{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:16:52Z","timestamp":1768007812734,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1053\/j.gastro.2003.08.035","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T17:58:00Z","timestamp":1122659880000},"page":"1598-1605","source":"Crossref","is-referenced-by-count":53,"title":["Subclinical intestinal inflammation and sacroiliac changes in relatives of patients with ankylosing spondylitis"],"prefix":"10.1053","volume":"125","author":[{"given":"Ingvar","family":"Bjarnason","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristjan O","family":"Helgason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1rni J","family":"Geirsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudmundur","family":"Sigthorsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga","family":"Reynisdottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gudbjartsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna S","family":"Einarsdottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Sherwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristleifur","family":"Kristjansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d3lafur","family":"Kjartansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjarni","family":"Thjodleifsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"suppl II","key":"10.1053\/j.gastro.2003.08.035_BIB1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/rheumatology\/XXVII.suppl_2.110","article-title":"Historical aspects of the etiology of rheumatoid arthritis","volume":"27","author":"Bywaters","year":"1988","journal-title":"Br J Rheumatol"},{"key":"10.1053\/j.gastro.2003.08.035_BIB2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/gut.42.3.387","article-title":"Peripheral arthropathies in inflammatory bowel disease","volume":"42","author":"Orchard","year":"1998","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2003.08.035_BIB3","first-page":"107","article-title":"Articular complications of ulcerative colitis","volume":"17","author":"Wright","year":"1966","journal-title":"Am J Proctol"},{"key":"10.1053\/j.gastro.2003.08.035_BIB4","first-page":"2860","article-title":"Spondyloarthropathy is underestimated in inflammatory bowel disease","volume":"27","author":"de Vlam","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1053\/j.gastro.2003.08.035_BIB5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF01237793","article-title":"Transplantation antigens in patients with Crohn\u2019s disease","volume":"20","author":"Russell","year":"1995","journal-title":"Am J Dig Dis"},{"key":"10.1053\/j.gastro.2003.08.035_BIB6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0889-857X(21)00706-7","article-title":"Gut and spondyloarthropathies","volume":"18","author":"Leirisalo-Repo","year":"1992","journal-title":"Rheumatol Dis Clin North Am"},{"key":"10.1053\/j.gastro.2003.08.035_BIB7","first-page":"294","article-title":"HLA B27 related arthritis and bowel inflammation: Part 2. Ileocolonoscopy and bowel histology in patients with HLA B27 related arthritis","volume":"12","author":"Mielants","year":"1985","journal-title":"J Rheumatol"},{"key":"10.1053\/j.gastro.2003.08.035_BIB8","series-title":"Spondylarthropathies. Involvement of the gut","first-page":"11","article-title":"Gut inflammation in the pathogenesis of idiopathic forms of reactive arthritis and in the peripheral joint involvement of ankylosing spondylitis","author":"Mielants","year":"1987"},{"issue":"suppl II","key":"10.1053\/j.gastro.2003.08.035_BIB9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/rheumatology\/XXVII.suppl_2.95","article-title":"Ileocolonoscopic findings in seronegative spondyloarthropathies","volume":"27","author":"Mielants","year":"1988","journal-title":"Br J Rheumatol"},{"key":"10.1053\/j.gastro.2003.08.035_BIB10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/art.1780370105","article-title":"High frequency of silent inflammatory bowel disease in spondylarthropathy","volume":"37","author":"Leirisalo-Repo","year":"1994","journal-title":"Arthritis Rheum"},{"key":"10.1053\/j.gastro.2003.08.035_BIB11","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1002\/1529-0131(200112)44:12<2728::AID-ART459>3.0.CO;2-8","article-title":"Inflammatory disease and spondylarthropathy","volume":"44","author":"Smale","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1053\/j.gastro.2003.08.035_BIB12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0016-5085(89)91557-6","article-title":"Ileocolonoscopy in seronegative spondylarthropathy","volume":"96","author":"De Vos","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.08.035_BIB13","first-page":"2273","article-title":"The evolution of spondyloarthropathies in relation to gut histology: II. Histological aspects","volume":"22","author":"Mielants","year":"1995","journal-title":"J Rheumatol"},{"key":"10.1053\/j.gastro.2003.08.035_BIB14","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/0016-5085(95)90708-4","article-title":"Intestinal permeability","volume":"108","author":"Bjarnason","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.08.035_BIB15","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/rheumatology\/33.7.644","article-title":"Intestinal permeability in patients with ankylosing spondylitis and their healthy relatives","volume":"33","author":"Martinez-Gonzales","year":"1994","journal-title":"Br J Rheumatol"},{"key":"10.1053\/j.gastro.2003.08.035_BIB16","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/S0016-5085(03)00383-4","article-title":"Subclinical intestinal inflammation","volume":"124","author":"Thjodleifsson","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.08.035_BIB17","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","article-title":"Evaluation of diagnostic criteria for ankylosing spondylitis","volume":"27","author":"Van der Linden","year":"1984","journal-title":"Arthritis Rheum"},{"key":"10.1053\/j.gastro.2003.08.035_BIB18","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/0016-5085(93)90667-2","article-title":"Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine","volume":"104","author":"Bjarnason","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.08.035_BIB19","series-title":"Inflammatory bowel disease","first-page":"451","article-title":"Ileitis in the spondylarthropathies","author":"De Vos","year":"1997"},{"key":"10.1053\/j.gastro.2003.08.035_BIB20","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/art.1780370806","article-title":"Nonsteroidal antiinflammatory drug-induced small intestinal inflammation and blood loss","volume":"37","author":"Hayllar","year":"1994","journal-title":"Arthritis Rheum"},{"key":"10.1053\/j.gastro.2003.08.035_BIB21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1136\/gut.45.3.362","article-title":"Faecal calprotectin","volume":"45","author":"Tibble","year":"1999","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2003.08.035_BIB22","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3109\/00365529209011186","article-title":"Assessment of the neutrophil dominating calprotectin in feces","volume":"27","author":"Roseth","year":"1992","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2003.08.035_BIB23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/gut.47.4.506","article-title":"A simple method for assessing intestinal inflammation in Crohn\u2019s disease","volume":"47","author":"Tibble","year":"2000","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2003.08.035_BIB24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00003086-199801000-00011","article-title":"Human leukocyte antigen B27 allele is not correlated with fibrodysplasia ossificans progressiva","volume":"346","author":"Calvert","year":"1998","journal-title":"Clin Orthop"},{"key":"10.1053\/j.gastro.2003.08.035_BIB25","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1086\/302759","article-title":"Estimation of variance components of quantitative traits in inbred populations","volume":"66","author":"Abney","year":"2000","journal-title":"Am J Hum Genet"},{"issue":"suppl 32","key":"10.1053\/j.gastro.2003.08.035_BIB26","first-page":"92","article-title":"Radiographic grading of sacroiliitis in Bechterew\u2019s syndrome and allied disorders","volume":"9","author":"Dale","year":"1980","journal-title":"Scand J Rheumatol"},{"key":"10.1053\/j.gastro.2003.08.035_BIB27","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1359\/jbmr.2000.15.6.1132","article-title":"Evidence for a major gene for bone mineral density in idiopathic osteoporotic families","volume":"15","author":"Cardon","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1053\/j.gastro.2003.08.035_BIB28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0140-6736(02)07284-7","article-title":"Crohn\u2019s disease","volume":"359","author":"Shanahan","year":"2002","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2003.08.035_BIB29","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0016-5085(00)70209-5","article-title":"Clinical phenotype is related to HLA genotype in the peripheral arthropathies in inflammatory bowel disease","volume":"118","author":"Orchard","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.08.035_BIB30","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0016-5085(99)70127-7","article-title":"Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats","volume":"116","author":"Rath","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.08.035_BIB31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0889-8553(01)00004-8","article-title":"Microbial factors in inflammatory bowel disease","volume":"31","author":"Farrell","year":"2002","journal-title":"Gastroenterol Clin North Am"},{"issue":"suppl","key":"10.1053\/j.gastro.2003.08.035_BIB32","first-page":"18","article-title":"HLA B27 and ankylosing spondylitis","volume":"3","author":"Contu","year":"1977","journal-title":"J Rheumatol"},{"key":"10.1053\/j.gastro.2003.08.035_BIB33","first-page":"153","article-title":"Occurrence of HLA antigens in patients with ankylosing spondylitis and in their families","volume":"31","author":"Konieczna","year":"1983","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"10.1053\/j.gastro.2003.08.035_BIB34","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/art.1780401015","article-title":"Susceptibility to ankylosing spondylitis in twins","volume":"40","author":"Brown","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1053\/j.gastro.2003.08.035_BIB35","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/1529-0131(200106)44:6<1396::AID-ART233>3.0.CO;2-A","article-title":"Is disease severity in ankylosing spondylitis genetically determined?","volume":"44","author":"Hamersma","year":"2001","journal-title":"Arthritis Rheum"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508503015257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508503015257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T06:11:56Z","timestamp":1626243116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508503015257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S0016508503015257"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2003.08.035","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}