{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:46:05Z","timestamp":1782186365133,"version":"3.54.5"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-47060"],"award-info":[{"award-number":["R01-47060"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1053\/j.ajkd.2018.06.032","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T13:41:45Z","timestamp":1539006105000},"page":"273-277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["CKD Due to a Novel Mitochondrial DNA Mutation: A Case Report"],"prefix":"10.1053","volume":"73","author":[{"given":"Fernando C.","family":"Fervenza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralitza H.","family":"Gavrilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samih H.","family":"Nasr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V.","family":"Irazabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl A.","family":"Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1053\/j.ajkd.2018.06.032_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0272-6386(12)80312-X","article-title":"Tubulointerstitial changes as a major determinant in\u00a0the progression of renal damage","volume":"20","author":"Nath","year":"1992","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"10.1053\/j.ajkd.2018.06.032_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrneph.2015.214","article-title":"Mitochondrial dysfunction in inherited renal disease and acute kidney injury","volume":"12","author":"Emma","year":"2016","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"10.1053\/j.ajkd.2018.06.032_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cell.2008.06.016","article-title":"A\u00a0mitochondrial protein compendium elucidates complex I disease biology","volume":"134","author":"Pagliarini","year":"2008","journal-title":"Cell"},{"issue":"1","key":"10.1053\/j.ajkd.2018.06.032_bib4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1046\/j.1523-1755.1998.00731.x","article-title":"Intracellular targets in heme protein-induced renal injury","volume":"53","author":"Nath","year":"1998","journal-title":"Kidney Int"},{"issue":"10","key":"10.1053\/j.ajkd.2018.06.032_bib5","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1681\/ASN.2017030247","article-title":"Pharmacologic approaches to improve mitochondrial function in AKI and CKD","volume":"28","author":"Szeto","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"4","key":"10.1053\/j.ajkd.2018.06.032_bib6","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ki.1997.140","article-title":"The kidney in mitochondrial cytopathies","volume":"51","author":"Niaudet","year":"1997","journal-title":"Kidney Int"},{"issue":"2","key":"10.1053\/j.ajkd.2018.06.032_bib7","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/PAS.0b013e3181cb4ed3","article-title":"Granular swollen epithelial cells: a histologic and diagnostic marker for mitochondrial nephropathy","volume":"34","author":"Kobayashi","year":"2010","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1053\/j.ajkd.2018.06.032_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1053\/ajkd.2003.50068","article-title":"A\u00a014-year-old male with asymptomatic proteinuria and hearing loss","volume":"41","author":"Nasr","year":"2003","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"10.1053\/j.ajkd.2018.06.032_bib9","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1038\/ki.1994.181","article-title":"Mitochondrial DNA deletion: a cause of chronic tubulointerstitial nephropathy","volume":"45","author":"Szabolcs","year":"1994","journal-title":"Kidney Int"},{"issue":"9","key":"10.1053\/j.ajkd.2018.06.032_bib10","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00467-005-1948-z","article-title":"Renal pathology\u00a0in children with mitochondrial diseases","volume":"20","author":"Martin-Hernandez","year":"2005","journal-title":"Pediatr Nephrol"},{"issue":"6","key":"10.1053\/j.ajkd.2018.06.032_bib11","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1053\/j.ajkd.2016.06.027","article-title":"MELAS syndrome and kidney disease without Fanconi syndrome or proteinuria: a case report","volume":"68","author":"Rudnicki","year":"2016","journal-title":"Am J Kidney Dis"},{"issue":"5806","key":"10.1053\/j.ajkd.2018.06.032_bib12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/290457a0","article-title":"Sequence and organization of the human mitochondrial genome","volume":"290","author":"Anderson","year":"1981","journal-title":"Nature"},{"issue":"26","key":"10.1053\/j.ajkd.2018.06.032_bib13","doi-asserted-by":"crossref","first-page":"14900","DOI":"10.1073\/pnas.94.26.14900","article-title":"Ancient mtDNA sequences in the human nuclear genome: a potential source of errors in identifying pathogenic mutations","volume":"94","author":"Wallace","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1053\/j.ajkd.2018.06.032_bib14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0002-9343(00)00612-4","article-title":"Reactive oxygen species and acute renal failure","volume":"109","author":"Nath","year":"2000","journal-title":"Am J Med"},{"issue":"6","key":"10.1053\/j.ajkd.2018.06.032_bib15","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1046\/j.1523-1755.2000.00101.x","article-title":"Renal response to repetitive exposure to heme proteins: chronic injury induced by an acute insult","volume":"57","author":"Nath","year":"2000","journal-title":"Kidney Int"},{"issue":"3","key":"10.1053\/j.ajkd.2018.06.032_bib16","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1086\/302546","article-title":"A\u00a0stop-codon mutation in the human mtDNA cytochrome c oxidase I gene disrupts the functional structure of complex IV","volume":"65","author":"Bruno","year":"1999","journal-title":"Am J Hum Genet"},{"issue":"5","key":"10.1053\/j.ajkd.2018.06.032_bib17","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1212\/WNL.55.5.644","article-title":"Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA","volume":"55","author":"Karadimas","year":"2000","journal-title":"Neurology"},{"issue":"1","key":"10.1053\/j.ajkd.2018.06.032_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10048-005-0015-z","article-title":"Introducing a novel human mtDNA mutation into the Paracoccus denitrificans COX I gene explains functional deficits in a patient","volume":"7","author":"Lucioli","year":"2006","journal-title":"Neurogenetics"},{"issue":"16","key":"10.1053\/j.ajkd.2018.06.032_bib19","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1093\/hmg\/11.16.1797","article-title":"Metabolic consequences of a novel missense mutation of the mtDNA CO I gene","volume":"11","author":"Varlamov","year":"2002","journal-title":"Hum Mol Genet"},{"issue":"11","key":"10.1053\/j.ajkd.2018.06.032_bib20","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1136\/jmg.35.11.895","article-title":"A\u00a0systematic mutation screen of 10 nuclear and 25 mitochondrial candidate genes in 21 patients with cytochrome c oxidase (COX) deficiency shows tRNA(Ser)(UCN) mutations in a subgroup with syndromal encephalopathy","volume":"35","author":"Jaksch","year":"1998","journal-title":"J\u00a0Med Genet"},{"issue":"2","key":"10.1053\/j.ajkd.2018.06.032_bib21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/1440-1681.12034","article-title":"Determinants of kidney oxygen consumption and their relationship to tissue oxygen tension in diabetes and hypertension","volume":"40","author":"Hansell","year":"2013","journal-title":"Clin Exp Pharmacol Physiol"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638618308400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638618308400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T03:17:36Z","timestamp":1759461456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638618308400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0272638618308400"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2018.06.032","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CKD Due to a Novel Mitochondrial DNA Mutation: A Case Report","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2018.06.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}]}}