{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:13:03Z","timestamp":1789395183911,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100018688","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","ajkd.org","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1053\/j.ajkd.2024.05.015","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T01:54:11Z","timestamp":1722304451000},"page":"675-685.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cumulative Blood Pressure Load and Incident CKD"],"prefix":"10.1053","volume":"84","author":[{"given":"Hye-Sun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeseul","family":"Seong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Jeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong Cheon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hyun","family":"Jhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9887","key":"10.1053\/j.ajkd.2024.05.015_bib1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0140-6736(13)60439-0","article-title":"Evolving importance of kidney disease: from subspecialty to global health burden","volume":"382","author":"Eckardt","year":"2013","journal-title":"Lancet"},{"issue":"17","key":"10.1053\/j.ajkd.2024.05.015_bib2","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","article-title":"Prevalence of chronic kidney disease in the United States","volume":"298","author":"Coresh","year":"2007","journal-title":"JAMA"},{"issue":"1","key":"10.1053\/j.ajkd.2024.05.015_bib3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: an update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int Suppl (2011)"},{"issue":"6","key":"10.1053\/j.ajkd.2024.05.015_bib4","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/CIRCULATIONAHA.115.018912","article-title":"Global disparities of hypertension prevalence and control: a systematic analysis of population-based studies from 90 countries","volume":"134","author":"Mills","year":"2016","journal-title":"Circulation"},{"issue":"4","key":"10.1053\/j.ajkd.2024.05.015_bib5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.7326\/0003-4819-159-4-201308200-00004","article-title":"Blood pressure and mortality in U.S. veterans with chronic kidney disease: a cohort study","volume":"159","author":"Kovesdy","year":"2013","journal-title":"Ann Intern Med"},{"issue":"7","key":"10.1053\/j.ajkd.2024.05.015_bib6","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1681\/ASN.2005101085","article-title":"Chronic kidney disease and mortality risk: a systematic review","volume":"17","author":"Tonelli","year":"2006","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"1","key":"10.1053\/j.ajkd.2024.05.015_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1053\/j.ajkd.2018.12.044","article-title":"Hypertension in CKD: core curriculum 2019","volume":"74","author":"Ku","year":"2019","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1053\/j.ajkd.2024.05.015_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.23876\/j.krcp.21.099","article-title":"Association between blood pressure and the risk of chronic kidney disease in treatment-na\u00efve hypertensive patients","volume":"41","author":"Lee","year":"2022","journal-title":"Kidney Res Clin Pract"},{"issue":"2","key":"10.1053\/j.ajkd.2024.05.015_bib9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1053\/j.ajkd.2020.12.013","article-title":"Association of blood pressure with the progression of CKD: findings from KNOW-CKD Study","volume":"78","author":"Lee","year":"2021","journal-title":"Am J Kidney Dis"},{"issue":"9","key":"10.1053\/j.ajkd.2024.05.015_bib10","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1681\/ASN.2020010084","article-title":"Association of longitudinal trajectories of systolic BP with risk of incident CKD: results from the Korean Genome and Epidemiology Study","volume":"31","author":"Joo","year":"2020","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"4","key":"10.1053\/j.ajkd.2024.05.015_bib11","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1053\/j.ajkd.2022.08.017","article-title":"Short-term blood pressure variability and incident CKD in patients with hypertension: findings from the Cardiovascular and Metabolic Disease Etiology Research Center-High Risk (CMERC-HI) Study","volume":"81","author":"Jhee","year":"2023","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"10.1053\/j.ajkd.2024.05.015_bib12","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/jch.13875","article-title":"The cumulative blood pressure load and target organ damage in patients with essential hypertension","volume":"22","author":"Zhou","year":"2020","journal-title":"J\u00a0Clin Hypertens (Greenwich)"},{"issue":"12","key":"10.1053\/j.ajkd.2024.05.015_bib13","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.jacc.2022.06.039","article-title":"Cumulative systolic blood pressure load and cardiovascular risk in patients with diabetes","volume":"80","author":"Wang","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"14","key":"10.1053\/j.ajkd.2024.05.015_bib14","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.jacc.2022.01.045","article-title":"Association of cumulative blood pressure with cognitive decline, dementia, and mortality","volume":"79","author":"Li","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"25","key":"10.1053\/j.ajkd.2024.05.015_bib15","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1016\/j.jacc.2015.04.042","article-title":"Cumulative blood pressure in early adulthood and cardiac dysfunction in middle age: the CARDIA Study","volume":"65","author":"Kishi","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"13","key":"10.1053\/j.ajkd.2024.05.015_bib16","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/eurheartj\/ehr003","article-title":"Renal function and target organ damage in hypertension","volume":"32","author":"Ruilope","year":"2011","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1053\/j.ajkd.2024.05.015_bib17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/jhh.2013.55","article-title":"Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage","volume":"28","author":"Mennuni","year":"2014","journal-title":"J\u00a0Hum Hypertens"},{"issue":"2","key":"10.1053\/j.ajkd.2024.05.015_bib18","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1093\/ije\/dyv316","article-title":"Cohort profile: the Korean Genome and Epidemiology Study (KoGES) Consortium","volume":"46","author":"Kim","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"18","key":"10.1053\/j.ajkd.2024.05.015_bib19","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1001\/jama.2012.3954","article-title":"Comparison of risk prediction using the CKD-EPI equation and the MDRD Study equation for estimated glomerular filtration rate","volume":"307","author":"Matsushita","year":"2012","journal-title":"JAMA"},{"issue":"9","key":"10.1053\/j.ajkd.2024.05.015_bib20","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A\u00a0new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"issue":"19","key":"10.1053\/j.ajkd.2024.05.015_bib21","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1016\/j.jacc.2017.11.006","volume":"71","author":"Whelton","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"9","key":"10.1053\/j.ajkd.2024.05.015_bib22","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1001\/archinte.161.9.1207","article-title":"Prevalence of high blood pressure and elevated serum creatinine level in the United States: findings from the third National Health and Nutrition Examination Survey (1988-1994)","volume":"161","author":"Coresh","year":"2001","journal-title":"Arch Intern Med"},{"issue":"4","key":"10.1053\/j.ajkd.2024.05.015_bib23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.7326\/M14-0488","article-title":"Time-updated systolic blood pressure and the progression of chronic kidney disease: a cohort study","volume":"162","author":"Anderson","year":"2015","journal-title":"Ann Intern Med"},{"issue":"17","key":"10.1053\/j.ajkd.2024.05.015_bib24","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJMoa0902066","article-title":"Strict blood-pressure control and progression of renal failure in children","volume":"361","author":"Wuhl","year":"2009","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1053\/j.ajkd.2024.05.015_bib25","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1161\/HYPERTENSIONAHA.119.14258","article-title":"Left ventricular mass and incident chronic kidney disease","volume":"75","author":"Agarwal","year":"2020","journal-title":"Hypertension"},{"issue":"5","key":"10.1053\/j.ajkd.2024.05.015_bib26","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/HYPERTENSIONAHA.121.17542","article-title":"Association between longitudinal blood pressure trajectory and the progression of chronic kidney disease: results from the KNOW-CKD","volume":"78","author":"Joo","year":"2021","journal-title":"Hypertension"},{"issue":"9","key":"10.1053\/j.ajkd.2024.05.015_bib27","article-title":"Resistant hypertension, time-updated blood pressure values and renal outcome in type 2 diabetes mellitus","volume":"6","author":"Viazzi","year":"2017","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"2","key":"10.1053\/j.ajkd.2024.05.015_bib28","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1159\/000488255","article-title":"Apparent treatment resistant hypertension, blood pressure control and the progression of chronic kidney disease in patients with type 2 diabetes","volume":"43","author":"Viazzi","year":"2018","journal-title":"Kidney Blood Press Res"},{"key":"10.1053\/j.ajkd.2024.05.015_bib29","article-title":"Predictive value of cumulative blood pressure for all-cause mortality and cardiovascular events","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"issue":"23","key":"10.1053\/j.ajkd.2024.05.015_bib30","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.jacc.2011.07.045","article-title":"Blood pressure in early adulthood, hypertension in middle age, and future cardiovascular disease mortality: HAHS (Harvard Alumni Health Study)","volume":"58","author":"Gray","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"3","key":"10.1053\/j.ajkd.2024.05.015_bib31","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jacc.2019.03.529","article-title":"Associations of blood pressure and cholesterol levels during young adulthood with later cardiovascular events","volume":"74","author":"Zhang","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"5","key":"10.1053\/j.ajkd.2024.05.015_bib32","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1001\/jama.2013.285122","article-title":"Blood pressure trajectories in early adulthood and subclinical atherosclerosis in middle age","volume":"311","author":"Allen","year":"2014","journal-title":"JAMA"},{"issue":"11","key":"10.1053\/j.ajkd.2024.05.015_bib33","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1001\/jamacardio.2018.2763","article-title":"Use of long-term cumulative blood pressure in cardiovascular risk prediction models","volume":"3","author":"Pool","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"9","key":"10.1053\/j.ajkd.2024.05.015_bib34","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1161\/CIRCULATIONAHA.119.042502","article-title":"Cumulative blood pressure exposure during young adulthood and mobility and cognitive function in midlife","volume":"141","author":"Mahinrad","year":"2020","journal-title":"Circulation"},{"issue":"11","key":"10.1053\/j.ajkd.2024.05.015_bib35","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.2215\/CJN.02450314","article-title":"Cumulative systolic BP and changes in urine albumin-to-creatinine ratios in nondiabetic participants of the multi-ethnic study of atherosclerosis","volume":"9","author":"Zemaitis","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"issue":"6","key":"10.1053\/j.ajkd.2024.05.015_bib36","article-title":"A\u00a0meta-analysis on prehypertension and chronic kidney disease","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1053\/j.ajkd.2024.05.015_bib37","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1053\/j.ajkd.2013.07.024","article-title":"Prehypertension and incidence of ESRD: a systematic review and meta-analysis","volume":"63","author":"Huang","year":"2014","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1053\/j.ajkd.2024.05.015_bib38","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1001\/jama.2019.21402","article-title":"Association of isolated diastolic hypertension as defined by the 2017 ACC\/AHA blood pressure guideline with incident cardiovascular outcomes","volume":"323","author":"McEvoy","year":"2020","journal-title":"JAMA"},{"issue":"6","key":"10.1053\/j.ajkd.2024.05.015_bib39","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1161\/CIRCULATIONAHA.113.004876","article-title":"Ambulatory hypertension subtypes and 24-hour systolic and diastolic blood pressure as distinct outcome predictors in 8341 untreated people recruited from 12 populations","volume":"130","author":"Li","year":"2014","journal-title":"Circulation"},{"issue":"3","key":"10.1053\/j.ajkd.2024.05.015_bib40","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/HJH.0000000000000070","article-title":"Overall cardiovascular prognosis of isolated systolic hypertension, isolated diastolic hypertension and pulse pressure defined with home measurements: the Finn-Home study","volume":"32","author":"Niiranen","year":"2014","journal-title":"J\u00a0Hypertens"},{"issue":"22","key":"10.1053\/j.ajkd.2024.05.015_bib41","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1161\/CIRCULATIONAHA.119.044838","article-title":"Cardiovascular risk of isolated systolic or diastolic hypertension in young adults","volume":"141","author":"Lee","year":"2020","journal-title":"Circulation"},{"issue":"7","key":"10.1053\/j.ajkd.2024.05.015_bib42","article-title":"Chronic kidney disease risk of isolated systolic or diastolic hypertension in young adults: a nationwide sample based-cohort study","volume":"10","author":"Bae","year":"2021","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"12","key":"10.1053\/j.ajkd.2024.05.015_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.xkme.2023.100728","article-title":"Isolated diastolic hypertension and kidney and cardiovascular outcomes in CKD: the Chronic Renal Insufficiency Cohort (CRIC) Study","volume":"5","author":"Al Saleh","year":"2023","journal-title":"Kidney Med"},{"issue":"suppl 4","key":"10.1053\/j.ajkd.2024.05.015_bib44","first-page":"S117","article-title":"KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","year":"2024","journal-title":"Kidney Int"},{"issue":"1","key":"10.1053\/j.ajkd.2024.05.015_bib45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1053\/j.ajkd.2010.12.026","article-title":"Diagnostic accuracy of urine dipsticks for detection of albuminuria in the general community","volume":"58","author":"White","year":"2011","journal-title":"Am J Kidney Dis"},{"issue":"10","key":"10.1053\/j.ajkd.2024.05.015_bib46","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s10157-023-02369-3","article-title":"Trace proteinuria detected via dipstick test is associated with kidney function decline and new-onset overt proteinuria: the Japan Specific Health Checkups (J-SHC) Study","volume":"27","author":"Kosugi","year":"2023","journal-title":"Clin Exp Nephrol"},{"issue":"1","key":"10.1053\/j.ajkd.2024.05.015_bib47","doi-asserted-by":"crossref","first-page":"52","DOI":"10.23876\/j.krcp.20.202","article-title":"Trends in epidemiologic characteristics of end-stage renal disease from 2019 Korean Renal Data System (KORDS)","volume":"40","author":"Hong","year":"2021","journal-title":"Kidney Res Clin Pract"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638624008941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638624008941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T09:02:26Z","timestamp":1732093346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638624008941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0272638624008941"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2024.05.015","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cumulative Blood Pressure Load and Incident CKD","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2024.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}]}}