{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:36:32Z","timestamp":1792179392916,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"crossref","award":["R01DK070910"],"award-info":[{"award-number":["R01DK070910"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"crossref","award":["R01DK083961"],"award-info":[{"award-number":["R01DK083961"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources (NCRR)","doi-asserted-by":"crossref","award":["KL2 RR024154"],"award-info":[{"award-number":["KL2 RR024154"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"crossref","award":["R01HS018721"],"award-info":[{"award-number":["R01HS018721"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1053\/j.ajkd.2014.10.018","type":"journal-article","created":{"date-parts":[[2014,12,6]],"date-time":"2014-12-06T18:16:25Z","timestamp":1417889785000},"page":"860-869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":170,"title":["Risk Factors for Acute Kidney Injury in Older Adults With Critical Illness: A Retrospective Cohort Study"],"prefix":"10.1053","volume":"65","author":[{"given":"Sandra L.","family":"Kane-Gill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentina E.","family":"Sileanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavan","family":"Murugan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Trietley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Handler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Kellum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1053\/j.ajkd.2014.10.018_bib1","doi-asserted-by":"crossref","first-page":"R73","DOI":"10.1186\/cc4915","article-title":"RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis","volume":"10","author":"Hoste","year":"2006","journal-title":"Crit Care"},{"issue":"6","key":"10.1053\/j.ajkd.2014.10.018_bib2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1053\/j.ajkd.2005.09.006","article-title":"Uncomplicated acute renal failure and hospital resource utilization: a retrospective multicenter analysis","volume":"46","author":"Fischer","year":"2005","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1053\/j.ajkd.2014.10.018_bib3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1161\/CIRCULATIONAHA.111.039909","article-title":"Short-term outcomes of acute myocardial infarction in\u00a0patients with acute kidney injury","volume":"125","author":"Fox","year":"2012","journal-title":"Circulation"},{"issue":"7","key":"10.1053\/j.ajkd.2014.10.018_bib4","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1097\/01.CCM.0000224227.70642.4F","article-title":"An assessment of the RIFLE criteria for acute renal failure in hospitalized patients","volume":"34","author":"Uchino","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1053\/j.ajkd.2014.10.018_bib5","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury","volume":"2","year":"2012","journal-title":"Kidney Int Suppl"},{"issue":"6","key":"10.1053\/j.ajkd.2014.10.018_bib6","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1093\/ndt\/gfm908","article-title":"Costs and outcomes of acute kidney injury (AKI) following cardiac surgery","volume":"23","author":"Dasta","year":"2008","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"10.1053\/j.ajkd.2014.10.018_bib7","first-page":"269","article-title":"Hospital-acquired acute kidney injury in Israel","volume":"11","author":"Shema","year":"2009","journal-title":"Isr Med Assoc J"},{"issue":"7","key":"10.1053\/j.ajkd.2014.10.018_bib8","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.294.7.813","article-title":"Acute renal failure in critically ill patients: a multinational, multicenter study","volume":"294","author":"Uchino","year":"2005","journal-title":"JAMA"},{"issue":"1","key":"10.1053\/j.ajkd.2014.10.018_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1681\/ASN.2012080800","article-title":"Temporal changes in incidence of dialysis-requiring AKI","volume":"24","author":"Hsu","year":"2013","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"9758","key":"10.1053\/j.ajkd.2014.10.018_bib10","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/S0140-6736(10)61271-8","article-title":"Glomerular filtration rate, proteinuria, and the incidence and consequences of\u00a0acute kidney injury: a cohort study","volume":"376","author":"James","year":"2010","journal-title":"Lancet"},{"key":"10.1053\/j.ajkd.2014.10.018_bib11","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/sj.ki.5002297","article-title":"Community-based incidence of acute renal failure","volume":"72","author":"Hsu","year":"2007","journal-title":"Kidney Int"},{"issue":"4","key":"10.1053\/j.ajkd.2014.10.018_bib12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1159\/000337487","article-title":"Acute kidney injury and mortality in hospitalized patients","volume":"35","author":"Wang","year":"2012","journal-title":"Am J Nephrol"},{"issue":"6","key":"10.1053\/j.ajkd.2014.10.018_bib13","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.semnephrol.2009.07.008","article-title":"Acute kidney injury in the elderly: problems and prospects","volume":"29","author":"Himmelfarb","year":"2009","journal-title":"Semin Nephrol"},{"issue":"4","key":"10.1053\/j.ajkd.2014.10.018_bib14","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1053\/j.jvca.2010.12.011","article-title":"Incidence- and mortality-related risk factors of acute kidney injury requiring hemofiltration in patients undergoing cardiac surgery: a single-center\u00a06-year experience","volume":"25","author":"Kowalik","year":"2011","journal-title":"J\u00a0Cardiothorac Vasc Anesth"},{"issue":"suppl 1","key":"10.1053\/j.ajkd.2014.10.018_bib15","doi-asserted-by":"crossref","first-page":"c19","DOI":"10.1159\/000328023","article-title":"Acute kidney injury in the elderly: predisposition to chronic kidney disease and vice versa","volume":"119","author":"Coca","year":"2011","journal-title":"Nephron Clin Pract"},{"issue":"3","key":"10.1053\/j.ajkd.2014.10.018_bib16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1001\/archinternmed.2011.1202","article-title":"Trends in the incidence of acute kidney injury in patients hospitalized with acute myocardial infarction","volume":"172","author":"Amin","year":"2012","journal-title":"Arch Intern Med"},{"issue":"2","key":"10.1053\/j.ajkd.2014.10.018_bib17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/SLA.0b013e31829654f3","article-title":"Acute kidney injury, renal function, and the elderly obese surgical patient: a matched case-control study","volume":"258","author":"Kelz","year":"2013","journal-title":"Ann Surg"},{"key":"10.1053\/j.ajkd.2014.10.018_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1681\/ASN.2007080837","article-title":"Acute kidney injury\u00a0increases risk of ESRD among elderly","volume":"20","author":"Ishani","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"4","key":"10.1053\/j.ajkd.2014.10.018_bib19","doi-asserted-by":"crossref","first-page":"R204","DOI":"10.1186\/cc2872","article-title":"Acute renal failure\u2014definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group","volume":"8","author":"Bellomo","year":"2004","journal-title":"Crit Care"},{"key":"10.1053\/j.ajkd.2014.10.018_bib20","article-title":"Risk factors for development of acute kidney injury in critically ill patients: a systematic review and meta-analysis of observational studies","author":"Cartin-Ceba","year":"2012","journal-title":"Crit Care Res Pract"},{"issue":"6876","key":"10.1053\/j.ajkd.2014.10.018_bib21","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/bmj.306.6876.481","article-title":"Incidence of severe acute renal failure in adults: results of a community based study","volume":"306","author":"Feest","year":"1993","journal-title":"BMJ"},{"issue":"1","key":"10.1053\/j.ajkd.2014.10.018_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1532-5415.1990.tb01592.x","article-title":"Incidence and prognosis of acute renal failure in older patients","volume":"38","author":"Pascual","year":"1990","journal-title":"J\u00a0Am Geriatr Soc"},{"issue":"2","key":"10.1053\/j.ajkd.2014.10.018_bib23","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1681\/ASN.V62144","article-title":"The elderly patient with acute renal failure","volume":"6","author":"Pascual","year":"1995","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"4","key":"10.1053\/j.ajkd.2014.10.018_bib24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0306-4573(91)90091-Y","article-title":"The Medical Archival System: an information retrieval system based on distributed parallel processing","volume":"27","author":"Yount","year":"1991","journal-title":"Inf Proc Manag"},{"key":"10.1053\/j.ajkd.2014.10.018_bib25","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.2146\/ajhp060045","article-title":"ADE rates for high cost and frequently used drugs in the ICU: redirecting pharmacist\u2019s time toward ADE prevention efforts","volume":"63","author":"Kane-Gill","year":"2006","journal-title":"Am J Health Syst Pharm"},{"key":"10.1053\/j.ajkd.2014.10.018_bib26","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1378\/chest.100.6.1619","article-title":"The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults","volume":"100","author":"Knaus","year":"1991","journal-title":"Chest"},{"key":"10.1053\/j.ajkd.2014.10.018_bib27","unstructured":"Sileanu F, Murugan R, Lucko N, et al. Acute kidney injury in \u201clow-risk\u201d patients in intensive care. Clin J Am Soc Nephrol., in press."},{"issue":"12 suppl S","key":"10.1053\/j.ajkd.2014.10.018_bib28","first-page":"A153","article-title":"Hypotension within 24 hours of ICU admission is associated with increased mortality and developing of acute kidney injury [abstract]","volume":"35","author":"Salmon","year":"2007","journal-title":"Crit Care Med"},{"issue":"12","key":"10.1053\/j.ajkd.2014.10.018_bib29","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/ndt\/gfp766","article-title":"A\u00a0comparison of three methods to estimate baseline creatinine for RIFLE classification","volume":"25","author":"Zavada","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"10.1053\/j.ajkd.2014.10.018_bib30","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/1536867X0200200307","article-title":"From the help desk: comparing areas under receiver operating characteristic curves from two or more probit or logit models","volume":"2","author":"Cleves","year":"2002","journal-title":"Stata J"},{"key":"10.1053\/j.ajkd.2014.10.018_bib31","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/CCM.0b013e318205df85","article-title":"Implementation of a real-time computerized sepsis alert in nonintensive care unit patients","volume":"39","author":"Sawyer","year":"2011","journal-title":"Crit Care Med"},{"key":"10.1053\/j.ajkd.2014.10.018_bib32","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ijmedinf.2011.04.005","article-title":"Computerized detection of adverse drug reactions in the medical ICU","volume":"80","author":"Kane-Gill","year":"2011","journal-title":"Int J Med Inform"},{"key":"10.1053\/j.ajkd.2014.10.018_bib33","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1097\/CCM.0b013e3182387a6b","article-title":"Impact of real-time electronic alerting of acute kidney injury on therapeutic intervention and progression of RIFLE class","volume":"40","author":"Colpaert","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1053\/j.ajkd.2014.10.018_bib34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nrneph.2011.50","article-title":"Computerized decision support systems: improving patient safety in nephrology","volume":"7","author":"Chang","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"10.1053\/j.ajkd.2014.10.018_bib35","doi-asserted-by":"crossref","first-page":"f4930","DOI":"10.1136\/bmj.f4930","article-title":"Acute kidney injury: summary of NICE guidance","volume":"347","author":"Ftouh","year":"2013","journal-title":"BMJ"},{"key":"10.1053\/j.ajkd.2014.10.018_bib36","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1053\/ajkd.2002.32766","article-title":"Hospital-acquired renal insufficiency","volume":"39","author":"Nash","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2014.10.018_bib37","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1681\/ASN.2006010073","article-title":"Validity of International Classification of Diseases, Ninth Revision, Clinical Modification codes for acute renal failure","volume":"17","author":"Waikar","year":"2006","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2014.10.018_bib38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1053\/j.ajkd.2005.04.029","article-title":"Identification of individuals with CKD from Medicare claims data: a validation study","volume":"46","author":"Winkelmayer","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2014.10.018_bib39","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1001\/jama.1996.03530430033035","article-title":"Effect of acute renal failure on mortality. A cohort analysis","volume":"275","author":"Levy","year":"1996","journal-title":"JAMA"},{"key":"10.1053\/j.ajkd.2014.10.018_bib40","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1056\/NEJMoa0902413","article-title":"Intensity of continuous renal-replacement therapy in critically ill patients","volume":"361","author":"Bellomo","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.ajkd.2014.10.018_bib41","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1053\/j.ajkd.2008.03.005","article-title":"Recovery of kidney function after acute kidney injury in the elderly: a systematic review and meta-analysis","volume":"52","author":"Schmitt","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2014.10.018_bib42","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/cc12503","article-title":"Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury","volume":"17","author":"Kashani","year":"2013","journal-title":"Crit Care"},{"key":"10.1053\/j.ajkd.2014.10.018_bib43","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/cpt1976195part1489","article-title":"Adverse drug reactions\u2014a matter of opinion","volume":"19","author":"Karch","year":"1976","journal-title":"Clin Pharmacol Ther"},{"key":"10.1053\/j.ajkd.2014.10.018_bib44","doi-asserted-by":"crossref","first-page":"e8525","DOI":"10.1136\/bmj.e8525","article-title":"Concurrent use of diuretics angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and acute kidney injury: nested case-control study","volume":"346","author":"Lapi","year":"2013","journal-title":"BMJ"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638614013754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638614013754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T02:33:33Z","timestamp":1759458813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638614013754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0272638614013754"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2014.10.018","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk Factors for Acute Kidney Injury in Older Adults With Critical Illness: A Retrospective Cohort Study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2014.10.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}