{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:12:28Z","timestamp":1785863548377,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1053\/j.ajkd.2004.12.017","type":"journal-article","created":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T10:49:26Z","timestamp":1134470966000},"page":"762-768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Thrombotic thrombocytopenic purpura in a patient treated with imatinib mesylate: True association or mere coincidence?"],"prefix":"10.1053","volume":"45","author":[{"given":"Ziyad","family":"Al Aly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Philoct\u00eate Ashley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Gellens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther A.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.ajkd.2004.12.017_bib1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2165\/00002018-200124070-00002","article-title":"Drug-induced thrombotic microangiopathy","volume":"24","author":"Pisoni","year":"2001","journal-title":"Drug Saf"},{"key":"10.1053\/j.ajkd.2004.12.017_bib2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1055\/s-2004-835675","article-title":"Molecular mechanisms in thrombotic thrombocytopenic purpura","volume":"30","author":"Tsai","year":"2004","journal-title":"Semin Thromb Hemost"},{"key":"10.1053\/j.ajkd.2004.12.017_bib3","first-page":"50","article-title":"Drug-induced thrombotic thrombocytopenic purpura","volume":"10","year":"2001","journal-title":"Prescrire Int"},{"key":"10.1053\/j.ajkd.2004.12.017_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/00007890-199301000-00039","article-title":"FK506-associated thrombotic thrombocytopenic purpura","volume":"55","author":"Holman","year":"1993","journal-title":"Transplantation"},{"key":"10.1053\/j.ajkd.2004.12.017_bib5","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00062752-200109000-00004","article-title":"Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome","volume":"8","author":"Medina","year":"2001","journal-title":"Curr Opin Hematol"},{"key":"10.1053\/j.ajkd.2004.12.017_bib6","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1056\/NEJMoa025217","article-title":"A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome","volume":"348","author":"Cools","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ajkd.2004.12.017_bib7","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood.V83.10.2759.2759","article-title":"The idiopathic hypereosinophilic syndrome","volume":"83","author":"Weller","year":"1994","journal-title":"Blood"},{"key":"10.1053\/j.ajkd.2004.12.017_bib8","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1084\/jem.183.3.1071","article-title":"Expansion of cytokine-producing CD4-CD8- T cells associated with abnormal Fas expression and hypereosinophilia","volume":"183","author":"Simon","year":"1996","journal-title":"J Exp Med"},{"key":"10.1053\/j.ajkd.2004.12.017_bib9","doi-asserted-by":"crossref","first-page":"78","DOI":"10.7326\/0003-4819-97-1-78","article-title":"NIH conference. The idiopathic hypereosinophilic syndrome. Clinical, pathophysiologic, and therapeutic considerations","volume":"97","author":"Fauci","year":"1982","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.ajkd.2004.12.017_bib10","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/0091-6749(94)90348-4","article-title":"Response of six patients with idiopathic hypereosinophilic syndrome to interferon alfa","volume":"94","author":"Butterfield","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"10.1053\/j.ajkd.2004.12.017_bib11","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1182\/blood-2002-10-3103","article-title":"Imatinib therapy for hypereosinophilic syndrome and other eosinophilic disorders","volume":"101","author":"Pardanani","year":"2003","journal-title":"Blood"},{"key":"10.1053\/j.ajkd.2004.12.017_bib12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.semcancer.2004.03.002","article-title":"Targeted treatment of hypereosinophilic syndromes and chronic eosinophilic leukemias with imatinib mesylate","volume":"14","author":"Coutre","year":"2004","journal-title":"Semin Cancer Biol"},{"key":"10.1053\/j.ajkd.2004.12.017_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1053\/j.seminoncol.2004.03.035","article-title":"Platelet-derived growth factor receptor inhibition to treat idiopathic hypereosinophilic syndrome","volume":"31","author":"Stone","year":"2004","journal-title":"Semin Oncol"},{"key":"10.1053\/j.ajkd.2004.12.017_bib14","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1182\/blood-2003-01-0081","article-title":"Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome","volume":"101","author":"Cortes","year":"2003","journal-title":"Blood"},{"key":"10.1053\/j.ajkd.2004.12.017_bib15","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1182\/blood-2003-06-1824","article-title":"The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia","volume":"103","author":"Gotlib","year":"2004","journal-title":"Blood"},{"key":"10.1053\/j.ajkd.2004.12.017_bib16","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","article-title":"Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia","volume":"344","author":"Druker","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ajkd.2004.12.017_bib17","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJM200104053441402","article-title":"Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome","volume":"344","author":"Druker","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ajkd.2004.12.017_bib18","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1182\/blood.V98.6.1842","article-title":"Decreased von Willebrand factor protease activity associated with thrombocytopenic disorders","volume":"98","author":"Moore","year":"2001","journal-title":"Blood"},{"key":"10.1053\/j.ajkd.2004.12.017_bib19","first-page":"1","article-title":"Clinical features of fifteen patients with the hypereosinophilic syndrome","volume":"52","author":"Spry","year":"1983","journal-title":"Q J Med"},{"key":"10.1053\/j.ajkd.2004.12.017_bib20","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/S0161-6420(82)34625-4","article-title":"Ophthalmologic abnormalities in the hypereosinophilic syndrome","volume":"89","author":"Chaine","year":"1982","journal-title":"Ophthalmology"},{"key":"10.1053\/j.ajkd.2004.12.017_bib21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1526-0968.2003.00127.x","article-title":"Drug-induced thrombotic thrombocytopenic purpura\/hemolytic uremic syndrome","volume":"8","author":"Dlott","year":"2004","journal-title":"Ther Apher Dial"},{"key":"10.1053\/j.ajkd.2004.12.017_bib22","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1002\/(SICI)1097-0142(19990615)85:12<2583::AID-CNCR14>3.0.CO;2-#","article-title":"Thrombotic microangiopathy associated with interferon therapy for patients with chronic myelogenous leukemia","volume":"85","author":"Ravandi-Kashani","year":"1999","journal-title":"Cancer"},{"key":"10.1053\/j.ajkd.2004.12.017_bib23","first-page":"1334","article-title":"[Thrombotic thrombocytopenic purpura after administration of ticlopidine]","volume":"37","author":"Kodama","year":"1996","journal-title":"Rinsho Ketsueki"},{"key":"10.1053\/j.ajkd.2004.12.017_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1634\/theoncologist.9-3-271","article-title":"Indications for imatinib mesylate therapy and clinical management","volume":"9","author":"Guilhot","year":"2004","journal-title":"Oncologist"},{"key":"10.1053\/j.ajkd.2004.12.017_bib25","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1056\/NEJM200411113512024","article-title":"Oligospermia in a patient receiving imatinib therapy for the hypereosinophilic syndrome","volume":"351","author":"Seshadri","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ajkd.2004.12.017_bib26","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1080\/1042819031000079140","article-title":"Acute renal failure secondary to imatinib mesylate treatment in chronic myeloid leukemia","volume":"44","author":"Pou","year":"2003","journal-title":"Leuk Lymphoma"},{"key":"10.1053\/j.ajkd.2004.12.017_bib27","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/ndt\/17.4.685","article-title":"Renal failure associated with a specific inhibitor of BCR-ABL tyrosine kinase, STI 571","volume":"17","author":"Kitiyakara","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2004.12.017_bib28","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/S0140-6736(03)13554-4","article-title":"Gynaecomastia in men with chronic myeloid leukaemia after imatinib","volume":"361","author":"Gambacorti-Passerini","year":"2003","journal-title":"Lancet"},{"key":"10.1053\/j.ajkd.2004.12.017_bib29","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJM199811263392202","article-title":"von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome","volume":"339","author":"Furlan","year":"1998","journal-title":"N Engl J Med"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638604017421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638604017421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T01:28:52Z","timestamp":1759454932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638604017421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0272638604017421"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2004.12.017","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombotic thrombocytopenic purpura in a patient treated with imatinib mesylate: True association or mere coincidence?","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2004.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}