{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:13:05Z","timestamp":1787004785741,"version":"build-2736575974"},"reference-count":18,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1053\/j.ajkd.2007.08.030","type":"journal-article","created":{"date-parts":[[2008,2,22]],"date-time":"2008-02-22T12:20:30Z","timestamp":1203682830000},"page":"487-490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Association of a Factor H Mutation With Hemolytic Uremic Syndrome Following a Diarrheal Illness"],"prefix":"10.1053","volume":"51","author":[{"given":"Matthew M.","family":"Edey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Mead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Strain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy H.J.","family":"Goodship","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Suren","family":"Kanagasundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.ajkd.2007.08.030_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1056\/NEJMra020528","article-title":"Thrombotic microangiopathies","volume":"347","author":"Moake","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ajkd.2007.08.030_bib2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJMoa011033","article-title":"Prothrombotic coagulation abnormalities preceding the hemolytic-uremic syndrome","volume":"346","author":"Chandler","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1053\/j.ajkd.2007.08.030_bib3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0140-6736(94)91227-0","article-title":"Haemolytic-uraemic syndrome: Basic science","volume":"343","author":"Moake","year":"1994","journal-title":"Lancet"},{"key":"10.1053\/j.ajkd.2007.08.030_bib4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/humu.20435","article-title":"The interactive factor H-atypical haemolytic uraemic syndrome mutation database and website: Update and integration of membrane cofactor protein and factor I mutations with structural models","volume":"28","author":"Saunders","year":"2007","journal-title":"Hum Mutat"},{"key":"10.1053\/j.ajkd.2007.08.030_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/sj.ki.5000269","article-title":"Deletion of Lys224 in regulatory domain 4 of factor H reveals a novel pathomechanism for dense deposit disease (MPGN II)","volume":"70","author":"Licht","year":"2006","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2007.08.030_bib6","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1038\/sj.emboj.7601052","article-title":"Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome","volume":"25","author":"Jokiranta","year":"2006","journal-title":"EMBO J"},{"key":"10.1053\/j.ajkd.2007.08.030_bib7","doi-asserted-by":"crossref","first-page":"16512","DOI":"10.1074\/jbc.M513611200","article-title":"Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure","volume":"281","author":"Herbert","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1053\/j.ajkd.2007.08.030_bib8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1681\/ASN.2005080868","article-title":"Factor H and atypical hemolytic uremic syndrome: Mutations in the C-terminus cause structural changes and defective recognition functions","volume":"17","author":"Jozsi","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2007.08.030_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/jmbi.2001.5337","article-title":"Molecular modelling of the C-terminal domains of factor H of human complement","volume":"316","author":"Perkins","year":"2002","journal-title":"J Mol Biol"},{"key":"10.1053\/j.ajkd.2007.08.030_bib10","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/ng912","article-title":"Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H","volume":"31","author":"Pickering","year":"2002","journal-title":"Nat Genet"},{"key":"10.1053\/j.ajkd.2007.08.030_bib11","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1084\/jem.20070301","article-title":"Spontaneous haemolytic uraemic syndrome triggered by complement factor H lacking surface recognition domains","volume":"204","author":"Pickering","year":"2007","journal-title":"J Exp Med"},{"key":"10.1053\/j.ajkd.2007.08.030_bib12","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/S0140-6736(98)01267-7","article-title":"Escherichia coli O157:H7","volume":"352","author":"Mead","year":"1998","journal-title":"Lancet"},{"key":"10.1053\/j.ajkd.2007.08.030_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/humu.20268","article-title":"An interactive web database of factor H-associated hemolytic uremic syndrome mutations: Insights into the structural consequences of disease-associated mutations","volume":"27","author":"Saunders","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1053\/j.ajkd.2007.08.030_bib14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2215\/CJN.00050505","article-title":"Outcome of renal transplantation in patients with non-Shiga toxin-associated hemolytic uremic syndrome: Prognostic significance of genetic background","volume":"1","author":"Bresin","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2007.08.030_bib15","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/S0140-6736(02)08560-4","article-title":"Combined kidney and liver transplantation for familial haemolytic uraemic syndrome","volume":"359","author":"Remuzzi","year":"2002","journal-title":"Lancet"},{"key":"10.1053\/j.ajkd.2007.08.030_bib16","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s00467-003-1371-2","article-title":"Attempted treatment of factor H deficiency by liver transplantation","volume":"19","author":"Cheong","year":"2004","journal-title":"Pediatr Nephrol"},{"key":"10.1053\/j.ajkd.2007.08.030_bib17","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/j.1600-6143.2005.00783.x","article-title":"Hemolytic uremic syndrome: A fatal outcome after kidney and liver transplantation performed to correct factor H gene mutation","volume":"5","author":"Remuzzi","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1053\/j.ajkd.2007.08.030_bib18","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1111\/j.1600-6143.2006.01375.x","article-title":"Favorable long-term outcome after liver-kidney transplant for recurrent hemolytic uremic syndrome associated with a factor H mutation","volume":"6","author":"Saland","year":"2006","journal-title":"Am J Transplant"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638607015934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638607015934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T01:49:56Z","timestamp":1759456196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638607015934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0272638607015934"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2007.08.030","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of a Factor H Mutation With Hemolytic Uremic Syndrome Following a Diarrheal Illness","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2007.08.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}