{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:20:46Z","timestamp":1791645646789,"version":"4.3.4"},"reference-count":52,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1053\/j.ajkd.2006.06.012","type":"journal-article","created":{"date-parts":[[2006,9,26]],"date-time":"2006-09-26T11:12:24Z","timestamp":1159269144000},"page":"596-605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"title":["Comparison of Low-Dose Gentamicin With Minocycline as Catheter Lock Solutions in the Prevention of Catheter-Related Bacteremia"],"prefix":"10.1053","volume":"48","author":[{"given":"Uday S.","family":"Nori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anup","family":"Manoharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatole","family":"Besarab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.ajkd.2006.06.012_bib1","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/ndt\/gfh729","article-title":"The spectrum of infection-related morbidity in hospitalized haemodialysis patients","volume":"20","author":"Allon","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2006.06.012_bib2","series-title":"USRDS 2003 Annual Data Report","year":"2003"},{"key":"10.1053\/j.ajkd.2006.06.012_bib3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1523-1755.2002.00117.x","article-title":"Vascular access use in Europe and the United States: Results from the DOPPS","volume":"61","author":"Pisoni","year":"2002","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2006.06.012_bib4","series-title":"2005 Annual Report, End-Stage Renal Disease Clinical Performance Measures Project","year":"2005"},{"issue":"suppl 1","key":"10.1053\/j.ajkd.2006.06.012_bib5","first-page":"S65","article-title":"Unraveling the realities of vascular access: The Network 11 experience","volume":"7","author":"Besarab","year":"2000","journal-title":"Adv Ren Replace Ther"},{"key":"10.1053\/j.ajkd.2006.06.012_bib6","first-page":"47","article-title":"\u201cFistula first\u201d initiative pushes for new standards in access care","volume":"18","author":"Neumann","year":"2004","journal-title":"Nephrol News Issues"},{"issue":"suppl 3","key":"10.1053\/j.ajkd.2006.06.012_bib7","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/S0272-6386(04)01101-1","article-title":"Vascular access results from the Dialysis Outcomes and Practice Patterns Study (DOPPS): Performance against Kidney Disease Outcomes Quality Initiative (K\/DOQI) Clinical Practice Guidelines","volume":"44","author":"Rayner","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2006.06.012_bib8","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/ndt\/16.10.1975","article-title":"Treatment and prevention of catheter-related infections in haemodialysis patients","volume":"16","author":"Blankestijn","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2006.06.012_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/j.ajkd.2004.10.006","article-title":"USRDS 2004 Annual Data Report","volume":"45","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2006.06.012_bib10","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1067\/mic.2002.120904","article-title":"New national surveillance system for hemodialysis-associated infections: Initial results","volume":"30","author":"Tokars","year":"2002","journal-title":"Am J Infect Control"},{"key":"10.1053\/j.ajkd.2006.06.012_bib11","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1053\/j.ajkd.2004.08.030","article-title":"Long-term survival of dialysis patients with bacterial endocarditis in the United States","volume":"44","author":"Shroff","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2006.06.012_bib12","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1001\/jama.293.24.3012","article-title":"Staphylococcus aureus endocarditis: A consequence of medical progress","volume":"293","author":"Fowler","year":"2005","journal-title":"JAMA"},{"key":"10.1053\/j.ajkd.2006.06.012_bib13","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/infdis\/168.2.400","article-title":"Ultrastructural analysis of indwelling vascular catheters: A quantitative relationship between luminal colonization and duration of placement","volume":"168","author":"Raad","year":"1993","journal-title":"J Infect Dis"},{"key":"10.1053\/j.ajkd.2006.06.012_bib14","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1128\/AAC.45.4.999-1007.2001","article-title":"Riddle of the biofilm resistance","volume":"45","author":"Lewis","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1053\/j.ajkd.2006.06.012_bib15","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/424134a","article-title":"Bacterial communication: Tiny teamwork","volume":"424","author":"Greenberg","year":"2003","journal-title":"Nature"},{"key":"10.1053\/j.ajkd.2006.06.012_bib16","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/ndt\/15.7.1035","article-title":"Insufficient penetration of systemic vancomycin into the PermCath lumen","volume":"15","author":"Bastani","year":"2000","journal-title":"Nephrol Dial Transplant"},{"issue":"RR10","key":"10.1053\/j.ajkd.2006.06.012_bib17","first-page":"1","article-title":"Guidelines for the prevention of intravascular catheter-related infections","volume":"51","year":"2002","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1053\/j.ajkd.2006.06.012_bib18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1046\/j.1525-139X.2003.16087.x","article-title":"Catheter management protocol for catheter-related bacteremia prophylaxis","volume":"16","author":"Beathard","year":"2003","journal-title":"Semin Dial"},{"key":"10.1053\/j.ajkd.2006.06.012_bib19","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1440-1797.2005.00382.x","article-title":"Prevention of catheter-related bloodstream infections: An appraisal of developments in designing an infection-resistant \u2018dream dialysis-catheter.\u2019","volume":"10","author":"Saxena","year":"2005","journal-title":"Nephrology (Carlton)"},{"key":"10.1053\/j.ajkd.2006.06.012_bib20","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0899-9007(98)00013-6","article-title":"Elimination of intraluminal colonization by antibiotic lock in silicone vascular catheters","volume":"14","author":"Andris","year":"1998","journal-title":"Nutrition"},{"key":"10.1053\/j.ajkd.2006.06.012_bib21","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1046\/j.1523-1755.2002.00201.x","article-title":"Management of hemodialysis catheter-related bacteremia with an adjunctive antibiotic lock solution","volume":"61","author":"Krishnasami","year":"2002","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2006.06.012_bib22","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/ndt\/gfh041","article-title":"Treatment of catheter-related bacteraemia with an antibiotic lock protocol: Effect of bacterial pathogen","volume":"19","author":"Poole","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2006.06.012_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000082007","article-title":"Saving infected catheters: Why and how","volume":"23","author":"Allon","year":"2005","journal-title":"Blood Purif"},{"key":"10.1053\/j.ajkd.2006.06.012_bib24","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0272-6386(04)01078-9","article-title":"Dialysis catheter-related bacteremia: Treatment and prophylaxis","volume":"44","author":"Allon","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2006.06.012_bib25","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1086\/502578","article-title":"A randomized, controlled trial of a new vascular catheter flush solution (minocycline-EDTA) in temporary hemodialysis access","volume":"26","author":"Bleyer","year":"2005","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1053\/j.ajkd.2006.06.012_bib26","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/01.inf.0000141740.82420.e6","article-title":"Antibiotic lock with vancomycin and urokinase can successfully treat colonized central venous catheters in pediatric cancer patients","volume":"23","author":"Se Sio","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"10.1053\/j.ajkd.2006.06.012_bib27","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1097\/01.ASN.0000022890.29656.22","article-title":"Prevention of tunneled hemodialysis catheter-related infections using catheter-restricted filling with gentamicin and citrate: A randomized controlled study","volume":"13","author":"Dogra","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2006.06.012_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1086\/514518","article-title":"Minocycline and ethylenediaminetetraacetate for the prevention of recurrent vascular catheter infections","volume":"25","author":"Raad","year":"1997","journal-title":"Clin Infect Dis"},{"issue":"RR-10","key":"10.1053\/j.ajkd.2006.06.012_bib29","first-page":"1","article-title":"Guidelines for the prevention of intravascular catheter-related infections","volume":"51","author":"O\u2019Grady","year":"2002","journal-title":"MMWR Recomm Rep"},{"key":"10.1053\/j.ajkd.2006.06.012_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1523-1755.1999.00512.x","article-title":"The hemodialysis catheter conundrum: Hate living with them, but can\u2019t live without them","volume":"56","author":"Schwab","year":"1999","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2006.06.012_bib31","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1046\/j.1523-1755.1999.0550031081.x","article-title":"Septicemia in dialysis patients: Incidence, risk factors, and prognosis","volume":"55","author":"Powe","year":"1999","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2006.06.012_bib32","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1523-1755.2005.00414.x","article-title":"Septecemia, access, and cardiovascular disease in dialysis patients: The USRDS Wave 2 Study","volume":"68","author":"Ishani","year":"2005","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2006.06.012_bib33","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1053\/j.ajkd.2005.04.019","article-title":"Clinical and economic outcomes of Staphylococcus aureus septicemia in ESRD patients receiving hemodialysis","volume":"46","author":"Nissenson","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2006.06.012_bib34","first-page":"116","article-title":"Gentamicin pharmacokinetics during hemodialysis in patients suffering from chronic renal failure","volume":"15","author":"Letourneau-Saheb","year":"1977","journal-title":"Int J Clin Pharmacol Biopharm"},{"key":"10.1053\/j.ajkd.2006.06.012_bib35","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1523-1755.2004.00806.x","article-title":"Locking of tunneled hemodialysis catheters with gentamicin and heparin","volume":"66","author":"McIntyre","year":"2004","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2006.06.012_bib36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/sj.ki.5000012","article-title":"Prevention of uncuffed hemodialysis catheter-related bacteremia using an antibiotic lock technique: A prospective, randomized clinical trial","volume":"69","author":"Kim","year":"2006","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2006.06.012_bib37","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1128\/AAC.46.2.327-332.2002","article-title":"Efficacy of minocycline and EDTA lock solution in preventing catheter-related bacteremia, septic phlebitis, and endocarditis in rabbits","volume":"46","author":"Raad","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1053\/j.ajkd.2006.06.012_bib38","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1128\/AAC.47.11.3580-3585.2003","article-title":"In vitro and ex vivo activities of minocycline and EDTA against microorganisms embedded in biofilm on catheter surfaces","volume":"47","author":"Raad","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1053\/j.ajkd.2006.06.012_bib39","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1542\/peds.2004-2674","article-title":"A vancomycin-heparin lock solution for prevention of nosocomial bloodstream infection in critically ill neonates with peripherally inserted central venous catheters: A prospective, randomized trial","volume":"116","author":"Garland","year":"2005","journal-title":"Pediatrics"},{"key":"10.1053\/j.ajkd.2006.06.012_bib40","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/jac\/dkh488","article-title":"Treatment of long-term intravascular catheter-related bacteraemia with antibiotic lock: Randomized, placebo-controlled trial","volume":"55","author":"Rijnders","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1053\/j.ajkd.2006.06.012_bib41","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1093\/ndt\/16.10.2072","article-title":"Risk of heparin lock-related bleeding when using indwelling venous catheter in haemodialysis","volume":"16","author":"Karaaslan","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2006.06.012_bib42","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.MAT.0000159742.15560.93","article-title":"Loss of catheter locking solution caused by fluid density","volume":"51","author":"Polaschegg","year":"2005","journal-title":"ASAIO J"},{"key":"10.1053\/j.ajkd.2006.06.012_bib43","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1093\/ndt\/17.12.2189","article-title":"Superior antimicrobial activity of trisodium citrate over heparin for catheter locking","volume":"17","author":"Weijmer","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2006.06.012_bib44","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1128\/AAC.32.11.1627","article-title":"Inhibitory effect of disodium EDTA upon the growth of Staphylococcus epidermidis in vitro: Relation to infection prophylaxis of Hickman catheters","volume":"32","author":"Root","year":"1988","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1053\/j.ajkd.2006.06.012_bib45","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/BF00307769","article-title":"Changes in cell wall glycoprotein composition of Candida albicans associated to the inhibition of germ tube formation by EDTA","volume":"161","author":"Gil","year":"1994","journal-title":"Arch Microbiol"},{"key":"10.1053\/j.ajkd.2006.06.012_bib46","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1046\/j.1469-0691.2001.00233.x","article-title":"Lack of antimicrobial activity of sodium heparin for treating experimental catheter-related infection due to Staphylococcus aureus using the antibiotic-lock technique","volume":"7","author":"Capdevila","year":"2001","journal-title":"Clin Microbiol Infect"},{"key":"10.1053\/j.ajkd.2006.06.012_bib47","first-page":"189A","article-title":"Reduced incidence of hemodialysis (HD) catheter related bacteremia (CRB) using a weekly citrate-gentamicin lock","volume":"11","author":"Lynn","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2006.06.012_bib48","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1681\/ASN.2004100870","article-title":"Randomized, clinical trial comparison of trisodium citrate 30% and heparin as catheter-locking solution in hemodialysis patients","volume":"16","author":"Weijmer","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2006.06.012_bib49","unstructured":"US Food and Drug Administration: FDA issues warning on Tricitrasol dialysis anticoagulant. FDA Talk Paper. Rockville, MD, US Department of Health and Human Services, April 14, 2000. Available at: \/\/www.fda.gov\/bbs\/topics\/ANSWERS\/ANS01009.html. Accessed August 1, 2006"},{"key":"10.1053\/j.ajkd.2006.06.012_bib50","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1523-1755.2005.091_5.x","article-title":"Prospective study of gentamicin locking of tunnelled dialysis catheters: The effect on infection rates and CRP","volume":"67","author":"Lambie","year":"2005","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2006.06.012_bib51","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1093\/ndt\/gfh014","article-title":"Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution","volume":"19","author":"Betjes","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2006.06.012_bib52","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1086\/375234","article-title":"Prophylaxis against dialysis catheter-related bacteremia with a novel antimicrobial lock solution","volume":"36","author":"Allon","year":"2003","journal-title":"Clin Infect Dis 15"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638606010833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638606010833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T01:46:14Z","timestamp":1759455974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638606010833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0272638606010833"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2006.06.012","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of Low-Dose Gentamicin With Minocycline as Catheter Lock Solutions in the Prevention of Catheter-Related Bacteremia","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2006.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}