{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:39:25Z","timestamp":1790023165055,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1053\/j.ajkd.2013.11.028","type":"journal-article","created":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T15:30:39Z","timestamp":1391873439000},"page":"843-850","source":"Crossref","is-referenced-by-count":24,"title":["Chronic Ifosfamide Toxicity: Kidney Pathology and Pathophysiology"],"prefix":"10.1053","volume":"63","author":[{"given":"Shreeram","family":"Akilesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemie","family":"Juaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy S.","family":"Duffield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1053\/j.ajkd.2013.11.028_bib1","doi-asserted-by":"crossref","first-page":"922","DOI":"10.2215\/CJN.09980912","article-title":"Long-term nephrotoxicity in adult survivors of childhood cancer","volume":"8","author":"Dekkers","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"issue":"5","key":"10.1053\/j.ajkd.2013.11.028_bib2","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1177\/009127009903900504","article-title":"Risk factors for long-term outcome of ifosfamide-induced nephrotoxicity in children","volume":"39","author":"Loebstein","year":"1999","journal-title":"J\u00a0Clin Pharmacol"},{"issue":"32","key":"10.1053\/j.ajkd.2013.11.028_bib3","doi-asserted-by":"crossref","first-page":"5350","DOI":"10.1200\/JCO.2008.17.5257","article-title":"Long-term evaluation of ifosfamide-related nephrotoxicity in children","volume":"27","author":"Oberlin","year":"2009","journal-title":"J\u00a0Clin Oncol"},{"issue":"10","key":"10.1053\/j.ajkd.2013.11.028_bib4","first-page":"1636","article-title":"Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study. United Kingdom Children's Cancer Study Group","volume":"82","author":"Skinner","year":"2000","journal-title":"Br J Cancer"},{"issue":"9027","key":"10.1053\/j.ajkd.2013.11.028_bib5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0140-6736(96)03480-0","article-title":"Risk factors for ifosfamide nephrotoxicity in children","volume":"348","author":"Skinner","year":"1996","journal-title":"Lancet"},{"issue":"4","key":"10.1053\/j.ajkd.2013.11.028_bib6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/pbc.20858","article-title":"Ifosfamide-induced nephrotoxicity in 593 sarcoma patients: a report from the Late Effects Surveillance System","volume":"48","author":"Stohr","year":"2007","journal-title":"Pediatr Blood Cancer"},{"issue":"9","key":"10.1053\/j.ajkd.2013.11.028_bib7","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.ejca.2012.03.009","article-title":"Long term renal toxicity of ifosfamide in adult patients\u20145 year data","volume":"48","author":"Farry","year":"2012","journal-title":"Eur J Cancer"},{"issue":"1","key":"10.1053\/j.ajkd.2013.11.028_bib8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1021\/mp100329u","article-title":"New clues for nephrotoxicity induced by ifosfamide: preferential renal uptake via the human organic cation transporter 2","volume":"8","author":"Ciarimboli","year":"2011","journal-title":"Mol Pharm"},{"issue":"8","key":"10.1053\/j.ajkd.2013.11.028_bib9","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/0006-2952(93)90310-S","article-title":"Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes","volume":"45","author":"Weber","year":"1993","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"10.1053\/j.ajkd.2013.11.028_bib10","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0006-2952(92)90596-B","article-title":"Effects of alkylating metabolites of ifosfamide and its bromo analogues on DNA of HeLa cells","volume":"43","author":"Studzian","year":"1992","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1053\/j.ajkd.2013.11.028_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0027-5107(92)90089-K","article-title":"Cytogenetic mechanisms in the selective toxicity of cyclophosphamide analogs and metabolites towards avian embryonic B lymphocytes in\u00a0vivo","volume":"268","author":"Wilmer","year":"1992","journal-title":"Mutat Res"},{"issue":"8517","key":"10.1053\/j.ajkd.2013.11.028_bib12","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0140-6736(86)92227-0","article-title":"Dechloroethylation of ifosfamide and neurotoxicity","volume":"2","author":"Goren","year":"1986","journal-title":"Lancet"},{"issue":"8","key":"10.1053\/j.ajkd.2013.11.028_bib13","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1681\/ASN.V1281615","article-title":"Human kidney tubules detoxify chloroacetaldehyde, a presumed nephrotoxic metabolite of ifosfamide","volume":"12","author":"Dubourg","year":"2001","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"11","key":"10.1053\/j.ajkd.2013.11.028_bib14","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/0006-2952(89)90419-X","article-title":"The effect of ifosfamide and its metabolites on intracellular glutathione levels in\u00a0vitro and in\u00a0vivo","volume":"38","author":"Lind","year":"1989","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"10.1053\/j.ajkd.2013.11.028_bib15","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00204-007-0275-5","article-title":"Mechanisms of the ifosfamide-induced inhibition of endocytosis in the rat proximal kidney tubule","volume":"82","author":"Yaseen","year":"2008","journal-title":"Arch Toxicol"},{"issue":"2","key":"10.1053\/j.ajkd.2013.11.028_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/dc.2840010210","article-title":"Radiation-induced atypia. A review","volume":"1","author":"Murad","year":"1985","journal-title":"Diagn Cytopathol"},{"issue":"7","key":"10.1053\/j.ajkd.2013.11.028_bib17","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00467-011-1815-z","article-title":"Karyomegalic-like nephropathy, Ewing's sarcoma and ifosfamide therapy","volume":"26","author":"McCulloch","year":"2011","journal-title":"Pediatr Nephrol"},{"issue":"8","key":"10.1053\/j.ajkd.2013.11.028_bib18","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/ng.2347","article-title":"FAN1 mutations cause\u00a0karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair","volume":"44","author":"Zhou","year":"2012","journal-title":"Nat Genet"},{"issue":"8","key":"10.1053\/j.ajkd.2013.11.028_bib19","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1002\/stem.1130","article-title":"Characterization of renal progenitors committed toward tubular lineage and their regenerative potential in renal tubular injury","volume":"30","author":"Angelotti","year":"2012","journal-title":"Stem Cells"},{"issue":"3","key":"10.1053\/j.ajkd.2013.11.028_bib20","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.stem.2008.01.014","article-title":"Intrinsic epithelial cells repair the kidney after injury","volume":"2","author":"Humphreys","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"22","key":"10.1053\/j.ajkd.2013.11.028_bib21","doi-asserted-by":"crossref","first-page":"9226","DOI":"10.1073\/pnas.1100629108","article-title":"Repair of injured proximal tubule does not involve specialized progenitors","volume":"108","author":"Humphreys","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1053\/j.ajkd.2013.11.028_bib22","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/jat.2550150510","article-title":"Nephrotoxicity of ifosfamide in rats","volume":"15","author":"Springate","year":"1995","journal-title":"J\u00a0Appl Toxicol"},{"issue":"5","key":"10.1053\/j.ajkd.2013.11.028_bib23","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1200\/JCO.1990.8.5.899","article-title":"Carboplatin, etoposide, and ifosfamide as intensive chemotherapy for small-cell lung cancer","volume":"8","author":"Smith","year":"1990","journal-title":"J\u00a0Clin Oncol"},{"issue":"1","key":"10.1053\/j.ajkd.2013.11.028_bib24","first-page":"193","article-title":"Thrombotic microangiopathy as a complication of high-dose chemotherapy for breast cancer","volume":"18","author":"Fisher","year":"1996","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"10.1053\/j.ajkd.2013.11.028_bib25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s002770050516","article-title":"Use of cyclophosphamide in the treatment of thrombotic thrombocytopenic purpura complicating systemic lupus erythematosus: report of two cases","volume":"78","author":"Perez-Sanchez","year":"1999","journal-title":"Ann Hematol"},{"issue":"4","key":"10.1053\/j.ajkd.2013.11.028_bib26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/rheumatology\/ken510","article-title":"A\u00a0comparison of thrombotic thrombocytopenic purpura in an inception cohort of patients with and without systemic lupus erythematosus","volume":"48","author":"Letchumanan","year":"2009","journal-title":"Rheumatology"},{"issue":"1","key":"10.1053\/j.ajkd.2013.11.028_bib27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/00007890-199301000-00039","article-title":"FK506-associated thrombotic thrombocytopenic purpura","volume":"55","author":"Holman","year":"1993","journal-title":"Transplantation"},{"issue":"8","key":"10.1053\/j.ajkd.2013.11.028_bib28","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1200\/JCO.1991.9.8.1495","article-title":"Ifosfamide, Fanconi's syndrome, and rickets","volume":"9","author":"Pratt","year":"1991","journal-title":"J\u00a0Clin Oncol"},{"issue":"5","key":"10.1053\/j.ajkd.2013.11.028_bib29","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/BF02113264","article-title":"Tubular function and histological findings in ifosfamide-induced renal Fanconi syndrome\u2014a report of two cases","volume":"151","author":"Rossi","year":"1992","journal-title":"Eur J Pediatr"},{"issue":"1","key":"10.1053\/j.ajkd.2013.11.028_bib30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/(SICI)1096-911X(199607)27:1<57::AID-MPO11>3.0.CO;2-2","article-title":"Ifosfamide nephrotoxicity in children: histopathological features in two cases","volume":"27","author":"Morland","year":"1996","journal-title":"Med Pediatr Oncol"},{"issue":"2","key":"10.1053\/j.ajkd.2013.11.028_bib31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000013321","article-title":"End-stage renal interstitial fibrosis in an adult ten years after ifosfamide therapy","volume":"18","author":"Friedlaender","year":"1998","journal-title":"Am J Nephrol"},{"issue":"3","key":"10.1053\/j.ajkd.2013.11.028_bib32","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000045416","article-title":"End-stage chronic renal failure secondary to cisplatin and ifosfamide combination chemotherapy","volume":"82","author":"Giron","year":"1999","journal-title":"Nephron"},{"issue":"3","key":"10.1053\/j.ajkd.2013.11.028_bib33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/713688923","article-title":"Tubulointerstitial nephritis following high-dose ifosfamide in three breast cancer patients","volume":"32","author":"Hill","year":"2000","journal-title":"Pathology"},{"issue":"11","key":"10.1053\/j.ajkd.2013.11.028_bib34","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/sj.ki.5002182","article-title":"Electrolyte abnormalities and progressive renal failure in a cancer patient","volume":"71","author":"Schlondorff","year":"2007","journal-title":"Kidney Int"},{"issue":"5","key":"10.1053\/j.ajkd.2013.11.028_bib35","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF00292414","article-title":"Severe renal failure following high-dose ifosfamide and mesna","volume":"23","author":"Willemse","year":"1989","journal-title":"Cancer Chemother Pharmacol"},{"issue":"3","key":"10.1053\/j.ajkd.2013.11.028_bib36","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/1097-0142(19950801)76:3<497::AID-CNCR2820760321>3.0.CO;2-C","article-title":"Severe, irreversible renal failure after ifosfamide treatment. A clinicopathologic report of two patients","volume":"76","author":"Berns","year":"1995","journal-title":"Cancer"},{"issue":"2","key":"10.1053\/j.ajkd.2013.11.028_bib37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0022-3476(05)80520-7","article-title":"Acute ifosfamide-induced proximal tubular toxic reaction","volume":"118","author":"Devalck","year":"1991","journal-title":"J\u00a0Pediatr"},{"issue":"8702","key":"10.1053\/j.ajkd.2013.11.028_bib38","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/0140-6736(90)91275-F","article-title":"Ifosfamide for children with solid tumours","volume":"335","author":"Jenney","year":"1990","journal-title":"Lancet"},{"issue":"9034","key":"10.1053\/j.ajkd.2013.11.028_bib39","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/S0140-6736(05)64446-7","article-title":"Ifosfamide nephrotoxicity: deleterious effect of previous cisplatin administration","volume":"348","author":"Martinez","year":"1996","journal-title":"Lancet"}],"updated-by":[{"DOI":"10.1053\/j.ajkd.2014.06.012","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000}}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638614000201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638614000201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T10:37:50Z","timestamp":1688985470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638614000201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0272638614000201"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2013.11.028","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}