{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:18:09Z","timestamp":1791001089169,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1053\/j.ajkd.2019.11.010","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T03:38:26Z","timestamp":1581046706000},"page":"508-512","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["AKI\u2014A Relevant Safety End Point?"],"prefix":"10.1053","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6470-6959","authenticated-orcid":false,"given":"Ian E.","family":"McCoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn M.","family":"Chertow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1053\/j.ajkd.2019.11.010_bib1","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1001\/jama.2014.11100","article-title":"The PCORI perspective on patient-centered outcomes research","volume":"312","author":"Frank","year":"2014","journal-title":"JAMA"},{"issue":"4","key":"10.1053\/j.ajkd.2019.11.010_bib2","doi-asserted-by":"crossref","first-page":"R204","DOI":"10.1186\/cc2872","article-title":"Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group","volume":"8","author":"Bellomo","year":"2004","journal-title":"Crit Care"},{"issue":"1","key":"10.1053\/j.ajkd.2019.11.010_bib3","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury","volume":"2","year":"2012","journal-title":"Kidney Int Suppl"},{"issue":"11","key":"10.1053\/j.ajkd.2019.11.010_bib4","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1681\/ASN.2004090740","article-title":"Acute kidney injury, mortality, length of stay, and costs in hospitalized patients","volume":"16","author":"Chertow","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"5","key":"10.1053\/j.ajkd.2019.11.010_bib5","doi-asserted-by":"crossref","first-page":"966","DOI":"10.2215\/CJN.08781010","article-title":"Fluid balance, diuretic use, and mortality in acute kidney injury","volume":"6","author":"Grams","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"issue":"9","key":"10.1053\/j.ajkd.2019.11.010_bib6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1056\/NEJMoa1005419","article-title":"Diuretic strategies in patients with acute decompensated heart failure","volume":"364","author":"Felker","year":"2011","journal-title":"N\u00a0Engl J Med"},{"issue":"19","key":"10.1053\/j.ajkd.2019.11.010_bib7","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1161\/CIRCULATIONAHA.117.030112","article-title":"Worsening renal function in patients with acute heart failure undergoing aggressive diuresis is not associated with tubular injury","volume":"137","author":"Ahmad","year":"2018","journal-title":"Circulation"},{"issue":"10","key":"10.1053\/j.ajkd.2019.11.010_bib8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cardfail.2016.06.423","article-title":"Relevance of changes in serum creatinine during a heart failure trial of decongestive strategies: insights from the DOSE Trial","volume":"22","author":"Brisco","year":"2016","journal-title":"J\u00a0Card Fail"},{"issue":"6","key":"10.1053\/j.ajkd.2019.11.010_bib9","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005552","article-title":"Renal effects of intensive volume removal in heart failure patients with preexisting worsening renal function","volume":"12","author":"Rao","year":"2019","journal-title":"Circ Heart Fail"},{"issue":"3","key":"10.1053\/j.ajkd.2019.11.010_bib10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/ki.2011.79","article-title":"An acute fall in estimated glomerular filtration rate during treatment with losartan predicts a slower decrease in long-term renal function","volume":"80","author":"Holtkamp","year":"2011","journal-title":"Kidney Int"},{"issue":"8","key":"10.1053\/j.ajkd.2019.11.010_bib11","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1681\/ASN.2018121261","article-title":"Implications of early decline in eGFR due to intensive BP control for cardiovascular outcomes in SPRINT","volume":"30","author":"Beddhu","year":"2019","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"1","key":"10.1053\/j.ajkd.2019.11.010_bib12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/HYPERTENSIONAHA.118.12060","article-title":"Acute increases in serum creatinine after starting angiotensin-converting enzyme inhibitor-based therapy and effects of its continuation on major clinical outcomes in type 2 diabetes mellitus","volume":"73","author":"Ohkuma","year":"2019","journal-title":"Hypertension"},{"issue":"6","key":"10.1053\/j.ajkd.2019.11.010_bib13","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1161\/CIRCHEARTFAILURE.111.963256","article-title":"Prognostic importance of early worsening renal function after initiation of angiotensin-converting enzyme inhibitor therapy in patients with cardiac dysfunction","volume":"4","author":"Testani","year":"2011","journal-title":"Circ Heart Fail"},{"issue":"9","key":"10.1053\/j.ajkd.2019.11.010_bib14","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.2215\/CJN.03060319","article-title":"Association of acute increases in plasma creatinine after renin-angiotensin blockade with subsequent outcomes","volume":"14","author":"Fu","year":"2019","journal-title":"Clin J Am Soc Nephrol"},{"issue":"9","key":"10.1053\/j.ajkd.2019.11.010_bib15","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.amjmed.2007.02.025","article-title":"Prerenal success in chronic kidney disease","volume":"120","author":"Hirsch","year":"2007","journal-title":"Am J Med"},{"issue":"5","key":"10.1053\/j.ajkd.2019.11.010_bib16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/ki.2011.405","article-title":"Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury","volume":"81","author":"Bucaloiu","year":"2012","journal-title":"Kidney Int"},{"issue":"4","key":"10.1053\/j.ajkd.2019.11.010_bib17","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1681\/ASN.2006070756","article-title":"Incidence and outcomes in acute kidney injury: a comprehensive population-based study","volume":"18","author":"Ali","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"8","key":"10.1053\/j.ajkd.2019.11.010_bib18","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s00134-015-3934-7","article-title":"Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study","volume":"41","author":"Hoste","year":"2015","journal-title":"Intensive Care Med"},{"issue":"6","key":"10.1053\/j.ajkd.2019.11.010_bib19","first-page":"579","article-title":"Disentanglement of the acute kidney injury syndrome","volume":"18","author":"Chawla","year":"2012","journal-title":"Curr Opin Crit Care"},{"issue":"5","key":"10.1053\/j.ajkd.2019.11.010_bib20","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/sj.ki.5002743","article-title":"The RIFLE criteria and mortality in acute kidney injury: a systematic review","volume":"73","author":"Ricci","year":"2008","journal-title":"Kidney Int"},{"issue":"3","key":"10.1053\/j.ajkd.2019.11.010_bib21","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jacc.2011.10.854","article-title":"Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study","volume":"59","author":"Nickolas","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"5","key":"10.1053\/j.ajkd.2019.11.010_bib22","doi-asserted-by":"crossref","first-page":"844","DOI":"10.2215\/CJN.12791211","article-title":"Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology","volume":"7","author":"Palevsky","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"issue":"9","key":"10.1053\/j.ajkd.2019.11.010_bib23","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1056\/NEJMoa1711586","article-title":"Balanced crystalloids versus saline in noncritically ill adults","volume":"378","author":"Self","year":"2018","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1053\/j.ajkd.2019.11.010_bib24","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMoa1711584","article-title":"Balanced crystalloids versus saline in critically ill adults","volume":"378","author":"Semler","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.ajkd.2019.11.010_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jcrc.2019.07.004","article-title":"Hypotension within one-hour from starting CRRT is associated with in-hospital mortality","volume":"54","author":"Shawwa","year":"2019","journal-title":"J\u00a0Crit Care"},{"issue":"3","key":"10.1053\/j.ajkd.2019.11.010_bib26","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1681\/ASN.2017060694","article-title":"Long-term clinical outcomes after early initiation of RRT in critically ill patients with AKI","volume":"29","author":"Meersch","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2019.11.010_bib27","first-page":"1","article-title":"Fluid overload associates with major adverse kidney events in critically ill patients with acute kidney injury requiring continuous renal replacement therapy","author":"Woodward","year":"2019","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1053\/j.ajkd.2019.11.010_bib28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneph.2017.184","article-title":"Paradigms of acute kidney injury in the intensive care setting","volume":"14","author":"Kellum","year":"2018","journal-title":"Nat Rev Nephrol"},{"issue":"4","key":"10.1053\/j.ajkd.2019.11.010_bib29","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000469669","article-title":"Serum creatinine: not so simple!","volume":"136","author":"Delanaye","year":"2017","journal-title":"Nephron"},{"issue":"12","key":"10.1053\/j.ajkd.2019.11.010_bib30","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1136\/heartjnl-2018-314158","article-title":"Change in renal function associated with drug treatment in heart failure: national guidance","volume":"105","author":"Clark","year":"2019","journal-title":"Heart"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638619311680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638619311680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T03:27:33Z","timestamp":1759462053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638619311680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0272638619311680"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2019.11.010","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AKI\u2014A Relevant Safety End Point?","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2019.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}]}}