{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:16:10Z","timestamp":1778915770030,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1053\/j.gastro.2003.11.048","type":"journal-article","created":{"date-parts":[[2004,2,25]],"date-time":"2004-02-25T21:55:49Z","timestamp":1077746149000},"page":"674-682","source":"Crossref","is-referenced-by-count":55,"title":["Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection"],"prefix":"10.1053","volume":"126","author":[{"given":"Giovanni","family":"Monteleone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Del Vecchio Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampiero","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Vavassori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Monteleone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Colantoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Battista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi Giusto","family":"Spagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Borrelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas T.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Pallone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2003.11.048_BIB1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1146\/annurev.micro.54.1.615","article-title":"The disease spectrum of Helicobacter pylori","volume":"54","author":"Ernst","year":"2000","journal-title":"Annu Rev Microbiol"},{"key":"10.1053\/j.gastro.2003.11.048_BIB2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/35006081","article-title":"The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer","volume":"404","author":"El-Omar","year":"2000","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2003.11.048_BIB3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1023\/A:1021963007225","article-title":"Role of NF-\u03baB and AP-1 on Helicobacter pylori-induced IL-8 expression in AGS cells","volume":"48","author":"Chu","year":"2003","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2003.11.048_BIB4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1042\/bj20020555","article-title":"Mitogen-activated protein kinases and nuclear factor-\u03baB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages","volume":"368","author":"Bhattacharyya","year":"2002","journal-title":"Biochem J"},{"key":"10.1053\/j.gastro.2003.11.048_BIB5","first-page":"951","article-title":"Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin","volume":"63","author":"Cover","year":"2003","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2003.11.048_BIB6","doi-asserted-by":"crossref","first-page":"962","DOI":"10.4049\/jimmunol.158.2.962","article-title":"T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease","volume":"158","author":"D\u2019Elios","year":"1997","journal-title":"J Immunol"},{"key":"10.1053\/j.gastro.2003.11.048_BIB7","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.165.2.1022","article-title":"Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-\u03b3, gene-deficient mice","volume":"165","author":"Smythies","year":"2000","journal-title":"J Immunol"},{"key":"10.1053\/j.gastro.2003.11.048_BIB8","doi-asserted-by":"crossref","first-page":"7456","DOI":"10.4049\/jimmunol.166.12.7456","article-title":"The role of T-cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice","volume":"166","author":"Eaton","year":"2001","journal-title":"J Immunol"},{"key":"10.1053\/j.gastro.2003.11.048_BIB9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.immunol.16.1.137","article-title":"Regulation of immune responses by TGF-\u03b2","volume":"16","author":"Letterio","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"10.1053\/j.gastro.2003.11.048_BIB10","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1084\/jem.180.5.1587","article-title":"Transforming growth factor \u03b2","volume":"180","author":"Wahl","year":"1994","journal-title":"J Exp Med"},{"issue":"suppl 2","key":"10.1053\/j.gastro.2003.11.048_BIB11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1365-2036.16.s2.3.x","article-title":"Conditional loss of TGF-\u03b2 signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice","volume":"16","author":"Hahm","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2003.11.048_BIB12","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1093\/emboj\/18.5.1280","article-title":"Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T-cell responsiveness to TGF-\u03b2","volume":"18","author":"Yang","year":"1999","journal-title":"EMBO J"},{"key":"10.1053\/j.gastro.2003.11.048_BIB13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1172\/JCI12821","article-title":"Blocking Smad7 restores TGF-\u03b21 signaling in chronic inflammatory bowel disease","volume":"108","author":"Monteleone","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2003.11.048_BIB14","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1136\/gut.33.4.472","article-title":"Gliadin induced changes in the expression of MHC-class IIa by human small intestinal epithelium. Organ culture studies celiac disease mucosa","volume":"33","author":"Fais","year":"1992","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2003.11.048_BIB15","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1128\/IAI.64.7.2829-2833.1996","article-title":"Effect of Helicobacter pylori on gastric epithelial cell migration and proliferation in vitro","volume":"64","author":"Ricci","year":"1996","journal-title":"Infect Immun"},{"key":"10.1053\/j.gastro.2003.11.048_BIB16","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0016-5085(97)70128-8","article-title":"Interleukin 12 is expressed and actively released by Crohn\u2019s disease intestinal lamina propria mononuclear cells","volume":"112","author":"Monteleone","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2003.11.048_BIB17","first-page":"1703","article-title":"Establishment and characterization of an in vitro model system for human adenocarcinoma of the stomach","volume":"43","author":"Barranco","year":"1983","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2003.11.048_BIB18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/37284","article-title":"TGF-\u03b2 signalling from cell membrane to nucleus through SMAD proteins","volume":"390","author":"Heldin","year":"1997","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2003.11.048_BIB19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)81696-7","article-title":"Smads","volume":"95","author":"Derynck","year":"1998","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2003.11.048_BIB20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/39369","article-title":"Identification of Smad7, a TGF-\u03b2-inducible antagonist of TGF-\u03b2 signalling","volume":"389","author":"Nakao","year":"1997","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2003.11.048_BIB21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0955-0674(97)80067-1","article-title":"The state of the STATs","volume":"9","author":"Horvath","year":"1997","journal-title":"Curr Opin Cell Biol"},{"key":"10.1053\/j.gastro.2003.11.048_BIB22","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/17826","article-title":"Inhibition of transforming growth factor-\u03b2\/SMAD signalling by the interferon-\u03b3\/STAT pathway","volume":"397","author":"Ulloa","year":"1999","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2003.11.048_BIB23","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","article-title":"A novel transcription factor, T-bet, directs Th1 lineage commitment","volume":"100","author":"Szabo","year":"2000","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2003.11.048_BIB24","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/gut.36.6.874","article-title":"Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon \u03b3 antibody","volume":"36","author":"Przemioslo","year":"1995","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2003.11.048_BIB25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1101\/gad.14.2.187","article-title":"A mechanism of suppression of TGF-\u03b2\/SMAD signaling by NF-\u03baB\/RelA","volume":"14","author":"Bitzer","year":"2000","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2003.11.048_BIB26","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1084\/jem.192.5.695","article-title":"Inhibition of E-selectin gene expression by transforming growth factor \u03b2 in endothelial cells involves coactivator integration of Smad and nuclear factor-\u03baB-mediated signals","volume":"192","author":"Di Chiara","year":"2000","journal-title":"J Exp Med"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508503019590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508503019590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:54:28Z","timestamp":1682643268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508503019590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0016508503019590"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2003.11.048","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}