{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:33:16Z","timestamp":1790821996905,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1053\/j.ajkd.2014.11.016","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T01:15:39Z","timestamp":1421198139000},"page":"543-549","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":255,"title":["Allopurinol and Progression of CKD and Cardiovascular Events: Long-term Follow-up of a Randomized Clinical Trial"],"prefix":"10.1053","volume":"65","author":[{"given":"Marian","family":"Goicoechea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Garcia de Vinuesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Verdalles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Macias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"P\u00e9rez de Jose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Cede\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Linares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Lu\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.ajkd.2014.11.016_bib1","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.2215\/CJN.01580210","article-title":"Effect of allopurinol in chronic kidney disease (CKD) progression and cardiovascular risk","volume":"5","author":"Goicoechea","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2014.11.016_bib2","first-page":"403","article-title":"Does hiperuricemia affect mortality? A prospective cohort study of Japanese male workers","volume":"10","author":"Tomita","year":"2000","journal-title":"J\u00a0Epidemiol"},{"key":"10.1053\/j.ajkd.2014.11.016_bib3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1001\/archinternmed.2008.605","article-title":"Risk factors for end-stage renal disease: 25-year follow up","volume":"168","author":"Hsu","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.ajkd.2014.11.016_bib4","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1093\/ndt\/gfq262","article-title":"The relationship between serum uric acid and chronic kidney disease among Appalachian adults","volume":"25","author":"Cain","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2014.11.016_bib5","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1681\/ASN.2007101075","article-title":"Uric acid and incident kidney disease in the community","volume":"19","author":"Weiner","year":"2008","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2014.11.016_bib6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1053\/j.ajkd.2010.01.019","article-title":"Association of uric acid with change in kidney function in healthy normotensive individuals","volume":"2","author":"Bellomo","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2014.11.016_bib7","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s11255-007-9253-3","article-title":"Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearance, and proteinuria in patients with normal renal function","volume":"39","author":"Kanbay","year":"2007","journal-title":"Int Urol Nephrol"},{"issue":"5","key":"10.1053\/j.ajkd.2014.11.016_bib8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000105142","article-title":"The effect of mild hyperuricemia on urinary transforming growth factor beta and the progression of chronic kidney disease","volume":"27","author":"Talaat","year":"2007","journal-title":"Am J Nephrol"},{"key":"10.1053\/j.ajkd.2014.11.016_bib9","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1681\/ASN.2010111185","article-title":"Allopurinol benefits left ventricular mass and endothelial dysfunction in chronic kidney disease","volume":"22","author":"Kao","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"2","key":"10.1053\/j.ajkd.2014.11.016_bib10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/j.ajkd.2007.05.013","article-title":"Relationship of uric acid with progression of kidney disease","volume":"50","author":"Chonchol","year":"2007","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1053\/j.ajkd.2014.11.016_bib11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/1471-2369-15-205","article-title":"Prevalence of chronic kidney disease and associated factors among the Chinese population in Taian, China","volume":"15","author":"Xue","year":"2014","journal-title":"BMC Nephrol"},{"key":"10.1053\/j.ajkd.2014.11.016_bib12","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1053\/j.ajkd.2008.12.021","article-title":"Uric acid and long-term outcomes in CKD","volume":"53","author":"Madero","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2014.11.016_bib13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.ajkd.2005.10.006","article-title":"Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level","volume":"47","author":"Siu","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2014.11.016_bib14","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.2215\/CJN.11451210","article-title":"A\u00a0randomized study of allopurinol on endothelial function and estimated glomerular filtration rate in asymptomatic hyperuricemic subjects with normal renal function","volume":"6","author":"Kanbay","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2014.11.016_bib15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000331453","article-title":"Clinical outcome of hyperuricemia in IgA nephropathy: a retrospective cohort study and randomized controlled trial","volume":"35","author":"Shi","year":"2012","journal-title":"Kidney Blood Press Res"},{"key":"10.1053\/j.ajkd.2014.11.016_bib16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1161\/HYPERTENSIONAHA.111.171488","article-title":"Effect of a reduction in uric acid on renal outcomes during losartan treatment: a post hoc analysis of the Reduction of Endpoints in Non-Insulin Dependent Diabetes Mellitus With the Angiontensin II Antagonist Losartan Trial","volume":"58","author":"Miao","year":"2011","journal-title":"Hypertension"},{"key":"10.1053\/j.ajkd.2014.11.016_bib17","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1161\/CIRCULATIONAHA.106.651117","article-title":"High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid","volume":"114","author":"George","year":"2006","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2014.11.016_bib18","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1007\/s00125-007-0817-7","article-title":"Lowering serum urate does not improve endothelial function in patients with type 2 diabetes","volume":"50","author":"Waring","year":"2007","journal-title":"Diabetology"},{"key":"10.1053\/j.ajkd.2014.11.016_bib19","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1053\/j.ajkd.2014.04.024","article-title":"Uric acid levels, kidney function, and cardiovascular mortality in US\u00a0adults: National Health and Nutrition Examination Survey (NHANES) 1988-1994 and 1999-2002","volume":"64","author":"Odden","year":"2014","journal-title":"Am J Kidney Dis"},{"issue":"suppl 5","key":"10.1053\/j.ajkd.2014.11.016_bib20","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.3949\/ccjm.75.Suppl_5.S13","article-title":"The role of hyperuricemia and gout in kidney and cardiovascular disease","volume":"75","author":"Edwards","year":"2008","journal-title":"Clev Clin J Med"},{"key":"10.1053\/j.ajkd.2014.11.016_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.atherosclerosis.2008.05.022","article-title":"Uric acid: a marker of increased cardiovascular risk","volume":"202","author":"Gagliardi","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1053\/j.ajkd.2014.11.016_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/j.ajkd.2010.01.024","article-title":"Is high serum uric acid a risk marker or a target for treatment? Examination of its independent effect in a large cohort with low cardiovascular risk","volume":"56","author":"Wen","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2014.11.016_bib23","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1253\/circj.CJ-08-0626","article-title":"Uric acid and left ventricular hyperthrophy in Japanese men","volume":"73","author":"Mitsuhashi","year":"2009","journal-title":"Circ J"},{"key":"10.1053\/j.ajkd.2014.11.016_bib24","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/S0140-6736(10)60391-1","article-title":"Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial","volume":"375","author":"Norman","year":"2010","journal-title":"Lancet"},{"key":"10.1053\/j.ajkd.2014.11.016_bib25","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/HJH.0b013e32835200f9","article-title":"An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection: a post-hoc analysis of the RENAAL and IDNT trials","volume":"30","author":"Smink","year":"2012","journal-title":"J\u00a0Hypertens"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638614014760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638614014760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T02:29:41Z","timestamp":1759458581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638614014760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S0272638614014760"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2014.11.016","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725317073.793528712","asserted-by":"object"}]},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allopurinol and Progression of CKD and Cardiovascular Events: Long-term Follow-up of a Randomized Clinical Trial","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2014.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}