{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:53:26Z","timestamp":1790628806096,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1053\/j.gastro.2003.11.012","type":"journal-article","created":{"date-parts":[[2004,2,4]],"date-time":"2004-02-04T10:14:23Z","timestamp":1075889663000},"page":"476-487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant mice"],"prefix":"10.1053","volume":"126","author":[{"given":"Duan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Mei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"H\u00e5kanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda C.","family":"Samuelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens F.","family":"Rehfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Friis-Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2003.11.012_BIB1","series-title":"Physiology of the gastrointestinal tract","first-page":"1171","article-title":"The ECL cells","author":"H\u00e5kanson","year":"1994"},{"key":"10.1053\/j.gastro.2003.11.012_BIB2","series-title":"Physiology of the gastrointestinal tract","first-page":"1119","article-title":"The Gastric H,K ATPase","author":"Sachs","year":"1994"},{"key":"10.1053\/j.gastro.2003.11.012_BIB3","first-page":"G1","article-title":"Physiological mechanisms of cholecystokinin action on pancreatic secretion","volume":"217","author":"Owyang","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-0115(97)01018-5","article-title":"Neurohormonal regulation of histamine and pancreastatin secretion from isolated rat stomach ECL cells","volume":"71","author":"Lindstr\u00f6m","year":"1997","journal-title":"Regul Pept"},{"key":"10.1053\/j.gastro.2003.11.012_BIB5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0016-5085(93)90719-S","article-title":"Histamine secretion from rat enterochromaffinlike cells","volume":"105","author":"Prinz","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.11.012_BIB6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1113\/jphysiol.1980.sp013361","article-title":"Effects of various gastrointestinal peptides on parietal cells and endocrine cells in the oxyntic mucosa of rat stomach","volume":"305","author":"El Munshid","year":"1980","journal-title":"J Physiol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0026-0495(90)90232-2","article-title":"Gastric somatostatin","volume":"39","author":"Makhlouf","year":"1990","journal-title":"Metabolism"},{"key":"10.1053\/j.gastro.2003.11.012_BIB8","first-page":"G287","article-title":"Cholecystokinin inhibits gastric acid secretion through type \u201cA\u201d cholecystokinin receptors and somatostatin in rats","volume":"263","author":"Lloyd","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB9","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0031-6997(24)01427-3","article-title":"International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors","volume":"51","author":"Noble","year":"1999","journal-title":"Pharmacol Rev"},{"key":"10.1053\/j.gastro.2003.11.012_BIB10","first-page":"G561","article-title":"Impaired gastric acid secretion in gastrin deficient mice","volume":"274","author":"Friis-Hansen","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB11","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0016-5085(97)70199-9","article-title":"Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice","volume":"113","author":"Koh","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.11.012_BIB12","doi-asserted-by":"crossref","first-page":"11825","DOI":"10.1073\/pnas.93.21.11825","article-title":"G protein-coupled cholecystokinin-B\/gastrin receptors are responsible for physiological cell growth of the stomach in vivo","volume":"93","author":"Nagata","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2003.11.012_BIB13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0016-5085(97)90000-7","article-title":"Abnormal gastric histology and decreased acid production in cholecystokinin-B\/gastrin receptor deficient mice","volume":"112","author":"Langhans","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.11.012_BIB14","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/gast.2002.34746","article-title":"Differentiation of gastric ECL cells is altered in CCK2 receptor deficient mice","volume":"123","author":"Chen","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.11.012_BIB15","first-page":"G1302","article-title":"Pancreatic function in CCK-deficient mice","volume":"276","author":"Lacourse","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1172\/JCI4901","article-title":"The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight","volume":"103","author":"Kopin","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2003.11.012_BIB17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1748-1716.1983.tb07308.x","article-title":"Mechanisms of inhibition of gastric acid secretin by vagal denervation in the rat","volume":"119","author":"Vallgren","year":"1983","journal-title":"Acta Physiol Scand"},{"key":"10.1053\/j.gastro.2003.11.012_BIB18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1748-1716.1982.tb07055.x","article-title":"Effects of vagotomy on gastric acid secretion in the rat","volume":"115","author":"H\u00e5kanson","year":"1982","journal-title":"Acta Physiol Scand"},{"key":"10.1053\/j.gastro.2003.11.012_BIB19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0014-2999(87)90436-5","article-title":"Effects of cimetidine, atropine, and pirenzepine on basal and stimulated gastric acid secretion in the rat","volume":"138","author":"Ekelund","year":"1987","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB20","first-page":"145","article-title":"Vagal regulation of acid secretion and gastrin release","volume":"67","author":"Debas","year":"1994","journal-title":"Yale J Biol Med"},{"key":"10.1053\/j.gastro.2003.11.012_BIB21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0167-0115(00)00217-2","article-title":"Neurohormonal regulation of secretion from isolated rat stomach ECL cells","volume":"97","author":"Lindstr\u00f6m","year":"2001","journal-title":"Regul Pept"},{"key":"10.1053\/j.gastro.2003.11.012_BIB22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1749-6632.1998.tb11173.x","article-title":"The pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1-R) is expressed on gastric ECL cells","volume":"865","author":"Zeng","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"10.1053\/j.gastro.2003.11.012_BIB23","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1038\/sj.bjp.0704419","article-title":"ECL-cell histamine mobilization in conscious rats","volume":"134","author":"Norl\u00e9n","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0016-5085(98)70199-4","article-title":"Galanin inhibition of enterochromaffin-like cell function","volume":"115","author":"Zeng","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.11.012_BIB25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0167-0115(00)00176-2","article-title":"Gastrin as a growth factor in the gastrointestinal tract","volume":"93","author":"Koh","year":"2000","journal-title":"Regul Pept"},{"key":"10.1053\/j.gastro.2003.11.012_BIB26","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3109\/00365529009095518","article-title":"Effects of endogenous and exogenous cholecystokinin and of infusion with the cholecystokinin antagonist L-364,718 on pancreatic and gastrointestinal growth","volume":"25","author":"Axelson","year":"1990","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev.physiol.63.1.49","article-title":"Gastrin, CCK, signaling, and cancer","volume":"63","author":"Rozengurt","year":"2001","journal-title":"Annu Rev Physiol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB28","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/clinchem\/45.4.549","article-title":"A library of sequence-specific radioimmunoassays for human chromogranin A","volume":"45","author":"Jensen","year":"1999","journal-title":"Clin Chem"},{"key":"10.1053\/j.gastro.2003.11.012_BIB29","first-page":"73","article-title":"Sequence-specific radioimmunoassays for cholecystokinin, gastrin and somatostatin","volume":"1","author":"Rehfeld","year":"1980","journal-title":"Biomed Res"},{"key":"10.1053\/j.gastro.2003.11.012_BIB30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/00365517209081114","article-title":"Production and evaluation of antibodies for the radioimmunoassay of gastrin","volume":"30","author":"Rehfeld","year":"1972","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1053\/j.gastro.2003.11.012_BIB31","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/clinchem\/44.5.991","article-title":"Accurate measurement of cholecystokinin in plasma","volume":"44","author":"Rehfeld","year":"1998","journal-title":"Clin Chem"},{"key":"10.1053\/j.gastro.2003.11.012_BIB32","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate- phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1053\/j.gastro.2003.11.012_BIB33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF00492340","article-title":"Histamine in endocrine cells in the stomach","volume":"86","author":"H\u00e5kanson","year":"1986","journal-title":"Histochemistry"},{"key":"10.1053\/j.gastro.2003.11.012_BIB34","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/BF00936080","article-title":"Electron microscopic identification of the histamine-storing argyrophil (enterochromaffin-like) cells in the rat stomach","volume":"122","author":"H\u00e5kanson","year":"1971","journal-title":"Z Zellforsch Mikrosk Anat"},{"key":"10.1053\/j.gastro.2003.11.012_BIB35","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/BF00331767","article-title":"Light and electron microscopic identification of the histamine-storing argyrophil (ECL) cell in murine stomach and of its equivalent in other mammals","volume":"118","author":"Capella","year":"1971","journal-title":"Z Zellforsch Mikrosk Anat"},{"key":"10.1053\/j.gastro.2003.11.012_BIB36","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s004410050558","article-title":"Ultrastructure of enterochromaffin-like cells in rat stomach","volume":"283","author":"Chen","year":"1996","journal-title":"Cell Tissue Res"},{"key":"10.1053\/j.gastro.2003.11.012_BIB37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0074-7696(08)61637-X","article-title":"Stereological principles for morphometry in electron microscopic cytology","volume":"26","author":"Weibel","year":"1969","journal-title":"Int Rev Cytol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB38","series-title":"Principles and techniques of electron microscopy. Biological applications","first-page":"237","article-title":"Stereological techniques for electron microscopic morphometry","author":"Weibel","year":"1973"},{"key":"10.1053\/j.gastro.2003.11.012_BIB39","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0016-5085(19)32847-1","article-title":"Quantitative ultrastructural studies on inhibited and on partly stimulated gastric parietal cells","volume":"67","author":"Helander","year":"1974","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.11.012_BIB40","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1083\/jcb.63.2.364","article-title":"Studies on the depletion and accumulation of microvilli and changes in the tubulovesicular compartment of mouse parietal cells in relation to gastric acid secretion","volume":"63","author":"Ito","year":"1974","journal-title":"J Cell Biol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0016-5085(86)90938-8","article-title":"Plasma gastrin and gastric enterochromaffin-like cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats","volume":"90","author":"Larsson","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.11.012_BIB42","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0016-5085(54)80008-4","article-title":"A quantative method for measuring spontaneous gastric acid secretion in the rat","volume":"26","author":"Shay","year":"1954","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.11.012_BIB43","first-page":"G607","article-title":"G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family","volume":"274","author":"Wank","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB44","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3109\/00365529309098297","article-title":"Hypercholecystokininemia produced by pancreaticobiliary diversion causes gastrin-like effects on enterochromaffin-like cells in the stomach of rats subjected to portocaval shunting or antrectomy","volume":"28","author":"Chen","year":"1993","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0167-0115(99)00016-6","article-title":"Histidine decarboxylase in rat stomach ECL cells","volume":"81","author":"Dartsch","year":"1999","journal-title":"Regul Pept"},{"key":"10.1053\/j.gastro.2003.11.012_BIB46","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1128\/MCB.20.13.4932-4947.2000","article-title":"Amino- and carboxy-terminal PEST domains mediate gastrin stabilization of rat L-histidine decarboxylase isoforms","volume":"20","author":"Fleming","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB47","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1113\/jphysiol.1980.sp013355","article-title":"Mechanisms of gastric acid secretion after pylorus and oesophagus ligation in the rat","volume":"305","author":"H\u00e5kanson","year":"1980","journal-title":"J Physiol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB48","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1476-5381.1977.tb08416.x","article-title":"The effect of atropine on acid secretion stimulated by acetylcholine, histamine, and gastrin on the isolated whole stomach of the rat","volume":"61","author":"Bunce","year":"1977","journal-title":"Br J Pharmacol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/00365529609031623","article-title":"Rat stomach enterochromaffin-like cells are not stimulated by pylorus ligation","volume":"31","author":"Zhao","year":"1996","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB50","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1172\/JCI7537","article-title":"PACAP type I receptor activation regulates ECL cells and gastric acid secretion","volume":"104","author":"Zeng","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2003.11.012_BIB51","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1139\/y87-302","article-title":"Vagal inhibition of gastric acid secretion","volume":"65","author":"Davison","year":"1987","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1053\/j.gastro.2003.11.012_BIB52","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1053\/gast.1997.v112.pm9024289","article-title":"Effect of cholinergic agonists on gastrin release from primary cultures of human antral G cells","volume":"112","author":"Koop","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.11.012_BIB53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000138871","article-title":"Muscarinic regulation of somatostatin release from primary cultures of human antral epithelial cells","volume":"44","author":"Buchan","year":"1992","journal-title":"Pharmacology"},{"key":"10.1053\/j.gastro.2003.11.012_BIB54","first-page":"153","article-title":"Effect of acetylcholine on the release of pancreatic and gastric somatostatin-like immunoreactivity in normal, chemically sympathectomized and indomethacin-treated dogs","volume":"29","author":"Schusdziarra","year":"1982","journal-title":"Hepatogastroenterology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508503017931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508503017931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:39:01Z","timestamp":1758033541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508503017931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S0016508503017931"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2003.11.012","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2004,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant mice","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2003.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Gastroenterological Association. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}