":"Stein","year":"1996","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2019.09.006_bib4","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1046\/j.1523-1755.1999.00617.x","article-title":"Bone mineral density and biochemical markers of bone turnover in patients with predialysis chronic renal failure","volume":"56","author":"Rix","year":"1999","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib5","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1093\/ndt\/gfg403","article-title":"Bone mineral density, biochemical markers and skeletal fractures in haemodialysis patients","volume":"18","author":"Urena","year":"2003","journal-title":"Nephrol Dial Transpl"},{"issue":"6","key":"10.1053\/j.ackd.2019.09.006_bib6","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.kint.2018.12.024","article-title":"Bone mineral density, bone turnover markers, and incident fractures in de novo kidney transplant recipients","volume":"95","author":"Evenepoel","year":"2019","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib7","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1007\/s00198-018-4592-8","article-title":"Association of renal function with bone mineral density and fracture risk in the Longitudinal Aging Study Amsterdam","volume":"29","author":"Chen","year":"2018","journal-title":"Osteoporos Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib8","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s00198-003-1435-y","article-title":"Relationship between age, renal function and bone mineral density in the US population","volume":"14","author":"Klawansky","year":"2003","journal-title":"Osteoporos Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib9","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1681\/ASN.2007050555","article-title":"The effect of raloxifene treatment in postmenopausal women with CKD","volume":"19","author":"Ishani","year":"2008","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1681\/ASN.2010121253","article-title":"Differences in bone quality in low- and high-turnover renal osteodystrophy","volume":"23","author":"Malluche","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib11","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.kint.2017.07.021","article-title":"Fractures in patients with CKD-diagnosis, treatment, and prevention: a review by members of the European Calcified Tissue Society and the European Renal Association of Nephrology Dialysis and Transplantation","volume":"92","author":"Pimentel","year":"2017","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib12","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/sj.ki.5001754","article-title":"Incidence and risk factors for hip or other bone fractures among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study","volume":"70","author":"Jadoul","year":"2006","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib13","first-page":"458","article-title":"Bone metabolism, vascular calcifications and mortality: associations beyond mere coincidence","volume":"18","author":"Rodriguez","year":"2005","journal-title":"J Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib14","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ki.2013.279","article-title":"High rates of death and hospitalization follow bone fracture among hemodialysis patients","volume":"85","author":"Tentori","year":"2014","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib15","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s00198-003-1405-4","article-title":"The effect of vertebral fracture as a risk factor for osteoporotic fracture and mortality in a Spanish population","volume":"14","author":"Naves","year":"2003","journal-title":"Osteoporos Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1053\/j.ajkd.2006.12.017","article-title":"Presence of abdominal aortic calcification is significantly associated with all-cause and cardiovascular mortality in maintenance hemodialysis patients","volume":"49","author":"Okuno","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2019.09.006_bib17","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/tri.12151","article-title":"Aortic calcifications and arterial stiffness as predictors of cardiovascular events in incident renal transplant recipients","volume":"26","author":"Claes","year":"2013","journal-title":"Transpl Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib18","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ki.2011.59","article-title":"Cell biological and physicochemical aspects of arterial calcification","volume":"79","author":"Neven","year":"2011","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib19","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/ki.2013.423","article-title":"Vascular calcification in chronic kidney disease: not all arteries are created equal","volume":"85","author":"Schlieper","year":"2014","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib20","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1161\/CIRCRESAHA.110.234914","article-title":"Arterial calcification in chronic kidney disease: key roles for calcium and phosphate","volume":"109","author":"Shanahan","year":"2011","journal-title":"Circ Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib21","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ki.2013.351","article-title":"Breast arterial calcification in chronic kidney disease: absence of smooth muscle apoptosis and osteogenic transdifferentiation","volume":"85","author":"O'Neill","year":"2014","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bone.2016.08.007","article-title":"Vertebral bone density associates with coronary artery calcification and is an independent predictor of poor outcome in end-stage renal disease patients","volume":"92","author":"Chen","year":"2016","journal-title":"Bone"},{"key":"10.1053\/j.ackd.2019.09.006_bib23","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00198-015-3233-8","article-title":"Inflammation and the bone-vascular axis in end-stage renal disease","volume":"27","author":"Viaene","year":"2016","journal-title":"Osteoporos Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib24","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00198-007-0539-1","article-title":"Progression of vascular calcifications is associated with greater bone loss and increased bone fractures","volume":"19","author":"Naves","year":"2008","journal-title":"Osteoporos Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib25","doi-asserted-by":"crossref","first-page":"450","DOI":"10.2215\/CJN.01870408","article-title":"Low bone volume\u2014a risk factor for coronary calcifications in hemodialysis patients","volume":"4","author":"Adragao","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bone.2014.03.048","article-title":"Inverse association between bone microarchitecture assessed by HR-pQCT and coronary artery calcification in patients with end-stage renal disease","volume":"64","author":"Cejka","year":"2014","journal-title":"Bone"},{"key":"10.1053\/j.ackd.2019.09.006_bib27","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1111\/j.1523-1755.2005.00239.x","article-title":"Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors","volume":"67","author":"Barreto","year":"2005","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib28","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1359\/JBMR.041221","article-title":"Decrease in thoracic vertebral bone attenuation with calcium-based phosphate binders in hemodialysis","volume":"20","author":"Raggi","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib29","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1210\/jc.2003-030964","article-title":"Aortic calcification and the risk of osteoporosis and fractures","volume":"89","author":"Schulz","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ackd.2019.09.006_bib30","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1359\/JBMR.050711","article-title":"Relationship between osteoporosis and cardiovascular disease in postmenopausal women","volume":"20","author":"Tanko","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/aje\/kwn303","article-title":"Association of coronary artery and aortic calcium with lumbar bone density: the MESA Abdominal Aortic Calcium Study","volume":"169","author":"Hyder","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.ackd.2019.09.006_bib32","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nrrheum.2012.120","article-title":"Osteoporosis\u2014a risk factor for cardiovascular disease?","volume":"8","author":"Lampropoulos","year":"2012","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"10.1053\/j.ackd.2019.09.006_bib33","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s00198-011-1762-3","article-title":"Is vascular calcification associated with bone mineral density and osteoporotic fractures in ambulatory, elderly women?","volume":"23","author":"Flipon","year":"2011","journal-title":"Osteoporos Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.molmed.2009.07.001","article-title":"Vascular calcification and bone disease: the calcification paradox","volume":"15","author":"Persy","year":"2009","journal-title":"Trends Mol Med"},{"key":"10.1053\/j.ackd.2019.09.006_bib35","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1097\/01.ASN.0000129337.50739.48","article-title":"Arterial calcifications and bone histomorphometry in end-stage renal disease","volume":"15","author":"London","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/ndt\/gfn466","article-title":"Vascular calcifications, vertebral fractures and mortality in haemodialysis patients","volume":"24","author":"Rodriguez-Garcia","year":"2009","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib37","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1093\/ndt\/gfq491","article-title":"The link between bone and coronary calcifications in CKD-5 patients on haemodialysis","volume":"26","author":"Asci","year":"2011","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/ndt\/gfp373","article-title":"Age-independent association between arterial and bone remodeling in mild-to-moderate chronic kidney disease","volume":"25","author":"Briet","year":"2010","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib39","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1046\/j.1523-1755.2002.00637.x","article-title":"Inflammation and outcome in end-stage renal failure: does female gender constitute a survival advantage?","volume":"62","author":"Stenvinkel","year":"2002","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib40","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/eurheartj\/ehq237","article-title":"Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation","volume":"31","author":"Hjortnaes","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1053\/j.ackd.2019.09.006_bib41","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nm0411-430","article-title":"The bone and beyond: a shift in calcium","volume":"17","author":"Khosla","year":"2011","journal-title":"Nat Med"},{"key":"10.1053\/j.ackd.2019.09.006_bib42","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1161\/CIRCRESAHA.110.234146","article-title":"Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification","volume":"108","author":"New","year":"2011","journal-title":"Circ Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib43","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2369-13-134","article-title":"Pro-inflammatory cytokines and bone fractures in CKD patients. An exploratory single centre study","volume":"13","author":"Panuccio","year":"2012","journal-title":"BMC Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib44","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1161\/01.CIR.0000020222.63035.C0","article-title":"Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure","volume":"106","author":"Oh","year":"2002","journal-title":"Circulation"},{"key":"10.1053\/j.ackd.2019.09.006_bib45","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/ndt\/15.7.1014","article-title":"Arterial stiffening and vascular calcifications in end-stage renal disease","volume":"15","author":"Guerin","year":"2000","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib46","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1161\/hc0502.102969","article-title":"Monocyte\/macrophage regulation of vascular calcification in\u00a0vitro","volume":"105","author":"Tintut","year":"2002","journal-title":"Circulation"},{"key":"10.1053\/j.ackd.2019.09.006_bib47","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1161\/ATVBAHA.107.153668","article-title":"Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-\/- mice","volume":"27","author":"Al-Aly","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.ackd.2019.09.006_bib48","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0140-6736(03)12710-9","article-title":"Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study","volume":"361","author":"Ketteler","year":"2003","journal-title":"Lancet"},{"key":"10.1053\/j.ackd.2019.09.006_bib49","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/jbmr.5650040422","article-title":"Interleukin-6 is produced by bone and modulated by parathyroid hormone","volume":"4","author":"Feyen","year":"1989","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib50","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/jbmr.5650040116","article-title":"Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclastlike cells in\u00a0vitro","volume":"4","author":"Pfeilschifter","year":"1989","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib51","first-page":"783","article-title":"Evaluation of bone remodeling in hemodialysis patients: serum biochemistry, circulating cytokines and bone histomorphometry","volume":"22","author":"Ferreira","year":"2009","journal-title":"J Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/ndt\/gfx222","article-title":"Inflammation induces osteoclast differentiation from peripheral mononuclear cells in chronic kidney disease patients: crosstalk between the immune and bone systems","volume":"33","author":"Cafiero","year":"2018","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib53","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S8756-3282(99)00162-3","article-title":"Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells","volume":"25","author":"Hofbauer","year":"1999","journal-title":"Bone"},{"key":"10.1053\/j.ackd.2019.09.006_bib54","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.191.2.275","article-title":"Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction","volume":"191","author":"Kobayashi","year":"2000","journal-title":"J Exp Med"},{"key":"10.1053\/j.ackd.2019.09.006_bib55","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1038\/sj.ki.5000311","article-title":"Osteoporosis in hemodialysis patients revisited by bone histomorphometry: a new insight into an old problem","volume":"69","author":"Barreto","year":"2006","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib56","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ki.2009.126","article-title":"Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification?","volume":"76","author":"Krueger","year":"2009","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib57","doi-asserted-by":"crossref","first-page":"590","DOI":"10.2215\/CJN.06420909","article-title":"Vitamins K and D status in stages 3-5 chronic kidney disease","volume":"5","author":"Holden","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib58","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/ki.2012.191","article-title":"Vitamin K intake and status are low in hemodialysis patients","volume":"82","author":"Cranenburg","year":"2012","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib59","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1681\/ASN.2010040339","article-title":"Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD","volume":"22","author":"Schlieper","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib60","doi-asserted-by":"crossref","first-page":"e47991","DOI":"10.1371\/journal.pone.0047991","article-title":"Vitamin k intake and plasma desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant recipients","volume":"7","author":"Boxma","year":"2012","journal-title":"PLoS One"},{"key":"10.1053\/j.ackd.2019.09.006_bib61","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/jbmr.3608","article-title":"Poor vitamin K status is associated with low bone mineral density and increased fracture risk in end-stage renal disease","volume":"34","author":"Evenepoel","year":"2019","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib62","doi-asserted-by":"crossref","first-page":"e0203157","DOI":"10.1371\/journal.pone.0203157","article-title":"The role of kidney transplantation and phosphate binder use in vitamin K status","volume":"13","author":"Jansz","year":"2018","journal-title":"PLoS One"},{"key":"10.1053\/j.ackd.2019.09.006_bib63","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/ki.2013.530","article-title":"Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation","volume":"86","author":"Kaesler","year":"2014","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib64","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1471-2369-15-145","article-title":"Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients","volume":"15","author":"Delanaye","year":"2014","journal-title":"BMC Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib65","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/ajh\/hpy049","article-title":"Inactive matrix Gla protein, arterial stiffness, and endothelial function in African American hemodialysis patients","volume":"31","author":"Fain","year":"2018","journal-title":"Am J Hypertens"},{"key":"10.1053\/j.ackd.2019.09.006_bib66","doi-asserted-by":"crossref","first-page":"568","DOI":"10.2215\/CJN.07081009","article-title":"The circulating inactive form of matrix gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report","volume":"5","author":"Schurgers","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib67","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/jbmr.1677","article-title":"Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study","volume":"27","author":"Fusaro","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib68","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1210\/jc.2003-031673","article-title":"Associations between vitamin K biochemical measures and bone mineral density in men and women","volume":"89","author":"Booth","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ackd.2019.09.006_bib69","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/jbmr.5650081012","article-title":"Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture","volume":"8","author":"Hodges","year":"1993","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib70","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bone.2015.05.046","article-title":"New insights into the biology of osteocalcin","volume":"82","author":"Zoch","year":"2016","journal-title":"Bone"},{"key":"10.1053\/j.ackd.2019.09.006_bib71","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/jbmr.2463","article-title":"Osteoblast-specific gamma-glutamyl carboxylase-deficient mice display enhanced bone formation with aberrant mineralization","volume":"30","author":"Azuma","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib72","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.3892\/etm.2017.4206","article-title":"Level of serum undercarboxylated osteocalcin correlates with bone quality assessed by calcaneal quantitative ultrasound sonometry in young Japanese females","volume":"13","author":"Suzuki","year":"2017","journal-title":"Exp Ther Med"},{"key":"10.1053\/j.ackd.2019.09.006_bib73","doi-asserted-by":"crossref","first-page":"43919","DOI":"10.1074\/jbc.M303136200","article-title":"Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR","volume":"278","author":"Tabb","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1053\/j.ackd.2019.09.006_bib74","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/aje\/kwm306","article-title":"Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study","volume":"167","author":"Shea","year":"2008","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.ackd.2019.09.006_bib75","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.bone.2013.08.021","article-title":"Prevention of arterial calcification corrects the low bone mass phenotype in MGP-deficient mice","volume":"57","author":"Marulanda","year":"2013","journal-title":"Bone"},{"key":"10.1053\/j.ackd.2019.09.006_bib76","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41586-018-0482-7","article-title":"Coupling of bone resorption and formation by RANKL reverse signalling","volume":"561","author":"Ikebuchi","year":"2018","journal-title":"Nature"},{"key":"10.1053\/j.ackd.2019.09.006_bib77","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bone.2004.03.012","article-title":"Skeletal changes in osteoprotegerin and receptor activator of nuclear factor-kappab ligand mRNA levels in primary hyperparathyroidism: effect of parathyroidectomy and association with bone metabolism","volume":"35","author":"Stilgren","year":"2004","journal-title":"Bone"},{"key":"10.1053\/j.ackd.2019.09.006_bib78","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1210\/endo.140.9.7131","article-title":"Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells","volume":"140","author":"Hofbauer","year":"1999","journal-title":"Endocrinology"},{"key":"10.1053\/j.ackd.2019.09.006_bib79","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/jcb.21414","article-title":"Dexamethasone promotes osteoclastogenesis by inhibiting osteoprotegerin through multiple levels","volume":"103","author":"Kondo","year":"2008","journal-title":"J Cell Biochem"},{"key":"10.1053\/j.ackd.2019.09.006_bib80","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/01.RES.0000149165.99974.12","article-title":"Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin","volume":"95","author":"Collin-Osdoby","year":"2004","journal-title":"Circ Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib81","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.clim.2009.07.011","article-title":"Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss","volume":"133","author":"Graham","year":"2009","journal-title":"Clin Immunol"},{"key":"10.1053\/j.ackd.2019.09.006_bib82","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1007\/s00125-014-3348-z","article-title":"RANKL-OPG and RAGE modulation in vascular calcification and diabetes: novel targets for therapy","volume":"57","author":"Ndip","year":"2014","journal-title":"Diabetologia"},{"key":"10.1053\/j.ackd.2019.09.006_bib83","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/01.ATV.0000012303.37971.DA","article-title":"RANK ligand and osteoprotegerin: paracrine regulators of bone metabolism and vascular function","volume":"22","author":"Schoppet","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.ackd.2019.09.006_bib84","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1161\/CIRCULATIONAHA.107.707380","article-title":"Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-\/-) mice","volume":"117","author":"Morony","year":"2008","journal-title":"Circulation"},{"key":"10.1053\/j.ackd.2019.09.006_bib85","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1084\/jem.192.4.463","article-title":"Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis","volume":"192","author":"Min","year":"2000","journal-title":"J Exp Med"},{"key":"10.1053\/j.ackd.2019.09.006_bib86","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1161\/hq1001.097102","article-title":"Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D","volume":"21","author":"Price","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.ackd.2019.09.006_bib87","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.2215\/CJN.03910411","article-title":"Correlates of osteoprotegerin and association with aortic pulse wave velocity in patients with chronic kidney disease","volume":"6","author":"Scialla","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib88","doi-asserted-by":"crossref","first-page":"e0166792","DOI":"10.1371\/journal.pone.0166792","article-title":"Association of serum osteoprotegerin levels with bone loss in chronic kidney disease: insights from the KNOW-CKD study","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS One"},{"key":"10.1053\/j.ackd.2019.09.006_bib89","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/ATVBAHA.109.199661","article-title":"Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality","volume":"30","author":"Lieb","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.ackd.2019.09.006_bib90","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/ndt\/gfv081","article-title":"Osteoprotegerin and sclerostin in chronic kidney disease prior to dialysis: potential partners in vascular calcifications","volume":"30","author":"Morena","year":"2015","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib91","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1093\/ndt\/gfh263","article-title":"Serum osteoprotegerin levels and the extent of vascular calcification in haemodialysis patients","volume":"19","author":"Nitta","year":"2004","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib92","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2215\/CJN.11191111","article-title":"Osteoprotegerin\/RANKL axis and progression of coronary artery calcification in hemodialysis patients","volume":"7","author":"Ozkok","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib93","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1681\/ASN.2005030260","article-title":"Plasma osteoprotegerin is associated with mortality in hemodialysis patients","volume":"17","author":"Morena","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib94","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2019.09.006_bib95","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/jbmr.2043","article-title":"RANKL inhibition with denosumab does not influence 3-year progression of aortic calcification or incidence of adverse cardiovascular events in postmenopausal women with osteoporosis and high cardiovascular risk","volume":"29","author":"Samelson","year":"2014","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib96","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"10.1053\/j.ackd.2019.09.006_bib97","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bone.2017.03.043","article-title":"Tissue expression and source of circulating \u03b1Klotho","volume":"100","author":"Olauson","year":"2017","journal-title":"Bone"},{"key":"10.1053\/j.ackd.2019.09.006_bib98","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature25451","article-title":"\u03b1-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling","volume":"553","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1053\/j.ackd.2019.09.006_bib99","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/978-1-4614-0887-1_9","article-title":"Secreted klotho and chronic kidney disease","volume":"728","author":"Hu","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"10.1053\/j.ackd.2019.09.006_bib100","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1681\/ASN.2014101030","article-title":"Renal production, uptake, and handling of circulating \u03b1Klotho","volume":"27","author":"Hu","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib101","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.kint.2016.07.040","article-title":"Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease","volume":"91","author":"Zhang","year":"2017","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib102","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.bone.2011.06.025","article-title":"Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in\u00a0vitro and in\u00a0vivo","volume":"49","author":"Rhee","year":"2011","journal-title":"Bone"},{"key":"10.1053\/j.ackd.2019.09.006_bib103","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.kint.2017.02.014","article-title":"Klotho expression in osteocytes regulates bone metabolism and controls bone formation","volume":"92","author":"Komaba","year":"2017","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib104","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI5705","article-title":"Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia","volume":"104","author":"Kawaguchi","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1053\/j.ackd.2019.09.006_bib105","doi-asserted-by":"crossref","first-page":"e60658","DOI":"10.1371\/journal.pone.0060658","article-title":"Arterial klotho expression and FGF23 effects on vascular calcification and function","volume":"8","author":"Lindberg","year":"2013","journal-title":"PLoS One"},{"key":"10.1053\/j.ackd.2019.09.006_bib106","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.arr.2016.09.001","article-title":"The role of the anti-ageing protein Klotho in vascular physiology and pathophysiology","volume":"35","author":"Mencke","year":"2017","journal-title":"Ageing Res Rev"},{"key":"10.1053\/j.ackd.2019.09.006_bib107","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/cvr\/cvv228","article-title":"Hunt for the culprit of cardiovascular injury in kidney disease","volume":"108","author":"Faul","year":"2015","journal-title":"Cardiovasc Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib108","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1681\/ASN.2013101033","article-title":"Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1\/CC chemokine receptor 2-mediated inflammation","volume":"26","author":"Zhou","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib109","doi-asserted-by":"crossref","first-page":"e56695","DOI":"10.1371\/journal.pone.0056695","article-title":"A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease","volume":"8","author":"Kitagawa","year":"2013","journal-title":"PLoS One"},{"key":"10.1053\/j.ackd.2019.09.006_bib110","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/bbrc.1998.8943","article-title":"Klotho protein protects against endothelial dysfunction","volume":"248","author":"Saito","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1053\/j.ackd.2019.09.006_bib111","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ki.2015.156","article-title":"Sclerostin and DKK1: new players in renal bone and vascular disease","volume":"88","author":"Evenepoel","year":"2015","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib112","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2215\/CJN.06550810","article-title":"Sclerostin and Dickkopf-1 in renal osteodystrophy","volume":"6","author":"Cejka","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib113","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1093\/ndt\/gft234","article-title":"Disturbances of Wnt\/beta-catenin pathway and energy metabolism in early CKD: effect of phosphate binders","volume":"28","author":"de Oliveira","year":"2013","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib114","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s00223-018-0491-4","article-title":"Association of serum sclerostin with bone sclerostin in chronic kidney disease is lost in glucocorticoid treated patients","volume":"104","author":"Boltenstal","year":"2019","journal-title":"Calcif Tissue Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib115","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1093\/ndt\/gft039","article-title":"Sclerostin: another bone-related protein related to all-cause mortality in haemodialysis?","volume":"28","author":"Viaene","year":"2013","journal-title":"Nephrol Dial Transpl"},{"issue":"11","key":"10.1053\/j.ackd.2019.09.006_bib116","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1210\/jc.2014-2372","article-title":"Relationship between serum sclerostin, bone metabolism markers, and bone mineral density in maintenance hemodialysis patients","volume":"99","author":"Ishimura","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ackd.2019.09.006_bib117","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jbmr.217","article-title":"Relation of age, gender, and bone mass to circulating sclerostin levels in women and men","volume":"26","author":"Modder","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib118","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1210\/jc.2013-3168","article-title":"Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study","volume":"99","author":"Register","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ackd.2019.09.006_bib119","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1002\/jbmr.1888","article-title":"Correlates of bone microarchitectural parameters and serum sclerostin levels in men: the STRAMBO study","volume":"28","author":"Szulc","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib120","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/ndt\/gfr270","article-title":"Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemodialysis patients","volume":"27","author":"Cejka","year":"2012","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib121","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00223-012-9595-4","article-title":"Circulating sclerostin and Dickkopf-1 (DKK1) in predialysis chronic kidney disease (CKD): relationship with bone density and arterial stiffness","volume":"90","author":"Thambiah","year":"2012","journal-title":"Calcif Tissue Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib122","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.110.234278","article-title":"The regulation of valvular and vascular sclerosis by osteogenic morphogens","volume":"109","author":"Bostrom","year":"2011","journal-title":"Circ Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib123","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1161\/ATVBAHA.113.300647","article-title":"Dkk1 and MSX2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells","volume":"33","author":"Cheng","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.ackd.2019.09.006_bib124","doi-asserted-by":"crossref","first-page":"F1136","DOI":"10.1152\/ajprenal.00684.2011","article-title":"In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt\/beta-catenin activation","volume":"303","author":"Martinez-Moreno","year":"2012","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1053\/j.ackd.2019.09.006_bib125","doi-asserted-by":"crossref","first-page":"e19595","DOI":"10.1371\/journal.pone.0019595","article-title":"The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells","volume":"6","author":"Zhu","year":"2011","journal-title":"PLoS One"},{"key":"10.1053\/j.ackd.2019.09.006_bib126","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bone.2009.09.006","article-title":"High phosphorus diet induces vascular calcification, a related decrease in bone mass and changes in the aortic gene expression","volume":"46","author":"Roman-Garcia","year":"2010","journal-title":"Bone"},{"issue":"3","key":"10.1053\/j.ackd.2019.09.006_bib127","first-page":"317","article-title":"Sclerostin as potential novel biomarker for aortic valve calcification: an in\u00a0vivo and ex\u00a0vivo study","volume":"22","author":"Koos","year":"2012","journal-title":"Heart"},{"key":"10.1053\/j.ackd.2019.09.006_bib128","doi-asserted-by":"crossref","first-page":"E428","DOI":"10.3390\/toxins11070428","article-title":"Sclerostin as regulatory molecule in vascular media calcification and the bone-vascular axis","volume":"11","author":"De Mar\u00e9","year":"2019","journal-title":"Toxins (Basel)"},{"key":"10.1053\/j.ackd.2019.09.006_bib129","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/ndt\/gfu301","article-title":"High levels of circulating sclerostin are associated with better cardiovascular survival in incident dialysis patients: results from the NECOSAD study","volume":"30","author":"Drechsler","year":"2014","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib130","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/1471-2369-15-190","article-title":"Serum sclerostin is an independent predictor of mortality in hemodialysis patients","volume":"15","author":"Goncalves","year":"2014","journal-title":"BMC Nephrol"},{"issue":"10","key":"10.1053\/j.ackd.2019.09.006_bib131","doi-asserted-by":"crossref","first-page":"E1854","DOI":"10.1210\/jc.2014-2042","article-title":"Serum sclerostin and adverse outcomes in non-dialyzed chronic kidney disease patients","volume":"99","author":"Kanbay","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ackd.2019.09.006_bib132","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000366449","article-title":"Clinical and biological determinants of sclerostin plasma concentration in hemodialysis patients","volume":"128","author":"Delanaye","year":"2014","journal-title":"Nephron Clin Pract"},{"issue":"8","key":"10.1053\/j.ackd.2019.09.006_bib133","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s00198-015-3127-9","article-title":"Serum sclerostin: the missing link in the bone-vessel cross-talk in hemodialysis patients?","volume":"26","author":"Pelletier","year":"2015","journal-title":"Osteoporos Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib134","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12882-018-1046-7","article-title":"Associations of sclerostin with carotid artery atherosclerosis and all-cause mortality in Chinese patients undergoing maintenance hemodialysis","volume":"19","author":"Chen","year":"2018","journal-title":"BMC Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib135","doi-asserted-by":"crossref","first-page":"e0199504","DOI":"10.1371\/journal.pone.0199504","article-title":"Circulating levels of sclerostin are associated with cardiovascular mortality","volume":"13","author":"Novo-Rodriguez","year":"2018","journal-title":"PLoS One"},{"key":"10.1053\/j.ackd.2019.09.006_bib136","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1210\/jc.2013-1521","article-title":"Sclerostin: another vascular calcification inhibitor?","volume":"98","author":"Claes","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ackd.2019.09.006_bib137","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1093\/ndt\/gfr591","article-title":"The connections between vascular calcification and bone health","volume":"26","author":"Cannata-Andia","year":"2011","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib138","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1056\/NEJMoa1305224","article-title":"Romosozumab in postmenopausal women with low bone mineral density","volume":"370","author":"McClung","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2019.09.006_bib139","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1056\/NEJMoa1708322","article-title":"Romosozumab or alendronate for fracture prevention in women with osteoporosis","volume":"377","author":"Saag","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2019.09.006_bib140","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab treatment in postmenopausal women with osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ackd.2019.09.006_bib141","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/S0140-6736(17)31613-6","article-title":"Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial","volume":"390","author":"Langdahl","year":"2017","journal-title":"Lancet"},{"key":"10.1053\/j.ackd.2019.09.006_bib142","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1681\/ASN.2013080818","article-title":"CKD-induced wingless\/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder","volume":"25","author":"Fang","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib143","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.kint.2016.06.041","article-title":"Parathyroid hormone metabolism and signaling in health and chronic kidney disease","volume":"90","author":"Evenepoel","year":"2016","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib144","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.coph.2015.03.005","article-title":"Parathyroid hormone: anabolic and catabolic actions on the skeleton","volume":"22","author":"Silva","year":"2015","journal-title":"Curr Opin Pharmacol"},{"key":"10.1053\/j.ackd.2019.09.006_bib145","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1002\/jbmr.459","article-title":"Intermittent PTH(1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites","volume":"26","author":"Prisby","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib146","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1053\/j.ajkd.2015.06.023","article-title":"Diagnostic accuracy of bone turnover markers and bone histology in patients with CKD treated by dialysis","volume":"67","author":"Sprague","year":"2016","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2019.09.006_bib147","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/jbmr.309","article-title":"Renal osteodystrophy in the first decade of the new millennium: analysis of 630 bone biopsies in black and white patients","volume":"26","author":"Malluche","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib148","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1161\/CIRCRESAHA.110.219899","article-title":"Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt\/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis","volume":"107","author":"Cheng","year":"2010","journal-title":"Circ Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib149","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/01.ATV.17.6.1135","article-title":"Parathyroid hormone-related peptide as a local regulator of vascular calcification: its inhibitory action on in\u00a0vitro calcification by bovine vascular smooth muscle cells","volume":"17","author":"Jono","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.ackd.2019.09.006_bib150","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1681\/ASN.2014020169","article-title":"Ankle-brachial index and bone turnover in patients on dialysis","volume":"26","author":"London","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib151","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.atherosclerosis.2008.10.043","article-title":"The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE-\/-) mice","volume":"205","author":"Ivanovski","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1053\/j.ackd.2019.09.006_bib152","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1681\/ASN.2005040342","article-title":"Calcimimetic R-568 decreases extraosseous calcifications in uremic rats treated with calcitriol","volume":"17","author":"Lopez","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib153","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/ndt\/gfq725","article-title":"The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis","volume":"26","author":"Raggi","year":"2011","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib154","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1681\/ASN.2014040414","article-title":"Effects of cinacalcet on fracture events in patients receiving hemodialysis: the EVOLVE Trial","volume":"26","author":"Moe","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib155","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/ndt\/gfq397","article-title":"Prevalence and clinical implications of testosterone deficiency in men with end-stage renal disease","volume":"26","author":"Carrero","year":"2011","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib156","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.2215\/CJN.10681210","article-title":"Endogenous testosterone, endothelial dysfunction, and cardiovascular events in men with nondialysis chronic kidney disease","volume":"6","author":"Yilmaz","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ackd.2019.09.006_bib157","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1053\/j.ajkd.2014.03.010","article-title":"Serum testosterone levels and mortality in men with CKD stages 3-4","volume":"64","author":"Khurana","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2019.09.006_bib158","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1053\/j.ajkd.2017.12.019","article-title":"Menopause in CKD","volume":"71","author":"Vellanki","year":"2018","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ackd.2019.09.006_bib159","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/ndt\/gfw084","article-title":"Sex hormones in women with kidney disease","volume":"31","author":"Ahmed","year":"2016","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib160","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s11914-018-0483-3","article-title":"Gonadal hormones in the pathogenesis and treatment of bone health in patients with chronic kidney disease: a systematic review and meta-analysis","volume":"16","author":"Aleksova","year":"2018","journal-title":"Curr Osteoporos Rep"},{"key":"10.1053\/j.ackd.2019.09.006_bib161","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ki.1997.109","article-title":"Circulating luteinizing hormone receptor inhibitor(s) in boys with chronic renal failure","volume":"51","author":"Dunkel","year":"1997","journal-title":"Kidney Int"},{"key":"10.1053\/j.ackd.2019.09.006_bib162","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ekir.2018.01.009","article-title":"Bioavailable testosterone is positively associated with bone mineral density in male\u00a0kidney transplantation candidates","volume":"3","author":"Jorgensen","year":"2018","journal-title":"Kidney Int Rep"},{"key":"10.1053\/j.ackd.2019.09.006_bib163","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1210\/jc.2015-4299","article-title":"Circulating sex steroids and vascular calcification in community-dwelling men: the Framingham Heart Study","volume":"101","author":"Travison","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ackd.2019.09.006_bib164","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1093\/ndt\/gfs383","article-title":"The vulnerable man: impact of testosterone deficiency on the uraemic phenotype","volume":"27","author":"Carrero","year":"2012","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib165","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1093\/ndt\/gfq847","article-title":"Low serum testosterone, arterial stiffness and mortality in male haemodialysis patients","volume":"26","author":"Kyriazis","year":"2011","journal-title":"Nephrol Dial Transpl"},{"key":"10.1053\/j.ackd.2019.09.006_bib166","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1161\/CIRCRESAHA.110.216846","article-title":"Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification","volume":"107","author":"Osako","year":"2010","journal-title":"Circ Res"},{"key":"10.1053\/j.ackd.2019.09.006_bib167","doi-asserted-by":"crossref","first-page":"24807","DOI":"10.1038\/srep24807","article-title":"Ablation of the androgen receptor from vascular smooth muscle cells demonstrates a role for testosterone in vascular calcification","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci Rep"},{"issue":"9","key":"10.1053\/j.ackd.2019.09.006_bib168","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41569-019-0211-4","article-title":"Testosterone replacement therapy and cardiovascular risk","volume":"16","author":"Gagliano-Juca","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"10.1053\/j.ackd.2019.09.006_bib169","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/ki.2015.80","article-title":"The vascular secret of Klotho","volume":"87","author":"Lewin","year":"2015","journal-title":"Kidney Int"},{"issue":"8","key":"10.1053\/j.ackd.2019.09.006_bib170","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/ndt\/gfx282","article-title":"Sclerostin and chronic kidney disease: the assay impacts what we (thought to) know","volume":"33","author":"Delanaye","year":"2018","journal-title":"Nephrol Dial Transplant"}],"container-title":["Advances in Chronic Kidney Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559519301703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1548559519301703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:02:35Z","timestamp":1761548555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1548559519301703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":170,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S1548559519301703"],"URL":"https:\/\/doi.org\/10.1053\/j.ackd.2019.09.006","relation":{},"ISSN":["1548-5595"],"issn-type":[{"value":"1548-5595","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone-Vascular Axis in Chronic Kidney Disease","name":"articletitle","label":"Article Title"},{"value":"Advances in Chronic Kidney Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ackd.2019.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the National Kidney Foundation, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}