{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:56:32Z","timestamp":1792659392054,"version":"4.5.0"},"reference-count":155,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1053\/j.ajkd.2005.05.009","type":"journal-article","created":{"date-parts":[[2005,7,27]],"date-time":"2005-07-27T13:12:21Z","timestamp":1122469941000},"page":"186-202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":131,"title":["Asymmetric Dimethylarginine: A Cardiovascular Risk Factor and a Uremic Toxin Coming of Age?"],"prefix":"10.1053","volume":"46","author":[{"given":"Jan T.","family":"Kielstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Zoccali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.ajkd.2005.05.009_bib1","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.1016\/S0021-9258(18)62716-4","article-title":"Isolation and identification of N-G,N-G- and N-G,N\u2019-G-dimethyl- arginine, N-epsilon-mono-, di-, and trimethyllysine, and glucosylgalactosyl- and galactosyl-delta-hydroxylysine from human urine","volume":"245","author":"Kakimoto","year":"1970","journal-title":"J Biol Chem"},{"key":"10.1053\/j.ajkd.2005.05.009_bib2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/0140-6736(92)90865-Z","article-title":"Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure","volume":"339","author":"Vallance","year":"1992","journal-title":"Lancet"},{"key":"10.1053\/j.ajkd.2005.05.009_bib3","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1046\/j.1523-1755.2003.00924.x","article-title":"Review on uremic toxins","volume":"63","author":"Vanholder","year":"2003","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib4","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1161\/01.ATV.0000168414.06853.f0","article-title":"ADMA in idiopathic pulmonary arterial hypertension","volume":"25","author":"Kielstein","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib5","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(01)07184-7","article-title":"Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine","volume":"358","author":"Valkonen","year":"2001","journal-title":"Lancet"},{"key":"10.1053\/j.ajkd.2005.05.009_bib6","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/S0140-6736(01)07217-8","article-title":"Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease","volume":"358","author":"Zoccali","year":"2001","journal-title":"Lancet"},{"key":"10.1053\/j.ajkd.2005.05.009_bib7","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1161\/01.CIR.0000126823.07732.D5","article-title":"Asymmetrical dimethylarginine","volume":"109","author":"Cooke","year":"2004","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib8","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","article-title":"The l-arginine-nitric oxide pathway","volume":"329","author":"Moncada","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ajkd.2005.05.009_bib9","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1161\/01.HYP.23.6.1121","article-title":"Nitric oxide synthase isozymes","volume":"23","author":"Forstermann","year":"1994","journal-title":"Hypertension"},{"key":"10.1053\/j.ajkd.2005.05.009_bib10","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1161\/01.ATV.0000081742.92006.59","article-title":"Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase","volume":"23","author":"Achan","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib11","doi-asserted-by":"crossref","first-page":"10501","DOI":"10.1016\/S0021-9258(18)82227-X","article-title":"Peptides with sequences similar to glycine, arginine-rich motifs in proteins interacting with RNA are efficiently recognized by methyltransferase(s) modifying arginine in numerous proteins","volume":"268","author":"Najbauer","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1053\/j.ajkd.2005.05.009_bib12","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1074\/jbc.M405295200","article-title":"PRMT7","volume":"280","author":"Lee","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1053\/j.ajkd.2005.05.009_bib13","doi-asserted-by":"crossref","first-page":"19866","DOI":"10.1074\/jbc.M000023200","article-title":"Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3","volume":"275","author":"Tang","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1053\/j.ajkd.2005.05.009_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1476-5381.1994.tb13026.x","article-title":"Metabolism of methylarginines by human vasculature","volume":"112","author":"MacAllister","year":"1994","journal-title":"Br J Pharmacol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/01.RES.87.2.99","article-title":"LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells","volume":"87","author":"Boger","year":"2000","journal-title":"Circ Res"},{"key":"10.1053\/j.ajkd.2005.05.009_bib16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1161\/01.HYP.0000097805.05108.16","article-title":"Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells","volume":"42","author":"Osanai","year":"2003","journal-title":"Hypertension"},{"key":"10.1053\/j.ajkd.2005.05.009_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/bj1540179","article-title":"Studies on the catabolism of Ng-methylarginine, Ng, Ng-dimethylarginine and Ng, Ng-dimethylarginine in the rabbit","volume":"154","author":"McDermott","year":"1976","journal-title":"Biochem J"},{"key":"10.1053\/j.ajkd.2005.05.009_bib18","doi-asserted-by":"crossref","first-page":"10205","DOI":"10.1016\/S0021-9258(18)81786-0","article-title":"Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase, from rat kidney","volume":"264","author":"Ogawa","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1053\/j.ajkd.2005.05.009_bib19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1042\/bj3430209","article-title":"Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases","volume":"343","author":"Leiper","year":"1999","journal-title":"Biochem J"},{"key":"10.1053\/j.ajkd.2005.05.009_bib20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1567-5688(03)00032-1","article-title":"The DDAH\/ADMA\/NOS pathway","volume":"4","author":"Tran","year":"2003","journal-title":"Atheroscler Suppl"},{"key":"10.1053\/j.ajkd.2005.05.009_bib21","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1038\/ki.1997.490","article-title":"Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney","volume":"52","author":"Tojo","year":"1997","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib22","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1681\/ASN.V131170","article-title":"Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease","volume":"13","author":"Kielstein","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib23","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1093\/ndt\/17.11.1999","article-title":"Net renal extraction of asymmetrical (ADMA) and symmetrical (SDMA) dimethylarginine in fasting humans","volume":"17","author":"Nijveldt","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2005.05.009_bib24","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/90387","article-title":"Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase","volume":"8","author":"Murray-Rust","year":"2001","journal-title":"Nat Struct Biol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib25","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.CIR.0000027109.14149.67","article-title":"Impaired nitric oxide synthase pathway in diabetes mellitus","volume":"106","author":"Lin","year":"2002","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib26","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1681\/ASN.2004090735","article-title":"Erythropoietin increases asymmetric dimethylarginine in endothelial cells","volume":"16","author":"Scalera","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib27","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1161\/hc4601.098514","article-title":"Homocysteine impairs the nitric oxide synthase pathway","volume":"104","author":"Stuhlinger","year":"2001","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib28","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1001\/jama.287.11.1420","article-title":"Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor","volume":"287","author":"Stuhlinger","year":"2002","journal-title":"JAMA"},{"key":"10.1053\/j.ajkd.2005.05.009_bib29","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/01.CIR.0000085067.55901.89","article-title":"Endothelial dysfunction induced by hyperhomocyst(e)inemia","volume":"108","author":"Stuhlinger","year":"2003","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib30","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1161\/01.CIR.0000109692.16004.AF","article-title":"Cytomegalovirus infection impairs the nitric oxide synthase pathway","volume":"109","author":"Weis","year":"2004","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib31","doi-asserted-by":"crossref","first-page":"13527","DOI":"10.1073\/pnas.212269799","article-title":"S-Nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity","volume":"99","author":"Leiper","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.ajkd.2005.05.009_bib32","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1161\/01.CIR.0000101924.04515.2E","article-title":"Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis. Genetic and physiological evidence","volume":"108","author":"Dayoub","year":"2003","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib33","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1093\/ndt\/gfg452","article-title":"Handling of asymmetrical dimethylarginine and symmetrical dimethylarginine by the rat kidney under basal conditions and during endotoxaemia","volume":"18","author":"Nijveldt","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2005.05.009_bib34","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1042\/CS20030363","article-title":"Acute Escherichia coli endotoxaemia decreases the plasma l-arginine\/asymmetrical dimethylarginine ratio in humans","volume":"106","author":"Mittermayer","year":"2004","journal-title":"Clin Sci (Lond)"},{"key":"10.1053\/j.ajkd.2005.05.009_bib35","first-page":"H1522","article-title":"Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase","volume":"269","author":"Faraci","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib36","first-page":"H2224","article-title":"Effects of an endogenous inhibitor of nitric oxide synthesis on postcapillary venules","volume":"268","author":"Kurose","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib37","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1161\/01.STR.30.10.2206","article-title":"Effects of some guanidino compounds on human cerebral arteries","volume":"30","author":"Segarra","year":"1999","journal-title":"Stroke"},{"key":"10.1053\/j.ajkd.2005.05.009_bib38","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/ki.1994.98","article-title":"Effects of guanidino and uremic compounds on nitric oxide pathways","volume":"45","author":"MacAllister","year":"1994","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/niox.1996.0106","article-title":"Interference of l-arginine analogues with l-arginine transport mediated by the y+ carrier hCAT-2B","volume":"1","author":"Closs","year":"1997","journal-title":"Nitric Oxide"},{"key":"10.1053\/j.ajkd.2005.05.009_bib40","doi-asserted-by":"crossref","first-page":"F989","DOI":"10.1152\/ajprenal.2001.280.6.F989","article-title":"Uremic levels of urea inhibit l-arginine transport in cultured endothelial cells","volume":"280","author":"Xiao","year":"2001","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib41","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1681\/ASN.V891437","article-title":"Serum levels of NG, NG-dimethyl-l-arginine, a potential endogenous nitric oxide inhibitor in dialysis patients","volume":"8","author":"Anderstam","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib42","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1046\/j.1523-1755.2001.59780009.x","article-title":"Relationship of asymmetric dimethylarginine to dialysis treatment and atherosclerotic disease","volume":"78","author":"Kielstein","year":"2001","journal-title":"Kidney Int Suppl"},{"key":"10.1053\/j.ajkd.2005.05.009_bib43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0378-4347(00)00034-7","article-title":"Determination of asymmetrical dimethylarginine by capillary electrophoresis-laser-induced fluorescence","volume":"741","author":"Causse","year":"2000","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.1053\/j.ajkd.2005.05.009_bib44","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0378-4347(96)00531-2","article-title":"Determination of N(G),N(G)-dimethylarginine in human plasma by high-performance liquid chromatography","volume":"692","author":"Chen","year":"1997","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.1053\/j.ajkd.2005.05.009_bib45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0003-2697(03)00157-X","article-title":"High-performance liquid chromatographic assay of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine in human plasma by derivatization with naphthalene-2,3-dicarboxaldehyde","volume":"318","author":"Marra","year":"2003","journal-title":"Anal Biochem"},{"key":"10.1053\/j.ajkd.2005.05.009_bib46","first-page":"231","article-title":"Simultaneous detection of arginine, asymmetric dimethylarginine, symmetric dimethylarginine and citrulline in human plasma and urine applying liquid chromatography-mass spectrometry with very straightforward sample preparation","volume":"798","author":"Martens-Lobenhoffer","year":"2003","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.1053\/j.ajkd.2005.05.009_bib47","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/jms.684","article-title":"Determination of arginine and asymmetric dimethylarginine (ADMA) in human plasma by liquid chromatography\/mass spectrometry with the isotope dilution technique","volume":"39","author":"Martens-Lobenhoffer","year":"2004","journal-title":"J Mass Spectrom"},{"key":"10.1053\/j.ajkd.2005.05.009_bib48","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.chroma.2005.01.052","article-title":"High-performance liquid chromatographic assay of N(G)-monomethyl-l-arginine, N(G),N(G)-dimethyl-l-arginine, and N(G),N(G)\u2019-dimethyl-l-arginine using 4-fluoro-7-nitro-2, 1,3-benzoxadiazole as a fluorescent reagent","volume":"1066","author":"Nonaka","year":"2005","journal-title":"J Chromatogr A"},{"key":"10.1053\/j.ajkd.2005.05.009_bib49","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0378-4347(96)00525-7","article-title":"Determination of dimethylated arginines in human plasma by high-performance liquid chromatography","volume":"692","author":"Pettersson","year":"1997","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.1053\/j.ajkd.2005.05.009_bib50","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0378-4347(00)00145-6","article-title":"Improved method for simultaneous determination of l-arginine and its mono- and dimethylated metabolites in biological samples by high-performance liquid chromatography","volume":"742","author":"Pi","year":"2000","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.1053\/j.ajkd.2005.05.009_bib51","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1515\/CCLM.2004.257","article-title":"Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay","volume":"42","author":"Schulze","year":"2004","journal-title":"Clin Chem Lab Med"},{"key":"10.1053\/j.ajkd.2005.05.009_bib52","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/jssc.200401918","article-title":"Capillary electrophoretic and micellar electrokinetic separations of asymmetric dimethyl-l-arginine and structurally related amino acids","volume":"27","author":"Trapp","year":"2004","journal-title":"J Sep Sci"},{"key":"10.1053\/j.ajkd.2005.05.009_bib53","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0378-4347(00)00399-6","article-title":"Determination of arginine and methylated arginines in human plasma by liquid chromatography-tandem mass spectrometry","volume":"748","author":"Vishwanathan","year":"2000","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.1053\/j.ajkd.2005.05.009_bib54","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jchromb.2003.09.001","article-title":"Quantitative determination of circulating and urinary asymmetric dimethylarginine (ADMA) in humans by gas chromatography-tandem mass spectrometry as methyl ester tri(N-pentafluoropropionyl) derivative","volume":"798","author":"Tsikas","year":"2003","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1053\/j.ajkd.2005.05.009_bib55","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/j.1476-5381.1993.tb13985.x","article-title":"Regional and cardiac haemodynamic effects of NG, NG,dimethyl-l-arginine and their reversibility by vasodilators in conscious rats","volume":"110","author":"Gardiner","year":"1993","journal-title":"Br J Pharmacol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib56","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/00005344-199609000-00014","article-title":"Central and peripheral effects of asymmetric dimethylarginine, an endogenous nitric oxide synthetase inhibitor","volume":"28","author":"Jin","year":"1996","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib57","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1038\/ki.1995.501","article-title":"Peritoneal dialysis solutions reverse the hemodynamic effects of nitric oxide synthesis inhibitors","volume":"48","author":"White","year":"1995","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib58","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1161\/01.ATV.0000136656.26019.6e","article-title":"Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice","volume":"24","author":"Suda","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib59","first-page":"513A","article-title":"Acute administration of the endogenous NO synthase inhibitor asymmetric dimethylarginine does not affect blood pressure and renal perfusion in man","volume":"12","author":"Kielstein","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib60","first-page":"F845","article-title":"Effects of systemic NO synthesis inhibition on RPF, GFR, UNa, and vasoactive hormones in healthy humans","volume":"270","author":"Bech","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib61","first-page":"F870","article-title":"Human renal and systemic hemodynamic, natriuretic, and neurohumoral responses to different doses of L-NAME","volume":"275","author":"Broere","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib62","first-page":"F1033","article-title":"Effects of NG-nitro-l-arginine methyl ester on renal function and blood pressure","volume":"261","author":"Lahera","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib63","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/01.CIR.0000105764.22626.B1","article-title":"Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans","volume":"109","author":"Kielstein","year":"2004","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib64","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000078838","article-title":"Subpressor dose asymmetric dimethylarginine modulates renal function in humans through nitric oxide synthase inhibition","volume":"27","author":"Kielstein","year":"2004","journal-title":"Kidney Blood Press Res"},{"key":"10.1053\/j.ajkd.2005.05.009_bib65","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/01.CIR.101.8.856","article-title":"Study on the relationship between plasma nitrite and nitrate level and salt sensitivity in human hypertension","volume":"101","author":"Fujiwara","year":"2000","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib66","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1161\/01.HYP.29.1.242","article-title":"Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension","volume":"29","author":"Matsuoka","year":"1997","journal-title":"Hypertension"},{"key":"10.1053\/j.ajkd.2005.05.009_bib67","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1056\/NEJM197403282901301","article-title":"Accelerated atherosclerosis in prolonged maintenance hemodialysis","volume":"290","author":"Lindner","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ajkd.2005.05.009_bib68","first-page":"F794","article-title":"Nitric oxide production is low in end-stage renal disease patients on peritoneal dialysis","volume":"276","author":"Schmidt","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib69","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1046\/j.1523-1755.2000.00281.x","article-title":"Total nitric oxide production is low in patients with chronic renal disease","volume":"58","author":"Schmidt","year":"2000","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib70","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1093\/ndt\/16.9.1823","article-title":"Dialysis improves endothelial function in humans","volume":"16","author":"Cross","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2005.05.009_bib71","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/j.1523-1755.1998.00851.x","article-title":"Hemodialysis and l-arginine, but not d-arginine, correct renal failure-associated endothelial dysfunction","volume":"53","author":"Hand","year":"1998","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib72","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1093\/ndt\/12.12.2623","article-title":"Altered flow-dependent vasodilatation of conduit arteries in maintenance haemodialysis","volume":"12","author":"Joannides","year":"1997","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2005.05.009_bib73","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/ki.1997.354","article-title":"Physiology and biochemistry of endothelial function in children with chronic renal failure","volume":"52","author":"Kari","year":"1997","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib74","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1046\/j.1523-1755.2003.00236.x","article-title":"Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-dominant polycystic kidney disease","volume":"64","author":"Wang","year":"2003","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib75","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0735-1097(01)01786-7","article-title":"Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation","volume":"39","author":"Hijmering","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib76","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1681\/ASN.V103594","article-title":"Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease","volume":"10","author":"Kielstein","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib77","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1681\/ASN.V132490","article-title":"Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease","volume":"13","author":"Zoccali","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib78","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1161\/01.CIR.99.9.1141","article-title":"Endogenous nitric oxide synthase inhibitor","volume":"99","author":"Miyazaki","year":"1999","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib79","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1161\/01.CIR.99.15.1991","article-title":"Relationship between left ventricular mass and endothelium-dependent vasodilation in never-treated hypertensive patients","volume":"99","author":"Perticone","year":"1999","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib80","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1681\/ASN.V12112458","article-title":"Prognostic value of ultrasonographic measurement of carotid intima media thickness in dialysis patients","volume":"12","author":"Benedetto","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib81","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/ki.1996.355","article-title":"Cardiac and arterial interactions in end-stage renal disease","volume":"50","author":"London","year":"1996","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib82","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1046\/j.1523-1755.2000.00936.x","article-title":"Postischemic vasodilation, endothelial activation, and cardiovascular remodeling in end-stage renal disease","volume":"57","author":"Pannier","year":"2000","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib83","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1523-1755.2002.00437.x","article-title":"Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients","volume":"62","author":"Zoccali","year":"2002","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib84","first-page":"335","article-title":"Morphometric characteristics of cardiac hypertrophy induced by long-term inhibition of NO synthase","volume":"45","author":"Sladek","year":"1996","journal-title":"Physiol Res"},{"key":"10.1053\/j.ajkd.2005.05.009_bib85","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/hc2901.091399","article-title":"Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E\/endothelial nitric oxide synthase double-knockout mice","volume":"104","author":"Kuhlencordt","year":"2001","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib86","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/hc1102.105261","article-title":"Plasma norepinephrine predicts survival and incident cardiovascular events in patients with end-stage renal disease","volume":"105","author":"Zoccali","year":"2002","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib87","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/01.ASN.0000106717.58091.F6","article-title":"Analysis of the relationship between norepinephrine and asymmetric dimethyl arginine levels among patients with end-stage renal disease","volume":"15","author":"Mallamaci","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib88","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1161\/01.CIR.0000095676.90936.80","article-title":"Kidney disease as a risk factor for development of cardiovascular disease","volume":"108","author":"Sarnak","year":"2003","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib89","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1046\/j.1523-1755.2001.0590041466.x","article-title":"Circulating endothelial nitric oxide synthase inhibitory factor in some patients with chronic renal disease","volume":"59","author":"Xiao","year":"2001","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib90","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1681\/ASN.V1181371","article-title":"Endothelium-dependent relaxation of small resistance vessels is impaired in patients with autosomal dominant polycystic kidney disease","volume":"11","author":"Wang","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib91","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1161\/01.CIR.0000138745.21879.27","article-title":"Endothelial dysfunction and mild renal insufficiency in essential hypertension","volume":"110","author":"Perticone","year":"2004","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib92","series-title":"J Am Coll Cardiol","article-title":"Asymmetric dimethylarginine (ADMA) and endothelial dysfunction in essential hypertension","author":"Perticone","year":"2005"},{"key":"10.1053\/j.ajkd.2005.05.009_bib93","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1681\/ASN.V371371","article-title":"Renal functional reserve in healthy elderly subjects","volume":"3","author":"Fliser","year":"1993","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib94","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/ki.1997.163","article-title":"Renal function in the elderly","volume":"51","author":"Fliser","year":"1997","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib95","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1046\/j.1523-1755.2001.0590031052.x","article-title":"Renal hemodynamic response to maximal vasodilating stimulus in healthy older subjects","volume":"59","author":"Fuiano","year":"2001","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib96","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.RES.34.3.309","article-title":"Senescence and the renal vasculature in normal man","volume":"34","author":"Hollenberg","year":"1974","journal-title":"Circ Res"},{"key":"10.1053\/j.ajkd.2005.05.009_bib97","first-page":"S126","article-title":"Aging abolishes the renal response to l-arginine infusion in essential hypertension","volume":"55","author":"Campo","year":"1996","journal-title":"Kidney Int Suppl"},{"key":"10.1053\/j.ajkd.2005.05.009_bib98","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1161\/01.HYP.30.2.252","article-title":"Aging and severity of hypertension attenuate endothelium-dependent renal vascular relaxation in humans","volume":"30","author":"Higashi","year":"1997","journal-title":"Hypertension"},{"key":"10.1053\/j.ajkd.2005.05.009_bib99","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1161\/01.CIR.0000060496.23144.A7","article-title":"Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects","volume":"107","author":"Kielstein","year":"2003","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib100","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1161\/01.ATV.0000141843.77133.fc","article-title":"Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl l-arginine accelerates endothelial cell senescence","volume":"24","author":"Scalera","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib101","first-page":"S35","article-title":"Nitric oxide","volume":"12","author":"Moncada","year":"1994","journal-title":"J Hypertens Suppl"},{"key":"10.1053\/j.ajkd.2005.05.009_bib102","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00001756-199205000-00008","article-title":"Role of nitric oxide in NMDA-evoked release of [3H]-dopamine from striatal slices","volume":"3","author":"Hanbauer","year":"1992","journal-title":"Neuroreport"},{"key":"10.1053\/j.ajkd.2005.05.009_bib103","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0014-2999(92)90223-Q","article-title":"Nitric oxide releases acetylcholine in the basal forebrain","volume":"216","author":"Prast","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib104","first-page":"367","article-title":"Regulation of programmed cell death in neuronal cells by nitric oxide","volume":"18","author":"Kang","year":"2004","journal-title":"In Vivo"},{"key":"10.1053\/j.ajkd.2005.05.009_bib105","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0165-0327(03)00135-6","article-title":"Increased (E)-4-hydroxy-2-nonenal and asymmetric dimethylarginine concentrations and decreased nitric oxide concentrations in the plasma of patients with major depression","volume":"80","author":"Selley","year":"2004","journal-title":"J Affect Disord"},{"key":"10.1053\/j.ajkd.2005.05.009_bib106","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1097\/01.ASN.0000131529.60019.FA","article-title":"Moderate renal impairment and risk of dementia among older adults","volume":"15","author":"Seliger","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib107","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1523-1755.2003.00101.x","article-title":"Elevated risk of stroke among patients with end-stage renal disease","volume":"64","author":"Seliger","year":"2003","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib108","doi-asserted-by":"crossref","first-page":"836","DOI":"10.3171\/jns.2004.101.5.0836","article-title":"Association between cerebrospinal fluid levels of asymmetric dimethyl-l-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage","volume":"101","author":"Jung","year":"2004","journal-title":"J Neurosurg"},{"key":"10.1053\/j.ajkd.2005.05.009_bib109","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00005344-200308000-00006","article-title":"Elevated levels of the serum endogenous inhibitor of nitric oxide synthase and metabolic control in rats with streptozotocin-induced diabetes","volume":"42","author":"Xiong","year":"2003","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib110","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1210\/jc.2004-0672","article-title":"Weight loss reduces circulating asymmetrical dimethylarginine concentrations in morbidly obese women","volume":"89","author":"Krzyzanowska","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ajkd.2005.05.009_bib111","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1530\/eje.0.1420493","article-title":"Thyrocyte release of asymmetric dimethylarginine does not account for human thyrocyte inhibition of endothelial cell cyclic GMP","volume":"142","author":"Millatt","year":"2000","journal-title":"Eur J Endocrinol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib112","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1210\/jc.2002-020905","article-title":"Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in hyperthyroid patients","volume":"87","author":"Hermenegildo","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ajkd.2005.05.009_bib113","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF02351006","article-title":"Mechanotransduction of bone cells in vitro","volume":"42","author":"Mullender","year":"2004","journal-title":"Med Biol Eng Comput"},{"key":"10.1053\/j.ajkd.2005.05.009_bib114","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S8756-3282(02)00955-9","article-title":"Effect of nitric oxide donor nitroglycerin on bone mineral density in a rat model of estrogen deficiency-induced osteopenia","volume":"32","author":"Hukkanen","year":"2003","journal-title":"Bone"},{"key":"10.1053\/j.ajkd.2005.05.009_bib115","first-page":"224","article-title":"Effect of age on bone mineral density and the serum concentration of endogenous nitric oxide synthase inhibitors in rats","volume":"52","author":"Lu","year":"2002","journal-title":"Comp Med"},{"key":"10.1053\/j.ajkd.2005.05.009_bib116","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1046\/j.1523-1755.2001.00011.x","article-title":"Effect of asymmetric dimethylarginine on osteoblastic differentiation","volume":"60","author":"Xiao","year":"2001","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib117","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1161\/01.CIR.0000091083.61609.DF","article-title":"Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine","volume":"108","author":"Holden","year":"2003","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib118","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1191\/1358863x02vm429ra","article-title":"The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function","volume":"7","author":"Maas","year":"2002","journal-title":"Vasc Med"},{"key":"10.1053\/j.ajkd.2005.05.009_bib119","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1177\/153537020222700915","article-title":"Chronic nitric oxide deficiency is associated with altered luteinizing hormone and follicle-stimulating hormone release in ovariectomized rats","volume":"227","author":"Barnes","year":"2002","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1053\/j.ajkd.2005.05.009_bib120","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1210\/jc.2004-2045","article-title":"Elevated plasma concentration of asymmetric dimethylarginine that is reduced by single dose testosterone administration in idiopathic hypogonadotropic hypogonadism patients","volume":"90","author":"Cakir","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ajkd.2005.05.009_bib121","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1161\/01.CIR.0000158487.80483.09","article-title":"Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis","volume":"111","author":"Jacobi","year":"2005","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib122","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"key":"10.1053\/j.ajkd.2005.05.009_bib123","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1073\/pnas.97.7.3422","article-title":"Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization","volume":"97","author":"Kalka","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.ajkd.2005.05.009_bib124","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1161\/01.CIR.0000096483.29777.50","article-title":"Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells","volume":"108","author":"Urbich","year":"2003","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib125","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1161\/01.CIR.0000143232.67642.7A","article-title":"Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase","volume":"110","author":"Landmesser","year":"2004","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib126","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/nm948","article-title":"Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells","volume":"9","author":"Aicher","year":"2003","journal-title":"Nat Med"},{"key":"10.1053\/j.ajkd.2005.05.009_bib127","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/01.CIR.0000109141.48980.37","article-title":"Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis","volume":"109","author":"Laufs","year":"2004","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2005.05.009_bib128","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0272-6386(99)70348-3","article-title":"Indices of activity of the nitric oxide system in hemodialysis patients","volume":"34","author":"Schmidt","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2005.05.009_bib129","doi-asserted-by":"crossref","first-page":"295","DOI":"10.5414\/CNP62295","article-title":"Low dialysance of asymmetric dimethylarginine (ADMA)\u2014In vivo and in vitro evidence of significant protein binding","volume":"62","author":"Kielstein","year":"2004","journal-title":"Clin Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib130","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1093\/oxfordjournals.ndt.a027213","article-title":"Concentration of dimethyl-l-arginine in the plasma of patients with end-stage renal failure","volume":"11","author":"MacAllister","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2005.05.009_bib131","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.niox.2004.10.002","article-title":"Relationship of asymmetric dimethylarginine to haemodialysis hypotension","volume":"11","author":"Bergamini","year":"2004","journal-title":"Nitric Oxide"},{"key":"10.1053\/j.ajkd.2005.05.009_bib132","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1046\/j.1523-1755.2001.59780019.x","article-title":"Increased reduction of dimethylarginines and lowered interdialytic blood pressure by the use of biocompatible membranes","volume":"78","author":"Schroder","year":"2001","journal-title":"Kidney Int Suppl"},{"key":"10.1053\/j.ajkd.2005.05.009_bib133","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/ndt\/gfh775","article-title":"Pre-dilution on-line haemofiltration vs low-flux haemodialysis","volume":"20","author":"Beerenhout","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2005.05.009_bib134","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/jcp.54.6.470","article-title":"Dimethylarginines in chronic renal failure","volume":"54","author":"Wahbi","year":"2001","journal-title":"J Clin Pathol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib135","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1006\/bbrc.1996.0279","article-title":"Elevated l-arginine\/dimethylarginine ratio contributes to enhanced systemic NO production by dietary l-arginine in hypercholesterolemic rabbits","volume":"219","author":"Bode-Boger","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.ajkd.2005.05.009_bib136","first-page":"593","article-title":"[Influence of l-arginine on development of atherosclerosis","volume":"130","author":"Bode-Boger","year":"2005","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1053\/j.ajkd.2005.05.009_bib137","first-page":"14","article-title":"l-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor","volume":"10","author":"Boger","year":"2005","journal-title":"Altern Med Rev"},{"key":"10.1053\/j.ajkd.2005.05.009_bib138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(00)01686-0","article-title":"Endogenous nitric oxide synthase inhibitors are responsible for the l-arginine paradox","volume":"478","author":"Tsikas","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1053\/j.ajkd.2005.05.009_bib139","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1046\/j.1523-1755.2001.00059.x","article-title":"Acute administration of l-arginine does not improve arterial endothelial function in chronic renal failure","volume":"60","author":"Cross","year":"2001","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2005.05.009_bib140","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1253\/jcj.65.775","article-title":"Renin-angiotensin system is involved in the mechanism of increased serum asymmetric dimethylarginine in essential hypertension","volume":"65","author":"Ito","year":"2001","journal-title":"Jpn Circ J"},{"key":"10.1053\/j.ajkd.2005.05.009_bib141","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0895-7061(02)02278-1","article-title":"Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N(G), N(G)-dimethylarginine in human essential hypertension","volume":"15","author":"Delles","year":"2002","journal-title":"Am J Hypertens"},{"key":"10.1053\/j.ajkd.2005.05.009_bib142","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ahj.2004.03.025","article-title":"Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension","volume":"148","author":"Napoli","year":"2004","journal-title":"Am Heart J"},{"key":"10.1053\/j.ajkd.2005.05.009_bib143","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1681\/ASN.2004100852","article-title":"Chronic angiotensin II receptor blockade reduces (intra)renal vascular resistance in patients with type 2 diabetes","volume":"16","author":"Fliser","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib144","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1053\/meta.2002.33349","article-title":"Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes","volume":"51","author":"Asagami","year":"2002","journal-title":"Metabolism"},{"key":"10.1053\/j.ajkd.2005.05.009_bib145","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1210\/jc.2003-030584","article-title":"Effect of hormone replacement therapy on plasma levels of the cardiovascular risk factor asymmetric dimethylarginine","volume":"88","author":"Post","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ajkd.2005.05.009_bib146","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1042\/CS20020309","article-title":"Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women","volume":"105","author":"Teerlink","year":"2003","journal-title":"Clin Sci (Lond)"},{"key":"10.1053\/j.ajkd.2005.05.009_bib147","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1567-5688(03)00033-3","article-title":"ADMA and oxidative stress","volume":"4","author":"Sydow","year":"2003","journal-title":"Atheroscler Suppl"},{"key":"10.1053\/j.ajkd.2005.05.009_bib148","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1079\/BJN2002779","article-title":"Folic acid treatment reduces elevated plasma levels of asymmetric dimethylarginine in hyperhomocysteinaemic subjects","volume":"89","author":"Holven","year":"2003","journal-title":"Br J Nutr"},{"key":"10.1053\/j.ajkd.2005.05.009_bib149","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1093\/ndt\/gfg406","article-title":"Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD)","volume":"18","author":"Saran","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2005.05.009_bib150","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0008-6363(02)00617-X","article-title":"ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia","volume":"57","author":"Sydow","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1053\/j.ajkd.2005.05.009_bib151","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1210\/jc.2004-1087","article-title":"Homocysteine-lowering therapy does not affect plasma ADMA concentrations in patients with peripheral artery disease","volume":"90","author":"Ziegler","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.ajkd.2005.05.009_bib152","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0021-9150(02)00206-X","article-title":"Increased levels of asymmetric dimethylarginine in populations at risk for atherosclerotic disease","volume":"166","author":"Eid","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1053\/j.ajkd.2005.05.009_bib153","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00005344-200302000-00010","article-title":"Effect of high-dose statin treatment on plasma concentrations of endogenous nitric oxide synthase inhibitors","volume":"41","author":"Paiva","year":"2003","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1053\/j.ajkd.2005.05.009_bib154","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/1071576031000083170","article-title":"Effects of simvastatin and l-arginine on vasodilation, nitric oxide metabolites and endogenous NOS inhibitors in hypercholesterolemic subjects","volume":"37","author":"Pereira","year":"2003","journal-title":"Free Radic Res"},{"key":"10.1053\/j.ajkd.2005.05.009_bib155","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.amjcard.2004.03.052","article-title":"Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia","volume":"94","author":"Lu","year":"2004","journal-title":"Am J Cardiol"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638605006220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638605006220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T01:31:06Z","timestamp":1759455066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638605006220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":155,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0272638605006220"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2005.05.009","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Asymmetric Dimethylarginine: A Cardiovascular Risk Factor and a Uremic Toxin Coming of Age?","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2005.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}