{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:35:41Z","timestamp":1790922941018,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004937","name":"Bundesministerium f\u00fcr Bildung und Forschung Dienststelle Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1053\/j.ajkd.2022.01.424","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T11:10:40Z","timestamp":1646997040000},"page":"483-494.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Heart-Type Fatty Acid Binding Protein, Cardiovascular Outcomes, and Death: Findings From the German CKD Cohort Study"],"prefix":"10.1053","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5265-8088","authenticated-orcid":false,"given":"Markus P.","family":"Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Nadal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Krane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Floege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turgay","family":"Saritas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Stockmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Meiselbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Nauck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Kronenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Uwe","family":"Eckardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Schiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Ulrich","family":"Prokosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"B\u00e4rthlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif B.","family":"Ekici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinah","family":"Becker-Grosspitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Alberth-Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Hausknecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Weigel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Walz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"K\u00f6ttgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla T.","family":"Schulthei\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fruzsina","family":"Kotsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Meder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erna","family":"Mitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Reinhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Schaeffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Baid-Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Theisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Haller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Menne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Zeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sommerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Theilinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"B\u00f6rner-Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Raschenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kollerits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Forer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Sch\u00f6nherr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansi","family":"Weissensteiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Oefner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Gronwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1053\/j.ajkd.2022.01.424_bib1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1096\/fasebj.13.8.805","article-title":"Requirement for the heart-type fatty acid binding protein in\u00a0cardiac fatty acid utilization","volume":"13","author":"Binas","year":"1999","journal-title":"FASEB J"},{"issue":"23","key":"10.1053\/j.ajkd.2022.01.424_bib2","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1093\/eurheartj\/ehn363","article-title":"Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T","volume":"29","author":"McCann","year":"2008","journal-title":"Eur Heart J"},{"issue":"21","key":"10.1053\/j.ajkd.2022.01.424_bib3","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/j.jacc.2007.08.021","article-title":"Heart-type fatty acid-binding protein predicts long-term mortality after acute coronary syndrome and identifies high-risk patients across the range of troponin values","volume":"50","author":"Kilcullen","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"23","key":"10.1053\/j.ajkd.2022.01.424_bib4","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1016\/j.jacc.2009.12.062","article-title":"Heart-type fatty acid-binding protein predicts long-term mortality and re-infarction in consecutive patients with suspected acute coronary syndrome who are troponin-negative","volume":"55","author":"Viswanathan","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"4","key":"10.1053\/j.ajkd.2022.01.424_bib5","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1093\/ndt\/gfr456","article-title":"The German Chronic Kidney Disease (GCKD) study: design and methods","volume":"27","author":"Eckardt","year":"2012","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"10.1053\/j.ajkd.2022.01.424_bib6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/ndt\/gfu294","article-title":"Disease burden and risk profile in referred patients with moderate chronic kidney disease: composition of the German Chronic Kidney Disease (GCKD) cohort","volume":"30","author":"Titze","year":"2015","journal-title":"Nephrol Dial Transplant"},{"issue":"9","key":"10.1053\/j.ajkd.2022.01.424_bib7","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A\u00a0new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"issue":"5","key":"10.1053\/j.ajkd.2022.01.424_bib8","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1053\/j.ajkd.2021.01.018","article-title":"Urine metabolite levels, adverse kidney outcomes, and mortality in CKD patients: a metabolome-wide association study","volume":"78","author":"Steinbrenner","year":"2021","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1053\/j.ajkd.2022.01.424_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0006-341X.2002.00001.x","article-title":"Model-checking techniques based on cumulative residuals","volume":"58","author":"Lin","year":"2002","journal-title":"Biometrics"},{"key":"10.1053\/j.ajkd.2022.01.424_bib10","series-title":"Handbook of Survival Analysis","first-page":"157","article-title":"Classical regression models for competing risks","author":"Beyersmann","year":"2014"},{"issue":"1","key":"10.1053\/j.ajkd.2022.01.424_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12882-016-0273-z","article-title":"Glycaemic control and antidiabetic therapy in patients with diabetes mellitus and chronic kidney disease\u2014cross-sectional data from the German Chronic Kidney Disease (GCKD) cohort","volume":"17","author":"Busch","year":"2016","journal-title":"BMC Nephrol"},{"issue":"8","key":"10.1053\/j.ajkd.2022.01.424_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202604","article-title":"Blood pressure control in chronic kidney disease: a cross-sectional analysis from the German Chronic Kidney Disease (GCKD) study","volume":"13","author":"Schneider","year":"2018","journal-title":"PLoS One"},{"key":"10.1053\/j.ajkd.2022.01.424_bib13","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1258\/acb.2009.009055","article-title":"Serum 99th centile values for two heart-type fatty acid binding protein assays","volume":"46","author":"Bathia","year":"2009","journal-title":"Ann Clin Biochem"},{"issue":"12","key":"10.1053\/j.ajkd.2022.01.424_bib14","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.amjcard.2018.02.039","article-title":"Comparison of the association between high-sensitivity troponin I and adverse cardiovascular outcomes in patients with versus without chronic kidney disease","volume":"121","author":"Sandesara","year":"2018","journal-title":"Am J Cardiol"},{"issue":"7","key":"10.1053\/j.ajkd.2022.01.424_bib15","article-title":"Effect modification of chronic kidney disease on the association of circulating and imaging cardiac biomarkers with outcomes","volume":"6","author":"Gregg","year":"2017","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"8","key":"10.1053\/j.ajkd.2022.01.424_bib16","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1161\/ATVBAHA.114.303465","article-title":"Cardiac and kidney markers for cardiovascular prediction in individuals with chronic kidney disease: the Atherosclerosis Risk in Communities study","volume":"34","author":"Matsushita","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"11","key":"10.1053\/j.ajkd.2022.01.424_bib17","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.ekir.2020.08.028","article-title":"Cardiac biomarkers and risk of mortality in CKD (the CRIC Study)","volume":"5","author":"Wang","year":"2020","journal-title":"Kidney Int Rep"},{"issue":"10041","key":"10.1053\/j.ajkd.2022.01.424_bib18","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0140-6736(16)30508-6","article-title":"The heart and vascular system in dialysis","volume":"388","author":"Wanner","year":"2016","journal-title":"Lancet"},{"key":"10.1053\/j.ajkd.2022.01.424_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1471-2369-14-229","article-title":"Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC)","volume":"14","author":"Dubin","year":"2013","journal-title":"BMC Nephrol"},{"issue":"21","key":"10.1053\/j.ajkd.2022.01.424_bib20","article-title":"Cardiac biomarkers and risk of incident heart failure in chronic kidney disease: the CRIC (Chronic Renal Insufficiency Cohort) Study","volume":"8","author":"Bansal","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"1","key":"10.1053\/j.ajkd.2022.01.424_bib21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jacc.2012.08.1003","article-title":"The circulating level of FABP3 is an indirect biomarker of microRNA-1","volume":"61","author":"Varrone","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"3","key":"10.1053\/j.ajkd.2022.01.424_bib22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.18295\/2075-0528.2806","article-title":"Serum level of heart-type fatty acid-binding protein in patients with chronic renal failure","volume":"9","author":"Al-Hadi","year":"2009","journal-title":"Sultan Qaboos Univ Med J"},{"issue":"9","key":"10.1053\/j.ajkd.2022.01.424_bib23","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1253\/circj.71.1452","article-title":"Circulating levels of heart-type fatty acid-binding protein in a general Japanese population: effects of age, gender, and physiologic characteristics","volume":"71","author":"Niizeki","year":"2007","journal-title":"Circ J"},{"issue":"3","key":"10.1053\/j.ajkd.2022.01.424_bib24","first-page":"886","article-title":"Novel biomarkers in patients with chronic kidney disease: an analysis of patients enrolled in the GCKD-Study","volume":"9","author":"Mirna","year":"2020","journal-title":"J\u00a0Clin Med"},{"issue":"19","key":"10.1053\/j.ajkd.2022.01.424_bib25","article-title":"Cardiac troponins for the diagnosis of acute myocardial infarction in chronic kidney disease","volume":"7","author":"Kraus","year":"2018","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"6","key":"10.1053\/j.ajkd.2022.01.424_bib26","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1053\/j.ajkd.2020.09.021","article-title":"Change in cardiac biomarkers and risk of incident heart failure and atrial fibrillation in CKD: the Chronic Renal Insufficiency Cohort (CRIC) Study","volume":"77","author":"Bansal","year":"2021","journal-title":"Am J Kidney Dis"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638622005261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638622005261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T03:43:50Z","timestamp":1759463030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638622005261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0272638622005261"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2022.01.424","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heart-Type Fatty Acid Binding Protein, Cardiovascular Outcomes, and Death: Findings From the German CKD Cohort Study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2022.01.424","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}]}}