{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:03:07Z","timestamp":1793829787861,"version":"4.6.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"am","delay-in-days":353,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008522","name":"University of Illinois at Chicago","doi-asserted-by":"publisher","award":["CTSA UL1RR029879"],"award-info":[{"award-number":["CTSA UL1RR029879"]}],"id":[{"id":"10.13039\/100008522","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008510","name":"University of Maryland","doi-asserted-by":"publisher","award":["UL1TR000439"],"award-info":[{"award-number":["UL1TR000439"]}],"id":[{"id":"10.13039\/100008510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008510","name":"University of Maryland","doi-asserted-by":"publisher","award":["GCRC M01 RR-16500"],"award-info":[{"award-number":["GCRC M01 RR-16500"]}],"id":[{"id":"10.13039\/100008510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK060963"],"award-info":[{"award-number":["U01DK060963"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK061028"],"award-info":[{"award-number":["U01DK061028"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK061022"],"award-info":[{"award-number":["U01DK061022"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK061021"],"award-info":[{"award-number":["U01DK061021"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK060902"],"award-info":[{"award-number":["U01DK060902"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK060984"],"award-info":[{"award-number":["U01DK060984"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK060980"],"award-info":[{"award-number":["U01DK060980"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK118736"],"award-info":[{"award-number":["R01DK118736"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK072231-91"],"award-info":[{"award-number":["R01DK072231-91"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K24DK092290"],"award-info":[{"award-number":["K24DK092290"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U24DK060990"],"award-info":[{"award-number":["U24DK060990"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007875","name":"Tulane University","doi-asserted-by":"publisher","award":["P20 GM109036"],"award-info":[{"award-number":["P20 GM109036"]}],"id":[{"id":"10.13039\/100007875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","award":["UL1 TR-000424"],"award-info":[{"award-number":["UL1 TR-000424"]}],"id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL134634"],"award-info":[{"award-number":["T32HL134634"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001463","name":"American Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001463","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007928","name":"Perelman School of Medicine, University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005977","name":"Kaiser Permanente","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006196","name":"Jet Propulsion Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000003"],"award-info":[{"award-number":["UL1TR000003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UCSF-CTSI UL1 RR-024131"],"award-info":[{"award-number":["UCSF-CTSI UL1 RR-024131"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008269","name":"Michigan Institute for Clinical and Health Research","doi-asserted-by":"publisher","award":["UL1TR000433"],"award-info":[{"award-number":["UL1TR000433"]}],"id":[{"id":"10.13039\/100008269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1053\/j.ajkd.2023.06.009","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T04:00:39Z","timestamp":1695268839000},"page":"208-215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Frailty and Cardiovascular Outcomes in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study"],"prefix":"10.1053","volume":"83","author":[{"given":"Mary","family":"Hannan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milda R.","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"McAdams-DeMarco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhumita Jena","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Vyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahraa","family":"Hajjiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"Carmona-Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Meza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Ricardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Lash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie L.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold I.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Go","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboob","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panduranga S.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vallabh O.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Unruh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9868","key":"10.1053\/j.ajkd.2023.06.009_bib1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet"},{"key":"10.1053\/j.ajkd.2023.06.009_bib2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/1471-2369-14-228","article-title":"Association of frailty and physical function in patients with non-dialysis CKD: a systematic review","volume":"14","author":"Walker","year":"2013","journal-title":"BMC Nephrol"},{"issue":"7","key":"10.1053\/j.ajkd.2023.06.009_bib3","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.amjmed.2009.01.026","article-title":"Frailty and chronic kidney disease: the Third National Health and Nutrition Evaluation Survey","volume":"122","author":"Wilhelm-Leen","year":"2009","journal-title":"Am J Med"},{"issue":"6","key":"10.1053\/j.ajkd.2023.06.009_bib4","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1053\/j.ajkd.2012.05.017","article-title":"A\u00a0prospective study of frailty in nephrology-referred patients with CKD","volume":"60","author":"Roshanravan","year":"2012","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1053\/j.ajkd.2023.06.009_bib5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000355568","article-title":"Physical performance and frailty in chronic kidney disease","volume":"38","author":"Reese","year":"2013","journal-title":"Am J Nephrol"},{"issue":"5","key":"10.1053\/j.ajkd.2023.06.009_bib7","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.ahj.2013.07.032","article-title":"Frailty and risk for heart failure in older adults: the health, aging, and body composition study","volume":"166","author":"Khan","year":"2013","journal-title":"Am Heart J"},{"issue":"8","key":"10.1053\/j.ajkd.2023.06.009_bib8","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1136\/heartjnl-2014-306472","article-title":"Cardiovascular risk profile and frailty in a population-based study of older British men","volume":"101","author":"Ramsay","year":"2015","journal-title":"Heart"},{"issue":"2","key":"10.1053\/j.ajkd.2023.06.009_bib9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.archger.2005.01.002","article-title":"Frailty, morbidity and survival","volume":"41","author":"Klein","year":"2005","journal-title":"Arch Gerontol Geriatr"},{"issue":"10","key":"10.1053\/j.ajkd.2023.06.009_bib10","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.jacc.2014.12.040","article-title":"Pre-frailty and risk of cardiovascular disease in elderly men and women: the Pro.V.A. Study","volume":"65","author":"Sergi","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"11","key":"10.1053\/j.ajkd.2023.06.009_bib11","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1681\/ASN.2007020221","article-title":"Significance of frailty among dialysis patients","volume":"18","author":"Johansen","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"1","key":"10.1053\/j.ajkd.2023.06.009_bib12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/ajt.12992","article-title":"Frailty and mortality in kidney transplant recipients","volume":"15","author":"McAdams-DeMarco","year":"2015","journal-title":"Am J Transplant"},{"issue":"2","key":"10.1053\/j.ajkd.2023.06.009_bib13","first-page":"106","article-title":"The prevalence, association, and clinical outcomes of frailty in maintenance dialysis patients","volume":"27","author":"Lee","year":"2017","journal-title":"J\u00a0Ren Nutr"},{"issue":"3","key":"10.1053\/j.ajkd.2023.06.009_bib14","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jamda.2020.09.033","article-title":"Frailty as a predictor of negative health outcomes in chronic kidney disease: a systematic review and meta-analysis","volume":"22","author":"Mei","year":"2021","journal-title":"J\u00a0Am Med Dir Assoc"},{"issue":"7 suppl 2","key":"10.1053\/j.ajkd.2023.06.009_bib15","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1097\/01.ASN.0000070149.78399.CE","article-title":"The Chronic Renal Insufficiency Cohort (CRIC) Study: design and methods","volume":"14","author":"Feldman","year":"2003","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"8","key":"10.1053\/j.ajkd.2023.06.009_bib16","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.2215\/CJN.00070109","article-title":"Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function","volume":"4","author":"Lash","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"issue":"19","key":"10.1053\/j.ajkd.2023.06.009_bib17","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1056\/NEJMoa2103753","article-title":"Race, genetic ancestry, and estimating kidney function in CKD","volume":"385","author":"Hsu","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1053\/j.ajkd.2023.06.009_bib18","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"issue":"2","key":"10.1053\/j.ajkd.2023.06.009_bib19","doi-asserted-by":"crossref","first-page":"M85","DOI":"10.1093\/geronj\/49.2.M85","article-title":"A\u00a0short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission","volume":"49","author":"Guralnik","year":"1994","journal-title":"J\u00a0Gerontol"},{"issue":"3","key":"10.1053\/j.ajkd.2023.06.009_bib20","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D Scale: a self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl Psychol Meas"},{"issue":"9","key":"10.1053\/j.ajkd.2023.06.009_bib21","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/aje\/kwf113","article-title":"Multi-Ethnic Study of Atherosclerosis: objectives and design","volume":"156","author":"Bild","year":"2002","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1053\/j.ajkd.2023.06.009_bib22","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1053\/j.ajkd.2016.03.429","article-title":"Race\/ethnicity and cardiovascular outcomes in adults with CKD: findings from the CRIC (Chronic Renal Insufficiency Cohort) and Hispanic CRIC Studies","volume":"68","author":"Lash","year":"2016","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10.1053\/j.ajkd.2023.06.009_bib23","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1053\/j.ajkd.2021.01.020","article-title":"Sex differences in cardiovascular outcomes in CKD: findings from the CRIC Study","volume":"78","author":"Toth-Manikowski","year":"2021","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1053\/j.ajkd.2023.06.009_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/01.CIR.88.1.107","article-title":"Survival after the onset of congestive heart failure in Framingham Heart Study subjects","volume":"88","author":"Ho","year":"1993","journal-title":"Circulation"},{"issue":"2","key":"10.1053\/j.ajkd.2023.06.009_bib25","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1681\/ASN.2014101045","article-title":"Electrocardiographic measures and prediction of cardiovascular and noncardiovascular death in CKD","volume":"27","author":"Deo","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2023.06.009_bib26","author":"Van der Laan"},{"issue":"5","key":"10.1053\/j.ajkd.2023.06.009_bib27","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/TA.0000000000002044","article-title":"Machine learning without borders? An adaptable tool to optimize mortality prediction in diverse clinical settings","volume":"85","author":"Christie","year":"2018","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"6","key":"10.1053\/j.ajkd.2023.06.009_bib28","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1053\/j.ajkd.2022.05.007","article-title":"Self-reported physical activity and cardiovascular events in adults with CKD: findings from the CRIC (Chronic Renal Insufficiency Cohort) Study","volume":"80","author":"Bruinius","year":"2022","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1053\/j.ajkd.2023.06.009_bib29","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1001\/jamacardio.2016.4652","article-title":"Absolute rates of heart failure, coronary heart disease, and stroke in chronic kidney disease: an analysis of 3 community-based cohort studies","volume":"2","author":"Bansal","year":"2017","journal-title":"JAMA Cardiol"},{"issue":"12","key":"10.1053\/j.ajkd.2023.06.009_bib30","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1681\/ASN.2018050514","article-title":"Cardiovascular events after new-onset atrial fibrillation in adults with CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study","volume":"29","author":"Bansal","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"5","key":"10.1053\/j.ajkd.2023.06.009_bib31","article-title":"Risk factors for heart failure in patients with chronic kidney disease: the CRIC (Chronic Renal Insufficiency Cohort) Study","volume":"6","author":"He","year":"2017","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1053\/j.ajkd.2023.06.009_bib32","first-page":"1","article-title":"mice: Multivariate imputation by chained equations in R","volume":"45","author":"Van Buuren","year":"2011","journal-title":"J\u00a0Stat Softw"},{"issue":"1","key":"10.1053\/j.ajkd.2023.06.009_bib33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cger.2010.08.001","article-title":"Exercise as an intervention for frailty","volume":"27","author":"Liu","year":"2011","journal-title":"Clin Geriatr Med"},{"issue":"1","key":"10.1053\/j.ajkd.2023.06.009_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12882-015-0202-6","article-title":"Association of frailty based on self-reported physical function with directly measured kidney function and mortality","volume":"16","author":"Delgado","year":"2015","journal-title":"BMC Nephrol"},{"issue":"4","key":"10.1053\/j.ajkd.2023.06.009_bib35","doi-asserted-by":"crossref","first-page":"552","DOI":"10.2215\/CJN.12480720","article-title":"Provider perception of frailty is associated with dialysis decision making in patients with advanced CKD","volume":"16","author":"Brar","year":"2021","journal-title":"CJASN"},{"issue":"1","key":"10.1053\/j.ajkd.2023.06.009_bib36","doi-asserted-by":"crossref","first-page":"140","DOI":"10.11124\/JBISRIR-2017-003382","article-title":"Effectiveness of interventions to prevent pre-frailty and frailty progression in older adults: a systematic review","volume":"16","author":"Ap\u00f3stolo","year":"2018","journal-title":"JBI Database System Rev Implement Rep"},{"issue":"3","key":"10.1053\/j.ajkd.2023.06.009_bib37","first-page":"383","article-title":"Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policies","volume":"46","author":"Puts","year":"2017","journal-title":"Age Ageing"},{"issue":"6","key":"10.1053\/j.ajkd.2023.06.009_bib38","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-035344","article-title":"The EX-FRAIL CKD trial: a study protocol for a pilot randomised controlled trial of a home-based exercise programme for pre-frail and frail, older adults with chronic kidney disease","volume":"10","author":"Nixon","year":"2020","journal-title":"BMJ Open"},{"key":"10.1053\/j.ajkd.2023.06.009_bib39","first-page":"CD003236","article-title":"Exercise training for adults with chronic kidney disease","volume":"10","author":"Heiwe","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"10.1053\/j.ajkd.2023.06.009_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.13450","article-title":"Prehabilitation prior to kidney transplantation: results from a pilot study","volume":"33","author":"McAdams-DeMarco","year":"2019","journal-title":"Clin Transplant"},{"issue":"9","key":"10.1053\/j.ajkd.2023.06.009_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.14017","article-title":"Protocolized exercise improves frailty parameters and lower extremity impairment: a promising prehabilitation strategy for kidney transplant candidates","volume":"34","author":"Lorenz","year":"2020","journal-title":"Clin Transplant"},{"issue":"2","key":"10.1053\/j.ajkd.2023.06.009_bib42","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/ckj\/sfx134","article-title":"Frailty and chronic kidney disease: current evidence and continuing uncertainties","volume":"11","author":"Nixon","year":"2018","journal-title":"Clin Kidney J"},{"key":"10.1053\/j.ajkd.2023.06.009_bib43","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.vph.2015.03.005","article-title":"The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review)","volume":"71","author":"Siti","year":"2015","journal-title":"Vascul Pharmacol"},{"key":"10.1053\/j.ajkd.2023.06.009_bib44","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.maturitas.2017.01.006","article-title":"Oxidative stress and frailty: a systematic review and synthesis of the best evidence","volume":"99","author":"Soysal","year":"2017","journal-title":"Maturitas"},{"issue":"1","key":"10.1053\/j.ajkd.2023.06.009_bib45","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1186\/s12889-019-7062-0","article-title":"Association between frailty and the combination of physical activity level and sedentary behavior in older adults","volume":"19","author":"Da Silva","year":"2019","journal-title":"BMC Public Health"},{"key":"10.1053\/j.ajkd.2023.06.009_bib46","doi-asserted-by":"crossref","unstructured":"Fitzgerald JD, Johnson L, Hire DG, et\u00a0al. Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults. J Am Heart Assoc. 4(2):e001288. doi:10.1161\/JAHA.114.001288","DOI":"10.1161\/JAHA.114.001288"},{"key":"10.1053\/j.ajkd.2023.06.009_bib47","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2147\/CIA.S126526","article-title":"Effect of frailty syndrome on treatment compliance in older hypertensive patients","volume":"12","author":"Chudiak","year":"2017","journal-title":"Clin Interv Aging"},{"key":"10.1053\/j.ajkd.2023.06.009_bib48","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.2147\/CIA.S113994","article-title":"The influence of frailty syndrome on medication adherence among elderly patients with hypertension","volume":"11","author":"Jankowska-Pola\u0144ska","year":"2016","journal-title":"Clin Interv Aging"},{"issue":"5","key":"10.1053\/j.ajkd.2023.06.009_bib49","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/ajcn\/83.5.1142","article-title":"Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study","volume":"83","author":"Cesari","year":"2006","journal-title":"Am J Clin Nutr"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638623008016?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638623008016?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:26:59Z","timestamp":1777541219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638623008016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S0272638623008016"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2023.06.009","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frailty and Cardiovascular Outcomes in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2023.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}]}}