{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T08:16:46Z","timestamp":1785917806794,"version":"3.56.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","ajkd.org","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1053\/j.ajkd.2024.03.021","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T01:41:16Z","timestamp":1715650876000},"page":"447-456.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinicopathological Characteristics of Light and Heavy Chain Deposition Disease: A Case Series"],"prefix":"10.1053","volume":"84","author":[{"given":"Yujie","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xumeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolan","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoshan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3816-5164","authenticated-orcid":false,"given":"Caihong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1053\/j.ajkd.2024.03.021_bib1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1053\/j.ajkd.2015.12.008","article-title":"AJKD atlas of renal pathology: light and heavy chain deposition disease","volume":"67","author":"Fogo","year":"2016","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1053\/j.ajkd.2024.03.021_bib2","first-page":"545","article-title":"Synthesis of abnormal heavy and light chains in multiple myeloma with visceral deposition of monoclonal immunoglobulin","volume":"42","author":"Preud\u2019Homme","year":"1980","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"10.1053\/j.ajkd.2024.03.021_bib3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.7326\/0003-4819-76-3-112-6-455","article-title":"Monoclonal immunoglobulin deposition disease: light chain and light and heavy chain deposition diseases and their relation to light chain amyloidosis: clinical features, immunopathology, and molecular analysis","volume":"112","author":"Buxbaum","year":"1990","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1053\/j.ajkd.2024.03.021_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF00196150","article-title":"Light chain deposition disease of the kidney. Morphological aspects in 24 patients","volume":"425","author":"Str\u00f8m","year":"1994","journal-title":"Vichows Arch"},{"issue":"4","key":"10.1053\/j.ajkd.2024.03.021_bib5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/ajh.2830500413","article-title":"Light-heavy chain deposition disease progressing to multiple myeloma: brief report: LCDD progressing to multiple myeloma","volume":"50","author":"Daliani","year":"1995","journal-title":"Am J Hematol"},{"issue":"7","key":"10.1053\/j.ajkd.2024.03.021_bib6","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1681\/ASN.V1271482","article-title":"Renal monoclonal immunoglobulin deposition disease: the disease spectrum","volume":"12","author":"Lin","year":"2001","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"1","key":"10.1053\/j.ajkd.2024.03.021_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0272-6386(03)00412-8","article-title":"Monoclonal gammopathy: significance and possible causality in renal disease","volume":"42","author":"Paueksakon","year":"2003","journal-title":"Am J Kidney Dis"},{"issue":"7","key":"10.1053\/j.ajkd.2024.03.021_bib8","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/ndt\/gfh822","article-title":"Recurrent light and heavy chain deposition disease after renal transplantation","volume":"20","author":"Alchi","year":"2005","journal-title":"Nephrol Dial Transplant"},{"issue":"9","key":"10.1053\/j.ajkd.2024.03.021_bib9","doi-asserted-by":"crossref","first-page":"970","DOI":"10.2169\/internalmedicine.44.970","article-title":"High dose chemotherapy and stem cell support in a patient of light- and heavy-chain deposition disease with abnormal marrow cell surface antigens and no monoclonal protein","volume":"44","author":"Sakakima","year":"2005","journal-title":"Intern Med"},{"issue":"6","key":"10.1053\/j.ajkd.2024.03.021_bib10","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.2215\/CJN.01730506","article-title":"Immunoglobulin light (heavy)-chain deposition disease: from molecular medicine to pathophysiology-driven therapy","volume":"1","author":"Ronco","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"issue":"10","key":"10.1053\/j.ajkd.2024.03.021_bib11","first-page":"2204","article-title":"A\u00a0Concurrence of light and heavy chain deposition disease and diabetic nephropathy","volume":"90","author":"Satirapoj","year":"2007","journal-title":"J\u00a0Med Assoc Thai"},{"issue":"01","key":"10.1053\/j.ajkd.2024.03.021_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5414\/CNP71009","article-title":"Clinicopathological features and prognosis in immunoglobulin light and heavy chain deposition disease","volume":"71","author":"Masai","year":"2009","journal-title":"Clin Nephrol"},{"issue":"2","key":"10.1053\/j.ajkd.2024.03.021_bib13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2215\/CJN.08640811","article-title":"Renal monoclonal immunoglobulin deposition disease: a report of 64 patients from a single institution","volume":"7","author":"Nasr","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"10.1053\/j.ajkd.2024.03.021_bib14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/ckj\/sfv002","article-title":"Light and heavy chain deposition disease associated with CH1 deletion","volume":"8","author":"Cohen","year":"2015","journal-title":"Clin Kidney J"},{"issue":"5","key":"10.1053\/j.ajkd.2024.03.021_bib15","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/ki.2015.201","article-title":"Bortezomib produces high hematological response rates with prolonged renal survival in monoclonal immunoglobulin deposition disease","volume":"88","author":"Cohen","year":"2015","journal-title":"Kidney Int"},{"issue":"1","key":"10.1053\/j.ajkd.2024.03.021_bib16","first-page":"109","article-title":"A case of light and heavy chain deposition disease","volume":"41","author":"Chen","year":"2016","journal-title":"J Central South Univ (Med Sci)"},{"issue":"6","key":"10.1053\/j.ajkd.2024.03.021_bib17","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1182\/blood-2018-09-872028","article-title":"Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study","volume":"133","author":"Joly","year":"2019","journal-title":"Blood"},{"issue":"1","key":"10.1053\/j.ajkd.2024.03.021_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/bjh.15420","article-title":"IgA kappa light and heavy chain deposition disease in multiple myeloma","volume":"183","author":"Sannier","year":"2018","journal-title":"Br J Haematol"},{"issue":"6","key":"10.1053\/j.ajkd.2024.03.021_bib19","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00277-016-2659-1","article-title":"Clinicopathological characteristics and outcomes of light chain deposition disease: an analysis of 48 patients in a single Chinese center","volume":"95","author":"Li","year":"2016","journal-title":"Ann Hematol"},{"issue":"5","key":"10.1053\/j.ajkd.2024.03.021_bib20","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1053\/j.ajkd.2019.08.013","article-title":"Heavy chain deposition disease: clinicopathologic characteristics of a Chinese case series","volume":"75","author":"Zhang","year":"2020","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1053\/j.ajkd.2024.03.021_bib21","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ki.2014.408","article-title":"Diagnosis of monoclonal gammopathy of renal significance","volume":"87","author":"Bridoux","year":"2015","journal-title":"Kidney Int"},{"issue":"12","key":"10.1053\/j.ajkd.2024.03.021_bib22","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol"},{"issue":"36","key":"10.1053\/j.ajkd.2024.03.021_bib23","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1200\/JCO.2011.37.7614","article-title":"New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes","volume":"30","author":"Palladini","year":"2012","journal-title":"J\u00a0Clin Oncol"},{"issue":"13","key":"10.1053\/j.ajkd.2024.03.021_bib24","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1200\/JCO.2015.65.0044","article-title":"International Myeloma Working Group recommendations for the diagnosis and management of myeloma-related renal impairment","volume":"34","author":"Dimopoulos","year":"2016","journal-title":"J\u00a0Clin Oncol"},{"issue":"15","key":"10.1053\/j.ajkd.2024.03.021_bib25","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1182\/blood-2014-04-570010","article-title":"A\u00a0staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis","volume":"124","author":"Palladini","year":"2014","journal-title":"Blood"},{"issue":"20","key":"10.1053\/j.ajkd.2024.03.021_bib26","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1056\/NEJMra1810907","article-title":"Monoclonal Gammopathy of Renal Significance","volume":"384","author":"Leung","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1053\/j.ajkd.2024.03.021_bib27","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.kint.2016.09.004","article-title":"Unravelling the immunopathological mechanisms of heavy chain deposition disease with implications for clinical management","volume":"91","author":"Bridoux","year":"2017","journal-title":"Kidney Int"},{"issue":"1","key":"10.1053\/j.ajkd.2024.03.021_bib28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.kint.2021.02.038","article-title":"Immunofluorescence staining for immunoglobulin heavy chain\/light chain on kidney biopsies is a valuable ancillary technique for the diagnosis of monoclonal gammopathy-associated kidney diseases","volume":"100","author":"Nasr","year":"2021","journal-title":"Kidney Int"},{"issue":"22","key":"10.1053\/j.ajkd.2024.03.021_bib29","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1182\/blood-2013-05-495929","article-title":"How I treat monoclonal gammopathy of renal significance (MGRS)","volume":"122","author":"Fermand","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1053\/j.ajkd.2024.03.021_bib30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41581-018-0077-4","article-title":"The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group [published correction appears in Nat Rev Nephrol. 2019;15(2):121]","volume":"15","author":"Leung","year":"2019","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"10.1053\/j.ajkd.2024.03.021_bib31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bbmt.2017.08.031","article-title":"High-dose melphalan and stem cell transplantation in patients on dialysis due to immunoglobulin light-chain amyloidosis and monoclonal immunoglobulin deposition disease","volume":"24","author":"Batalini","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"10.1053\/j.ajkd.2024.03.021_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/bjh.17052","article-title":"Daratumumab-based therapy for patients with monoclonal gammopathy of renal significance","volume":"193","author":"Kastritis","year":"2021","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1053\/j.ajkd.2024.03.021_bib33","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/leu.2012.197","article-title":"Immunoglobulin heavy\/light chain ratios improve paraprotein detection and monitoring, identify residual disease and correlate with survival in multiple myeloma patients","volume":"27","author":"Ludwig","year":"2013","journal-title":"Leukemia"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638624007571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638624007571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T19:00:24Z","timestamp":1726772424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638624007571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0272638624007571"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2024.03.021","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathological Characteristics of Light and Heavy Chain Deposition Disease: A Case Series","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2024.03.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}]}}