{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:06:57Z","timestamp":1792735617069,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009429","name":"Israel National Road Safety Authority","doi-asserted-by":"publisher","award":["T32 DK 007053"],"award-info":[{"award-number":["T32 DK 007053"]}],"id":[{"id":"10.13039\/100009429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1053\/j.ajkd.2016.01.030","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T08:32:04Z","timestamp":1460536324000},"page":"138-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":145,"title":["Membranous Nephropathy: A Journey From Bench to Bedside"],"prefix":"10.1053","volume":"68","author":[{"given":"Jean M.","family":"Francis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Laurence H.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-3120","authenticated-orcid":false,"given":"David J.","family":"Salant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1053\/j.ajkd.2016.01.030_bib1","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1172\/JCI109248","article-title":"Experimental glomerulonephritis in the isolated perfused rat kidney","volume":"62","author":"Couser","year":"1978","journal-title":"J\u00a0Clin Invest"},{"issue":"4","key":"10.1053\/j.ajkd.2016.01.030_bib2","first-page":"502","article-title":"Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V.\u00a0Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis","volume":"38","author":"Van Damme","year":"1978","journal-title":"Lab Invest"},{"issue":"1","key":"10.1053\/j.ajkd.2016.01.030_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ki.1980.1","article-title":"In situ immune complex formation and glomerular injury","volume":"17","author":"Couser","year":"1980","journal-title":"Kidney Int"},{"issue":"3","key":"10.1053\/j.ajkd.2016.01.030_bib4","first-page":"287","article-title":"Characterization of the antigen (gp600) of Heymann nephritis","volume":"50","author":"Makker","year":"1984","journal-title":"Lab Invest"},{"issue":"4909","key":"10.1053\/j.ajkd.2016.01.030_bib5","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1126\/science.2786251","article-title":"Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor","volume":"244","author":"Raychowdhury","year":"1989","journal-title":"Science"},{"issue":"18","key":"10.1053\/j.ajkd.2016.01.030_bib6","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1073\/pnas.79.18.5557","article-title":"The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border","volume":"79","author":"Kerjaschki","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1053\/j.ajkd.2016.01.030_bib7","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1084\/jem.157.2.667","article-title":"Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats","volume":"157","author":"Kerjaschki","year":"1983","journal-title":"J\u00a0Exp Med"},{"issue":"1","key":"10.1053\/j.ajkd.2016.01.030_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1084\/jem.166.1.109","article-title":"Initial events in the formation of immune deposits in passive Heymann nephritis","volume":"166","author":"Kerjaschki","year":"1987","journal-title":"J\u00a0Exp Med"},{"issue":"26","key":"10.1053\/j.ajkd.2016.01.030_bib9","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMoa012895","article-title":"Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies","volume":"346","author":"Debiec","year":"2002","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1053\/j.ajkd.2016.01.030_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00467-013-2717-z","article-title":"Membranous nephropathy: not just a disease for adults","volume":"30","author":"Ayalon","year":"2015","journal-title":"Pediatr Nephrol"},{"issue":"1","key":"10.1053\/j.ajkd.2016.01.030_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa0810457","article-title":"M-Type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy","volume":"361","author":"Beck","year":"2009","journal-title":"N\u00a0Engl J Med"},{"issue":"7","key":"10.1053\/j.ajkd.2016.01.030_bib12","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJMc1011678","article-title":"PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy","volume":"364","author":"Debiec","year":"2011","journal-title":"N\u00a0Engl J Med"},{"issue":"7","key":"10.1053\/j.ajkd.2016.01.030_bib13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/ki.2012.209","article-title":"Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy","volume":"82","author":"Hoxha","year":"2012","journal-title":"Kidney Int"},{"issue":"24","key":"10.1053\/j.ajkd.2016.01.030_bib14","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMoa1409354","article-title":"Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy","volume":"371","author":"Tomas","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1053\/j.ajkd.2016.01.030_bib15","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1056\/NEJMc1500130","article-title":"Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy","volume":"372","author":"Godel","year":"2015","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1053\/j.ajkd.2016.01.030_bib16","doi-asserted-by":"crossref","first-page":"e0138841","DOI":"10.1371\/journal.pone.0138841","article-title":"Prevalence of enhanced granular expression of thrombospondin type-1 domain-containing 7A in the glomeruli of Japanese patients with idiopathic membranous nephropathy","volume":"10","author":"Iwakura","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1053\/j.ajkd.2016.01.030_bib17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrneph.2013.125","article-title":"Treatment of idiopathic membranous nephropathy","volume":"9","author":"Hofstra","year":"2013","journal-title":"Nat Rev Nephrol"},{"issue":"3","key":"10.1053\/j.ajkd.2016.01.030_bib18","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2215\/CJN.04160413","article-title":"Glomerular diseases: membranous nephropathy\u2013a modern view","volume":"9","author":"Ponticelli","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2016.01.030_bib19","series-title":"Comprehensive Clinical Nephrology","first-page":"239","article-title":"Membranous nephropathy","author":"Salant","year":"2014"},{"issue":"6","key":"10.1053\/j.ajkd.2016.01.030_bib20","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.2215\/CJN.07210810","article-title":"Anti-phospholipase A2 receptor antibodies correlate with clinical status in idiopathic membranous nephropathy","volume":"6","author":"Hofstra","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"issue":"11","key":"10.1053\/j.ajkd.2016.01.030_bib21","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1093\/ndt\/gfv228","article-title":"Spontaneous remission of proteinuria is a frequent event in phospholipase A2 receptor antibody-negative patients with membranous nephropathy","volume":"30","author":"Hoxha","year":"2015","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"10.1053\/j.ajkd.2016.01.030_bib22","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10157-014-1054-2","article-title":"Prevalence of anti-phospholipase A2 receptor antibodies in Japanese patients with membranous nephropathy","volume":"19","author":"Akiyama","year":"2015","journal-title":"Clin Exp Nephrol"},{"issue":"2","key":"10.1053\/j.ajkd.2016.01.030_bib23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.autrev.2013.09.005","article-title":"Differential diagnosis of membranous nephropathy with autoantibodies to phospholipase A2 receptor 1","volume":"13","author":"Schlumberger","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1053\/j.ajkd.2016.01.030_bib24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cca.2013.03.015","article-title":"Development of a standardized ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy","volume":"421","author":"Dahnrich","year":"2013","journal-title":"Clin Chim Acta"},{"issue":"5","key":"10.1053\/j.ajkd.2016.01.030_bib25","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/ki.2012.486","article-title":"Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy","volume":"83","author":"Kanigicherla","year":"2013","journal-title":"Kidney Int"},{"key":"10.1053\/j.ajkd.2016.01.030_bib26","first-page":"143274","article-title":"Antiphospholipase A(2) receptor autoantibodies: a comparison of three different immunoassays for the diagnosis of idiopathic membranous nephropathy","volume":"2014","author":"Behnert","year":"2014","journal-title":"J\u00a0Immunol Res"},{"issue":"4","key":"10.1053\/j.ajkd.2016.01.030_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrneph.2012.35","article-title":"Pathogenesis of membranous nephropathy: recent advances and future challenges","volume":"8","author":"Ronco","year":"2012","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"10.1053\/j.ajkd.2016.01.030_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/MAJ.0b013e318267b5cd","article-title":"Detection of anti-PLA2R autoantibodies and IgG subclasses in post-allogeneic hematopoietic stem cell transplantation membranous nephropathy","volume":"346","author":"Huang","year":"2013","journal-title":"Am J Med Sci"},{"issue":"6","key":"10.1053\/j.ajkd.2016.01.030_bib29","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1681\/ASN.2010090967","article-title":"Anti-phospholipase A2 receptor antibody in membranous nephropathy","volume":"22","author":"Qin","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"30","key":"10.1053\/j.ajkd.2016.01.030_bib30","doi-asserted-by":"crossref","first-page":"e1243","DOI":"10.1097\/MD.0000000000001243","article-title":"Membranous nephropathy associated with immunological disorder-related liver disease: a retrospective study of 10 cases","volume":"94","author":"Dauvergne","year":"2015","journal-title":"Medicine (Baltimore)"},{"issue":"4-5","key":"10.1053\/j.ajkd.2016.01.030_bib31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000431331","article-title":"Renal phospholipase A2 receptor in hepatitis B virus-associated membranous nephropathy","volume":"41","author":"Xie","year":"2015","journal-title":"Am J Nephrol"},{"issue":"8","key":"10.1053\/j.ajkd.2016.01.030_bib32","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1093\/ndt\/gfr247","article-title":"An immunofluorescence test for phospholipase-A(2)-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis","volume":"26","author":"Hoxha","year":"2011","journal-title":"Nephrol Dial Transplant"},{"issue":"7","key":"10.1053\/j.ajkd.2016.01.030_bib33","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1093\/ndt\/gfs439","article-title":"Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy","volume":"28","author":"Svobodova","year":"2013","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"10.1053\/j.ajkd.2016.01.030_bib34","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1681\/ASN.2014010091","article-title":"Phospholipase A2 receptor antibodies in membranous nephropathy: unresolved issues","volume":"25","author":"Hofstra","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"5","key":"10.1053\/j.ajkd.2016.01.030_bib35","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/modpathol.2012.207","article-title":"Determination of primary versus secondary membranous glomerulopathy utilizing phospholipase A2 receptor staining in renal biopsies","volume":"26","author":"Larsen","year":"2013","journal-title":"Mod Pathol"},{"issue":"2","key":"10.1053\/j.ajkd.2016.01.030_bib36","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1681\/ASN.2014050502","article-title":"Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy","volume":"26","author":"Fresquet","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"6","key":"10.1053\/j.ajkd.2016.01.030_bib37","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/ki.2015.34","article-title":"Serum anti-PLA2R antibodies can be initially absent in idiopathic membranous nephropathy: seroconversion after prolonged follow-up","volume":"87","author":"van de Logt","year":"2015","journal-title":"Kidney Int"},{"issue":"5","key":"10.1053\/j.ajkd.2016.01.030_bib38","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/ki.2015.310","article-title":"Serial monitoring of anti-PLA2R in initial PLA2R-negative patients with primary membranous nephropathy","volume":"88","author":"Ramachandran","year":"2015","journal-title":"Kidney Int"},{"issue":"6","key":"10.1053\/j.ajkd.2016.01.030_bib39","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1053\/j.ajkd.2013.07.019","article-title":"Anti-phospholipase A2 receptor antibodies and malignancy in membranous nephropathy","volume":"62","author":"Timmermans","year":"2013","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1053\/j.ajkd.2016.01.030_bib40","doi-asserted-by":"crossref","first-page":"e62151","DOI":"10.1371\/journal.pone.0062151","article-title":"Autoantibodies against phospholipase A2 receptor in Korean patients with membranous nephropathy","volume":"8","author":"Oh","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1053\/j.ajkd.2016.01.030_bib41","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1681\/ASN.2010111125","article-title":"Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy","volume":"22","author":"Beck","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"10","key":"10.1053\/j.ajkd.2016.01.030_bib42","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1681\/ASN.2012030242","article-title":"Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy","volume":"23","author":"Hofstra","year":"2012","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"6","key":"10.1053\/j.ajkd.2016.01.030_bib43","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1681\/ASN.2013040430","article-title":"Phospholipase A2 receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy","volume":"25","author":"Hoxha","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"10","key":"10.1053\/j.ajkd.2016.01.030_bib44","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1681\/ASN.2014070640","article-title":"Anti-phospholipase\u00a0A2 receptor antibody titer predicts post-rituximab outcome of membranous nephropathy","volume":"26","author":"Ruggenenti","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2016.01.030_bib45","first-page":"3A","article-title":"Association of anti-PLA2R antibody level with clinical response to rituximab in idiopathic membranous nephropathy","volume":"20","author":"Beck","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"8","key":"10.1053\/j.ajkd.2016.01.030_bib46","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.2215\/CJN.10471013","article-title":"Association of anti-PLA(2)R antibodies with outcomes after immunosuppressive therapy in idiopathic membranous nephropathy","volume":"9","author":"Bech","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2016.01.030_bib47","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.biochi.2015.08.007","article-title":"Cross-reactivity of anti-PLA2R1 autoantibodies to rabbit and mouse PLA2R1 antigens and development of two novel ELISAs with different diagnostic performances in idiopathic membranous nephropathy","volume":"118","author":"Seitz-Polski","year":"2015","journal-title":"Biochimie"},{"issue":"10","key":"10.1053\/j.ajkd.2016.01.030_bib48","doi-asserted-by":"crossref","first-page":"e110681","DOI":"10.1371\/journal.pone.0110681","article-title":"PLA2R antibody levels and clinical outcome in patients with membranous nephropathy and non-nephrotic range proteinuria under treatment with inhibitors of the renin-angiotensin system","volume":"9","author":"Hoxha","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"10.1053\/j.ajkd.2016.01.030_bib49","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.2215\/CJN.03850414","article-title":"M-Type phospholipase A2 receptor autoantibodies and renal function in patients with primary membranous nephropathy","volume":"9","author":"Hoxha","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"issue":"8146","key":"10.1053\/j.ajkd.2016.01.030_bib50","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0140-6736(79)92118-4","article-title":"Strong association between idiopathic membranous nephropathy and HLA-DRW3","volume":"2","author":"Klouda","year":"1979","journal-title":"Lancet"},{"issue":"3","key":"10.1053\/j.ajkd.2016.01.030_bib51","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1399-0039.1982.tb00350.x","article-title":"HLA-DR3 and idiopathic membranous nephritis (IMN) association","volume":"20","author":"Le Petit","year":"1982","journal-title":"Tissue Antigens"},{"issue":"5","key":"10.1053\/j.ajkd.2016.01.030_bib52","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1399-0039.1989.tb01741.x","article-title":"A\u00a0DQA1 allele is strongly associated with idiopathic membranous nephropathy","volume":"34","author":"Vaughan","year":"1989","journal-title":"Tissue Antigens"},{"issue":"1","key":"10.1053\/j.ajkd.2016.01.030_bib53","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/ki.1992.24","article-title":"Analysis of HLA class II genes in Japanese patients with idiopathic membranous glomerulonephritis","volume":"41","author":"Ogahara","year":"1992","journal-title":"Kidney Int"},{"issue":"2","key":"10.1053\/j.ajkd.2016.01.030_bib54","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1399-0039.1997.tb02855.x","article-title":"Idiopathic and secondary membranous nephropathy and polymorphism at TAP1 and HLA-DMA loci","volume":"50","author":"Chevrier","year":"1997","journal-title":"Tissue Antigens"},{"issue":"3","key":"10.1053\/j.ajkd.2016.01.030_bib55","doi-asserted-by":"crossref","first-page":"c253","DOI":"10.1159\/000320194","article-title":"Single nucleotide polymorphisms in the phospholipase A2 receptor gene are associated with genetic susceptibility to idiopathic membranous nephropathy","volume":"117","author":"Kim","year":"2011","journal-title":"Nephron Clin Pract"},{"key":"10.1053\/j.ajkd.2016.01.030_bib56","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1423-0127-17-81","article-title":"Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan","volume":"17","author":"Liu","year":"2010","journal-title":"J\u00a0Biomed Sci"},{"issue":"7","key":"10.1053\/j.ajkd.2016.01.030_bib57","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1056\/NEJMoa1009742","article-title":"Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy","volume":"364","author":"Stanescu","year":"2011","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1053\/j.ajkd.2016.01.030_bib58","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1681\/ASN.2012070730","article-title":"Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy","volume":"24","author":"Coenen","year":"2013","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"8","key":"10.1053\/j.ajkd.2016.01.030_bib59","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1681\/ASN.2012080771","article-title":"Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy","volume":"24","author":"Lv","year":"2013","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"1","key":"10.1053\/j.ajkd.2016.01.030_bib60","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1053\/j.ajkd.2014.02.024","article-title":"Histopathologic effect of APOL1 risk alleles in PLA2R-associated membranous glomerulopathy","volume":"64","author":"Larsen","year":"2014","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1053\/j.ajkd.2016.01.030_bib61","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1681\/ASN.2013020166","article-title":"Genetic variants in membranous nephropathy: perhaps a perfect storm rather than a straightforward conformeropathy?","volume":"24","author":"Salant","year":"2013","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"9","key":"10.1053\/j.ajkd.2016.01.030_bib62","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1007\/s00018-007-7497-9","article-title":"Extended and bent conformations of the mannose receptor family","volume":"65","author":"Llorca","year":"2008","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"10.1053\/j.ajkd.2016.01.030_bib63","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1681\/ASN.2013121315","article-title":"Identification of the immunodominant epitope region in phospholipase A2 receptor-mediating autoantibody binding in idiopathic membranous nephropathy","volume":"26","author":"Kao","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2016.01.030_bib64","first-page":"17A","article-title":"Identification of distinct dominant and subdominant humoral epitopes within PLA2R1 in primary membranous nephropathy","volume":"25","author":"Beck","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2016.01.030_bib65","doi-asserted-by":"crossref","unstructured":"Seitz-Polski B, Dolla G, Payr\u00e9 C, et al. Epitope spreading in PLA2R1 is associated with bad prognosis in membranous nephropathy [published online ahead of print November 13, 2015]. J\u00a0Am Soc Nephrol. http:\/\/dx.doi.org\/10.1681\/ASN.2014111061.","DOI":"10.1681\/ASN.2014111061"},{"issue":"3","key":"10.1053\/j.ajkd.2016.01.030_bib66","first-page":"144","article-title":"Recurrence of membranous nephropathy after renal transplantation: probability, outcome and risk factors","volume":"50","author":"Cosyns","year":"1998","journal-title":"Clin Nephrol"},{"issue":"5","key":"10.1053\/j.ajkd.2016.01.030_bib67","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0272-6386(12)80685-8","article-title":"The recurrence of recurrent membranous glomerulopathy in a renal transplant recipient: case report and literature review","volume":"24","author":"Josephson","year":"1994","journal-title":"Am J Kidney Dis"},{"issue":"7","key":"10.1053\/j.ajkd.2016.01.030_bib68","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/ndt\/gfg102","article-title":"Recurrent glomerulonephritis following renal transplantation: an update","volume":"18","author":"Floege","year":"2003","journal-title":"Nephrol Dial Transplant"},{"issue":"10","key":"10.1053\/j.ajkd.2016.01.030_bib69","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1093\/ndt\/gfq223","article-title":"Long-term outcome of renal transplantation in patients with idiopathic membranous glomerulonephritis (MN)","volume":"25","author":"Moroni","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"10.1053\/j.ajkd.2016.01.030_bib70","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1111\/j.1600-6143.2008.02237.x","article-title":"Recurrent idiopathic membranous nephropathy after kidney transplantation: a surveillance biopsy study","volume":"8","author":"Dabade","year":"2008","journal-title":"Am J Transplant"},{"issue":"12","key":"10.1053\/j.ajkd.2016.01.030_bib71","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1111\/j.1600-6143.2009.02851.x","article-title":"Recurrent idiopathic membranous nephropathy: early diagnosis by protocol biopsies and treatment with anti-CD20 monoclonal antibodies","volume":"9","author":"El-Zoghby","year":"2009","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1053\/j.ajkd.2016.01.030_bib72","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/ndt\/gft299","article-title":"The ERA-EDTA database on recurrent glomerulonephritis following renal transplantation","volume":"29","author":"Floege","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"10.1053\/j.ajkd.2016.01.030_bib73","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMc1003066","article-title":"PLA2R autoantibodies and recurrent membranous nephropathy after transplantation","volume":"363","author":"Stahl","year":"2010","journal-title":"N\u00a0Engl J Med"},{"issue":"10","key":"10.1053\/j.ajkd.2016.01.030_bib74","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1111\/j.1600-6143.2011.03643.x","article-title":"Autoantibodies specific for the phospholipase A2 receptor in recurrent and de novo membranous nephropathy","volume":"11","author":"Debiec","year":"2011","journal-title":"Am J Transplant"},{"issue":"6","key":"10.1053\/j.ajkd.2016.01.030_bib75","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1111\/j.1600-6143.2011.03957.x","article-title":"Very early recurrence of anti-phospholipase A2 receptor-positive membranous nephropathy after transplantation","volume":"12","author":"Blosser","year":"2012","journal-title":"Am J Transplant"},{"issue":"5","key":"10.1053\/j.ajkd.2016.01.030_bib76","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/ajt.13133","article-title":"Anti-phospholipase A(2) receptor antibodies in recurrent membranous nephropathy","volume":"15","author":"Kattah","year":"2015","journal-title":"Am J Transplant"},{"issue":"8","key":"10.1053\/j.ajkd.2016.01.030_bib77","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1097\/TP.0000000000000630","article-title":"Antiphospholipase A2 receptor antibody levels predict the risk of posttransplantation recurrence of membranous nephropathy","volume":"99","author":"Quintana","year":"2015","journal-title":"Transplantation"},{"issue":"12","key":"10.1053\/j.ajkd.2016.01.030_bib78","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1093\/ndt\/gfu252","article-title":"Prediction of membranous nephropathy recurrence after transplantation by monitoring of anti-PLA2R1 (M-type phospholipase A2 receptor) autoantibodies: a case series of 15 patients","volume":"29","author":"Seitz-Polski","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"10.1053\/j.ajkd.2016.01.030_bib79","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1600-6143.2011.03818.x","article-title":"Increased risk of recurrence of membranous nephropathy after related donor kidney transplantation","volume":"12","author":"Andresdottir","year":"2012","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1053\/j.ajkd.2016.01.030_bib80","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1399-0012.2007.00741.x","article-title":"De novo membranous nephropathy associated with donor-specific alloantibody","volume":"22","author":"El Kossi","year":"2008","journal-title":"Clin Transplant"},{"issue":"2","key":"10.1053\/j.ajkd.2016.01.030_bib81","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1399-0012.2010.01213.x","article-title":"De novo membranous nephropathy and antibody-mediated rejection in transplanted kidney","volume":"25","author":"Honda","year":"2011","journal-title":"Clin Transplant"},{"issue":"3","key":"10.1053\/j.ajkd.2016.01.030_bib82","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.transproceed.2011.12.052","article-title":"C4d deposition and multilayering of peritubular capillary basement membrane in posttransplantation membranous nephropathy indicate its association with antibody-mediated injury","volume":"44","author":"Lim","year":"2012","journal-title":"Transplant Proc"},{"issue":"12","key":"10.1053\/j.ajkd.2016.01.030_bib83","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/j.1432-2277.2012.01548.x","article-title":"De novo membranous nephropathy (MN) in kidney allografts. A peculiar form of alloimmune disease?","volume":"25","author":"Ponticelli","year":"2012","journal-title":"Transpl Int"},{"issue":"10","key":"10.1053\/j.ajkd.2016.01.030_bib84","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1097\/TP.0b013e31828a947b","article-title":"Phospholipase A2 receptor (PLA2R) staining is useful in the determination of de novo versus recurrent membranous glomerulopathy","volume":"95","author":"Larsen","year":"2013","journal-title":"Transplantation"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638616007009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638616007009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T02:48:14Z","timestamp":1759459694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638616007009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0272638616007009"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2016.01.030","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Membranous Nephropathy: A Journey From Bench to Bedside","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2016.01.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}]}}