{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:46:41Z","timestamp":1790192801065,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1053\/j.ajkd.2017.06.024","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T16:00:21Z","timestamp":1502899221000},"page":"770-777","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Living Donor Kidney Transplantation in Atypical Hemolytic Uremic Syndrome: A Case Series"],"prefix":"10.1053","volume":"70","author":[{"given":"Caroline","family":"Duineveld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobien C.","family":"Verhave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan P.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C.A.J.","family":"van de Kar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack F.M.","family":"Wetzels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1053\/j.ajkd.2017.06.024_bib1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/ajt.12077","article-title":"Complement genes strongly predict recurrence and graft outcome in adult renal transplant recipients with atypical hemolytic and uremic syndrome","volume":"13","author":"Le Quintrec","year":"2013","journal-title":"Am J Transplant"},{"issue":"14","key":"10.1053\/j.ajkd.2017.06.024_bib2","first-page":"1379","article-title":"Eculizumab in atypical hemolytic-uremic syndrome","volume":"369","author":"Legendre","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1053\/j.ajkd.2017.06.024_bib3","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1111\/j.1600-6143.2012.04252.x","article-title":"Eculizumab for atypical hemolytic uremic syndrome recurrence in renal transplantation","volume":"12","author":"Zuber","year":"2012","journal-title":"Am J Transplant"},{"issue":"3","key":"10.1053\/j.ajkd.2017.06.024_bib4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.kint.2016.10.005","article-title":"Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a \u201cKidney Disease: Improving Global Outcomes\u201d (KDIGO) Controversies Conference","volume":"91","author":"Goodship","year":"2017","journal-title":"Kidney Int"},{"issue":"11","key":"10.1053\/j.ajkd.2017.06.024_bib5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrneph.2012.214","article-title":"Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies","volume":"8","author":"Zuber","year":"2012","journal-title":"Nat Rev Nephrol"},{"issue":"5","key":"10.1053\/j.ajkd.2017.06.024_bib6","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/01.TP.0000085083.74065.1B","article-title":"Renal transplantation in patients with hemolytic uremic syndrome: high rate of recurrence and increased incidence of acute rejections","volume":"76","author":"Artz","year":"2003","journal-title":"Transplantation"},{"issue":"4","key":"10.1053\/j.ajkd.2017.06.024_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.trre.2013.07.003","article-title":"Targeted strategies in the prevention and management of atypical HUS recurrence after kidney transplantation","volume":"27","author":"Zuber","year":"2013","journal-title":"Transplant Rev"},{"issue":"7","key":"10.1053\/j.ajkd.2017.06.024_bib8","first-page":"342","article-title":"Living kidney transplantation in adult patients with atypical haemolytic uraemic syndrome","volume":"71","author":"Verhave","year":"2013","journal-title":"Neth J Med"},{"key":"10.1053\/j.ajkd.2017.06.024_bib9","unstructured":"FH aHUS mutation database. http:\/\/www.fh-hus.org\/. Accessed May 21,\u00a02017."},{"key":"10.1053\/j.ajkd.2017.06.024_bib10","unstructured":"Human Gene Mutation Database (HGMD\u00ae). http:\/\/www.hgmd.cf.ac.uk\/ac\/index.php. Accessed May 21,\u00a02017."},{"issue":"6","key":"10.1053\/j.ajkd.2017.06.024_bib11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11906-014-0431-2","article-title":"Nguyen Dinh Cat A. Angiotensin II and vascular injury","volume":"16","author":"Montezano","year":"2014","journal-title":"Curr Hypertens Rep"},{"issue":"1","key":"10.1053\/j.ajkd.2017.06.024_bib12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2215\/CJN.00050505","article-title":"Outcome of renal transplanation in patients with non-Shiga toxin-associated hemolytic uremic syndrome: prognostic significance of genetic background","volume":"1","author":"Bresin","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"10.1053\/j.ajkd.2017.06.024_bib13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1600-6143.2005.01184.x","article-title":"Calcineurin inhibitor-free immunosuppression in renal allograft recipients with thrombotic microangiopathy\/hemolytic uremic syndrome","volume":"6","author":"\u00d8yen","year":"2006","journal-title":"Am J Transplant"},{"issue":"11","key":"10.1053\/j.ajkd.2017.06.024_bib14","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1097\/TP.0000000000000200","article-title":"Atypical hemolytic uremic syndrome recurrence after kidney transplantation","volume":"98","author":"Matar","year":"2014","journal-title":"Transplantation"},{"issue":"32","key":"10.1053\/j.ajkd.2017.06.024_bib15","doi-asserted-by":"crossref","first-page":"i115","DOI":"10.1093\/ndt\/gfw353","article-title":"Cost-effectiveness of eculizumab treatment after kidney transplantation in patients with atypical haemolytic uraemic syndrome","volume":"1","author":"Van den Brand","year":"2017","journal-title":"Nephrol Dial Transplant"},{"issue":"18","key":"10.1053\/j.ajkd.2017.06.024_bib16","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1182\/blood-2011-10-383281","article-title":"A\u00a0prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function","volume":"119","author":"Roumenina","year":"2012","journal-title":"Blood"},{"issue":"9","key":"10.1053\/j.ajkd.2017.06.024_bib17","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s00467-012-2183-z","article-title":"Novel C3 mutation p.Lys65Gln in aHUS affects complement factor H binding","volume":"27","author":"Volokhina","year":"2012","journal-title":"Pediatr Nephrol"},{"issue":"8","key":"10.1053\/j.ajkd.2017.06.024_bib18","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1172\/JCI16651","article-title":"Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome","volume":"111","author":"Manuelian","year":"2003","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.ajkd.2017.06.024_bib19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.molimm.2016.01.003","article-title":"Genetic analysis and functional characterization of novel mutations in a series of patients with atypical hemolytic uremic syndrome","volume":"71","author":"Szarvas","year":"2016","journal-title":"Mol Immunol"},{"issue":"2","key":"10.1053\/j.ajkd.2017.06.024_bib20","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.molimm.2015.02.013","article-title":"Functional characterization of two novel non-synonymous alterations in CD46 and a Q950H change in factor H found in atypical hemolytic uremic syndrome patients","volume":"65","author":"Mohlin","year":"2015","journal-title":"Mol Immunol"},{"issue":"7","key":"10.1053\/j.ajkd.2017.06.024_bib21","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1093\/ndt\/gfq010","article-title":"Genetic disorders in complement (regulating) genes in patients with atypical haemolytic uraemic syndrome (aHUS)","volume":"25","author":"Westra","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"10.1053\/j.ajkd.2017.06.024_bib22","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.semnephrol.2013.08.003","article-title":"Atypical hemolytic uremic syndrome","volume":"33","author":"Kavanagh","year":"2013","journal-title":"Semin Nephrol"},{"key":"10.1053\/j.ajkd.2017.06.024_bib23","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1186\/1471-2105-11-548","article-title":"Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfaces","volume":"11","author":"Venselaar","year":"2010","journal-title":"BMC Bioinform"},{"issue":"23","key":"10.1053\/j.ajkd.2017.06.024_bib24","doi-asserted-by":"crossref","first-page":"15650","DOI":"10.1074\/jbc.M900814200","article-title":"Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome","volume":"284","author":"Lehtinen","year":"2009","journal-title":"J\u00a0Biol Chem"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638617308363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638617308363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T02:59:19Z","timestamp":1759460359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638617308363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0272638617308363"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2017.06.024","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Living Donor Kidney Transplantation in Atypical Hemolytic Uremic Syndrome: A Case Series","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2017.06.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}]}}