{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:08:41Z","timestamp":1793124521651,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100014240","name":"American Kidney Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014240","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1053\/j.ajkd.2020.05.017","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T03:59:11Z","timestamp":1594871951000},"page":"765-774","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":136,"title":["The Difference Between Cystatin C\u2013 and Creatinine-Based Estimated GFR and Associations With Frailty and Adverse Outcomes: A Cohort Analysis of the Systolic Blood Pressure Intervention Trial (SPRINT)"],"prefix":"10.1053","volume":"76","author":[{"given":"O. Alison","family":"Potok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim H.","family":"Ix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Shlipak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amret T.","family":"Hawfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Rocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter T.","family":"Ambrosius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique E.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Pajewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjay","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dena E.","family":"Rifkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1053\/j.ajkd.2020.05.017_bib1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/ndt\/gfl744","article-title":"Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul Study","volume":"22","author":"Singh","year":"2007","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"10.1053\/j.ajkd.2020.05.017_bib2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1053\/j.ajkd.2013.03.027","article-title":"Update on cystatin C: incorporation into clinical practice","volume":"62","author":"Shlipak","year":"2013","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"10.1053\/j.ajkd.2020.05.017_bib3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1681\/ASN.2011030288","article-title":"Cystatin C is more than GFR, and this may be a good thing","volume":"22","author":"Rule","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"6","key":"10.1053\/j.ajkd.2020.05.017_bib4","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/ki.2008.638","article-title":"Factors other than glomerular filtration rate affect serum cystatin C levels","volume":"75","author":"Stevens","year":"2009","journal-title":"Kidney Int"},{"issue":"1","key":"10.1053\/j.ajkd.2020.05.017_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1053\/ajkd.2000.8237","article-title":"Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment","volume":"36","author":"Coll","year":"2000","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1053\/j.ajkd.2020.05.017_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa1114248","article-title":"Estimating glomerular filtration rate from serum creatinine and cystatin C","volume":"367","author":"Inker","year":"2012","journal-title":"N\u00a0Engl J Med"},{"issue":"23","key":"10.1053\/j.ajkd.2020.05.017_bib7","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1056\/NEJMra054415","article-title":"Assessing kidney function \u2014 measured and estimated glomerular filtration rate","volume":"354","author":"Stevens","year":"2006","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1053\/j.ajkd.2020.05.017_bib8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1053\/j.ajkd.2016.08.034","article-title":"Frailty, kidney function, and polypharmacy: the Atherosclerosis Risk in Communities (ARIC) Study","volume":"69","author":"Ballew","year":"2017","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1053\/j.ajkd.2020.05.017_bib9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/s12882-017-0759-3","article-title":"Prevalence and determinants of differences in cystatin C and creatinine-based estimated glomerular filtration rate in community-dwelling older adults: a cross-sectional study","volume":"18","author":"Legrand","year":"2017","journal-title":"BMC Nephrol"},{"issue":"22","key":"10.1053\/j.ajkd.2020.05.017_bib10","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A\u00a0randomized trial of intensive versus standard blood-pressure control","volume":"373","author":"Wright","year":"2015","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1053\/j.ajkd.2020.05.017_bib11","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1177\/1740774514537404","article-title":"The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT)","volume":"11","author":"Ambrosius","year":"2014","journal-title":"Clin Trials"},{"issue":"5","key":"10.1053\/j.ajkd.2020.05.017_bib12","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/gerona\/glv228","article-title":"Characterizing frailty status in the Systolic Blood Pressure Intervention Trial","volume":"71","author":"Pajewski","year":"2016","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"issue":"24","key":"10.1053\/j.ajkd.2020.05.017_bib13","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1001\/jama.2016.7050","article-title":"Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged\u00a0\u226575 years: a randomized clinical trial","volume":"315","author":"Williamson","year":"2016","journal-title":"JAMA"},{"key":"10.1053\/j.ajkd.2020.05.017_bib14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2318-8-24","article-title":"A\u00a0standard procedure for creating a frailty index","volume":"8","author":"Searle","year":"2008","journal-title":"BMC Geriatr"},{"issue":"9","key":"10.1053\/j.ajkd.2020.05.017_bib15","first-page":"10","article-title":"Validation of an index to estimate the prevalence of frailty among community-dwelling seniors","volume":"24","author":"Hoover","year":"2013","journal-title":"Health Rep"},{"issue":"4","key":"10.1053\/j.ajkd.2020.05.017_bib16","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1001\/jamainternmed.2016.9104","article-title":"Effect of intensive blood pressure control on gait speed and mobility limitation in adults 75 years or older: a randomized clinical trial","volume":"177","author":"Odden","year":"2017","journal-title":"JAMA Intern Med"},{"issue":"1","key":"10.1053\/j.ajkd.2020.05.017_bib17","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12877-016-0349-4","article-title":"Sarcopenia in daily practice: assessment and management","volume":"16","author":"Beaudart","year":"2016","journal-title":"BMC Geriatr"},{"issue":"5","key":"10.1053\/j.ajkd.2020.05.017_bib18","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1161\/HYPERTENSIONAHA.117.10479","article-title":"Blood Pressure Measurement in the Systolic Blood Pressure Intervention Trial (SPRINT)","volume":"71","year":"2018","journal-title":"Hypertension"},{"issue":"6","key":"10.1053\/j.ajkd.2020.05.017_bib19","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1053\/j.ajkd.2020.05.018","article-title":"The difference between cystatin C and creatinine-based estimated GFR and incident frailty: an analysis of the Cardiovascular Health Study (CHS)","volume":"76","author":"Potok","year":"2020","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1053\/j.ajkd.2020.05.017_bib20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10741-014-9460-9","article-title":"Chronic kidney disease and cardiovascular complications","volume":"20","author":"Di Lullo","year":"2015","journal-title":"Heart Fail Rev"},{"issue":"1","key":"10.1053\/j.ajkd.2020.05.017_bib21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1681\/ASN.2010050483","article-title":"Cystatin C identifies chronic kidney disease patients at higher risk for complications","volume":"22","author":"Peralta","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"4","key":"10.1053\/j.ajkd.2020.05.017_bib22","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"},{"issue":"5","key":"10.1053\/j.ajkd.2020.05.017_bib23","doi-asserted-by":"crossref","first-page":"648","DOI":"10.4103\/ijmr.IJMR_1777_18","article-title":"Body composition techniques","volume":"148","author":"Kuriyan","year":"2018","journal-title":"Indian J Med Res"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638620307873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638620307873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T03:27:56Z","timestamp":1759462076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638620307873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0272638620307873"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2020.05.017","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Difference Between Cystatin C\u2013 and Creatinine-Based Estimated GFR and Associations With Frailty and Adverse Outcomes: A Cohort Analysis of the Systolic Blood Pressure Intervention Trial (SPRINT)","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2020.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}]}}