{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:11:05Z","timestamp":1792987865217,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1053\/j.ajkd.2015.03.013","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T01:01:43Z","timestamp":1430960503000},"page":"479-488","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["The Phosphate Binder Ferric Citrate and Mineral Metabolism and Inflammatory Markers in Maintenance Dialysis Patients: Results From Prespecified Analyses of a Randomized Clinical Trial"],"prefix":"10.1053","volume":"66","clinical-trial-number":[{"clinical-trial-number":"nct01191255","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Peter N.","family":"Van Buren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia B.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie P.","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Sika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kausik","family":"Umanath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine D.","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahabul S.","family":"Arfeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isai G.","family":"Bowline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Chernin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Z.","family":"Fadem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Goral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Koury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin V.","family":"Sinsakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1053\/j.ajkd.2015.03.013_bib1","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1097\/01.ASN.0000133041.27682.A2","article-title":"Mineral metabolism, mortality, and morbidity in maintenance hemodialysis","volume":"15","author":"Block","year":"2004","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"4 suppl 3","key":"10.1053\/j.ajkd.2015.03.013_bib2","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease","volume":"42","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2015.03.013_bib3","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0140-6736(82)90049-6","article-title":"Hypercalcaemic osteomalacia due to aluminum toxicity","volume":"2","author":"Boyce","year":"1982","journal-title":"Lancet"},{"key":"10.1053\/j.ajkd.2015.03.013_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0272-6386(87)80058-6","article-title":"Microcytic anemia in dialysis patients: reversible marker of aluminum toxicity","volume":"9","author":"Swartz","year":"1987","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2015.03.013_bib5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1056\/NEJM197601222940402","article-title":"The dialysis encephalopathy syndrome. Possible aluminum intoxication","volume":"294","author":"Alfrey","year":"1976","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.ajkd.2015.03.013_bib6","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1111\/j.1523-1755.2004.00590.x","article-title":"Treatment of hyperphosphatemia in hemodialysis patients: the Calcium Acetate Renagel Evaluation (CARE Study)","volume":"65","author":"Qunibi","year":"2004","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2015.03.013_bib7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1046\/j.1523-1755.2002.00434.x","article-title":"Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients","volume":"62","author":"Chertow","year":"2002","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2015.03.013_bib8","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1053\/j.ajkd.2009.06.004","article-title":"Benefits and harms of phosphate binders in CKD: a systematic review of randomized controlled trials","volume":"54","author":"Navaneethan","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2015.03.013_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/ndt\/17.2.265","article-title":"An open-label, crossover study of a new phosphate-binding agent in haemodialysis patients: ferric citrate","volume":"17","author":"Yang","year":"2002","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"10.1053\/j.ajkd.2015.03.013_bib10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1053\/j.ajkd.2012.11.041","article-title":"Dose-response and efficacy of ferric citrate to treat hyperphosphatemia in hemodialysis patients: a short-term randomized trial","volume":"61","author":"Dwyer","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2015.03.013_bib11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1681\/ASN.2014020212","article-title":"Ferric citrate controls phosphorus and delivers iron in patients on dialysis","volume":"26","author":"Lewis","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2015.03.013_bib12","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ki.1990.294","article-title":"Influence of calcium acetate or calcium citrate on intestinal aluminum absorption","volume":"38","author":"Nolan","year":"1990","journal-title":"Kidney Int"},{"issue":"1","key":"10.1053\/j.ajkd.2015.03.013_bib13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1542-4758.2012.00711.x","article-title":"Rationale and study design of a three-period, 58-week trial of ferric citrate as a phosphate binder in patients with ESRD on dialysis","volume":"17","author":"Umanath","year":"2013","journal-title":"Hemodial Int"},{"issue":"1-2","key":"10.1053\/j.ajkd.2015.03.013_bib14","doi-asserted-by":"crossref","first-page":"c25","DOI":"10.1159\/000341922","article-title":"The safety and tolerability of ferric citrate as a phosphate binder in dialysis patients","volume":"121","author":"Sinsakul","year":"2012","journal-title":"Nephron Clin Pract"},{"key":"10.1053\/j.ajkd.2015.03.013_bib15","series-title":"PhosLo [package insert]","year":"2007"},{"key":"10.1053\/j.ajkd.2015.03.013_bib16","series-title":"Renvela [package insert]","year":"2010"},{"key":"10.1053\/j.ajkd.2015.03.013_bib17","first-page":"1","article-title":"Phosphorus binding with ferric citrate is associated wtih fewer hospitalizations and reduced hospitalization costs","volume":"13","author":"Rodby","year":"2014","journal-title":"Exp Rev Pharmacoecon Outcomes Res"},{"key":"10.1053\/j.ajkd.2015.03.013_bib18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ki.1982.37","article-title":"Dialysate aluminum concentration in renal bone disease","volume":"21","author":"Walker","year":"1982","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2015.03.013_bib19","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1681\/ASN.2004070573","article-title":"Activated injectable vitamin D and hemodialysis survival: a historical cohort study","volume":"16","author":"Teng","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2015.03.013_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000149239","article-title":"Long-term efficacy and safey profile of lanthanum carbonate: results for up to 6 years of treatment","volume":"110","author":"Hutchison","year":"2008","journal-title":"Nephron Clin Pract"},{"key":"10.1053\/j.ajkd.2015.03.013_bib21","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1111\/j.1523-1755.2005.00753.x","article-title":"Progressive accumulation of lanthanum in the liver or normal and uremic rats","volume":"68","author":"Slatopolsky","year":"2006","journal-title":"Kidney Int"},{"issue":"2","key":"10.1053\/j.ajkd.2015.03.013_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/ndt\/17.2.265","article-title":"An open-label, crossover study of a new phosphate-binding agent in haemodialysis patients: ferric citrate","volume":"17","author":"Yang","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2015.03.013_bib23","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/ndt\/gft483","article-title":"A\u00a0randomized trial of JTT-751 versus sevelamer hydrochloride in patients on hemodialysis","volume":"29","author":"Yokoyama","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2015.03.013_bib24","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ki.1989.142","article-title":"Influence of dietary constituents on intestinal absorption of aluminum","volume":"35","author":"Partridge","year":"1989","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2015.03.013_bib25","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/ki.1989.286","article-title":"Citrate: a major factor in the toxicity of orally administered aluminum compounds","volume":"36","author":"Molitoris","year":"1989","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2015.03.013_bib26","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1093\/ndt\/gfs368","article-title":"Association of malnutrition-inflammation complex and responsiveness to erthyropoeisis-stimulating agents in long-term hemodialysis patients","volume":"28","author":"Rattanasompattikul","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2015.03.013_bib27","doi-asserted-by":"crossref","unstructured":"Umanath K, Jalal DI, Greco BA, et al. Ferric citrate reduces intravenous iron and erythropoeisis-stimulating agent use in ESRD [published online ahead of print March 3, 2015]. J Am Soc Nephrol. http:\/\/dx.doi.org\/10.1681\/ASN.2014080842.","DOI":"10.1681\/ASN.2014080842"},{"key":"10.1053\/j.ajkd.2015.03.013_bib28","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1093\/ndt\/14.12.2907","article-title":"Long-term effects of sevelamer hydrochloride on the calcium x phosphate product and lipid profile of haemodialysis patients","volume":"14","author":"Chertow","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2015.03.013_bib29","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1046\/j.1523-1755.2002.00459.x","article-title":"Bile acid binding to sevelamer HCl","volume":"62","author":"Braunlin","year":"2002","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2015.03.013_bib30","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S0272-6386(99)70221-0","article-title":"A\u00a0comparison of the calcium-free phosphate binder sevelamer hydrochloride with calcium acetate in the treatment of hyperphosphatemia in hemodialysis patients","volume":"33","author":"Bleyer","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2015.03.013_bib31","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1053\/j.ajkd.2013.09.006","article-title":"The DOPPS practice monitor for US dialysis care: update on trends in anemia management 2 years into the bundle","volume":"62","author":"Fuller","year":"2013","journal-title":"Am J Kidney Dis"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638615005417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638615005417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T02:32:35Z","timestamp":1759458755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638615005417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0272638615005417"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2015.03.013","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Phosphate Binder Ferric Citrate and Mineral Metabolism and Inflammatory Markers in Maintenance Dialysis Patients: Results From Prespecified Analyses of a Randomized Clinical Trial","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2015.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}