{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:40:19Z","timestamp":1792798819495,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1053\/j.ajkd.2026.06.027","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:23:11Z","timestamp":1792682591000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Depressive Symptoms and Incident Peripheral Arterial Disease Among Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study"],"prefix":"10.1053","author":[{"given":"Mohammad","family":"Nizamuddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestin","family":"Missikpode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Lash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda H.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence J.","family":"Appel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie L.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Dember","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Go","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lee Hamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboob","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panduranga S.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1053\/j.ajkd.2026.06.027_bib1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1053\/j.ackd.2014.07.005","article-title":"Peripheral artery disease and chronic kidney disease: clinical synergy to improve outcomes","volume":"21","author":"Garimella","year":"2014","journal-title":"Adv Chronic Kidney Dis"},{"issue":"3","key":"10.1053\/j.ajkd.2026.06.027_bib2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.CIR.0000114519.75433.DD","article-title":"High prevalence of peripheral arterial disease in persons with renal insufficiency: results from the National Health and Nutrition Examination Survey 1999-2000","volume":"109","author":"O'Hare","year":"2004","journal-title":"Circulation"},{"issue":"2","key":"10.1053\/j.ajkd.2026.06.027_bib3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1681\/ASN.2005111204","article-title":"Kidney function and risk of peripheral arterial disease: results from the Atherosclerosis Risk in Communities (ARIC) Study","volume":"18","author":"Wattanakit","year":"2007","journal-title":"J Am Soc Nephrol"},{"issue":"13","key":"10.1053\/j.ajkd.2026.06.027_bib4","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.jacc.2009.06.017","article-title":"Association of chronic kidney disease with the spectrum of ankle brachial index the CHS (Cardiovascular Health Study)","volume":"54","author":"Ix","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"15","key":"10.1053\/j.ajkd.2026.06.027_bib5","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1093\/eurheartj\/ehp195","article-title":"Kidney function estimated from serum creatinine and cystatin C and peripheral arterial disease in NHANES 1999-2002","volume":"30","author":"Selvin","year":"2009","journal-title":"Eur Heart J"},{"issue":"4","key":"10.1053\/j.ajkd.2026.06.027_bib6","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2215\/CJN.04411007","article-title":"Combined effect of chronic kidney disease and peripheral arterial disease on all-cause mortality in a high-risk population","volume":"3","author":"Liew","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"issue":"5","key":"10.1053\/j.ajkd.2026.06.027_bib7","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1097\/01.ASN.0000061776.60146.02","article-title":"Impact of renal insufficiency on short-term morbidity and mortality after lower extremity revascularization: data from the Department of Veterans Affairs' National Surgical Quality Improvement Program","volume":"14","author":"O'Hare","year":"2003","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"10.1053\/j.ajkd.2026.06.027_bib8","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1177\/0003319715603184","article-title":"Long-Term Mortality After Invasive Angiography and Endovascular Revascularization in Patients With PAD Having Chronic Kidney Disease","volume":"67","author":"Gebauer","year":"2016","journal-title":"Angiology"},{"issue":"2","key":"10.1053\/j.ajkd.2026.06.027_bib9","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2215\/CJN.05600515","article-title":"CKD and Acute and Long-Term Outcome of Patients with Peripheral Artery Disease and Critical Limb Ischemia","volume":"11","author":"L\u00fcders","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"issue":"5","key":"10.1053\/j.ajkd.2026.06.027_bib10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1053\/j.ajkd.2019.08.028","article-title":"Peripheral Artery Disease: Its Adverse Consequences With and Without CKD","volume":"75","author":"Bourrier","year":"2020","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1053\/j.ajkd.2026.06.027_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/1358863X18824654","article-title":"Unique aspects of peripheral artery disease in patients with chronic kidney disease","volume":"24","author":"Arinze","year":"2019","journal-title":"Vasc Med"},{"issue":"1","key":"10.1053\/j.ajkd.2026.06.027_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.kint.2021.04.029","article-title":"Central and peripheral arterial diseases in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"100","author":"Johansen","year":"2021","journal-title":"Kidney Int"},{"issue":"7","key":"10.1053\/j.ajkd.2026.06.027_bib13","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/ndt\/gfv418","article-title":"Traditional and non-traditional risk factors for incident peripheral arterial disease among patients with chronic kidney disease","volume":"31","author":"Chen","year":"2016","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"10.1053\/j.ajkd.2026.06.027_bib14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.amjcard.2012.02.061","article-title":"Risk factors for peripheral arterial disease among patients with chronic kidney disease","volume":"110","author":"Chen","year":"2012","journal-title":"Am J Cardiol"},{"issue":"2 Suppl 1","key":"10.1053\/j.ajkd.2026.06.027_bib15","first-page":"S86","article-title":"Sex Differences in the Incidence of Peripheral Artery Disease in the Chronic Renal Insufficiency Cohort","volume":"9","author":"Wang","year":"2016","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1053\/j.ajkd.2026.06.027_bib16","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.avsg.2021.07.057","article-title":"The Association Between Socioeconomic Factors and Incident Peripheral Artery Disease in the Chronic Renal Insufficiency Cohort (CRIC)","volume":"80","author":"Stoecker","year":"2022","journal-title":"Ann Vasc Surg"},{"issue":"11","key":"10.1053\/j.ajkd.2026.06.027_bib17","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/ki.2010.38","article-title":"Sociodemographic factors contribute to the depressive affect among African Americans with chronic kidney disease","volume":"77","author":"Fischer","year":"2010","journal-title":"Kidney Int"},{"issue":"6","key":"10.1053\/j.ajkd.2026.06.027_bib18","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/ki.2011.153","article-title":"Elevated depressive affect is associated with adverse cardiovascular outcomes among African Americans with chronic kidney disease","volume":"80","author":"Fischer","year":"2011","journal-title":"Kidney Int"},{"issue":"1","key":"10.1053\/j.ajkd.2026.06.027_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1053\/j.ajkd.2011.12.033","article-title":"Factors associated with depressive symptoms and use of antidepressant medications among participants in the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC Studies","volume":"60","author":"Fischer","year":"2012","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1053\/j.ajkd.2026.06.027_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.xkme.2024.100790","article-title":"Depressive Symptoms, Antidepressants, and Clinical Outcomes in Chronic Kidney Disease: Findings from the CRIC Study","volume":"6","author":"Hernandez","year":"2024","journal-title":"Kidney Med"},{"issue":"5","key":"10.1053\/j.ajkd.2026.06.027_bib21","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1177\/1358863X18773161","article-title":"Review of biologic and behavioral risk factors linking depression and peripheral artery disease","volume":"23","author":"Ramirez","year":"2018","journal-title":"Vasc Med"},{"issue":"3","key":"10.1053\/j.ajkd.2026.06.027_bib22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/1474515116687222","article-title":"Depression in patients with peripheral arterial disease: A systematic review","volume":"16","author":"Brostow","year":"2017","journal-title":"Eur J Cardiovasc Nurs"},{"issue":"3","key":"10.1053\/j.ajkd.2026.06.027_bib23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1191\/1358863x05vm622oa","article-title":"Association of anger proneness, depression and low social support with peripheral arterial disease: the Atherosclerosis Risk in Communities Study","volume":"10","author":"Wattanakit","year":"2005","journal-title":"Vasc Med"},{"issue":"4","key":"10.1053\/j.ajkd.2026.06.027_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.112.002667","article-title":"Association between depression and peripheral artery disease: insights from the heart and soul study","volume":"1","author":"Grenon","year":"2012","journal-title":"J Am Heart Assoc"},{"issue":"7 Suppl 2","key":"10.1053\/j.ajkd.2026.06.027_bib25","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1097\/01.ASN.0000070149.78399.CE","article-title":"The Chronic Renal Insufficiency Cohort (CRIC) Study: Design and Methods","volume":"14","author":"Feldman","year":"2003","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"10.1053\/j.ajkd.2026.06.027_bib26","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.2215\/CJN.00070109","article-title":"Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function","volume":"4","author":"Lash","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1053\/j.ajkd.2026.06.027_bib27","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"BECK","year":"1961","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"10.1053\/j.ajkd.2026.06.027_bib28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2190\/M1TX-V1EJ-E43L-RKLF","article-title":"The Beck Depression Inventory as a screening device for major depression in renal dialysis patients","volume":"18","author":"Craven","year":"1988","journal-title":"Int J Psychiatry Med"},{"issue":"3","key":"10.1053\/j.ajkd.2026.06.027_bib29","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1053\/j.ajkd.2009.03.016","article-title":"Validation of depression screening scales in patients with CKD","volume":"54","author":"Hedayati","year":"2009","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10.1053\/j.ajkd.2026.06.027_bib30","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ekir.2018.10.001","article-title":"Depressive Symptoms Associate With Race and All-Cause Mortality in Patients With CKD","volume":"4","author":"Tuot","year":"2018","journal-title":"Kidney Int Rep"},{"issue":"4","key":"10.1053\/j.ajkd.2026.06.027_bib31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2215\/CJN.0000000655","article-title":"Validation of the Beck Depression Inventory in US Hispanic Patients with CKD","volume":"20","author":"Ricardo","year":"2025","journal-title":"Clin J Am Soc Nephrol"},{"issue":"12","key":"10.1053\/j.ajkd.2026.06.027_bib32","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.2215\/CJN.05540420","article-title":"Depression Screening Tools for Patients with Kidney Failure. A Systematic Review","volume":"15","author":"Kondo","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"issue":"12","key":"10.1053\/j.ajkd.2026.06.027_bib33","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.2215\/CJN.16381020","article-title":"Screening for Depression in People with Kidney Failure","volume":"15","author":"Gregg","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"10.1053\/j.ajkd.2026.06.027_bib34","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/CIRCULATIONAHA.109.192703","article-title":"Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond","volume":"121","author":"Jones","year":"2010","journal-title":"Circulation"},{"issue":"3","key":"10.1053\/j.ajkd.2026.06.027_bib35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ekir.2018.01.007","article-title":". Self-reported Medication Adherence and CKD Progression","volume":"3","author":"Cedillo-Couvert","year":"2018","journal-title":"Kidney Int Rep"},{"issue":"2","key":"10.1053\/j.ajkd.2026.06.027_bib36","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1053\/j.ajkd.2012.04.012","article-title":"Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study","volume":"60","author":"Anderson","year":"2012","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10.1053\/j.ajkd.2026.06.027_bib37","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/157340308784245810","article-title":"Critical review of the ankle brachial index","volume":"4","author":"Khan","year":"2008","journal-title":"Curr Cardiol Rev"},{"key":"10.1053\/j.ajkd.2026.06.027_bib38","unstructured":"U.S. Renal Data System. 2024 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2024."},{"issue":"1","key":"10.1053\/j.ajkd.2026.06.027_bib39","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ekir.2016.09.005","article-title":"Depression in Chronic Kidney Disease and End-Stage Renal Disease: Similarities and Differences in Diagnosis, Epidemiology, and Management","volume":"2","author":"Shirazian","year":"2016","journal-title":"Kidney international reports"},{"issue":"2","key":"10.1053\/j.ajkd.2026.06.027_bib40","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1097\/EDE.0000000000000253","article-title":"SAS macro for causal mediation analysis with survival data","volume":"26","author":"Valeri","year":"2015","journal-title":"Epidemiology"},{"key":"10.1053\/j.ajkd.2026.06.027_bib41","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1214\/aos\/1176350951","article-title":"A class of K-sample tests for comparing the cumulative incidence of a competing risk","volume":"16","author":"Gray","year":"1998","journal-title":"Ann Stat"},{"issue":"4","key":"10.1053\/j.ajkd.2026.06.027_bib42","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1046\/j.1523-1755.2003.00860.x","article-title":"Smoking and cardiovascular outcomes in dialysis patients: the United States Renal Data System Wave 2 study","volume":"63","author":"Foley","year":"2003","journal-title":"Kidney Int"},{"issue":"5 suppl 1","key":"10.1053\/j.ajkd.2026.06.027_bib43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3949\/ccjm.87.s1.03","article-title":"New treatments for peripheral artery disease","volume":"87","author":"Bartholomew","year":"2020","journal-title":"Cleve Clin J Med"},{"issue":"1","key":"10.1053\/j.ajkd.2026.06.027_bib44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2215\/CJN.10330819","article-title":"Exclusion of Persons with Kidney Disease in Trials of Peripheral Artery Disease: A Systematic Review of Randomized Trials","volume":"15","author":"Wen","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"issue":"19","key":"10.1053\/j.ajkd.2026.06.027_bib45","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1001\/jama.2017.17131","article-title":"Effect of Sertraline on Depressive Symptoms in Patients With Chronic Kidney Disease Without Dialysis Dependence: The CAST Randomized Clinical Trial","volume":"318","author":"Hedayati","year":"2017","journal-title":"JAMA"},{"issue":"6","key":"10.1053\/j.ajkd.2026.06.027_bib46","doi-asserted-by":"crossref","first-page":"369","DOI":"10.7326\/M18-2229","article-title":"Comparative Efficacy of Therapies for Treatment of Depression for Patients Undergoing Maintenance Hemodialysis: A Randomized Clinical Trial","volume":"170","author":"Mehrotra","year":"2019","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1053\/j.ajkd.2026.06.027_bib47","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2215\/CJN.0000000000000391","article-title":"Safety of Antidepressant Medications to Treat Comorbid Depression in CKD: Are We There Yet?","volume":"19","author":"Hedayati","year":"2024","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638626011819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638626011819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:06:34Z","timestamp":1792796794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638626011819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":47,"alternative-id":["S0272638626011819"],"URL":"https:\/\/doi.org\/10.1053\/j.ajkd.2026.06.027","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Depressive Symptoms and Incident Peripheral Arterial Disease Among Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.ajkd.2026.06.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}]}}