{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:45:20Z","timestamp":1779335120738,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T00:00:00Z","timestamp":1671235200000},"content-version":"am","delay-in-days":350,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","ajkd.org","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1053\/j.ajkd.2021.03.021","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T04:56:09Z","timestamp":1622177769000},"page":"36-44.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study"],"prefix":"10.1053","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-079X","authenticated-orcid":false,"given":"Jordana B.","family":"Cohen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihe","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajat","family":"Deo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P.","family":"Lash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboob","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Shafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie L.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Shlipak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myles","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan S.","family":"Go","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold I.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence J.","family":"Appel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panduranga S.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vallabh O.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond R.","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Unruh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1053\/j.ajkd.2021.03.021_bib2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1053\/j.ajkd.2014.09.023","article-title":"The future burden of CKD in the United States: a simulation model for the CDC CKD Initiative","volume":"65","author":"Hoerger","year":"2015","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"10.1053\/j.ajkd.2021.03.021_bib3","article-title":"Risk factors for heart failure in patients with chronic kidney disease: the CRIC (Chronic Renal Insufficiency Cohort) study","volume":"6","author":"He","year":"2017","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"2","key":"10.1053\/j.ajkd.2021.03.021_bib4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1053\/j.ajkd.2012.03.011","article-title":"Combined association of albuminuria and cystatin C-based estimated GFR with mortality, coronary heart disease, and heart failure outcomes: the Atherosclerosis Risk in Communities (ARIC) study","volume":"60","author":"Waheed","year":"2012","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"10.1053\/j.ajkd.2021.03.021_bib5","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.2215\/CJN.09741110","article-title":"Associations among estimated glomerular filtration rate, proteinuria, and adverse cardiovascular outcomes","volume":"6","author":"Bello","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"10.1053\/j.ajkd.2021.03.021_bib6","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1681\/ASN.2006101159","article-title":"Reduced kidney function as a risk factor for incident heart failure: the atherosclerosis risk in communities (ARIC) study","volume":"18","author":"Kottgen","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"12","key":"10.1053\/j.ajkd.2021.03.021_bib7","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1093\/ndt\/gfw218","article-title":"Markers of kidney disease and risk of subclinical and clinical heart failure in African Americans: the Jackson Heart Study","volume":"31","author":"Bansal","year":"2016","journal-title":"Nephrol Dial Transplant"},{"issue":"9889","key":"10.1053\/j.ajkd.2021.03.021_bib8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0140-6736(13)60595-4","article-title":"Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention","volume":"382","author":"Gansevoort","year":"2013","journal-title":"Lancet"},{"issue":"3","key":"10.1053\/j.ajkd.2021.03.021_bib9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1053\/j.ajkd.2018.09.012","article-title":"Use of measures of inflammation and kidney function for prediction of atherosclerotic vascular disease events and death in patients with CKD: findings from the CRIC study","volume":"73","author":"Amdur","year":"2019","journal-title":"Am J Kidney Dis"},{"issue":"11","key":"10.1053\/j.ajkd.2021.03.021_bib10","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1038\/s41591-019-0627-8","article-title":"Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease","volume":"25","author":"Lees","year":"2019","journal-title":"Nat Med"},{"issue":"9731","key":"10.1053\/j.ajkd.2021.03.021_bib11","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0140-6736(10)60674-5","article-title":"Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality: a collaborative meta-analysis of general population cohorts","volume":"375","author":"Matsushita","year":"2010","journal-title":"Lancet"},{"issue":"12","key":"10.1053\/j.ajkd.2021.03.021_bib12","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ki.2010.536","article-title":"Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts","volume":"79","author":"van der Velde","year":"2011","journal-title":"Kidney Int"},{"issue":"9854","key":"10.1053\/j.ajkd.2021.03.021_bib13","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/S0140-6736(12)61350-6","article-title":"Chronic Kidney Disease Prognosis Consortium. Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis","volume":"380","author":"Fox","year":"2012","journal-title":"Lancet"},{"issue":"4","key":"10.1053\/j.ajkd.2021.03.021_bib14","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.kint.2016.09.049","article-title":"Diagnosis and management of atherosclerotic cardiovascular disease in chronic kidney disease: a review","volume":"91","author":"Mathew","year":"2017","journal-title":"Kidney Int"},{"issue":"3","key":"10.1053\/j.ajkd.2021.03.021_bib15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1161\/CIRCULATIONAHA.109.865352","volume":"121","author":"Fox","year":"2010","journal-title":"Circulation"},{"issue":"7","key":"10.1053\/j.ajkd.2021.03.021_bib16","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S2213-8587(15)00040-6","article-title":"Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data","volume":"3","author":"Matsushita","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10","key":"10.1053\/j.ajkd.2021.03.021_bib17","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1001\/jama.289.10.1278","article-title":"Central challenges facing the national clinical research enterprise","volume":"289","author":"Sung","year":"2003","journal-title":"JAMA"},{"issue":"7 suppl 2","key":"10.1053\/j.ajkd.2021.03.021_bib18","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1097\/01.ASN.0000070149.78399.CE","article-title":"The Chronic Renal Insufficiency Cohort (CRIC) study: design and methods","volume":"14","author":"Feldman","year":"2003","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"8","key":"10.1053\/j.ajkd.2021.03.021_bib19","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.2215\/CJN.00070109","article-title":"Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function","volume":"4","author":"Lash","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"10.1053\/j.ajkd.2021.03.021_bib20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1053\/j.ajkd.2012.04.012","article-title":"Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) study","volume":"60","author":"Anderson","year":"2012","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"10.1053\/j.ajkd.2021.03.021_bib21","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1159\/000296250","article-title":"Variability of creatinine measurements in clinical laboratories: results from the CRIC study","volume":"31","author":"Joffe","year":"2010","journal-title":"Am J Nephrol"},{"issue":"11","key":"10.1053\/j.ajkd.2021.03.021_bib22","first-page":"e596","article-title":"2019 ACC\/AHA Guideline on the Primary Prevention of Cardiovascular Disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"140","author":"Arnett","year":"2019","journal-title":"Circulation"},{"issue":"23","key":"10.1053\/j.ajkd.2021.03.021_bib23","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1001\/jama.2011.826","article-title":"Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease","volume":"305","author":"Isakova","year":"2011","journal-title":"JAMA"},{"issue":"4","key":"10.1053\/j.ajkd.2021.03.021_bib24","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1053\/j.ajkd.2013.01.017","article-title":"Association of serum bicarbonate with risk of renal and cardiovascular outcomes in CKD: a report from the Chronic Renal Insufficiency Cohort (CRIC) study","volume":"62","author":"Dobre","year":"2013","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1053\/j.ajkd.2021.03.021_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/01.CIR.88.1.107","article-title":"Survival after the onset of congestive heart failure in Framingham Heart Study subjects","volume":"88","author":"Ho","year":"1993","journal-title":"Circulation"},{"issue":"2","key":"10.1053\/j.ajkd.2021.03.021_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s12561-016-9183-7","article-title":"Dynamic prediction of renal failure using longitudinal biomarkers in a cohort study of chronic kidney disease","volume":"9","author":"Li","year":"2017","journal-title":"Stat Biosci"},{"issue":"11","key":"10.1053\/j.ajkd.2021.03.021_bib27","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1177\/0962280220921553","article-title":"Dynamic prediction of competing risk events using landmark sub-distribution hazard model with multiple longitudinal biomarkers","volume":"29","author":"Wu","year":"2020","journal-title":"Stat Methods Med Res"},{"issue":"21","key":"10.1053\/j.ajkd.2021.03.021_bib28","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1002\/sim.4780132105","article-title":"Cox regression analysis of multivariate failure time data: the marginal approach","volume":"13","author":"Lin","year":"1994","journal-title":"Stat Med"},{"issue":"4","key":"10.1053\/j.ajkd.2021.03.021_bib29","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1053\/j.ajkd.2017.01.004","article-title":"From static to dynamic risk prediction: time is everything","volume":"69","author":"Greene","year":"2017","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"10.1053\/j.ajkd.2021.03.021_bib30","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2215\/CJN.10101014","article-title":"Change in multiple filtration markers and subsequent risk of cardiovascular disease and mortality","volume":"10","author":"Rebholz","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"issue":"12","key":"10.1053\/j.ajkd.2021.03.021_bib31","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1681\/ASN.2009010025","article-title":"Change in estimated GFR associates with coronary heart disease and mortality","volume":"20","author":"Matsushita","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"4","key":"10.1053\/j.ajkd.2021.03.021_bib32","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/ki.2012.443","article-title":"Change in the estimated glomerular filtration rate over time and risk of all-cause mortality","volume":"83","author":"Turin","year":"2013","journal-title":"Kidney Int"},{"issue":"24","key":"10.1053\/j.ajkd.2021.03.021_bib33","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1001\/jama.2014.6634","article-title":"Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality","volume":"311","author":"Coresh","year":"2014","journal-title":"JAMA"},{"issue":"8","key":"10.1053\/j.ajkd.2021.03.021_bib34","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.2215\/CJN.00470111","article-title":"GFR decline and mortality risk among patients with chronic kidney disease","volume":"6","author":"Perkins","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"issue":"12","key":"10.1053\/j.ajkd.2021.03.021_bib35","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1681\/ASN.2009050546","article-title":"Rapid decline of kidney function increases cardiovascular risk in the elderly","volume":"20","author":"Shlipak","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"20","key":"10.1053\/j.ajkd.2021.03.021_bib36","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1001\/archinte.168.20.2212","article-title":"Rapid kidney function decline and mortality risk in older adults","volume":"168","author":"Rifkin","year":"2008","journal-title":"Arch Intern Med"},{"issue":"21","key":"10.1053\/j.ajkd.2021.03.021_bib37","article-title":"Change of kidney function is associated with all-cause mortality and cardiovascular diseases: results from the Kailuan study","volume":"7","author":"Guo","year":"2018","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"3","key":"10.1053\/j.ajkd.2021.03.021_bib38","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2215\/CJN.04650514","article-title":"Development and validation of a model to predict 5-year risk of death without ESRD among older adults with CKD","volume":"10","author":"Bansal","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"issue":"12","key":"10.1053\/j.ajkd.2021.03.021_bib39","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1681\/ASN.2020040476","article-title":"Slope of kidney function and its association with longitudinal mortality and cardiovascular disease among individuals with CKD","volume":"31","author":"Orlandi","year":"2020","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"3","key":"10.1053\/j.ajkd.2021.03.021_bib40","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/CIRCOUTCOMES.110.957951","article-title":"Landmark analysis at the 25-year landmark point","volume":"4","author":"Dafni","year":"2011","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"4","key":"10.1053\/j.ajkd.2021.03.021_bib41","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1681\/ASN.2014010108","article-title":"High-sensitivity troponin T and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and risk of incident heart failure in patients with CKD: the Chronic Renal Insufficiency Cohort (CRIC) study","volume":"26","author":"Bansal","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"5","key":"10.1053\/j.ajkd.2021.03.021_bib42","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jacc.2009.07.069","article-title":"Dynamic cardiovascular risk assessment in elderly people. The role of repeated N-terminal pro-B-type natriuretic peptide testing","volume":"55","author":"deFilippi","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"}],"updated-by":[{"DOI":"10.1053\/j.ajkd.2022.04.001","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000}}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638621006296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638621006296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T19:09:16Z","timestamp":1680894556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638621006296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0272638621006296"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2021.03.021","relation":{"erratum":[{"id-type":"doi","id":"10.1053\/j.ajkd.2022.04.001","asserted-by":"object"}]},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2021.03.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}]}}