{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:48:56Z","timestamp":1790740136738,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1053\/j.ajkd.2017.04.014","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T19:00:29Z","timestamp":1496430029000},"page":"377-385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Serum Phosphorus and Risk of Cardiovascular Disease, All-Cause Mortality, or Graft Failure in Kidney Transplant Recipients: An Ancillary Study of the FAVORIT Trial Cohort"],"prefix":"10.1053","volume":"70","author":[{"given":"Basma","family":"Merhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Shireman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra A.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Kusek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Jacques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pfeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhumathi","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith C.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Joseph","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd E.","family":"Pesavento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifton E.","family":"Kew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"House","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginald","family":"Gohh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Levey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim H.","family":"Ix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bostom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.ajkd.2017.04.014_bib1","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1681\/ASN.2015020117","article-title":"Rationale and approaches to phosphate and fibroblast growth factor 23 reduction in CKD","volume":"26","author":"Isakova","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2017.04.014_bib2","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1053\/j.ajkd.2009.12.015","article-title":"Binder blinders\u2014niacin of omission?","volume":"55","author":"Bostom","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2017.04.014_bib3","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1681\/ASN.2010080894","article-title":"Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality","volume":"22","author":"Wolf","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2017.04.014_bib4","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1093\/ndt\/gfs409","article-title":"Serum level of fibroblast growth factor 23 in maintenance renal transplant patients","volume":"27","author":"S\u00e1nchez Fructuoso","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/j.ajkd.2017.04.014_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/jc.2014-3012","article-title":"Associations of 25(OH) and 1,25(OH)2 vitamin D with long-term outcomes in stable renal transplant recipients","volume":"100","author":"Keyzer","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1053\/j.ajkd.2017.04.014_bib6","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/TP.0b013e31819cd122","article-title":"Elevated serum phosphate predicts mortality in renal transplant recipients","volume":"87","author":"Connolly","year":"2009","journal-title":"Transplantation"},{"key":"10.1053\/j.ajkd.2017.04.014_bib7","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1399-0012.2010.01292.x","article-title":"Serum phosphate and calcium concentrations are associated with reduced patient survival following kidney transplantation","volume":"25","author":"Moore","year":"2011","journal-title":"Clin Transplant"},{"key":"10.1053\/j.ajkd.2017.04.014_bib8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/TP.0000000000000583","article-title":"Increased risk of all-cause mortality and renal graft loss in stable renal transplant recipients with hyperparathyroidism","volume":"99","author":"Pihlstr\u00f8m","year":"2015","journal-title":"Transplantation"},{"key":"10.1053\/j.ajkd.2017.04.014_bib9","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/kisup.2013.88","article-title":"A\u00a0phosphate-centric paradigm for pathophysiology and therapy of chronic kidney disease","volume":"3","author":"Kuro-O","year":"2013","journal-title":"Kidney Int Suppl"},{"key":"10.1053\/j.ajkd.2017.04.014_bib10","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1053\/j.ajkd.2015.01.009","article-title":"Serum phosphorus and progression of CKD and mortality: a meta-analysis of cohort studies","volume":"66","author":"Da","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2017.04.014_bib11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1432-2277.2006.00436.x","article-title":"Prognostic associations of serum calcium, phosphate and calcium phosphate concentration product with outcomes in kidney transplant recipients","volume":"20","author":"Schaeffner","year":"2007","journal-title":"Transpl Int"},{"key":"10.1053\/j.ajkd.2017.04.014_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/j.ajkd.2008.08.010","article-title":"Baseline characteristics of participants in the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) Trial","volume":"53","author":"Bostom","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2017.04.014_bib13","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1161\/CIRCULATIONAHA.110.000588","article-title":"Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial","volume":"123","author":"Bostom","year":"2011","journal-title":"Circulation"},{"key":"10.1053\/j.ajkd.2017.04.014_bib14","unstructured":"FAVORIT Data Dictionary and Analysis Manual. Version 5.0. Chapel Hill, NC: Prepared by the FAVORIT Data Coordinating Center, Collaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health University of North Carolina at Chapel Hill; February 1,\u00a02013."},{"key":"10.1053\/j.ajkd.2017.04.014_bib15","first-page":"72A","article-title":"Albuminuria and cardiovascular disease, kidney failure and death in stable kidney transplant recipients [abstract]","volume":"24","author":"John","year":"2013","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2017.04.014_bib16","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1111\/j.1600-6143.2012.04101.x","article-title":"Kidney function and risk of cardiovascular disease and mortality in kidney transplant recipients: the FAVORIT trial","volume":"12","author":"Weiner","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1053\/j.ajkd.2017.04.014_bib17","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1053\/j.ajkd.2014.01.436","article-title":"Performance of creatinine-based GFR estimating equations in solid-organ transplant recipients","volume":"63","author":"Shaffi","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/j.ajkd.2017.04.014_bib18","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1016\/j.transproceed.2012.09.041","article-title":"The effects of mineral metabolism markers on renal transplant outcomes","volume":"44","author":"Marc\u00e9n","year":"2012","journal-title":"Transplant Proc"},{"key":"10.1053\/j.ajkd.2017.04.014_bib19","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1096\/fj.09-152488","article-title":"Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging","volume":"24","author":"Ohnishi","year":"2010","journal-title":"FASEB J"},{"key":"10.1053\/j.ajkd.2017.04.014_bib20","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.2215\/CJN.00810110","article-title":"Serum phosphate and mortality in patients with chronic kidney disease","volume":"5","author":"Eddington","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2017.04.014_bib21","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/MNH.0000000000000237","article-title":"Novel assessments of systemic calcification propensity","volume":"25","author":"Pasch","year":"2016","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"2","key":"10.1053\/j.ajkd.2017.04.014_bib22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2215\/CJN.04720416","article-title":"Blood calcification propensity, cardiovascular events, and survival in patients receiving hemodialysis in the EVOLVE Trial","volume":"12","author":"Pasch","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2017.04.014_bib23","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.matbio.2004.09.007","article-title":"Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice","volume":"23","author":"Sitara","year":"2004","journal-title":"Matrix Biol"},{"key":"10.1053\/j.ajkd.2017.04.014_bib24","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1096\/fj.05-5432fje","article-title":"Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process","volume":"20","author":"Razzaque","year":"2006","journal-title":"FASEB J"},{"key":"10.1053\/j.ajkd.2017.04.014_bib25","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.2353\/ajpath.2006.060329","article-title":"Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals","volume":"169","author":"Sitara","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1053\/j.ajkd.2017.04.014_bib26","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1681\/ASN.2006121385","article-title":"Role of hyper-phosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice","volume":"18","author":"Stubbs","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2017.04.014_bib27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/path.2409","article-title":"Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23","volume":"216","author":"DeLuca","year":"2008","journal-title":"J\u00a0Pathol"},{"key":"10.1053\/j.ajkd.2017.04.014_bib28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1096\/fj.08-114397","article-title":"In\u00a0vivo genetic evidence for Klotho-dependent, fibroblast growth factor 23 (Fgf23)-mediated regulation of systemic phosphate homeostasis","volume":"23","author":"Nakatani","year":"2009","journal-title":"FASEB J"},{"key":"10.1053\/j.ajkd.2017.04.014_bib29","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1161\/CIRCGENETICS.108.847814","article-title":"In\u00a0vivo genetic evidence for suppressing vascular and soft tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin-D levels","volume":"2","author":"Ohnishi","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1053\/j.ajkd.2017.04.014_bib30","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1172\/JCI61405","article-title":"FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality","volume":"122","author":"Shalhoub","year":"2012","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.ajkd.2017.04.014_bib31","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000346784","article-title":"Phosphate toxicity and vascular mineralization","volume":"180","author":"Razzaque","year":"2013","journal-title":"Contrib Nephrol"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638617306753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638617306753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T03:03:08Z","timestamp":1759460588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638617306753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0272638617306753"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2017.04.014","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum Phosphorus and Risk of Cardiovascular Disease, All-Cause Mortality, or Graft Failure in Kidney Transplant Recipients: An Ancillary Study of the FAVORIT Trial Cohort","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2017.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}